Recommendations for daytime, evening, and nighttime indoor light exposure to best support physiology, sleep, and wakefulness in healthy adults

PLoS Biology, Journal Year: 2022, Volume and Issue: 20(3), P. e3001571 - e3001571

Published: March 17, 2022

Ocular light exposure has important influences on human health and well-being through modulation of circadian rhythms sleep, as well neuroendocrine cognitive functions. Prevailing patterns do not optimally engage these actions for many individuals, but advances in our understanding the underpinning mechanisms emerging lighting technologies now present opportunities to adjust promote optimal physical mental performance. A newly developed, international standard provides a SI-compliant way quantifying influence intrinsically photosensitive, melanopsin-expressing, retinal neurons that mediate effects. The report recommendations lighting, based an expert scientific consensus expressed easily measured quantity (melanopic equivalent daylight illuminance (melaponic EDI)) defined within this standard. are supported by detailed analysis sensitivity circadian, neuroendocrine, alerting responses ocular provide straightforward framework inform design practice.

Language: Английский

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Fatigue and its management in the workplace

Neuroscience & Biobehavioral Reviews, Journal Year: 2018, Volume and Issue: 96, P. 272 - 289

Published: Nov. 2, 2018

Fatigue and workplace sleepiness are consequences of modern industrial society. is a complex biological phenomenon that occurs as function time awake, time-of-day, workload, health, off-duty lifestyle. two major factors – the homeostatic drive for sleep circadian rhythm sleepiness. The greatest cause fatigue insufficient or disrupted sleep. Excessive in on highways serious safety hazard, results numerous accidents adverse mental physical health outcomes. Evidence-based strategies promote better optimize work/rest schedules can mitigate impact loss. Proper nap scheduling, work breaks, modeling monitoring tools, detection technologies, pharmacological countermeasures be implemented at home and/or to reduce performance hazards. Education about obtaining adequate sleep, dangers terms both cognitive consequences, availability scientifically-proven sleep-enhancement alertness-management essential.

Language: Английский

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Melanopsin and the Intrinsically Photosensitive Retinal Ganglion Cells: Biophysics to Behavior

Neuron, Journal Year: 2019, Volume and Issue: 104(2), P. 205 - 226

Published: Oct. 1, 2019

Language: Английский

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The cognitive impact of light: illuminating ipRGC circuit mechanisms

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(3), P. 159 - 175

Published: Jan. 26, 2024

Language: Английский

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Light, Alertness, and Alerting Effects of White Light: A Literature Overview

Journal of Biological Rhythms, Journal Year: 2018, Volume and Issue: 33(6), P. 589 - 601

Published: Sept. 7, 2018

Light is known to elicit non-image-forming responses, such as effects on alertness. This has been reported especially during light exposure at night. Nighttime results might not be translatable the day. article aims provide an overview of (1) neural mechanisms regulating alertness, (2) ways measuring and quantifying (3) current literature specifically regarding different intensities white various measures correlates alertness daytime. In general, present provides inconclusive alerting intensity daytime, particularly for objective However, research paradigms employed in earlier studies differed substantially, most tested only a limited set lighting conditions. Therefore, potential more intense should investigated systematic, dose-dependent manner with multiple within one experimental paradigm over course

Language: Английский

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Non-image forming effects of illuminance and correlated color temperature of office light on alertness, mood, and performance across cognitive domains

Building and Environment, Journal Year: 2018, Volume and Issue: 149, P. 253 - 263

Published: Dec. 4, 2018

Language: Английский

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How to Report Light Exposure in Human Chronobiology and Sleep Research Experiments

Clocks & Sleep, Journal Year: 2019, Volume and Issue: 1(3), P. 280 - 289

Published: June 26, 2019

Exposure to light has short- and long-term impacts on non-visual responses in humans. While many aspects related sensitivity have been characterised (such as the action spectrum for melatonin suppression), much remains be elucidated. Here, we provide a set of minimum reporting guidelines stimulus conditions involving an intervention chronobiology, sleep research environmental psychology experiments. Corresponding current state-of-the-art knowledge (June 2019), these are (i) measure report spectral power distribution acute from observer’s point view; (ii) background environment (iii), make spectra available tabulated form, (iv) α-opic (ir)radiances illuminance; (v) describe timing properties (duration pattern); (vi) spatial (spatial arrangement extent), (vii) measurement equipment. We supplement with optional suggestions discuss limitations scheme.

