Neurological and psychiatric presentations associated with human monkeypox virus infection: A systematic review and meta-analysis

EClinicalMedicine, Journal Year: 2022, Volume and Issue: 52, P. 101644 - 101644

Published: Sept. 8, 2022

Neuropsychiatric presentations of monkeypox (MPX) infection have not been well characterised, despite evidence nervous system involvement associated with the related smallpox infection.

Language: Английский

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Clinical, Prognostic, and Longitudinal Functional and Neuropsychological Features of West Nile Virus Neuroinvasive Disease in the United States: A Systematic Review and Meta‐Analysis

Annals of Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Objective West Nile virus (WNV) is the most common cause of arboviral disease in United States. Approximately 1% infections involve nervous system, commonly resulting encephalitis (WNE), meningitis (WNM), or acute flaccid paralysis (AFP). Methods In this systematic review, we characterized comprehensively diagnostic and clinical features WNV neuroinvasive (WNND) States, as well evidence regarding prognostic factors long‐term outcomes WNND. Results We identified 47 relevant studies reporting data on longitudinal Across studies, presenting symptoms were fever (88%), nausea/vomiting (58%), fatigue (50%) coupled neurologically with headache (50%), altered mental status (39%), focal weakness (32%). Pooled mortality was 9.2%, 42.1% reported cases required intensive care unit (ICU) admission. meta‐analyses, chronic kidney (odds ratio [OR] = 5.99, 95% confidence interval [CI] 2.71–13.23), diabetes mellitus (OR 2.43, CI 1.54–3.84), hypertension 4.01, 2.39–6.72) associated an increased risk mortality. Multidomain neurocognitive impairment several at post‐hospitalization follow‐up, although marked heterogeneity between study methodology. Subjective impairment, notably (37–75%), memory concerns (11–57%), concentration deficits (17–48%), depression (17–38%), also follow‐up. Interpretation These findings underscore significant morbidity WNND setting. Our may additionally provide utility for stratification hospitalized patients suggest need further evaluation novel therapeutics to prevent substantial disease‐associated disability. ANN NEUROL 2025

Language: Английский

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Mapping Extracellular Space Features of Viral Encephalitis to Evaluate the Proficiency of Anti‐Viral Drugs

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(18)

Published: Jan. 20, 2024

Abstract The extracellular space (ECS) is an important barrier against viral attack on brain cells, and dynamic changes in ECS microstructure characteristics are closely related to the progression of encephalitis efficacy antiviral drugs. However, mapping precise morphological rheological features still challenging so far. Here, a robust approach developed using single‐particle diffusional fingerprinting quantum dots combined with machine learning map predict These results demonstrated that this can characterize microrheology geometry at different stages infection identify subtle induced by drug treatments. This provides potential platform for proficiency assessment expected offer reliable basis clinical translation

Language: Английский

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Neurotrophin Signaling Impairment by Viral Infections in the Central Nervous System

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(10), P. 5817 - 5817

Published: May 22, 2022

Neurotrophins, such as nerve growth factor (NGF), brain-derived neurotrophic (BDNF), and neurotrophin 3 (NT-3), NT-4, NT-5, are proteins involved in several important functions of the central nervous system. The activation signaling pathways these neurotrophins, or even by their immature form, pro-neurotrophins, starts with recognition cellular receptors, tropomyosin receptor kinase (Trk) 75 kD NT receptors (p75NTR). Trk is considered to have a high affinity for attachment specific while p75NTR has less neurotrophins. correct functioning contributes proper brain development, neuronal survival, synaptic plasticity. Unbalanced levels neurotrophins pro-neurotrophins been associated neurological disorders, illustrating importance molecules Furthermore, reports indicated that viruses can alter normal interfering pathways. This work discusses system, pathways, how affect them.

Language: Английский

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Tick-Borne Encephalitis (TBE): From Tick to Pathology

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(21), P. 6859 - 6859

Published: Oct. 30, 2023

Tick-borne encephalitis (TBE) is a viral arthropod infection, endemic to large parts of Europe and Asia, characterised by neurological involvement, which can range from mild severe, in 33-60% cases, it leads post-encephalitis syndrome long-term morbidity. While TBE virus, now identified as Orthoflavivirus encephalitidis, was originally isolated 1937, the pathogenesis not fully appreciated with mode transmission (blood, tick, alimentary), strain, host immune response, age, likely helping shape disease phenotype that we explore this review. Importantly, incidence increasing, due global warming, its epidemiology evolving, new foci reported across UK. As such, better understanding symptomatology, diagnostics, treatment, prevention required inform healthcare professionals going forward, review addresses detail. To end, need for robust national surveillance data randomised control trial regarding use various antivirals (e.g., Galidesivir 7-deaza-2'-CMA), monoclonal antibodies, glucocorticoids improve management outcomes TBE.

