NeuroMolecular Medicine, Journal Year: 2024, Volume and Issue: 26(1)
Published: Dec. 8, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Aug. 7, 2024
Multicellular organisms are composed of diverse cell types that must coordinate their behaviors through communication. Cell-cell communication (CCC) is essential for growth, development, differentiation, tissue and organ formation, maintenance, physiological regulation. Cells communicate direct contact or at a distance using ligand-receptor interactions. So cellular encompasses two processes: signal conduction generation intercellular transmission signals, transduction reception procession signals. Deciphering networks critical understanding metabolism. First, we comprehensively review the historical milestones in CCC studies, followed by detailed description mechanisms molecule importance main signaling pathways they mediate maintaining biological functions. Then systematically introduce series human diseases caused abnormalities progress clinical applications. Finally, summarize various methods monitoring interactions, including imaging, proximity-based chemical labeling, mechanical force analysis, downstream analysis strategies, single-cell technologies. These aim to illustrate how functions depend on these interactions complexity regulatory regulate crucial processes, homeostasis, immune responses diseases. In addition, this enhances our processes occur after cell-cell binding, highlighting its application discovering new therapeutic targets biomarkers related precision medicine. This collective provides foundation developing targeted drugs personalized treatments.
Language: Английский
Citations
37
Biomolecules, Journal Year: 2022, Volume and Issue: 12(11), P. 1676 - 1676
Published: Nov. 11, 2022
Damage or loss of brain cells and impaired neurochemistry, neurogenesis, synaptic nonsynaptic plasticity the lead to dementia in neurodegenerative diseases, such as Alzheimer's disease (AD). Injury synapses neurons accumulation extracellular amyloid plaques intracellular neurofibrillary tangles are considered main morphological neuropathological features AD. Age, genetic epigenetic factors, environmental stressors, lifestyle contribute risk AD onset progression. These factors associated with structural functional changes brain, leading cognitive decline. Biomarkers reflect cause specific function, especially pathways neurotransmission, neuroinflammation, bioenergetics, apoptosis, oxidative nitrosative stress. Even initial stages, is Aβ neurotoxicity, mitochondrial dysfunction, tau neurotoxicity. The integrative amyloid-tau-mitochondrial hypothesis assumes that primary neurotoxicity oligomers oligomers, their mutual synergy. For development new efficient drugs, targeting elimination potentiation effects, unwanted protein interactions biomarkers (mainly dysfunction) early stage seems promising.
Language: Английский
Citations
53
MedComm, Journal Year: 2023, Volume and Issue: 4(3)
Published: June 1, 2023
Exosomes are extracellular vesicles with diameters of about 100 nm that naturally secreted by cells into body fluids. They derived from endosomes and wrapped in lipid membranes. involved intracellular metabolism intercellular communication. contain nucleic acids, proteins, lipids, metabolites the cell microenvironment cytoplasm. The contents exosomes can reflect their cells' origin allow observation tissue changes states under disease conditions. Naturally have specific biomolecules act as "fingerprint" parent cells, changed pathological conditions be used biomarkers for diagnosis. low immunogenicity, small size, cross blood-brain barrier. These characteristics make unique engineering carriers. incorporate therapeutic drugs achieve targeted drug delivery. carriers therapy still infancy, but exosome provides a new perspective cell-free therapy. This review discussed relationship occurrence treatment some neuropsychiatric diseases. In addition, future applications diagnosis disorders were evaluated this review.
