Medical Records,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 17, 2024
Background:
Aim
of
this
study
was
to
investigate
the
relationship
between
autonomic
nervous
system
and
meibomian
gland
activity
through
pupillary
diameter
values.
Methods:
55
volunteers
aged
16-41
years
participated
in
study.
Dry
eye
patients
with
a
visual
acuity
10/10
according
Snellen
threshold
were
included
Participants
underwent
static
measurements
under
different
light
intensities
dynamic
measure
dilation
velocity.
Results:
Static
(scotopic,
mesopic
ve
photopic)
patient
group
averaged
5.93±1.21,
4.70±0.86
3.99±0.97
mm,
respectively,
while
those
control
5.82±0.99,
4.87±0.83
3.87±0.90
respectively.
Pupillary
velocity
0.14±0.04
0.12±0.03
mm/sec
group.
Conclusion:
This
is
first
function
function.
The
present
contributed
literature
by
showing
that
there
no
Behavior Research Methods,
Journal Year:
2021,
Volume and Issue:
54(6), P. 2720 - 2739
Published: Dec. 16, 2021
Abstract
We
introduce
PyPlr
—a
versatile,
integrated
system
of
hardware
and
software
to
support
a
broad
spectrum
research
applications
concerning
the
human
pupillary
light
reflex
(PLR).
is
custom
Python
library
for
integrating
research-grade
video-based
eye-tracker
with
source
streamlining
stimulus
design,
optimisation
delivery,
device
synchronisation,
extraction,
cleaning,
analysis
pupil
data.
additionally
describe
how
full-field,
homogenous
stimulation
retina
can
be
realised
low-cost
sphere
that
serves
as
an
alternative
more
complex
Maxwellian
view
setup.
Users
integrate
their
own
source,
but
we
provide
full
native
high-end,
commercial
10-primary
engine
offers
advanced
control
over
temporal
spectral
properties
stimuli
well
calibration
utilities.
Here,
in
detail
demonstrate
its
capabilities
two
example
applications:
(1)
pupillometer-style
measurement
parametrisation
PLR
flashes
white
light,
(2)
comparing
post-illumination
response
(PIPR)
long
short-wavelength
light.
The
holds
promise
researchers
who
would
favour
flexible
approach
studying
ability
employ
wide
range
temporally
spectrally
varying
stimuli,
including
simple
narrowband
stimuli.
LEUKOS The Journal of the Illuminating Engineering Society of North America,
Journal Year:
2022,
Volume and Issue:
19(3), P. 294 - 307
Published: Oct. 24, 2022
We
introduce
a
lighting
technology
designed
to
produce
photoreceptor-directed
lights
(PrD).
This
photoreceptor-enhanced
light
therapy
(PELT)
differs
from
conventional
supplemental
by
using
multiple
limited-bandwidth
primaries
generate
spectra
that
appear
white,
and
are
tailored
circadian
equivalent
(CE)
for
selectively
increasing
or
decreasing
the
relative
activation
levels
of
specific
photoreceptor
classes
in
human
eye.
Rather
than
designing
device
match
spectrum's
shape,
we
optimize
available
hardware,
so
it
best
matches
biological
effects
spectrum.
It
goes
beyond
three
four
dimensions
(three
cones
plus
melanopsin)
consider
responses
mediated
via
all
five
(including
rhodopsin);
inclusion
fifth
class
is
non-trivial
both
implementation
effect.
Here,
describe
technical
specifications
PELT
its
calibration
procedures.
Photoreceptor-directed
with
variable
melanopsin
rhodopsin
excitations
equal
photometric
luminance
presented.
Device
application
examples
provided
include
personalized
patients
sensitivity
loss,
healthy
people
exposed
extreme
seasonal
work-related
variation
their
ambient
patterns,
as
stimulus
generator
evaluate
on
health
behavior
expressing
intrinsically
photosensitive
retinal
ganglion
cells
(ipRGCs).
In
integrative
practice,
method
extends
dynamic
control
potency
over
large
range,
independent
perceived
changes
correlated
color
temperature
(CCT).
Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring,
Journal Year:
2024,
Volume and Issue:
16(3)
Published: July 1, 2024
Abstract
Easily
applied
diagnostic
tools
such
as
digital
biomarkers
for
Alzheimer's
disease
(AD)
are
urgently
needed
due
to
the
recent
approval
of
disease‐modifying
therapies.
We
aimed
determine
performance
hand‐held,
quantitative
light
reflex
pupillometry
(qLRP)
in
patients
with
AD
a
proof‐of‐concept,
cross‐sectional
study.
Participants
underwent
qLRP
at
university
memory
clinic
from
August
2022
October
2023.
fitted
multivariable
logistic
regression
models
qLRP,
sex,
and
age
predictors
evaluated
area
under
receiver
operating
characteristics
curve
(AUROC).
In
total,
107
AD,
44
mixed
vascular
cognitive
dysfunction
(VCD),
53
dementia
Lewy
bodies
(DLB),
50
healthy
controls
(HCs)
were
included.
