Roles of Oxidative Stress in Synaptic Dysfunction and Neuronal Cell Death in Alzheimer’s Disease

Antioxidants, Journal Year: 2023, Volume and Issue: 12(8), P. 1628 - 1628

Published: Aug. 17, 2023

Alzheimer’s disease (AD) is a brain disorder that progressively undermines memory and thinking skills by affecting the hippocampus entorhinal cortex. The main histopathological hallmarks of AD are presence abnormal protein aggregates (Aβ tau), synaptic dysfunction, aberrant proteostasis, cytoskeletal abnormalities, altered energy homeostasis, DNA RNA defects, inflammation, neuronal cell death. However, oxidative stress or damage also evident commonly overlooked considered consequence advancement dementia symptoms. control onset linked to activity amyloid-β peptide, which may serve as both antioxidant pro-oxidant molecules. Furthermore, correlated with proteins, nucleic acids, lipids in vulnerable populations, ultimately lead death through different molecular mechanisms. By recognizing an integral feature AD, alternative therapeutic preventive interventions developed tested potential complementary therapies for this devastating neurodegenerative disease.

Language: Английский

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Non-Enzymatic Antioxidants against Alzheimer’s Disease: Prevention, Diagnosis and Therapy

Antioxidants, Journal Year: 2023, Volume and Issue: 12(1), P. 180 - 180

Published: Jan. 12, 2023

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive memory loss and cognitive decline. Although substantial research has been conducted to elucidate the complex pathophysiology of AD, therapeutic approach still limited efficacy in clinical practice. Oxidative stress (OS) established as an early driver several age-related diseases, including neurodegeneration. In increased levels reactive oxygen species mediate neuronal lipid, protein, nucleic acid peroxidation, mitochondrial dysfunction, synaptic damage, inflammation. Thus, identification novel antioxidant molecules capable detecting, preventing, counteracting AD onset progression utmost importance. However, although studies have published, comprehensive up-to-date overviews principal anti-AD agents harboring properties remain scarce. this narrative review, we summarize role vitamins, minerals, flavonoids, non-flavonoids, mitochondria-targeting molecules, organosulfur compounds, carotenoids non-enzymatic antioxidants with diagnostic, preventative, potential, thereby offering insights into relationship between OS

Language: Английский

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Types of memory, dementia, Alzheimer’s disease, and their various pathological cascades as targets for potential pharmacological drugs

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 96, P. 102289 - 102289

Published: April 1, 2024

Language: Английский

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Alzheimer’s Disease as Type 3 Diabetes: Understanding the Link and Implications

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11955 - 11955

Published: Nov. 7, 2024

Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are two prevalent conditions that present considerable public health issue in aging populations worldwide. Recent research has proposed a novel conceptualization of AD as "type 3 diabetes", highlighting the critical roles insulin resistance impaired glucose metabolism pathogenesis disease. This article examines implications this association, exploring potential new avenues for treatment preventive strategies AD. Key evidence linking to emphasizes metabolic processes contribute neurodegeneration, including inflammation, oxidative stress, alterations signaling pathways. By framing within context, we can enhance our understanding its etiology, which turn may influence early diagnosis, plans, measures. Understanding manifestation opens up possibility employing therapeutic incorporate lifestyle modifications use antidiabetic medications mitigate cognitive decline. integrated approach improve patient outcomes deepen comprehension intricate relationship between neurodegenerative diseases disorders.

Language: Английский

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A Combinational Therapy for Preventing and Delaying the Onset of Alzheimer’s Disease: A Focus on Probiotic and Vitamin Co-Supplementation

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 202 - 202

Published: Feb. 5, 2024

Alzheimer’s disease is a progressive neurodegenerative disorder with complex etiology, and effective interventions to prevent or delay its onset remain global health challenge. In recent years, there has been growing interest in the potential role of probiotic vitamin supplementation as complementary strategies for prevention. This review paper explores current scientific literature on use probiotics vitamins, particularly A, D, E, K, B-complex context prevention management. We delve into mechanisms through which may modulate gut–brain interactions neuroinflammation while vitamins play crucial roles neuronal cognitive function. The also examines collective impact this combinational therapy reducing risk factors associated disease, such oxidative stress, inflammation, gut dysbiosis. By providing comprehensive overview existing evidence mechanisms, aims shed light promise co-supplementation multifaceted approach combat offering insights possible avenues future research clinical application.

