Journal of Pharmacological Sciences,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Object
recognition
memory
is
an
animal's
ability
to
discriminate
between
novel
and
familiar
items
supported
by
neural
activities
in
not
only
the
perirhinal
cortex
but
also
hippocampus
prefrontal
cortex.
Since
we
previously
demonstrated
that
ramelteon
enhanced
object
mice,
sought
correlates
of
improvement.
We
recorded
activity
mice
while
they
performed
a
task.
found
theta
oscillations
were
when
ramelteon-treated
explored
both
objects.
Moreover,
showed
high
coherence
phases
at
low
gamma
frequencies
assume
enhancement
indicative
increased
cholinergic
melatonin
receptor
activation.
High
hippocampal
network
sampling
objects
suggests
better
cognitive
operations
for
discrimination
novelty
familiarity.
The
current
study
sheds
light
upon
physiological
consequences
activation,
further
contributing
improved
functions.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 24, 2024
In
preclinical
Alzheimer's
disease
(AD),
spatial
learning
and
memory
is
impaired.
We
reported
similar
impairments
in
3xTg-AD
mice
on
a
virtual
maze
(VM)
spatial-reorientation-task
that
requires
using
landmarks
to
navigate.
Hippocampal
(HPC)-cortical
dysfunction
during
sleep
(important
for
consolidation)
potential
mechanism
AD.
previously
found
deficits
HPC-cortical
coordination
coinciding
with
VM
the
next
day.
Some
forms
of
40
Hz
stimulation
seem
clear
AD
pathology
mice,
improve
functional
connectivity
patients.
Thus,
we
implanted
recording
array
targeting
parietal
cortex
(PC)
HPC
assess
HPC-PC
coordination,
an
optical
fiber
or
sham
optogenetic
3xTg/PV
Current Opinion in Behavioral Sciences,
Journal Year:
2024,
Volume and Issue:
59, P. 101433 - 101433
Published: July 4, 2024
Brain
rhythms
are
known
to
play
a
relevant
role
in
many
cognitive
functions.
In
particular,
coupling
between
theta
and
gamma
oscillations
was
first
observed
the
hippocampus,
where
it
is
assumed
implement
code
for
organizing
multiple
items
memory.
More
recent
advances,
however,
demonstrate
that
this
mechanism
ubiquitously
present
brain
plays
not
only
working
memory
but
also
episodic
semantic
memory,
attention,
emotion,
dreaming,
imagination.
Furthermore,
altered
mental
states
neurological
disorders
show
profound
alterations
theta–gamma
code.
review,
which
summarizes
most
experimental
theoretical
evidence,
we
suggest
substantial
capacity
integrate
information
characteristic
of
entrainment
fundamental
implementing
conscious
processes.
Frontiers in Neuroscience,
Journal Year:
2024,
Volume and Issue:
18
Published: July 19, 2024
Parkinson's
disease
(PD)
is
a
prevalent
neurodegenerative
disorder
affecting
millions
globally.
It
encompasses
both
motor
and
non-motor
symptoms,
with
notable
impact
on
patients'
quality
of
life.
Electroencephalogram
(EEG)
non-invasive
tool
that
increasingly
utilized
to
investigate
neural
mechanisms
in
PD,
identify
early
diagnostic
markers,
assess
therapeutic
responses.
Journal of Pharmacological Sciences,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Object
recognition
memory
is
an
animal's
ability
to
discriminate
between
novel
and
familiar
items
supported
by
neural
activities
in
not
only
the
perirhinal
cortex
but
also
hippocampus
prefrontal
cortex.
Since
we
previously
demonstrated
that
ramelteon
enhanced
object
mice,
sought
correlates
of
improvement.
We
recorded
activity
mice
while
they
performed
a
task.
found
theta
oscillations
were
when
ramelteon-treated
explored
both
objects.
Moreover,
showed
high
coherence
phases
at
low
gamma
frequencies
assume
enhancement
indicative
increased
cholinergic
melatonin
receptor
activation.
High
hippocampal
network
sampling
objects
suggests
better
cognitive
operations
for
discrimination
novelty
familiarity.
The
current
study
sheds
light
upon
physiological
consequences
activation,
further
contributing
improved
functions.
