Sleep disorders in rheumatoid arthritis, axial spondyloarthritis and psoriatic arthritis

Rheumatology International, Journal Year: 2025, Volume and Issue: 45(2)

Published: Jan. 22, 2025

Language: Английский

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Different temporal relationship between sex hormones and sleep status in midlife women: a longitudinal cohort study

Sexual Medicine, Journal Year: 2025, Volume and Issue: 13(1)

Published: Feb. 1, 2025

Fluctuation in sex hormones and the occurrence of sleep disturbance are 2 major health challenges among midlife women. However, temporal relationship between them remains unclear. This study included 2488 females (mean ± SD age, 49.0 2.70 years) with an average follow-up 6.95 years. We constructed a composite score by summing items related to problems reflect comprehensive status participants Study Women's Health Across Nation. Cross-lagged path analysis was used examine status. Sensitivity analyses were conducted nonoverweight overweight groups adjusted for vasomotor symptoms main model. In this study, we aimed women using cross-lagged analysis. The primary outcomes results After adjusting race, income, menopausal status, body mass index, hormone therapy use, smoking, drinking, coefficients from baseline follicle-stimulating (FSH) estradiol (E2) 0.054 (P = .017) -0.054 .016), respectively. coefficient dehydroepiandrosterone sulfate (DHAS) 0.042 .017). testosterone not statistically significant. group, patterns same as total sample, point estimates larger. relationships group nonsignificant. adjustment model, basically consistent. Given sleep, our findings will provide scientific perspectives benefit management transition menopause. longitudinal theoretical model distinguish Limitations include limited causal evidence observational studies, unknown confounders, careful extrapolation. There distinct unidirectional (1) FSH, E2, DHAS (2) sleep. Changes FSH E2 occurred earlier than change while later. contrast, there no

Language: Английский

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Adolescent sleep and the foundations of prefrontal cortical development and dysfunction

Progress in Neurobiology, Journal Year: 2022, Volume and Issue: 218, P. 102338 - 102338

Published: Aug. 10, 2022

Modern life poses many threats to good-quality sleep, challenging brain health across the lifespan. Curtailed or fragmented sleep may be particularly damaging during adolescence, when disruption by delayed chronotypes and societal pressures coincides with our brains preparing for adult via intense refinement of neural connectivity. These vulnerabilities converge on prefrontal cortex, one last regions mature a central hub limbic-cortical circuits underpinning decision-making, reward processing, social interactions emotion. Even subtle cortical development adolescence therefore have enduring impact. In this review, we integrate synaptic circuit mechanisms, glial biology, neurophysiology epidemiology, frame hypothesis highlighting implications adolescent circuitry cortex. Convergent evidence underscores importance acknowledging, quantifying optimizing sleep's contributions normative lifelong mental health.

Language: Английский

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Sleep Quality and Its Affecting Factors among Hemodialysis Patients: A Multicenter Cross-Sectional Study

Healthcare, Journal Year: 2023, Volume and Issue: 11(18), P. 2536 - 2536

Published: Sept. 14, 2023

(1) Background: Sleep quality is one of the most important clinical outcomes hemodialysis (HD) patients, as it can affect their physical and mental health. This study aimed to investigate sleep its affecting factors among patients with HD. (2) Methods: A cross-sectional design was used HD in two cities Saudi Arabia. The data were collected during period from January December 2022. convenience sample 250 selected this study. Data using Arabic version Pittsburgh Quality Index (PSQI). (3) Results: About two-thirds participants (63.6%) had normal sleep, while one-third poor (36.4%). There a significant relationship between participants’ age where who aged more than 50 poorer those younger (p < 0.001). Male married significantly female single = 0.011 0.015, respectively). In addition, retired, higher number dependents, did not adhere exercise, comorbidities other groups 0.002, 0.016, 0.023, <0.001, level education, financial status, distance home dialysis center, satisfaction at time no influence on patients. multiple linear regression shows that exercise 0.017), 0.008), duration 0.020) independent (4) Conclusions: sleep. differences patients’ age, gender, marital sleep-quality levels. Moreover, groups. Future studies should develop appropriate interventions address problem

Language: Английский

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Sleep duration, sleep efficiency, and amyloid β among cognitively healthy later-life adults: a systematic review and meta-analysis

BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 8, 2024

Abstract Background Abnormal amyloid β (Aβ) deposits in the brain are a hallmark of Alzheimer’s disease (AD). Insufficient sleep duration and poor quality risk factors for developing AD. Sleep may play role Aβ regulation, but magnitude relationship between deposition remains unclear. This systematic review examines (i.e., efficiency) with later-life adults. Methods A search PubMed, CINAHL, Embase, PsycINFO generated 5,005 published articles. Fifteen studies met inclusion criteria qualitative syntheses; thirteen quantitative syntheses related to Aβ; nine efficiency Aβ. Results Mean ages samples ranged from 63 76 years. Studies measured using cerebrospinal fluid, serum, positron emission tomography scans two tracers: Carbone 11-labeled Pittsburgh compound B or fluorine 18-labeled. was subjectively interviews questionnaires, objectively polysomnography actigraphy. Study analyses accounted demographic lifestyle factors. Based on 13 eligible articles, our synthesis demonstrated that average association not statistically significant (Fisher’s Z = -0.055, 95% CI -0.117 ~ 0.008). We found longer self-report is associated lower -0.062, -0.119 -0.005), whereas 0.002, -0.108 0.113). 9 articles efficiency, also 0.048, -0.066 0.161). Conclusion The findings this suggest shorter self-reported higher levels. Given heterogeneous nature measures outcomes, it still difficult determine exact Future larger sample sizes should focus comprehensive characteristics use longitudinal designs better understand

