The long-term effects of maternal deprivation on the number and size of inhibitory interneurons in the rat amygdala and nucleus accumbens DOI Creative Commons
Dubravka Aleksić, Joko Poleksić, Gorana Agatonovic

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: June 26, 2023

There is an increasing evidence supporting the hypothesis that traumatic experiences during early developmental periods might be associated with psychopathology later in life. Maternal deprivation (MD) rodents has been proposed as animal model for certain aspects of neuropsychiatric disorders.To determine whether early-life stress leads to changes GABAergic, inhibitory interneurons limbic system structures, specifically amygdala and nucleus accumbens, 9-day-old Wistar rats were exposed a 24 h MD. On postnatal day 60 (P60), sacrificed morphometric analysis their brains compared control group.Results show MD affect GABAergic interneurons, leading decrease density size calcium-binding proteins parvalbumin-, calbindin-, calretinin-expressing accumbens.This study indicates life number morphology most probably due loss neurons development it further contributes understanding effects maternal on brain development.

Language: Английский

Adverse Life Experiences and Brain Function DOI Creative Commons
Niki Hosseini-Kamkar,

Mahdieh Varvani Farahani,

Maja Nikolic

et al.

JAMA Network Open, Journal Year: 2023, Volume and Issue: 6(11), P. e2340018 - e2340018

Published: Nov. 1, 2023

Importance Adverse life experiences have been proposed to contribute diverse mental health problems through an association with corticolimbic functioning. Despite compelling evidence from animal models, findings studies in humans mixed; activation likelihood estimation (ALE) meta-analyses failed identify a consistent of adverse events brain function. Objective To investigate the adversity exposure altered reactivity using multilevel kernel density analyses (MKDA), meta-analytic approach considered more robust than ALE small sample sizes and methodological differences between studies. Data Sources Searches were conducted PsycInfo, Medline, EMBASE, Web Science inception May 4, 2022. The following search term combinations used for each database: trauma , posttraumatic stress disorder ( PTSD ), abuse maltreatment poverty or ; functional magnetic resonance imaging fMRI ) neuroimaging; emotion regulation memory processing inhibitory control executive functioning reward . Study Selection Task-based within 4 domains (emotion processing, control, processing) that included measure whole-brain coordinate results reported Talairach Montreal Neurological Institute space included. Conference abstracts, books, reviews, meta-analyses, opinions, studies, articles not English, fewer 5 participants excluded. Extraction Synthesis Using Preferred Reporting Items Systematic Reviews Meta-Analyses reporting guideline, 2 independent reviewers assessed abstracts full-text entry criteria. A third reviewer resolved conflicts errors data extraction. pooled random-effects model analysis occurred August November Main Outcomes Measures Peak x-axis (left-right), y-axis (posterior-anterior), z-axis (inferior-superior) coordinates extracted all submitted MKDA meta-analyses. Results total 83 meta-analysis, yielding combined 5242 801 coordinates. Adversity was associated higher amygdala (familywise error rate corrected at P < .001; = 22; −4; −17) lower prefrontal cortical 10; 60; 10) across range task domains. These responses only observed adult clearest among those who had exposed severe threat trauma. Conclusions Relevance In this meta-analysis function, prior challenges. might better how diminishes ability cope later stressors produces enduring susceptibility problems.

Language: Английский

Citations

29
Early-life stress induces persistent astrocyte dysfunction associated with fear generalisation DOI Open Access

Mathias Guayasamin,

Lewis R Depaauw-Holt,

Ifeoluwa I Adedipe

et al.

Published: Jan. 15, 2025

Early-life stress can have lifelong consequences, enhancing susceptibility and resulting in behavioural cognitive deficits. While the effects of early-life on neuronal function been well-described, we still know very little about contribution non-neuronal brain cells. Investigating complex interactions between distinct cell types is critical to fully understand how cellular changes manifest as deficits following stress. Here, using male female mice report that induces anxiety-like behaviour fear generalisation an amygdala-dependent learning memory task. These were associated with impaired synaptic plasticity, increased neural excitability, astrocyte hypofunction. Genetic perturbation amygdala by either reducing calcium activity or network was sufficient replicate cellular, synaptic, Our data reveal a role astrocytes tuning emotionally salient provide mechanistic links stress, hypofunction,

Language: Английский

Citations

1
From Play Date to Stress Fate: Juvenile Social Play Rescues Stress‐Induced Changes in Adult Social Behavior DOI
Conner J. Whitten, Jeffrey R. Kelly, Alex Gillespie

et al.

Developmental Psychobiology, Journal Year: 2025, Volume and Issue: 67(1)

Published: Jan. 1, 2025

ABSTRACT Long‐term effects of social play on neural and behavioral development remain unclear. We investigated whether just 1 h juvenile could rescue the deprivation stress‐related behavior markers plasticity. Syrian hamsters were reared from postnatal days 21–43 in three conditions: peer isolation, isolation with daily sessions (dyadic play), or group‐housed littermates. In adulthood, subjects exposed to acute defeat stress, we examined changes perineuronal net (PNN) expression surrounding parvalbumin (PV) neurons prelimbic (PL), infralimbic (IL), basolateral amygdala (BLA). Peer led exaggerated submissive defensive a conditioned test, but dyadic rescued heightened response both males females. females, reduced PNN/PV coexpression PL IL compared control groups opportunities for play. Males showed elevated agonistic when returned their littermates 1‐h encounters. These findings indicate has long‐lasting PNN PV cells medial prefrontal cortex, which allows species’ typical greater stress resistance adulthood. The ability highlights powerful role interactions development.