Language: Английский
Citations
31
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 925, P. 171774 - 171774
Published: March 18, 2024
Language: Английский
Citations
14
Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 3921 - 3948
Published: June 1, 2024
Abstract: Alzheimer's disease (AD) is the most common neurodegenerative illness, characterized by memory loss and cognitive decline, accounting for 60– 80% of dementia cases. AD senile plaques made up amyloid β (Aβ) protein, intracellular neurofibrillary tangles caused hyperphosphorylation tau protein linked with microtubules, neuronal loss. Currently, therapeutic treatments nanotechnological developments are effective in treating symptoms AD, but a cure illness has not yet been found. Recently, increased study extracellular vesicles (EVs) led to growing awareness their significant involvement disorders, including AD. Exosomes small that transport various components messenger RNAs, non-coding proteins, lipids, DNA, other bioactive compounds from one cell another, facilitating information transmission material movement. There evidence indicating exosomes have complex functions may dual role contributing death also helping alleviate pathological progression disease. Therefore, primary aim this review outline updated understandings on biogenesis many generation, conveyance, distribution, elimination hazardous proteins related This intended provide novel insights understanding development, specific treatment, early detection Keywords: disease, exosomes, pathogenesis, diagnosis, treatment
Language: Английский
Citations
11
Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15
Published: June 16, 2023
Alzheimer’s disease (AD) is the most common neurodegenerative characterized by progressive loss of memory and cognitive dysfunction. The primary pathological hallmarks AD are senile plaques formed deposition amyloid β (Aβ) protein, intracellular neurofibrillary tangles resulting from hyperphosphorylation microtubule-associated protein tau, neurons. At present, although exact pathogenesis still unclear there a lack effective treatment for in clinical practice, researchers have never stopped exploring pathogenic mechanism AD. In recent years, with rise research extracellular vesicles (EVs), people gradually realize that EVs also play important roles diseases. Exosomes, as member small EVs, regarded carriers information exchange material transport between cells. Many cells central nervous system can release exosomes both physiological conditions. Exosomes derived damaged nerve not only participate Aβ production oligomerization, but disseminate toxic proteins tau to neighboring neurons, thereby acting “seeds” amplify effects misfolded proteins. Furthermore, may be involved degradation clearance process Aβ. There increasing evidence suggest multiple Just like double-edged sword, pathology direct or indirect way, causing neuronal loss, alleviating progression this review, we summarize discuss current reported findings on role
Language: Английский
Citations
18
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 11054 - 11054
Published: July 4, 2023
Alzheimer’s disease (AD) and Parkinson’s (PD) are the most common neurodegenerative diseases (NDDs) threatening lives of millions people worldwide, including especially elderly people. Currently, due to lack a timely diagnosis proper intervention strategy, AD PD largely remain incurable. Innovative therapy highly desired. Exosomes small vesicles that present in various bodily fluids, which contain proteins, nucleic acids, active biomolecules, play crucial role intercellular communication. In recent years, exosomes pathogenesis, early diagnosis, treatment has attracted ascending attention. However, exact pathogenesis theragnostic not been fully illustrated. review, we first introduce biogenesis, components, uptake, function exosomes. Then elaborate on involvement PD. Moreover, application therapeutics is also summarized discussed. Additionally, serving as drug carriers deliver medications central nervous system specifically addressed. The potential explored, discussing their applications treatment, well current limitations. Given limitation exosomes, propose future perspectives for better utilizing NDDs. Hopefully, it would pave ways expanding biological fundamental research theranostics
Language: Английский
Citations
14
Current Stem Cell Research & Therapy, Journal Year: 2023, Volume and Issue: 19(6), P. 852 - 864
Published: July 27, 2023
Extracellular vesicles (EVs) are one of the crucial means intercellular communication, which takes many different forms. They heterogeneous, secreted by a range cell types, and can be generally classified into microvesicles exosomes depending on their location function. Exosomes small EVs with diameters about 30-150 nm diverse sources.
Language: Английский
Citations
14
Life, Journal Year: 2022, Volume and Issue: 13(1), P. 121 - 121
Published: Dec. 31, 2022
Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disease and the most common adult motor neuron disease. The pathogenesis complex with perturbation of multiple pathways proposed, including mitochondrial dysfunction, RNA processing, glutamate excitotoxicity, endoplasmic reticulum stress, protein homeostasis endosomal transport/extracellular vesicle (EV) secretion. EVs are nanoscopic membrane-bound particles that released from cells, involved in intercellular communication proteins, lipids genetic material, there increasing evidence their role ALS. After discussing biogenesis EVs, we review roles propagation pathological proteins ALS, such as TDP-43, SOD1 FUS, contribution to pathology. We also discuss ALS related genes which EV formation vesicular trafficking, before considering dysregulation found how these have been investigated potential biomarkers. Finally, highlight use therapeutic agents particular derived mesenchymal stem cells drug delivery vectors for treatment strategies.
Language: Английский
Citations
19
Life Sciences, Journal Year: 2025, Volume and Issue: 365, P. 123468 - 123468
Published: Feb. 13, 2025
Language: Английский
Citations
0