Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Jan. 5, 2023
Abstract
The
number
of
T
cells
that
infiltrate
tumor
tissues
in
hepatocellular
carcinoma
(HCC)
is
significantly
low.
molecular
mechanism
underlying
cell
proliferation
poorly
understood.
present
study
revealed
during
the
process
infiltration
from
adjacent
to
tissues,
NGF-NGFR
communication
inefficiency
occurred
HCC
patients.
Importantly,
cell-secreted
NGF
interacted
with
NGFR
on
membranes
infiltrated
cells,
which
promoted
these
through
mitotic
spindle
signal
activation.
Mechanistically,
activation
was
mediated
by
HDAC1
unclear
trans-localization-inhibited
PREX1
expression.
Further,
PD-1
mAb
acted
synergistically
suppress
progression
both
mouse
model
and
In
addition,
NGF–NGFR
positively
correlated
PD-1/PDL-1
However,
expressions
were
low
responsible
for
incursive
clinicopathological
features
disappointing
prognosis
Collectively,
results
suggested
impaired
immunotherapy
could,
therefore,
be
utilized
as
a
novel
therapeutic
target
treatment
patients
clinical
practice.
Cancer Medicine,
Journal Year:
2024,
Volume and Issue:
13(3)
Published: Jan. 10, 2024
Abstract
Background
The
mechanism
of
decreased
T
cells
infiltrating
tumor
tissues
in
hepatocellular
carcinoma
is
poorly
understood.
Methods
Cells
were
separated
from
the
single‐cell
RNA‐sequence
dataset
patients
(GSE149614)
for
cell‐cell
communication.
Flow
cytometry,
EDU
staining,
H3‐Ser28
confocal
immunofluorescence
western
blotting
and
naked
microsubcutaneous
tumors
performed
NGF‐NGFR
promoting
proliferation.
Results
present
study
has
revealed
that
during
process
T‐cell
infiltration
adjacent
to
tissues,
an
inefficiency
communication
occurs
tissues.
Importantly,
NGF
secreted
by
interacts
with
NGFR
on
membranes
infiltrated
cells,
thereby
proliferation
through
activation
mitotic
spindle
signals.
Mechanistically,
mediation
signal
executed
HDAC1‐mediated
inhibition
unclear
trans‐localization
PREX1.
Furthermore,
PD‐1
mAb
acts
synergistically
suppress
progression
both
mouse
models
HCC
patients.
Additionally,
was
positively
correlates
PD‐1/PDL‐1
expression.
However,
expressions
are
low
which
responsible
invasive
clinicopathological
features
disappointing
prognosis
Conclusion
Inefficiency
impairs
immunotherapy
could
thus
be
utilized
as
a
novel
therapeutic
target
treatment
clinical
practice.
Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 12, 2025
Abstract
Neurodegenerative
diseases
(NDDs)
cause
a
progressive
loss
of
neurons.
Since
NDDs
are
multifactorial,
the
precise
etiology
varies
on
basis
type
disease
and
patient
history.
Cohort
studies
case
have
demonstrated
potential
link
between
viral
infections
onset
or
progression
NDDs.
Recent
findings
concerning
mechanisms
by
which
neuropathic
occur
provided
more
insights
into
importance
such
connections.
In
this
review,
we
aim
to
elaborate
occurrence
effects
viruses
from
epidemiological,
clinical,
biological
perspectives
while
highlighting
treatments
challenges.
One
key
players
in
neuropathogenesis
is
neuroinflammation
caused
immune
response
virus;
can
due
both
neurotropic
nonneurotropic
viruses.
The
COVID-19
pandemic
has
raised
concerns
about
whether
vaccines
essential
for
preventing
may
play
part
exacerbating
accelerating
By
classifying
common
associated
with
them
further
delving
their
cellular
pathways,
review
provides
advance
development
diagnostic
methods.
Graphical
Neurochemical Research,
Journal Year:
2024,
Volume and Issue:
49(4), P. 1034 - 1048
Published: Jan. 10, 2024
Abstract
The
COVID-19
pandemic
catalyzed
the
swift
development
and
distribution
of
mRNA
vaccines,
including
BNT162b2,
to
address
disease.
Concerns
have
arisen
about
potential
neurodevelopmental
implications
these
especially
in
susceptible
groups
such
as
pregnant
women
their
offspring.
This
study
aimed
investigate
gene
expression
WNT,
brain-derived
neurotrophic
factor
(BDNF)
levels,
specific
cytokines,
m-TOR
expression,
neuropathology,
autism-related
neurobehavioral
outcomes
a
rat
model.
Pregnant
rats
received
BNT162b2
vaccine
during
gestation.
Subsequent
evaluations
on
male
female
offspring
included
autism-like
behaviors,
neuronal
counts,
motor
performance.
Molecular
techniques
were
applied
quantify
WNT
expressions,
BDNF
cytokines
brain
tissue
samples.
findings
then
contextualized
within
extant
literature
identify
mechanisms.
Our
reveal
that
significantly
alters
levels
both
rats,
suggesting
profound
impact
key
pathways.
Notably,
exhibited
pronounced
characterized
by
marked
reduction
social
interaction
repetitive
patterns
behavior.
Furthermore,
there
was
substantial
decrease
counts
critical
regions,
indicating
neurodegeneration
or
altered
neurodevelopment.
Male
also
demonstrated
impaired
performance,
evidenced
reduced
coordination
agility.
research
provides
insights
into
effects
certain
markers
More
extensive
studies
are
needed
confirm
observations
humans
explore
exact
A
comprehensive
understanding
risks
rewards
vaccination,
pregnancy,
remains
essential.
