Myelin Disruption, Neuroinflammation, and Oxidative Stress Induced by Sulfite in the Striatum of Rats Are Mitigated by the pan-PPAR agonist Bezafibrate DOI Creative Commons
Nícolas Manzke Glänzel, Belisa Parmeggiani, Mateus Grings

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(12), P. 1557 - 1557

Published: June 6, 2023

Sulfite predominantly accumulates in the brain of patients with isolated sulfite oxidase (ISOD) and molybdenum cofactor (MoCD) deficiencies. Patients present severe neurological symptoms basal ganglia alterations, pathophysiology which is not fully established. Therapies are ineffective. To elucidate pathomechanisms ISOD MoCD, we investigated effects intrastriatal administration on myelin structure, neuroinflammation, oxidative stress rat striatum. decreased FluoromyelinTM basic protein staining, suggesting abnormalities. also increased staining NG2, a marker oligodendrocyte progenitor cells. In line this, reduced viability MO3.13 cells, express oligodendroglial markers. Furthermore, altered expression interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-10 (IL-10), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) heme oxygenase-1 (HO-1), indicating neuroinflammation redox homeostasis disturbances. Iba1 another was by sulfite. These data suggest that changes induced contribute to MoCD. Notably, post-treatment bezafibrate (BEZ), pan-PPAR agonist, mitigated alterations markers IL-1β, IL-6, iNOS HO-1 cell decrease further prevented. Moreover, pre-treatment BEZ attenuated some effects. findings show modulation PPAR as potential opportunity for therapeutic intervention these disorders.

Language: Английский

Transgenerational hormesis in healthy aging and antiaging medicine from bench to clinics: Role of food components DOI
Vittorio Calabrese, Naomi Osakabe, Rosalba Siracusa

et al.

Mechanisms of Ageing and Development, Journal Year: 2024, Volume and Issue: 220, P. 111960 - 111960

Published: July 5, 2024

Language: Английский

Citations

4
Nrf2 Pathway in Huntington’s Disease (HD): What Is Its Role? DOI Open Access
Paolo Tucci, Roberta Lattanzi, Cinzia Severini

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(23), P. 15272 - 15272

Published: Dec. 3, 2022

Huntington’s disease (HD) is an autosomal dominant neurodegenerative that occurs worldwide. Despite some progress in understanding the onset of HD, drugs block or delay symptoms are still not available. In recent years, many treatments have been proposed; among them, nuclear transcriptional factor-2 (Nrf2) enhancer compounds proposed as potential therapeutic agents to treat HD. Nrf2 triggers endogenous antioxidant pathway activated different disorders. Probably, stimulation during either early phase before HD symptoms’ onset, could slow prevent striatum degeneration. this review, we present scientific literature supporting role and prophylactic compound.

Language: Английский

Citations

19
Jiao-tai-wan Improves Cognitive Impairment by Regulating Nrf2/ARE/HO-1 Signaling Pathway in APP/PS1 mice DOI
Xin-Chen Wang, Guangliang Wu, Haiyan Cai

et al.

Published: April 23, 2025

Abstract Backgroud Alzheimer's disease (AD) is a chronic, progressive, and destructive neurodegenerative disorder that severely affects human memory, intelligence, behavioral abilities. Jiao Tai Wan (JTW) classic formula composed of two traditional Chinese medicines, coptis chinensis (CC) cinnamon (CIN), the ratio CC CIN 10:1. JTW has effects promoting cognitive function, improving learning memory function. But specific mechanism not been systematically studied. Method: We conducted Morris water maze Y-maze tests, polymerase chain reaction (PCR), assay kit ELISA, nissl's staining, western blotting to verified improvement function on APP/PS1 mice. Result: Through experiments, can improved spatial exploration abilities Nissl’s staining PCR detection BDNF, NGF, SYP showed lesions in By detecting activities A β 1-40, 1-42, α - secretase, γ as well cholinergic labeling enzymes Ach, AchE, ChAT cerebral amyloidosis nervous system model The inflammatory factors oxidative stress indicators revealed inhibited activity stress. Western Blotting was used detect Nrf2/ARE/HO-1 pathway, result regulate pathway Conclusion: JTW enhanced Nrf2, regulated increased nerve growth factors, system, stress, ameliorated dysfunction

Language: Английский

Citations

0
Gamma-delta T cells suppress microbial metabolites that activate striatal neurons and induce repetitive/compulsive behavior in mice DOI
Laura M. Cox, Bruna K. Tatematsu, Lydia Guo