Language: Английский

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Sleep Across the Lifespan: A Neurobehavioral Perspective

Current Sleep Medicine Reports, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 5, 2025

Language: Английский

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Association of Sleep Duration With Serum Estradiol Concentrations Among American Men and Women: Evidence From NHANES 2013–2016

International Journal of Endocrinology, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Objective: To evaluate the association between sleep duration with serum estradiol concentrations and its variation by sex age in American adults. Methods: Data were analyzed for 5406 men women (≥ 20 years old) who participated cycles of National Health Nutrition Examination Survey 2013–2016, a cross‐sectional study. Total (pg/mL) was measured categorized (low, normal, high) based on NHANES protocol. Sleep classified as ≤ 6, 6–9, ≥ 9 h. Weighted multivariable adjusted multinomial logistic regression models conducted to assess these associations. Results: Our analysis revealed no significant associations among both women. Specifically, comparisons durations (≤ 6 h) reference group (6–9 across various categories showed odds ratios low high that remained statistically nonsignificant fully models. These findings suggest that, unlike previous studies linking variations other hormones, do not appear be significantly affected differences either all groups studied. Conclusion: The lack indicates may influence levels general population results underscore importance continued research into how influences hormonal balance. However, it is important note data we used are from study, which cannot establish causal relationship estradiol. Future should investigate additional factors, such genetic predispositions, lifestyle habits, environmental influences, modulate hormone levels.

Language: Английский

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Sex differences in reward-based operant conditioning performance and neurotransmitter changes following chronic sleep restriction stress in rats

Behavioral and Brain Functions, Journal Year: 2025, Volume and Issue: 21(1)

Published: Feb. 28, 2025

Sleep deprivation significantly impairs cognitive function, which disrupts daily life. However, sex differences in these impairments are not well understood, as most preclinical studies primarily use male animals, neglecting potential between sexes. This study aims to investigate sex-specific function under sleep using reward-based operant conditioning tasks. Sprague-Dawley rats were pre-trained on a lever-press task and subsequently divided into control chronic restriction (CSR) groups. The CSR group underwent 14 days of restriction. After modeling, assessed the open field test, retraining lever-pressing task, signal discrimination extinction evaluate motor abilities, memory formation, learning, flexibility. impaired performance both sexes, with requiring more time exhibiting lower accuracy. In showed longer feeding latency accuracy compared females. also specifically increased frequency responses rats. enhanced exploration females higher frequencies than males. Biochemically, induced alterations, including elevated serum MDA MAO levels males serotonin, dopamine, epinephrine Although activation was observed metabolites tryptophan-kynurenine pathway, evident kynurenic acid metabolism prefrontal cortex. female rats, significant observed. Male exhibited discrimination, while learning These accompanied by CSR-induced oxidative stress, neurotransmitter dysregulation, disturbances tryptophan metabolic pathway. findings underscore importance considering understanding effects developing targeted intervention strategies.

Language: Английский

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A prospective study to investigate circadian rhythms as health indicator in women’s aging

npj Women s Health, Journal Year: 2025, Volume and Issue: 3(1)

Published: Feb. 28, 2025

Abstract The circadian clock plays a crucial role in regulating the timing of numerous physiological processes. Its dysregulation has severe implications for organism’s homeostasis and is among main characteristics aging. As women age transition through menopause, disruptions rhythms may occur, leading to symptoms such as insomnia, mood changes, or altered energy levels. In this prospective non-randomized cohort study, we seek characterize better understand alterations across various stages their reproductive cycle, both with without daily routine (e.g., specific diet, light exposure). Understanding intricate relationship between female health during aging process essential developing targeted interventions mitigate promote overall well-being menopausal women. Findings from study will be used devise tailored rhythm assessments women, facilitating alleviation menopause-related promoting healthy

Language: Английский

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Unraveling sleep quality in menopausal women: objective assessments and self-reported experiences – a mini-review

Climacteric, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: March 11, 2025

Sleep is a cornerstone of health, playing an integral role in both physiological and psychological functions. However, it vulnerable to variety factors including menopause. According available research, the onset menopause transition may not necessarily worsen sleep architecture could even enhance it, leading conflict between assessment subjective objective complaints. This discrepancy highlights complex relationship quality. Understanding this remains challenging due limited number longitudinal studies small sample sizes. review explores findings from assessments menopausal women examines impact hormone therapy on

Language: Английский

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