Ultra-processed foods and human health: An umbrella review and updated meta-analyses of observational evidence

Clinical Nutrition, Journal Year: 2024, Volume and Issue: 43(6), P. 1386 - 1394

Published: April 18, 2024

Ultra-processed food (UPF) intake has increased sharply over the last few decades and been consistently asserted to be implicated in development of non-communicable diseases. We aimed evaluate update existing observational evidence for associations between ultra-processed consumption human health.

Language: Английский

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(Poly)phenols and Multiple Sclerosis: Results from an Observational Cross-Sectional Study

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 188 - 188

Published: Feb. 6, 2025

(Poly)phenols are a wide and heterogeneous class of substances with several potential health benefits. Their role in neuroprotection cognition is still questionable. This study’s scope to examine the possible association between total individual (poly)phenol intake, major dietary sources, severity multiple sclerosis (MS) cohort MS patients. Participants’ demographics, physical activity, smoking, information were collected, alongside clinical parameters including Expanded Disability Status Score (EDSS), Multiple Sclerosis Severity (MSSS), phenotype, current therapy. A validated 110-item food frequency questionnaire (FFQ) was used assess participants’ habits. The content foods estimated using Phenol-Explorer database. Data from 106 participants analyzed. high intake vegetables associated 4.6-fold higher probability mild (95% CI: 1.49, 14.28), whereas no found for other beverage sources. Hydroxycinnamic acids significantly related MSSS (OR: 6.55, 95% 2.15, 19.92). Although coffee differed patients severe (90.5 ± 53.9 vs. 59.4 40.8 mL/d, respectively), linear regression analysis did not confirm an MSSS. hydroxycinnamic may impact severity. Coffee’s remains unclear needs be further investigated.

Language: Английский

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Industrial Use of Phosphate Food Additives: A Mechanism Linking Ultra-Processed Food Intake to Cardiorenal Disease Risk?

Nutrients, Journal Year: 2023, Volume and Issue: 15(16), P. 3510 - 3510

Published: Aug. 9, 2023

The consumption of ultra-processed food (UPF) keeps rising, and at the same time, an increasing number epidemiological studies are linking high rates UPF with serious health outcomes, such as cardiovascular disease, in general population. Many potential mechanisms, either isolation or combination, can explain negative effects UPF. In this review, we have addressed role inorganic phosphate additives, commonly added to a wide variety foods, factors contributing on cardiorenal disease. Inorganic phosphates rapidly efficiently absorbed, elevated serum lead effects, directly through tissue/vessel calcification indirectly release mineral-regulating hormones, parathyroid hormone, fibroblast growth factor-23. An association between bone disease among patients chronic kidney is well-accepted by nephrologists. Epidemiological demonstrated dietary intake mortality, even American magnitude additives these associations remains be determined, initial step should determine precise estimates population exposure supply.

Language: Английский

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Associations between diet and disease progression and symptomatology in multiple sclerosis: A systematic review of observational studies

Multiple Sclerosis and Related Disorders, Journal Year: 2024, Volume and Issue: 87, P. 105636 - 105636

Published: April 17, 2024

Language: Английский

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Gut microbiota in multiple sclerosis and animal models

FEBS Journal, Journal Year: 2024, Volume and Issue: unknown

Published: May 30, 2024

Multiple sclerosis (MS) is a chronic central nervous system (CNS) neurodegenerative and neuroinflammatory disease marked by host immune reaction that targets destroys the neuronal myelin sheath. MS correlating animal models show comorbidities, including intestinal barrier disruption alterations of commensal microbiome. It accepted diet plays crucial role in shaping microbiota composition overall gastrointestinal (GI) tract health, suggesting an interplay between nutrition neuroinflammation via gut‐brain axis. Unfortunately, poor health lead to modifications could significant responses host, inflammation neurobehavioral changes. Beneficial microbial metabolites are essential for homeostasis control. This review will highlight importance gut context inflammatory models. Additionally, community restoration how it affects GI integrity be discussed.

Language: Английский

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Longitudinal associations between quality of diet and disability over 7.5 years in an international sample of people with multiple sclerosis

European Journal of Neurology, Journal Year: 2023, Volume and Issue: 30(10), P. 3200 - 3211

Published: July 12, 2023

Modifiable lifestyle factors, including diet, have been implicated in multiple sclerosis (MS) progression, but prospective evidence is limited. The aim of this study was to examine relationships between quality diet and subsequent disability over 7.5 years an international cohort people living with MS (pwMS).Data from 602 participants the HOLISM (Health Outcomes Lifestyle In a Sample Multiple sclerosis) were analysed. Quality assessed using modified Diet Habits Questionnaire (DHQ). Disability Patient-determined Severity Score (P-MSSS). Characteristics by log-binomial, log-multinomial linear regression, adjusted for demographic clinical covariates, as appropriate.Higher baseline total DHQ scores (>80-89, >89%) associated lower risks increased P-MSSS at (adjusted risk ratio [aRR] 0.46, 95% confidence interval [CI] 0.23, 0.91 aRR 0.48, CI 0.26, 0.89, respectively), less accrual (aβ = -0.38, -0.78, 0.01 aβ -0.44, -0.81, -0.06). Of domains, fat subscore most strongly disability. Participants reducing baseline-to-2.5- had greater (aRR 2.77, 1.18, 6.53) higher 0.30, 0.01, 0.60). reporting meat dairy consumption 2.06, 1.23, 3.45 2.02, 1.25, 3.25) 0.28, 0.02, 0.54 0.43, 0.16, 0.69, respectively). However, reported confounded diet. Changes or inconsistently disability.We show first time robust long-term associations progression pwMS. Subject replication, dietary modification may represent point intervention

