Recent Advances in the Development of Lipid-, Metal-, Carbon-, and Polymer-Based Nanomaterials for Antibacterial Applications DOI Creative Commons
Ruohua Ren,

Chiaxin Lim,

Shiqi Li

et al.

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(21), P. 3855 - 3855

Published: Nov. 1, 2022

Infections caused by multidrug-resistant (MDR) bacteria are becoming a serious threat to public health worldwide. With an ever-reducing pipeline of last-resort drugs further complicating the current dire situation arising due antibiotic resistance, there has never been greater urgency attempt discover potential new antibiotics. The use nanotechnology, encompassing broad range organic and inorganic nanomaterials, offers promising solutions. Organic including lipid-, polymer-, carbon-based have inherent antibacterial activity or can act as nanocarriers in delivering agents. Nanocarriers, owing protection enhanced bioavailability encapsulated drugs, ability enable increased concentration drug be delivered infected site reduce associated toxicity elsewhere. On other hand, metal-based nanomaterials exhibit multivalent mechanisms that combat MDR effectively occurrence bacterial resistance. These great for prevention treatment infection. Recent advances field nanotechnology enabling researchers utilize nanomaterial building blocks intriguing ways create multi-functional nanocomposite materials. materials, formed carbon-, blocks, opened avenue unprecedented physiochemical properties activities being observed when compared their mono-constituent parts. This review covers latest nanotechnologies used design development nano- materials fight with different purposes. Our aim is discuss summarize these recently established respective nanocomposites, application, challenges applications treating bacteria. In addition, we prospects antimicrobial look forward develop emphasizing clinical translation.

Language: Английский

Biofabrication of nanoparticles: sources, synthesis, and biomedical applications DOI Creative Commons
Deepak Kulkarni, Rushikesh S. Sherkar,

Chaitali S. Shirsathe

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: May 2, 2023

Graphical Abstract Sources for biogenic synthesis: The synthesis sources include but are not limited to bacteria, fungi, algae, yeasts, marine and plant sources.

Language: Английский

Citations

114
Recent Advances in Plant-Mediated Zinc Oxide Nanoparticles with Their Significant Biomedical Properties DOI Creative Commons
Muhanad Alhujaily, Salim Albukhaty, Mohammad Yusuf

et al.

Bioengineering, Journal Year: 2022, Volume and Issue: 9(10), P. 541 - 541

Published: Oct. 11, 2022

Compared to traditional physical and chemical approaches, nanobiotechnology plant-based green synthesis procedures offer significant advantages, as well having a greater range of medical biotechnological applications. Nanoparticles zinc oxide (ZnO NPs) have recently been recognized promising option for many industries, including optics, electrics, packaged foods, medicine, due their biocompatibility, low cytotoxicity, cost-effectiveness. Several studies shown that ions are important in triggering cell apoptosis by promoting the generation reactive oxygen species (ROSs) releasing (Zn2+), which toxic cells. The nature chemicals used ZnO nanoparticles limits clinical utility. An overview recent developments NP is presented this review, emphasizing plant parts reducing agents applications, antimicrobial, anticancer, antioxidant, anti-inflammatory properties, key mechanisms action these applications facilitate further research on biomedical fields future.

Language: Английский

Citations

94
The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future? DOI Creative Commons
Peter Takáč, Radka Michalková, Martina Čižmáriková

et al.

Life, Journal Year: 2023, Volume and Issue: 13(2), P. 466 - 466

Published: Feb. 7, 2023

Cancer is a fatal disease with complex pathophysiology. Lack of specificity and cytotoxicity, as well the multidrug resistance traditional cancer chemotherapy, are most common limitations that often cause treatment failure. Thus, in recent years, significant efforts have concentrated on development modernistic field called nano-oncology, which provides possibility using nanoparticles (NPs) aim to detect, target, treat diseases. In comparison conventional anticancer strategies, NPs provide targeted approach, preventing undesirable side effects. What more, nanoparticle-based drug delivery systems shown good pharmacokinetics precise targeting, reduced resistance. It has been documented that, cells, promote reactive oxygen species (ROS) production, induce cell cycle arrest apoptosis, activate ER (endoplasmic reticulum) stress, modulate various signaling pathways, etc. Furthermore, their ability inhibit tumor growth vivo also documented. this paper, we reviewed role silver (AgNPs) nanomedicine, discussing numerous mechanisms by they render properties under both vitro conditions, potential diagnosis cancer.

Language: Английский

Citations

94
Selenium Nanoparticles: Green Synthesis and Biomedical Application DOI Creative Commons

Е. О. Михайлова

Molecules, Journal Year: 2023, Volume and Issue: 28(24), P. 8125 - 8125

Published: Dec. 15, 2023

Selenium nanoparticles (SeNPs) are extremely popular objects in nanotechnology. "Green" synthesis has special advantages due to the growing necessity for environmentally friendly, non-toxic, and low-cost methods. This review considers biosynthesis mechanism of bacteria, fungi, algae, plants, including role various biological substances processes reducing selenium compounds SeNPs their further packaging. Modern information approaches possible biomedical use presented: antimicrobial, antiviral, anticancer, antioxidant, anti-inflammatory, other properties, as well mechanisms these processes, that have important potential therapeutic value.

Language: Английский

Citations

45
Iron oxide decorated hexagonal boron nitride modified electrochemical sensor for the detection of nitrofurantoin in human urine samples DOI

Gokul Sridharan,

Colin Godwin,

Raji Atchudan

et al.