Language: Английский

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The Involvement of Ascorbic Acid in Cancer Treatment

Molecules, Journal Year: 2024, Volume and Issue: 29(10), P. 2295 - 2295

Published: May 13, 2024

Vitamin C (VC), also known as ascorbic acid, plays a crucial role water-soluble nutrient within the human body, contributing to variety of metabolic processes. Research findings suggest that increased doses VC demonstrate potential anti-tumor capabilities. This review delves into mechanisms absorption and its implications for cancer management. Building upon these foundational insights, we explore modern delivery systems VC, evaluating use in diverse treatment methods. These include starvation therapy, chemodynamic therapy (CDT), photothermal/photodynamic (PTT/PDT), electrothermal immunotherapy, cellular reprogramming, chemotherapy, radiotherapy, various combination therapies.

Language: Английский

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Ascorbate and its transporter SVCT2: The dynamic duo's integrated roles in CNS neurobiology and pathophysiology

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 212, P. 448 - 462

Published: Jan. 3, 2024

Ascorbate is a small antioxidant molecule essential for the proper development and function of brain. transported into brain between cells via Sodium vitamin C co-transporter 2 (SVCT2). This review provides an in-depth analysis ascorbate's physiology, including how ascorbate absorbed from food CNS, emphasizing cellular mechanisms recycling release in different CNS compartments. Additionally, delves various functions its impact on epigenetic modulation, synaptic plasticity, neurotransmission. It also emphasizes role neuromodulation involvement neurodevelopmental processes disorders. Furthermore, it analyzes relationship duo ascorbate/SVCT2 neuroinflammation, particularly effects microglial activation, cytokine release, oxidative stress responses, highlighting association with neurodegenerative diseases, such as Alzheimer's disease (AD). Overall, this crucial dynamic physiology pathology need further research to fully comprehend significance neurobiological context potential therapeutic applications.

Language: Английский

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Serum vitamin C levels and their correlation with chronic kidney disease in adults: a nationwide study

Renal Failure, Journal Year: 2024, Volume and Issue: 46(1)

Published: Jan. 8, 2024

Introduction Inflammation and oxidative stress play significant roles in the development of chronic kidney disease (CKD). Given recognized antioxidant properties vitamin C, our study aimed to explore correlation between CKD serum C levels.

Language: Английский

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Restoring Impaired Neurogenesis and Alleviating Oxidative Stress by Cyanidin against Bisphenol A-induced Neurotoxicity: In Vivo and In Vitro Evidence

Current Drug Discovery Technologies, Journal Year: 2024, Volume and Issue: 21(2)

Published: Jan. 26, 2024

Background: Bisphenol A (BPA) is a known neurotoxic compound with potentially harmful effects on the nervous system. Cyanidin (CYN) has shown promise as neuroprotective agent. Objective: The current study aims to determine efficacy of CYN against BPA-induced neuropathology. Methods: In vitro experiments utilized PC12 cells were pre-treated gradient doses and further stimulated 10ng/ml BPA. DPPH radical scavenging activity, catalase total ROS nitric oxide activity done. vivo assessments employed doublecortin immunohistochemistry brain in BPA-exposed Sprague-Dawley rats. Further, silico molecular docking all proteins involved canonical Wnt signaling was performed using Autodock v4.2 tool BIOVIA Discovery Studio Visualizer. Results: IC50 values ascorbic acid determined dose-response curves, it found be 24.68 ± 0.563µg/ml 20.69 1.591µg/ml, respectively. BPA-stimulated pretreated showed comparable (p=0.0287). reactive species production by CYN-treated significantly decreased compared (p<0.0001). Moreover, inhibited BPA control vivo, positively affected immature neuron quantity, correlating dosage. During analysis, exhibited binding affinity > -7Kcal/mol key associated Wnt/β-catenin cascade. Conclusion: Conclusively, our finding suggests that counteracting BPAinduced oxidative stress, improving compromised neurogenesis hippocampal cortical regions, displaying notable interactions proteins. Thereby, could render its potential neuropathology

Language: Английский

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The evidence to date: implications of l-ascorbic acid in the pathophysiology of aging

The Journal of Physiological Sciences, Journal Year: 2024, Volume and Issue: 74(1)

Published: May 11, 2024

L-Ascorbic acid, commonly known as vitamin C, has been used not only for disease prevention and in complementary alternative medicine, but also anti-aging purposes. However, the scientific evidence is yet sufficient. Here, we review physiological functions of C its relationship with various pathological conditions, including our previous findings, discuss prospects application healthy longevity. In summary, levels are associated lifespan several animal models. Furthermore, clinical studies have shown that blood lower middle-aged older adults than younger adults. Lower observed conditions such chronic kidney obstructive pulmonary elderly. These observations suggest implications age-related mechanisms owing to functions.

Language: Английский

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