Biotechnic & Histochemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 13
Published: April 30, 2025
Glial
precursor
cells
are
among
the
major
types
of
glia
in
dorsal
root
ganglias
(DRGs)
peripheral
nervous
system.
Previous
studies
have
shown
that
transdifferentiation
DRGs-derived
glial
contributes
to
neurogenesis.
In
present
study,
we
investigated
mRNA
expression
profiles
and
examined
effects
differential
mRNAs
(DEMs)
during
differentiation
derived
from
rat
DRGs.
We
characterized
DRGs
explants
using
immunofluorescence.
Sequencing
was
subsequently
conducted,
followed
by
enrichment
analysis
utilizing
gene
ontology
(GO)
terms
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathways.
The
identified
genes
were
subjected
protein-protein
interaction
(PPI)
network
process
establishment
a
sciatic
nerve
injury
(SNI)
model
detection
key
Wnt
Neurotrophin
pathways
SNI
rats
via
qRT-PCR.
Additionally,
terminal
deoxynucleotidyl
transferase
dUTP
nick-end
labeling
(TUNEL)
assay
employed
assess
apoptosis
detected
neuronal
cells.
More
DEMs
GO
on
third
day
transdifferentiation,
accompanied
morphological
alterations
cells;
is,
some
presented
neuronal-like
phenotypic
characteristics
(the
early
marker
Tuj1
positive).
KEGG
PPI
analyses
revealed
play
crucial
roles
cell
into
After
knocking
down
cadherin-associated
protein
beta
1
(Ctnnβ1)
model,
number
apoptotic
significantly
reduced,
Wnt4
Ntrk3
increased.
Ctnnβ1
may
be
crosstalk
factor
between
negatively
regulates
Critical Reviews in Food Science and Nutrition,
Journal Year:
2023,
Volume and Issue:
unknown, P. 1 - 20
Published: May 22, 2023
Epigallocatechin
gallate
(EGCG),
a
naturally
occurring
active
ingredient
unique
to
tea,
has
been
shown
have
neuroprotective
potential.
There
is
growing
evidence
of
its
potential
advantages
in
the
prevention
and
treatment
neuroinflammation,
neurodegenerative
diseases,
neurological
damage.
Neuroimmune
communication
an
important
physiological
mechanism
including
immune
cell
activation
response,
cytokine
delivery.
EGCG
shows
great
by
modulating
signals
related
autoimmune
response
improving
between
nervous
system
system,
effectively
reducing
inflammatory
state
function.
During
neuroimmune
communication,
promotes
secretion
neurotrophic
factors
into
repair
damaged
neurons,
improves
intestinal
microenvironmental
homeostasis,
ameliorates
pathological
phenotypes
through
molecular
cellular
mechanisms
brain-gut
axis.
Here,
we
discuss
signaling
exchange
involving
communication.
We
further
emphasize
that
role
dependent
on
modulatory
immunity
neurology
neurologically
diseases.
Frontiers in Molecular Neuroscience,
Journal Year:
2024,
Volume and Issue:
17
Published: May 21, 2024
Background
Multiple
sclerosis
(MS)
is
an
immune-mediated
disease
characterized
by
inflammatory
demyelinating
lesions
in
the
central
nervous
system.
Studies
have
shown
that
inflammation
vital
to
both
onset
and
progression
of
MS,
where
aging
plays
a
key
role
it.
However,
potential
mechanisms
on
how
aging-related
(inflammaging)
promotes
MS
not
been
fully
understood.
Therefore,
there
urgent
need
integrate
underlying
between
inflammaging
meaningful
prediction
models
are
needed.
Methods
First,
were
developed
using
machine
learning
methods,
respectively.
Then,
integrated
model
was
used
identify
relative
risk
factors,
identifying
essential
“aging-inflammation-disease”
triples.
Finally,
series
bioinformatics
analyses
(including
network
analysis,
enrichment
sensitivity
pan-cancer
analysis)
further
explore
MS.
Results
A
factors
identified,
such
as
protein
homeostasis,
cellular
neurodevelopment
energy
metabolism.
The
indices
validated
different
cancer
types.
various
integrated,
even
theories
immunosenescence
confirmed.
Conclusion
In
conclusion,
our
study
systematically
investigated
relationships
through
computational
approaches,
could
present
novel
thought
for
other
diseases.
Journal of Personalized Medicine,
Journal Year:
2022,
Volume and Issue:
12(11), P. 1877 - 1877
Published: Nov. 9, 2022
COVID-19
continues
to
afflict
the
global
population,
causing
several
pathological
diseases
and
exacerbating
co-morbidities
due
SARS-CoV-2's
high
mutation.
Recent
interest
has
been
devoted
some
neuronal
manifestations
increased
levels
of
Nerve
Growth
Factor
(NGF)
Brain-derived
Neurotrophic
(BDNF)
in
bloodstream
during
SARS-CoV-2
infection,
neurotrophins
that
are
well-known
for
their
multifactorial
actions
on
neuro-immune-endocrine
visual
functions.
Nineteen
(19)
patients
were
enrolled
this
monocentric
prospective
study
subjected
anamnesis
biosamples
collection
(saliva
blood)
at
hospitalization
(acute
phase)
6
months
later
(remission
phase).
NGF
BDNF
quantified
by
ELISA,
biochemical
data
related
biostrumental
measurements.
Increased
saliva
serum
acute
phase
infection
(hospitalized
patients),
reduced
observed
next
phase),
never
matching
baseline
values.
Salivary
circulating
would
suggest
possibility
considering
sera
as
useful
matrices
quickly
screening
neurotrophins,
addition
SARS-CoV2
antigens
RNA.
Overall,
findings
described
herein
highlight
importance
dynamic
biomarkers
monitoring
disease
reinforces
using
quick,
non-invasive
screening.