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 117, P. 242 - 254

Published: Jan. 26, 2024

Language: Английский

Citations

3
Glucose-6-Phosphate Dehydrogenase, Redox Homeostasis and Embryogenesis DOI Open Access
Po‐Hsiang Chen, Wen-Ye Tjong,

Hung‐Chi Yang

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(4), P. 2017 - 2017

Published: Feb. 11, 2022

Normal embryogenesis requires complex regulation and precision, which depends on multiple mechanistic details. Defective can occur by various mechanisms. Maintaining redox homeostasis is of importance during embryogenesis. NADPH, as produced from the action glucose-6-phosphate dehydrogenase (G6PD), has an important role in homeostasis, serving a cofactor for glutathione reductase recycling oxidized NADPH oxidases nitric oxide synthases generation reactive oxygen (ROS) nitrogen species (RNS). Oxidative stress differentially influences cell fate While low levels (eustress) ROS RNS promote growth differentiation, supra-physiological concentrations lead to demise embryonic lethality. G6PD-deficient cells organisms have been used models determining signaling regulating proliferation, differentiation migration. Embryogenesis also modulated anti-oxidant enzymes, transcription factors, microRNAs, factors pathways, are dependent regulation. Crosstalk among microRNAs essential

Language: Английский

Citations

14
Somatic Mutations and Alzheimer’s Disease DOI

Jocelyn Downey,

Jacqueline C. K. Lam, Victor O. K. Li

et al.

Journal of Alzheimer s Disease, Journal Year: 2022, Volume and Issue: 90(2), P. 475 - 493

Published: Sept. 20, 2022

Alzheimer's disease (AD) represents a global health challenge, with an estimated 55 million people suffering from the non-curable across world. While amyloid-β plaques and tau neurofibrillary tangles in brain define AD proteinopathy, it has become evident that diverse coding non-coding regions of genome may significantly contribute to neurodegeneration. The diversity factors associated pathogenesis, coupled age-associated damage, suggests series triggering events be required initiate AD. Since somatic mutations accumulate aging, aging is major risk factor for AD, there great potential mutational drive disease. Indeed, recent data Gozes team/laboratories as well other leading laboratories correlated accumulation progression tauopathy. In this review, we lay current perspectives on principal genetic causes, highlighting contribution pathogenesis late onset roles artificial intelligence big can play accelerating progress causal mutation markers/biomarkers identification, drug discovery/repurposing, have been highlighted future neurodegenerations, aim bring hope vulnerable population.

Language: Английский

Citations

13
Empagliflozin Dampens Doxorubicin-Induced Chemobrain in Rats: The Possible Involvement of Oxidative Stress and PI3K/Akt/mTOR/NF-κB/TNF-α Signaling Pathways DOI
Rania M. Abdelsalam,

Hatem W Hamam,

Noha M Eissa

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 20, 2024

Language: Английский

Citations

2
Disturbance of Mitochondrial Dynamics, Endoplasmic Reticulum–Mitochondria Crosstalk, Redox Homeostasis, and Inflammatory Response in the Brain of Glutaryl-CoA Dehydrogenase-Deficient Mice: Neuroprotective Effects of Bezafibrate DOI
Bianca Seminotti, Morgana Brondani, Rafael Teixeira Ribeiro

et al.

Molecular Neurobiology, Journal Year: 2022, Volume and Issue: 59(8), P. 4839 - 4853

Published: May 31, 2022

Language: Английский

Citations

11
Disturbances in mitochondrial bioenergetics and control quality and unbalanced redox homeostasis in the liver of a mouse model of mucopolysaccharidosis type II DOI
Camila Vieira Pinheiro, Rafael Teixeira Ribeiro, Ana Cristina Roginski

et al.

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: March 18, 2024

Language: Английский

Citations

2
Glucoraphanin Triggers Rapid Antidepressant Responses in a Rat Model of Beta Amyloid-Induced Depressive-like Behaviour DOI Creative Commons
Paolo Tucci, María Bové, Vladyslav Sikora

et al.

Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(9), P. 1054 - 1054

Published: Aug. 26, 2022

Glucoraphanin (GRA) is a natural compound that has shown beneficial effects in chronic diseases and central nervous system disorders. Moreover, GRA displayed antidepressant activity preclinical models. We have previously demonstrated single intracerebroventricular administration of soluble amyloid-beta 1-42 (sAβ 1-42) rat evokes depressive-like phenotype by increasing immobility frequency the forced swimming test (FST). The aim this work was to investigate effect naïve sAβ-1-42-treated rats using FST. Behavioural analyses were accompanied neurochemical biochemical measurements prefrontal cortex (PFC), such as serotonin (5-HT), noradrenaline (NA), kynurenine (KYN), tryptophan (TRP), reactive oxygen species (ROS) transcription nuclear factor kappa B (NF-kB) levels. reported at dose 50 mg/kg reduced FST increased 5-HT NA levels PFC compared controls. At same dose, reverted sAβ administration, restored NF-kB, KYN ROS PFC. In conclusion, rapidly reverting behaviour, together with alterations, might represent safe candidate for treatment depression.

Language: Английский

Citations

10