Language: Английский

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Beyond the acute phase: a comprehensive literature review of long-term sequelae resulting from infectious diseases

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 31, 2024

Infectious diseases have consistently served as pivotal influences on numerous civilizations, inducing morbidity, mortality, and consequently redirecting the course of history. Their impact extends far beyond acute phase, characterized by majority symptom presentations, to a multitude adverse events sequelae that follow viral, parasitic, fungal, or bacterial infections. In this context, myriad related various infectious been identified, spanning short long-term durations. Although these are known affect thousands individuals individually, comprehensive evaluation all potential effects has yet be undertaken. We present literature review delineating primary attributable major diseases, categorized systems, symptoms, duration. This compilation serves crucial resource, illuminating ramifications for healthcare professionals worldwide. Moreover, highlights substantial burden impose global health economies, facet often overshadowed predominant focus phase. Patients frequently discharged following resolution with minimal follow-up comprehend address sequelae. emphasizes pressing need sustained vigilance, thorough patient monitoring, strategic management, rigorous research understand mitigate lasting economic impacts more fully.

Language: Английский

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Attention Deficit/Hyperactivity Disorder in Adults: Position of Portuguese Experts on Diagnosis and Treatment

Acta Médica Portuguesa, Journal Year: 2025, Volume and Issue: 38(3), P. 187 - 196

Published: March 3, 2025

Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental that often persists into adulthood, affecting approximately 1.5% - 3% of the adult population in Portugal. Untreated ADHD adults associated with increased risks substance abuse, criminality, poor academic and professional performance. Less than 20% are properly diagnosed treated due to overlapping symptoms other psychopathological comorbidities, lack awareness, prejudice surrounding this disorder. This position paper results from expert meetings involving six Portuguese experts managing ADHD. It aims guide diagnostic treatment strategies, as well address main barriers limitations these patients within context, specifically regarding diagnosis treatment. Furthermore, it seeks clarify demystify misconceptions, increase medical promote discussion for development guidelines improve diagnosis, treatment, quality life

Language: Английский

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Diagnostic accuracy of multiplex real-time PCR for detecting viruses associated with encephalitis: A systematic review and meta-analysis protocol

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0318805 - e0318805

Published: March 13, 2025

Background Encephalitis is the most common infectious disease of central nervous system and associated with high morbidity, mortality, disability. Therefore, rapid accurate diagnosis crucial to provide patients timely appropriate therapeutic intervention. In this study, a comprehensive systematic review meta-analysis will be conducted summarize available data evaluate diagnostic accuracy multiplex real-time polymerase chain reaction (PCR) in detection viral encephalitis. Methods We search PubMed, MEDLINE, EMBASE, Web Science (WoS), Scopus Cochrane Library databases for studies evaluating PCR encephalitis caused by viruses from January 2014 December 2024. Observational study designs full text exported included. Risk bias assessed using Quality Assessment Diagnostic Accuracy Studies (QUADAS-2) tool. Analyses performed “mada” package R software (R Foundation Statistical Computing, Vienna, Austria), Summary Receiver Operating Characteristic (SROC) calculated “midas” STATA version 15.0 (Stata Corp., College Station, TX, USA). Certainty evidence Grading Recommendations Assessment, Development Evaluation (GRADE) software. Results The results clinical assay that cause encephalitis, including sensitivity, specificity, positive predictive value (PPV), negative (NPV), likelihood ratio (LR+), (LR-). Finally, we intent submit peer-reviewed journal publication. Conclusion This aims current causing Importantly, focuses on use helps clinicians better understand its role CNS diseases. Systematic registration PROSPERO number: CRD42023485942

Language: Английский

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Square the Circle: Diversity of Viral Pathogens Causing Neuro-Infectious Diseases

Viruses, Journal Year: 2024, Volume and Issue: 16(5), P. 787 - 787

Published: May 15, 2024

Neuroinfections rank among the top ten leading causes of child mortality globally, even in high-income countries. The crucial determinants for successful treatment lie timing and swiftness diagnosis. Although viruses constitute majority infectious neuropathologies, diagnosing treating viral neuroinfections remains challenging. Despite technological advancements, etiology disease undetermined over half cases. identification pathogen becomes more difficult when infection is caused by atypical pathogens or multiple simultaneously. Furthermore, modern surge global passenger traffic has led to an increase cases infections not endemic local areas. This review aims systematize summarize information on neuroinvasive pathogens, encompassing their geographic distribution transmission routes. Emphasis placed rare involving aiming offer a comprehensive structured catalog agents with neurovirulence potential.

Language: Английский

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Meningoencefaliti infettive e suppurazioni intracraniche dell’adulto

EMC - Anestesia-Rianimazione, Journal Year: 2025, Volume and Issue: 30(1), P. 1 - 18

Published: Jan. 20, 2025

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