Our
showed
similar
discriminatory
ability
(AUROC
range
0.74‐0.81)
when
distinguishing
HCs
other
dementias.
The
seems
promising
bedside
biomarker
aid
diagnosing
AD.
Highlights
demonstrated
disease.
robust
sensitivity
analyses.
may
assist
evaluation
Journal of Occupational Medicine and Toxicology,
Journal Year:
2021,
Volume and Issue:
16(1)
Published: Sept. 7, 2021
Abstract
Background
The
PLR
(pupillary
light
reflex)
can
be
a
marker
for
pathological
medical
conditions,
such
as
neurodegenerative
or
mental
health
disorders
and
diseases
well
physiological
alterations,
age,
sex
iris
color.
alterations
have
been
described
in
people
after
alcohol
consumption,
well.
However,
the
effect
of
sleep
deprivation
on
parameters
is
still
under
debate.
Methods
aim
this
study
was
to
investigate
feasibility
measurements
sleep-deprived
alcohol-exposed
participants.
In
addition,
we
wanted
identify
that
were
altered
by
exposure.
Results
Altogether
n
=
50
participants
included
study.
Differences
initial
diameter
(d
init
),
latency
(∆t
lat
acceleration
contraction
velocity
(ϑ
con
quarter
dilatation
1/4dil
half
time
1/2
line
integral
(L(0.3500))
evaluated
between
baseline,
deprivation,
generalized
linear
mixed
models
design,
could
observe
statistically
significant
associations
type
exposure
first
pulse
(all
p
<
0.05).
participants’
showed
association
dependence
second
(
Conclusion
Our
delivers
promising
results
further
develop
devices
may
conditions
impair
ability
work
drive.
Ophthalmology and Therapy,
Journal Year:
2023,
Volume and Issue:
12(4), P. 2133 - 2156
Published: June 7, 2023
This
study
aimed
to
examine
the
performance
of
binocular
chromatic
pupillometry
for
objective
and
rapid
detection
primary
open-angle
glaucoma
(POAG),
explore
association
between
pupillary
light
response
(PLR)
features
structural
glaucomatous
macular
damage.Forty-six
patients
(mean
age
41.00
±
13.03
years)
with
POAG
23
healthy
controls
42.00
11.08
were
enrolled.
All
participants
underwent
sequenced
PLR
tests
full-field,
superior/inferior
quadrant-field
stimuli
using
a
head-mounted
pupillometer.
The
constricting
amplitude,
velocity,
time
max
constriction/dilation,
post-illumination
pupil
(PIPR)
analyzed.
inner
retina
thickness
volume
measurements
determined
by
spectral
domain
optical
coherence
tomography.In
full-field
stimulus
experiment,
dilation
was
inversely
correlated
perifoveal
(r
=
-
0.429,
P
<
0.001)
0.364,
0.001).
Dilation
(AUC
0.833)
showed
good
diagnostic
performance,
followed
constriction
amplitude
0.681)
PIPR
0.620).
In
superior
negatively
inferior
0.451,
0.417,
in
best
0.909).
(P
well
0.299,
0.304,
0.001).The
use
offers
patient-friendly
approach
detect
POAG,
while
impairment
may
serve
as
potential
indicator
damage.
Frontiers in Neuroscience,
Journal Year:
2023,
Volume and Issue:
17
Published: Aug. 15, 2023
Alzheimer’s
disease
(AD)
is
the
leading
cause
of
dementia,
and
its
prevalence
increasing
expected
to
continue
increase
over
next
few
decades.
Because
this,
there
an
urgent
requirement
determine
a
way
diagnose
disease,
target
interventions
delay
ideally
stop
onset
symptoms,
specifically
those
impacting
cognition
daily
livelihood.
The
pupillary
light
response
(PLR)
controlled
by
sympathetic
parasympathetic
branches
autonomic
nervous
system,
impairments
have
been
related
AD.
However,
most
these
studies
that
assess
PLR
occur
in
patients
who
already
diagnosed
with
AD,
rather
than
are
at
higher
risk
for
but
without
diagnosis.
Determining
whether
similarly
impaired
subjects
before
AD
diagnosis
made
cognitive
symptoms
begin,
important
step
using
as
diagnostic
tool.
Specifically,
identifying
specific
at-risk
groups,
considering
both
genetic
non-genetic
factors,
imperative.
It
possible
may
be
association
some
factors
not
others,
potentially
indicating
different
pathways
neurodegeneration
could
distinguished
PLR.
In
this
work,
we
review
common
lifestyle-based
identify
established
relationships
between
evidence
here
shows
many
including
traumatic
brain
injury,
ocular
intracranial
hypertension,
alcohol
consumption,
depression,
diabetes,
directly
changes
Other
currently
lack
sufficient
literature
make
any
conclusions
relating
shown
links
system;
further
research
should
conducted
their
relation
