Limbic Neuropeptidergic Modulators of Emotion and Their Therapeutic Potential for Anxiety and Post-Traumatic Stress Disorder

Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 41(5), P. 901 - 910

Published: Jan. 20, 2021

Post-traumatic stress disorder (PTSD) is characterized by hypervigilance, increased reactivity to unpredictable versus predictable threat signals, deficits in fear extinction, and an inability discriminate between safety. First-line pharmacotherapies for psychiatric disorders have limited therapeutic efficacy PTSD. However, recent studies advanced our understanding of the roles several limbic neuropeptides regulation defensive behaviors neural processes that are disrupted For example, preclinical shown blockers tachykinin pathways, such as Tac2 pathway, attenuate memory consolidation mice thus might unique potential early post-trauma interventions prevent PTSD development. Targeting this pathway also be beneficial regulating other symptoms PTSD, including trauma-induced aggressive behavior. In addition, clinical important role angiotensin receptors extinction promise using II receptor blockade reduce symptom severity. Additional demonstrated oxytocin foster accurate discrimination facilitating responses threats. Complementary human imaging demonstrate targets intranasal compare its with well-established anxiolytic treatments. Finally, promising data from subjects a selective vasopressin 1A antagonist reduces anxiety induced This review highlights these novel treatment core elements pathophysiology.

Language: Английский

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Oxytocin levels in response to CRH administration in hypopituitarism and hypothalamic damage: a randomized, crossover, placebo-controlled trial

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 18, 2025

Increasing evidence supports the presence of oxytocin deficiency (OXT-D) in patients with hypopituitarism and hypothalamic damage (HHD), that might be associated neuropsychological deficits sexual dysfunction, leading to worse quality life (QoL). Therefore, identifying a provocative test diagnose an OXT-D will important. Corticotropin-releasing hormone (CRH) is candidate for such as it increases secretion animal models. This study aimed examine effects CRH on release HHD compared healthy controls (HC) describe psychopathology, function QoL their associations oxytocin. single-blind, randomized, placebo-controlled, proof-of-concept (NCT04902235) crossover assignment (CRH vs. placebo). Nineteen (10 females) 20 HC (11 completed two visits, receiving or placebo random order validated questionnaires assess QoL. Samples were collected over 120 min Linear mixed-effects regression model evaluated change after CRH/placebo HC. administration did not impact concentrations across groups time (p = 0.97). had greater psychopathology (most ps < 0.05), dysfunction 0.03) 0.001) HC, nevertheless, baseline area under curve significantly QoL, neither In conclusion, does appear suitable diagnosing HHD. Identifying reliable diagnostic remains crucial. Alternative tests biomarkers should explored.

Language: Английский

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Establishment of the miniature fish speciesDanionella translucidaas a genetically and optically tractable neuroscience model

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2018, Volume and Issue: unknown

Published: Oct. 16, 2018

Summary Integrative studies of the diverse neuronal networks that govern social behavior are hindered by lack methods to record neural activity comprehensively across entire brain. The recent development miniature fish Danionella cerebrum as a model organism offers one potential solution, small size and optical transparency these animals makes it possible visualize circuit throughout nervous system 1–4 . Here, we establish feasibility using for socially reinforced learning showing adult exhibit strong affiliative tendencies, interactions can serve reinforcer in an appetitive conditioning paradigm. Fish exhibited acute ability identify conspecifics distinguish them from closely related species, which was mediated both visual particularly olfactory cues. These behaviors were abolished pharmacological genetic interference with oxytocin signaling, demonstrating conservation key mechanisms observed other vertebrates 5–11 Our work validates tool understanding brain general, its modulation neuropeptide signaling particular.

Language: Английский

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Dynamic regulation of oxytocin neuronal circuits in the sequential processes of prosocial behavior in rodent models

Current Research in Neurobiology, Journal Year: 2021, Volume and Issue: 2, P. 100011 - 100011

Published: Jan. 1, 2021

The expression of positive social (i.e., prosocial) behavior is governed by a multitude sensory and cognitive abilities to identify recognize key features potential partners, elucidate individual status, maintain appropriate behaviors. Oxytocin (OT) neuropeptide that has been implicated as major player in regulating prosocial behavior, much its role situations uncovered. As inherently comprises sequential processes related multimodal assessments interactive features, comprehensive approach understanding the functions OT these sequences required. Here, author discusses recent evidence illustrating functioning neural circuits processing components including detection/recognition cues via olfactory bulb through cortices, evaluation paraventricular nucleus hypothalamus medial amygdala, maintenance behaviors ventral tegmental area accumbens. A review rodent studies with an emphasis on mice rats also provided investigate effects interaction other neurotransmitters, such serotonin dopamine, characterize neuromodulatory mechanisms mediate engagements. further highlights function temporal dynamic specific circuits.