Journal of the Taiwan Institute of Chemical Engineers, Journal Year: 2024, Volume and Issue: 163, P. 105320 - 105320

Published: Jan. 3, 2024

Language: Английский

Citations

30
Nanoengineered chitosan functionalized titanium dioxide biohybrids for bacterial infections and cancer therapy DOI Creative Commons
Mohammad Shabib Akhtar,

Chandrasekaran Karthikeyan,

Sharmila Saminathan

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 14, 2024

Abstract Nanoengineered chitosan functionalized titanium dioxide biohybrids (CTiO 2 @NPs) were prepared with Amomum subulatum Roxb extract via one-pot green method and assessed by UV–Vis spectroscopy, XRD, SEM EDAX analyses. As revealed XRD pattern, the nanohybrids exhibits a rutile TiO crystallites around 45 nm in size. The emergence of Ti–O–Ti bond is identified observing peak between 400 800 cm −1 . A wide bandgap (4.8 eV) has been observed CTiO @NPs, due to quantum confinement effects oxygen vacancies reveal intriguing potential developed for various applications. Surface flaws an emission band at 382, 437, 482, 517, 556 nm. They also exhibit better antibacterial performances using well diffusion against Staphylococcus aureus , Bacillus substilis Klebsiella pneumonia Escherichia coli @NPs discovered have free radical scavenging activity on DPPH analysis IC 50 value as 95.80 μg/mL standard (Vitamin C) 87.62 μg/mL. exhibited anticancer properties osteosarcoma (MG-63) cell line. All these findings suggest that there forum further useful therapeutic Therefore, we claim nano-engineered carbohydrated phytohybrid promising solution bacterial infections bone cancer.

Language: Английский

Citations

23
Application of Fourier Transform Infrared (FTIR) Spectroscopy in Characterization of Green Synthesized Nanoparticles DOI Creative Commons
Sylwia Pasieczna‐Patkowska, Marcin Cichy, Jolanta Flieger

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 684 - 684

Published: Feb. 4, 2025

The fundamental principle of Fourier Transform Infrared (FTIR) spectroscopy is based on the vibration and rotation atoms, it has become a universal widely used spectral methodology for detection internal molecular structures in diverse range fields. A considerable number review articles pertaining to applications FTIR have been published recent years. Nevertheless, comprehensive summary application nanoparticles’ (NPs’) green synthesis yet be presented. In present paper, we propose series case studies that demonstrate analysis metal oxide NPs synthesized using processes. Furthermore, presented position functional group bands spectra are responsible reduction, capping stabilization NPs. this review, explore advantages limitations methodologies overcoming these challenges. We also potential solutions complex spectra. intended serve as compendium information researchers engaged field NPs, utilizing research tool.

Language: Английский

Citations

6
Date seeds polysaccharides as novel capping agents for selenium nanoparticles: Synthesis, characterization, stability, biological activities, and gut microbiota modulation DOI
Athira Jayasree Subhash, Gafar Babatunde Bamigbade, M. Z. Abdin

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 470, P. 142746 - 142746

Published: Jan. 2, 2025

Language: Английский

Citations

2
Gelatin/PLA-loaded gold nanocomposites synthesis using Syzygium cumini fruit extract and their antioxidant, antibacterial, anti-inflammatory, antidiabetic and anti-Alzheimer’s activities DOI Creative Commons
Manickam Rajkumar,

S. I. Davis Presley,

Nathiya Thiyagarajulu

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 15, 2025

Nanotechnology has experienced significant advancements, attracting considerable attention in various biomedical applications. This innovative study synthesizes and characterizes Ge/PLA/AuNCs (gelatin/PLA/gold nanocomposites) using Syzygium cumini extract to evaluate their The UV–Visible spectroscopy results an absorption peak at 534 nm were primarily confirmed by synthesis. FTIR spectrum showed functional groups the XRD patterns crystalline shape structure of nanocomposites. FESEM HRTEM a oval with average particle size 21 nm. Ge/PLA/AuNC's remarkable antioxidant activity, as evidenced DPPH (70.84 ± 1.64%), ABTS activity (86.17 1.96%), reducing power (78.42 1.48%) concentration 100 μg/mL was observed. zone inhibition against Staphylococcus aureus (19.45 0.89 mm) Echericia coli (20.83 0.97 revealed excellent antibacterial Ge/PLA/AuNCs. anti-diabetic supported α-amylase (82.56 1.49%) α-glucosidase (80.27 1.57%). anti-Alzheimer AChE (76.37 1.18%) BChE (85.94 1.38%) enzymes. In vivo studies zebrafish embryos that have biocompatibility nontoxicity. SH-SY5Y cell line demonstrated improved viability (95.27 1.62%) enhanced neuronal growth following treatment. conclusion, present highlights cost-effective non-toxic properties Furthermore, it presents attractive promising approach for future

Language: Английский

Citations

2
Adsorption of pharmaceutical products from aqueous solutions on functionalized carbon nanotubes by conventional and green methods: A critical review DOI
Emanuele Dutra Valente Duarte, Mariana Gomes Oliveira, Marcela Pires Spaolonzi

et al.

Journal of Cleaner Production, Journal Year: 2022, Volume and Issue: 372, P. 133743 - 133743

Published: Aug. 24, 2022

Language: Английский

Citations

59