Language: Английский

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Longitudinal Neuroimaging over 30 Days: Temporal Characteristics of Migraine

Annals of Neurology, Journal Year: 2020, Volume and Issue: 87(4), P. 646 - 651

Published: Feb. 7, 2020

Objective Although migraine is defined by the headache and headache‐associated symptoms, true beginning of a attack lies in premonitory phase. To understand generation attacks, one needs to investigate phase before starts. The characterized well‐described complex symptoms. Its duration, however, not clearly defined, there are no biomarkers help define when this Methods Here, we used functional magnetic resonance imaging (MRI) elucidate duration spontaneous human attacks. Because attacks hardly predictable thereby difficult catch, scanned 9 patients daily over minimum period 30 days using well‐established paradigm for MRI trigeminal nociception. Results Seven were included analysis, thus providing cumulative data 27 including scans before, during, after pain as well interictal scans. As response painful stimulation, activation hypothalamus was present within last 48 hours onset but earlier. Interpretation Using hypothalamic potential marker unique dataset, our corroborated migraine. We suggest applying time criterion future studies focusing on cycle. ANN NEUROL 2020;87:646–651

Language: Английский

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Sleep–wake-driven and circadian contributions to daily rhythms in gene expression and chromatin accessibility in the murine cortex

Proceedings of the National Academy of Sciences, Journal Year: 2019, Volume and Issue: 116(51), P. 25773 - 25783

Published: Nov. 27, 2019

The timing and duration of sleep results from the interaction between a homeostatic sleep-wake-driven process periodic circadian process, involves changes in gene regulation expression. Unraveling contributions both processes their to transcriptional epigenomic regulatory dynamics requires sampling over time under conditions unperturbed perturbed sleep. We profiled mRNA expression chromatin accessibility cerebral cortex mice 3-d period, including 6-h deprivation (SD) on day 2. used mathematical modeling integrate series data with sleep-wake history, which established that large proportion rhythmic genes are governed by varying degrees sometimes working opposition. Remarkably, SD caused long-term effects gene-expression dynamics, outlasting phenotypic recovery, most strikingly illustrated damped oscillation core clock genes, Arntl/Bmal1, suggesting enforced wakefulness directly impacts molecular machinery. Chromatin proved highly plastic dynamically affected SD. Dynamics distal regions, rather than promoters, correlated expression, implying result constitutively accessible promoters influence enhancers or repressors. Serum response factor (SRF) was predicted as regulator driving immediate response, SRF activity mirrors build-up release pressure. Our demonstrate single, short has aftereffects at genomic level highlights importance distribution diurnal rhythmicity processes.

Language: Английский

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Environment shapes sleep patterns in a wild nocturnal primate

Scientific Reports, Journal Year: 2019, Volume and Issue: 9(1)

Published: July 9, 2019

Abstract Among primates, the suborder Haplorhini is considered to have evolved a consolidated monophasic sleep pattern, with diurnal species requiring shorter duration than nocturnal species. Only few primate been systematically studied in their natural habitat where environmental variables, including temperature and light, major influence on activity patterns. Here we report first study performed wild. We fitted seven wild Javan slow lorises ( Nycticebus javanicus ) West Java, Indonesia accelerometers that collected data, installed climate loggers each individual’s home range collect ambient readings (over 321 days total). All individuals showed strictly pattern of displayed striking synchronisation onset cessation relation sunset sunrise. The longest rest episodes were typically clustered near beginning towards end light period, this was inversely related daily fluctuations temperature. relationship between patterns, levels suggests role environment shaping architecture waking sleep. concluded well-known phenotypic variability amount across may represent an adaptation changes environment. Our data suggest patterns shaped by pressures observed phylogenetic inertia evolution humans.

Language: Английский

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