Language: Английский

Citations

1
Chondroitin sulfate glycan sulfation patterns influence histochemical labeling of perineuronal nets: a comparative study of interregional distribution in human and mouse brain DOI Creative Commons
Claudia Belliveau, Stéphanie Théberge,

Stefanie Netto

et al.

Glycobiology, Journal Year: 2024, Volume and Issue: 34(8)

Published: June 22, 2024

Abstract Perineuronal nets (PNNs) are a condensed subtype of extracellular matrix that form net-like coverings around certain neurons in the brain. PNNs primarily composed chondroitin sulfate (CS) proteoglycans from lectican family consist CS-glycosaminoglycan side chains attached to core protein. CS disaccharides can exist various isoforms with different sulfation patterns. Literature suggests disaccharide patterns influence function as well their labeling. This study was conducted characterize such interregional pattern differences adult human (n = 81) and mouse 19) brains. Liquid chromatography tandem mass spectrometry used quantify five patterns, which were then compared immunolabeling using Wisteria Floribunda Lectin (WFL) identify CS-glycosaminoglycans anti-aggrecan proteoglycans. In healthy brains, significant regional species-specific single versus double-labeling identified. A secondary analysis investigate how early-life stress impacts these PNN features discovered although increases WFL+ density, code double PNN-labeling distributions remained unaffected both species. These results underscore complexity traditional research, emphasizing need consider heterogeneity future experiments.

Language: Английский

Citations

7
Fetal development of the human amygdala DOI
Damir Mulc, Dinko Smilović, Željka Krsnik

et al.

The Journal of Comparative Neurology, Journal Year: 2024, Volume and Issue: 532(1)

Published: Jan. 1, 2024

Abstract The intricate development of the human amygdala involves a complex interplay diverse processes, varying in speed and duration. In humans, transient cytoarchitectural structures deliquesce, leading to formation functionally distinct nuclei as result multiple interdependent developmental events. This study compares amygdala's conjunction with specific antibody reactivity for neuronal, glial, neuropil, radial glial fibers, synaptic, extracellular matrix, myelin components 39 fetal brains. We recognized that early period, continuation embryonic is still dominated by relatively uniform histogenetic processes. typical appearance ovoid cell clusters lateral nucleus during midfetal period most likely associated migration axonal growth processes developing brain. Notably, synaptic markers are firstly detected corticomedial group nuclei, while immunoreactivity panaxonal neurofilament marker SMI 312 found dorsally. late characterized protracted process evidenced presence doublecortin SOX‐2 ventrally, prospective paralaminar nucleus, reinforced vimentin last remaining fibers. Nearing term 99 indicates perinatal myelination becomes prominent primarily along major pathways, laying foundation more pronounced functional maturation. comprehensively elucidates rate sequence maturational events amygdala, highlighting key role prenatal its behavioral, autonomic, endocrine regulation, subsequent implications both normal functioning psychiatric disorders.

Language: Английский

Citations

4
Serotonergic neuromodulation of synaptic plasticity DOI
Guilherme Shigueto Vilar Higa, Felipe José Costa Viana, José Fernando de Oliveira

et al.

Neuropharmacology, Journal Year: 2024, Volume and Issue: 257, P. 110036 - 110036

Published: June 12, 2024

Language: Английский

Citations

4
Noradrenergic alterations associated with early life stress DOI Creative Commons

M Sheppard,

Jalil Rasgado‐Toledo, Niall W. Duncan

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 164, P. 105832 - 105832

Published: July 29, 2024

Significant stress in childhood or adolescence is linked to both structural and functional changes the brain human analogous animal models. In addition, neuromodulators, such as noradrenaline (NA), show life-long alterations response these early life stressors, which may impact upon sensitivity time course of key adrenergic activities, rapid autonomic responses (the 'fight flight response'). The locus-coeruleus noradrenergic (LC-NA) network, a stress-responsive network brain, displays numerous significant early- stress. Here, we review relationship between NA neurobiological associated with set out future lines research that can illuminate how circuits circulating neurotransmitters adapt stressors.

Language: Английский

Citations

4
Chronic stress-induced neuroplasticity in the prefrontal cortex: Structural, functional, and molecular mechanisms from development to aging DOI
Sami A. Algaidi

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149461 - 149461

Published: Jan. 1, 2025

Language: Английский

Citations

0
Early-life stress induces persistent astrocyte dysfunction associated with fear generalisation DOI Creative Commons

Mathias Guayasamin,

Lewis R Depaauw-Holt,

Ifeoluwa I Adedipe

et al.

eLife, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 5, 2025

Early-life stress can have lifelong consequences, enhancing susceptibility and resulting in behavioural cognitive deficits. While the effects of early-life on neuronal function been well-described, we still know very little about contribution non-neuronal brain cells. Investigating complex interactions between distinct cell types is critical to fully understand how cellular changes manifest as deficits following stress. Here, using male female mice report that induces anxiety-like behaviour fear generalisation an amygdala-dependent learning memory task. These were associated with impaired synaptic plasticity, increased neural excitability, astrocyte hypofunction. Genetic perturbation amygdala by either reducing calcium activity or network was sufficient replicate cellular, synaptic, Our data reveal a role astrocytes tuning emotionally salient provide mechanistic links stress, hypofunction,

Language: Английский

Citations

0
Early life stress and brain development: Neurobiological and behavioral effects of chronic stress DOI
Subia Jamil, Muhammad Liaquat Raza, Nasrollah Moradikor

et al.

Progress in brain research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0