Language: Английский

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Birth, love, and fear: Physiological networks from pregnancy to parenthood

Comprehensive Psychoneuroendocrinology, Journal Year: 2022, Volume and Issue: 11, P. 100138 - 100138

Published: April 26, 2022

Pregnancy and childbirth are among the most dramatic physiological emotional transformations of a lifetime. Despite their central importance to human survival, many gaps remain in our understanding temporal progression mechanisms underlying transition new parenthood. The goal this paper is outline development maternal-infant dyad from late pregnancy postpartum period, provide framework investigate using non-invasive timeseries. We focus on interaction neuroendocrine, emotional, autonomic outputs context pregnancy, parturition, post-partum. then propose that coupled dynamics these can be leveraged map both physiologic pathologic This approach could address knowledge enable early detection or prediction problems, with personalized depth broad population scale.

Language: Английский

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Neuromodulatory functions exerted by oxytocin on different populations of hippocampal neurons in rodents

Frontiers in Cellular Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Feb. 2, 2023

Oxytocin (OT) is a neuropeptide widely known for its peripheral hormonal effects (i.e., parturition and lactation) central neuromodulatory functions, related especially to social behavior social, spatial, episodic memory. The hippocampus key structure these it innervated by oxytocinergic fibers, contains OT receptors (OTRs). hippocampal OTR distribution not homogeneous among subregions types of neuronal cells, reflecting the specificity oxytocin's modulatory action. In this review, we describe most recent discoveries in OT/OTR signaling hippocampus, focusing primarily on electrophysiological modulation OTR-expressing neurons. We then look at effect has balance excitation/inhibition synaptic plasticity each subregion. Additionally, review downstream signaling, which underlies observed different neuron. Overall, comprehensively summarizes advancements unraveling functions exerted specific networks.

Language: Английский

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Quiet wakefulness: the influence of intraperitoneal and intranasal oxytocin on sleep–wake behavior and neurophysiology in rats

SLEEP, Journal Year: 2023, Volume and Issue: 46(7)

Published: April 11, 2023

Abstract Study Objectives Exogenous administration of the neuropeptide oxytocin exerts diverse effects on various neurobehavioral processes, including sleep and wakefulness. Since can enhance attention to social fear-related environmental cues, it should promote arousal However, as attenuate stress, reduce activity, elicit anxiolysis, might also prime brain for rest, sleep. At present, little research has comprehensively characterized neuropsychopharmacology oxytocin-induced sleep–wake behavior no reconciliation these two competing hypotheses been proposed. Methods This study explored outcomes using radiotelemetry-based polysomnography in adult male female Wistar rats. Oxytocin was administered via intraperitoneal (i.p.; 0.1, 0.3 1 mg·kg−1) intranasal (i.n.; 0.06, 1, 3 routes. Caffeine (i.p. i.n.; 10 a wake-promoting positive control. To ascertain mechanism action, pretreatment experiments with receptor (OXTR) antagonist L-368,899 5 followed by were conducted. Results In both rats, i.p. promoted quiet wakefulness at cost suppressing active wakefulness, non-rapid eye movement (NREM) rapid (REM) Several mediated OXTR binding. contrast, i.n. did not alter most any dose tested. Both caffeine demonstrated effects. Conclusions These findings help reconcile behavior: promotes wakefulness—a state restful awareness compatible oxytocin’s anxiolytic its enhancement processing complex stimuli.

Language: Английский

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Oxytocin-mediated social preference and socially reinforced reward learning in the miniature fish Danionella cerebrum

Current Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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The potential role of oxytocin in addiction: What is the target process?

Current Opinion in Pharmacology, Journal Year: 2021, Volume and Issue: 58, P. 8 - 20

Published: April 9, 2021

Language: Английский

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Immunoglobulin G is a natural oxytocin carrier which modulates oxytocin receptor signaling: relevance to aggressive behavior in humans

Discover Mental Health, Journal Year: 2023, Volume and Issue: 3(1)

Published: Oct. 19, 2023

Oxytocin is a neuropeptide produced mainly in the hypothalamus and secreted CNS blood. In brain, it plays major role promoting social interactions. Here we show that human plasma about 60% of oxytocin naturally bound to IgG which modulates receptor signaling. Further, found violent aggressive inmates were characterized by lower affinity for oxytocin, causing decreased carrier capacity reduced activation as compared men from general population. Moreover, peripheral administration together with oxytocin-reactive resident mice resident-intruder test, c-fos several brain regions involved regulation aggressive/defensive behavior correlating attack number duration. We conclude natural protein modulating signaling can be relevant biological mechanisms behavior.

Language: Английский

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