Odor and reward-evoked GABAergic neuronal activity in the basal forebrain influences olfactory-guided behavior in mice DOI Creative Commons
Stephen J. Moss, Evelyne K. Tantry,

Elaine H. Le

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Sept. 4, 2022

ABSTRACT Sensory perception relies on the flexible detection and interpretation of stimuli across variable contexts, conditions, behavioral states. The basal forebrain is a hub for state regulation, supplying dense cholinergic GABAergic projections to various brain regions involved in sensory processing. Of neurons forebrain, parvalbumin (PV) somatostatin (SST) subtypes serve opposing roles towards regulating To elucidate role circuits sensory-guided behavior, we investigated signaling dynamics during odor-guided decision-making. We used fiber photometry record cell type-specific activity an odor discrimination task correlated temporal patterns PV SST neuronal with olfactory performance. found that while both PV-expressing SST-expressing were activated by odors, selectively suppressed reward whereas activated. Notably, chemogenetic inhibition BF modestly altered decision bias favor reward-seeking optogenetic presentations improved accuracy. Together, these results suggest bidirectional neuron distinctly influence decision-making guided behavior. SIGNIFICANCE STATEMENT This study reveals distinct Fiber shows parvalbumin-expressing are rewards, somatostatin-expressing activated, establishing unique recruitment reinforcement. Chemogenetic interventions demonstrate divergent behavior perception. research provides new insights into how shape

Language: Английский

Development of the mammalian main olfactory bulb DOI Creative Commons
Candida Tufo,

Subathra Poopalasundaram,

Ana Dorrego-Rivas

et al.

Development, Journal Year: 2022, Volume and Issue: 149(3)

Published: Feb. 1, 2022

ABSTRACT The mammalian main olfactory bulb is a crucial processing centre for the sense of smell. forms early during development and functional from birth. However, system continues to mature change throughout life as target constitutive adult neurogenesis. Our Review synthesises current knowledge prenatal, postnatal development, focusing on maturation, morphology, functions interactions its diverse constituent glutamatergic GABAergic cell types. We highlight not only great advances in understanding made recent years, but also gaps our present that most urgently require addressing.

Language: Английский

Citations

54
Extrinsic neuromodulation in the rodent olfactory bulb DOI Creative Commons
Daniela Brunert, Markus Rothermel

Cell and Tissue Research, Journal Year: 2020, Volume and Issue: 383(1), P. 507 - 524

Published: Dec. 23, 2020

Abstract Evolutionarily, olfaction is one of the oldest senses and pivotal for an individual’s health survival. The olfactory bulb (OB), as first relay station in brain, known to heavily process sensory information. To adapt animal’s needs, OB activity can be influenced by many factors either from within (intrinsic neuromodulation) or outside (extrinsic which include neurotransmitters, neuromodulators, hormones, neuropeptides. Extrinsic sources seem special importance receives massive efferent input numerous brain centers even outweighing nose. Here, we review neuromodulatory processes rodent such extrinsic sources. We will discuss neuromodulation according points origin, receptors involved, affected circuits, changes behavior. In end, give a brief outlook on potential future directions research OB.

Language: Английский

Citations

48
Co-transmitting interneurons in the mouse olfactory bulb regulate olfactory detection and discrimination DOI Creative Commons
Ariel M. Lyons‐Warren, Evelyne K. Tantry, Stephen J. Moss

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(12), P. 113471 - 113471

Published: Nov. 18, 2023

Co-transmission of multiple neurotransmitters from a single neuron increases the complexity signaling information within defined neuronal circuits. Superficial short-axon cells in olfactory bulb release both dopamine and γ-aminobutyric acid (GABA), yet specific targets these their respective roles olfaction have remained unknown. Here, we implement intersectional genetics mice to selectively block GABA or superficial identify distinct cellular targets, impact on circuit function, behavioral contribution each neurotransmitter toward behaviors. We provide functional anatomical evidence for divergent cell onto downstream neurons shape patterns mitral firing that contribute olfactory-related

Language: Английский

Citations

11
Long-Range GABAergic Inhibition Modulates Spatiotemporal Dynamics of the Output Neurons in the Olfactory Bulb DOI Creative Commons
Pablo S. Villar,

Ruilong Hu,

Ricardo C. Araneda

et al.

Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 41(16), P. 3610 - 3621

Published: March 9, 2021

Local interneurons of the olfactory bulb (OB) are densely innervated by long-range GABAergic neurons from basal forebrain (BF), suggesting that this top-down inhibition regulates early processing in system. However, how inputs modulate OB output neurons, mitral/tufted cells, is unknown. Here, male and female mice acute brain slices, we show optogenetic activation BF produced distinct local circuit effects can influence activity cells spatiotemporal domains. Activation axons a fast disinhibition consistent with rapid synchronous release GABA onto glomerular inframitral circuits OB, which also reduced spike precision response to simulated stimuli. In addition, modulated oscillations layer-specific manner. The intensity locally evoked θ was decreased on circuit, while γ were granule cells. Furthermore, input dendrodendritic Together, these results suggest well suited temporal spatial aspects circuits. SIGNIFICANCE STATEMENT Disruption (BF) impairs discrimination similar odors, yet centrifugal influences neuronal remains unclear. exclusively target inhibitory having functional disinhibitory effect mitral Phasic reduces lowers oscillatory directly modulating extent inhibition. These circuit-level dynamics odor coding OB.

Language: Английский

Citations

27
Target-specific control of olfactory bulb periglomerular cells by GABAergic and cholinergic basal forebrain inputs DOI Creative Commons
Didier De Saint Jan

eLife, Journal Year: 2022, Volume and Issue: 11

Published: Feb. 28, 2022

The olfactory bulb (OB), the first relay for odor processing in brain, receives dense GABAergic and cholinergic long-range projections from basal forebrain (BF) nuclei that provide information about internal state behavioral context of animal. However, targets, impact, dynamic these afferents are still unclear. How BF synaptic inputs modulate activity diverse subtypes periglomerular (PG) interneurons using optogenetic stimulation loose cell-attached or whole-cell patch-clamp recording OB slices adult mice were studied this article. potently blocked PG cells firing except a minority calretinin-expressing which GABA release elicited spiking. Parallel excited previously overlooked cell subtype via activation M1 muscarinic receptors. Low-frequency axons drove persistent cells, thereby increasing tonic inhibition principal neurons. Taken together, findings suggest modality-specific can orchestrate glomeruli multiple, potentially independent, inhibitory excitatory target-specific pathways.

Language: Английский

Citations

15
Dynamic Cholinergic Tone in the Basal Forebrain Reflects Reward-Seeking and Reinforcement During Olfactory Behavior DOI Creative Commons

Elizabeth Hanson,

Katie L. Brandel-Ankrapp, Benjamin R. Arenkiel

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2021, Volume and Issue: 15

Published: Feb. 2, 2021

Sensory perception underlies how we internalize and interact with the external world. In order to adapt changing circumstances interpret signals in a variety of contexts, sensation needs be reliable, but sensory input flexible. An important mediator this flexibility is top-down regulation from cholinergic basal forebrain. Basal forebrain projection neurons serve as pacemakers gatekeepers for downstream neural networks, modulating circuit activity across diverse neuronal populations. This control necessary cue detection, learning, memory, disproportionately disrupted neurodegenerative diseases associated cognitive decline. Intriguingly, signaling acts locally within sculpt output neurons. To determine local impacts pathways that participate regulation, sought define dynamics during motivated behavior learning. Toward this, utilized fiber photometry genetically encoded acetylcholine indicator GAChR2.0 temporal patterns olfactory-guided, behaviors We show reliably increased reward seeking behaviors, was strongly suppressed by delivery go/no-go olfactory-cued discrimination task. The observed transient reduction tone mirrored suppression GABAergic activity. Together, these findings suggest changes rapidly reflect reward-seeking positive reinforcement may impact circuitry modulates olfaction.