Language: Английский

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Dietary Inflammatory Score (DIS)’s and Lifestyle Inflammatory Score (LIS)’s Impact on Multiple Sclerosis Severity

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 526 - 526

Published: Jan. 31, 2025

Background/Objectives: Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system with variable degrees inflammation and gliosis. Diet lifestyle factors could influence MS development also contribute to inflammation. The current study aims evaluate relationship between dietary inflammatory potential multiple severity. Methods: A cross-sectional design was employed. Data collection included demographic, neurological, nutritional information. Dietary Inflammatory Score (DIS) Lifestyle (LIS) were calculated based on reference protocol. Results: One hundred seven participants (69.2% female; mean age, 50.6 ± 11.6 years) completed study. anti-inflammatory LIS group had significantly higher proportions normal-weight (p = 0.000) physically active 0.022) participants. greater proportion women exhibited compared men (80% vs. 20%; p 0.023). No relation retrieved DIS, LIS, Severity (MSSS). When analyzing single DIS components, leafy greens associated severity (OR 1.67; 95% CI, 1.50–18.74; 0.009). Among “high physical activity” 5.51; 1.66–18.30; 0.005) “heavy drinking” 5.61; 1.19–26.47; 0.029) related lower Conclusions: Although no differences found in total Scores, some their components might be connected Further intervention studies are needed validate these findings.

Language: Английский

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From prevention to management: Exploring the impact of diet on multiple sclerosis

Translational Neuroscience, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 1, 2025

Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system characterized by neuroinflammation and progressive neurodegeneration. Growing evidence suggests that dietary interventions may influence MS progression symptom management modulating inflammation, oxidative stress, gut microbiota composition. This narrative review examines effects Mediterranean, plant-based, ketogenic, Wahls, Swank, intermittent fasting, gluten-free diets, alongside key nutrients such as omega-3 fatty acids, vitamin D, polyphenols, antioxidants. Among these, Mediterranean plant-based diets have shown most consistent benefits, including reductions in fatigue, improved quality life, modulation inflammatory markers. The Wahls Swank show promise but are primarily supported studies from their respective research groups, raising concerns about long-term adherence nutritional adequacy. ketogenic diet fasting yielded mixed findings, with some suggesting benefits for fatigue neuroprotection, while others highlight potential metabolic risks. supplementation lack robust evidence, inconsistent findings across studies. Additionally, ultra-processed foods high saturated fats been associated increased inflammation greater severity. Despite promising limitations small sample sizes, short follow-up durations, study design inconsistencies prevent definitive conclusions. Future should prioritize large-scale, randomized controlled trials to establish efficacy, safety, sustainability management. Mechanistic standardized protocols also needed better understand role control.

Language: Английский

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Associations between Mediterranean Diet Adherence, Quality of Life, and Mental Health in Patients with Multiple Sclerosis: A Cross-Sectional Study

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(2), P. 199 - 199

Published: Feb. 11, 2024

Background: The Mediterranean diet (MD) is well-known as a which may exert protective effect against neurodegenerative diseases, including multiple sclerosis (MS). To date, only few clinical surveys have assessed the potential effects of MD in patients with MS. purpose present study to evaluate compliance on disease disability, quality life, physical activity, depressive symptomatology, and blood biochemical parameters related nutritional status MS patients, considering several socio-demographic, anthropometric, lifestyle characteristics. Methods: This cross-sectional conducted 558 adults aged 18–64 years. Relevant questionnaires were utilized socio-demographic anthropometric parameters, disability (Expanded Disability Status Scale, EDSS), multidimensional health-related (MS Quality Life-54, MSQOL-54), activity levels (International Physical Activity Questionnaire, IPAQ), depression (Beck Depression Inventory II, BDI-II), adherence (MedDietScore), while retrieved from patients’ medical records. Results: Enhanced was independently associated decreased frequency overweight/obesity, well abdominal obesity, suffering Elevated also incidence advanced higher prevalence elevated an improved lower symptoms, certain are effective indicators iron deficiency malnutrition. Conclusions: found that slow down promoting better life mental health Future prospective required obtain conclusive results.

Language: Английский

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Microbiota, diet, and the gut–brain axis in multiple sclerosis and stroke

European Journal of Immunology, Journal Year: 2023, Volume and Issue: 53(11)

Published: July 20, 2023

Intestinal microbiota can influence the phenotype and function of immune cell responses through dissemination bacterial antigens or metabolites. Diet is one major forces shaping composition metabolism, contributing to host homeostasis disease susceptibility. Currently, nutrition a complementary alternative approach management metabolic neurological diseases cancer. However, knowledge exact mechanism action diet on gut-brain communication only developing in recent years. Here, we reviewed current effect axis patients with two different central nervous system diseases, multiple sclerosis stroke. We have also highlighted open questions field that believe are important address gain deeper understanding mechanisms by which directly indirectly affect via microbiota. think this will up new approaches treatment, diagnosis, monitoring various diseases.

Language: Английский

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