Language: Английский

Citations

20
Olfactory neurogenesis plays different parts at successive stages of life, implications for mental health DOI Creative Commons

Jules Dejou,

Nathalie Mandairon, Anne Didier

et al.

Frontiers in Neural Circuits, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 8, 2024

The olfactory bulb is a unique site of continuous neurogenesis, primarily generating inhibitory interneurons, process that begins at birth and extends through infancy adulthood. This review examines the characteristics focusing on granule cells, most numerous how their age maturation affect function. Adult-born while immature, contribute to experience-dependent plasticity circuit by enabling structural functional synaptic changes. In contrast, cells born early in life form foundational elements circuit, potentially facilitating innate information processing. implications these neonatal memory impact adult perception, particularly response aversive events susceptibility emotional disorders, warrant further investigation.

Language: Английский

Citations

2
Activation of basal forebrain-to-lateral habenula circuitry drives reflexive aversion and suppresses feeding behavior DOI Creative Commons
Jessica Swanson, Joshua Ortiz‐Guzman, Snigdha Srivastava

et al.

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Dec. 21, 2022

Abstract Environmental cues and internal states such as mood, reward, or aversion directly influence feeding behaviors beyond homeostatic necessity. The hypothalamus has been extensively investigated for its role in feeding. However, many of the neural circuits that drive more complex, non-homeostatic integrate valence sensory (such taste smell) remain unknown. Here, we describe a basal forebrain (BF)-to-lateral habenula (LHb) circuit modulates behavior. Using viral-mediated mapping, identified population glutamatergic neurons within BF project to LHb, which responds diverse cues, including aversive food-related odors. Optogenetic activation BF-to-LHb circuitry drives robust, reflexive-like aversion. Furthermore, this suppresses eat fasted state. Together, these data reveal modulating LHb-associated by sensing environmental cues.

Language: Английский

Citations

11
Long-range GABAergic projections contribute to cortical feedback control of sensory processing DOI Creative Commons
Camille Mazo, Antoine Nissant, Soham Saha

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Nov. 12, 2022

Abstract In the olfactory system, cortex sends glutamatergic projections back to first stage of processing, bulb (OB). Such corticofugal excitatory circuits — a canonical circuit motif described in all sensory systems— dynamically adjust early processing. Here, we uncover inhibitory feedback OB, originating from subpopulation GABAergic neurons anterior and innervating both local output OB neurons. vivo imaging network modeling showed that optogenetic activation cortical drives net subtractive inhibition spontaneous odor-evoked activity as well neurons, stimulation enhances separation population odor responses tufted cells, but not mitral cells. Targeted pharmacogenetic silencing axon terminals impaired discrimination similar mixtures. Thus, represent an additional control

Language: Английский

Citations

10
Oxytocin signaling is necessary for synaptic maturation of adult-born neurons DOI Open Access
Brandon Pekarek, Mikhail Y Kochukov, Brittney Lozzi

et al.

Genes & Development, Journal Year: 2022, Volume and Issue: 36(21-24), P. 1100 - 1118

Published: Nov. 1, 2022

Neural circuit plasticity and sensory response dynamics depend on forming new synaptic connections. Despite recent advances toward understanding the consequences of plasticity, mechanisms driving are unknown. Adult-born neurons within olfactory bulb have proven to be a powerful model for studying providing broad accessible avenue into neuron development, migration, integration. We others shown that efficient adult-born integration hinges presynaptic activity in form diverse signaling peptides. Here, we demonstrate novel oxytocin-dependent mechanism maturation reveal spatial temporal enrichment oxytocin receptor expression murine bulb, with peaking during activity-dependent Using viral labeling, confocal microscopy, cell type-specific RNA-seq, promotes newly integrating by regulating their morphological development mature AMPARs other structural proteins.

Language: Английский

Citations

10