Advanced Predictive Analytics for Fetal Heart Rate Variability Using Digital Twin Integration

Sensors, Journal Year: 2025, Volume and Issue: 25(5), P. 1469 - 1469

Published: Feb. 27, 2025

Fetal heart rate variability (FHRV) is a critical indicator of fetal well-being and autonomic nervous system development during labor. Traditional monitoring methods often provide limited insights, potentially leading to delayed interventions suboptimal outcomes. This study proposes an advanced predictive analytics approach by integrating approximate entropy analysis with hidden Markov model (HMM) within digital twin framework enhance real-time monitoring. We utilized dataset 469 electrocardiogram (ECG) recordings, each exceeding one hour in duration, ensure sufficient temporal information for reliable modeling. The FHRV data were preprocessed partitioned into parasympathetic sympathetic components based on downward non-downward beat detection. Approximate was calculated quantify the complexity patterns, revealing significant correlations umbilical cord blood gas parameters, particularly pH levels. HMM developed four states representing discrete levels eight observed derived from data. By employing Baum–Welch Viterbi algorithms training decoding, respectively, effectively captured dependencies provided early predictions acid–base status. Experimental results demonstrated that achieved 85% 79% testing accuracy balanced distribution, improving 78% 71% imbalanced dataset. integration this offers benefits timely clinical interventions, prenatal

Language: Английский

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Gestational and Early Childhood Exposure to Barium and Cardiometabolic Risk in Preschoolers: Findings From the Ma’anshan Birth Cohort Study in China

Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Background Animal studies suggest cardiovascular systems may be primary targets for barium toxicity. This study aims to examine longitudinal associations of prenatal and early childhood exposure with cardiometabolic risk (CMR) in preschoolers. Methods Results We determined serum or plasma concentrations during 3 trimesters, delivery, (5 years) from 2291 mother–child dyads within the Ma'anshan Birth Cohort. CMR scores were calculated by summing standardized z glucose, insulin, triglycerides, waist circumference, mean blood pressure, high‐density lipoprotein cholesterol among 5‐year‐old children. employed multiple linear regression informant models investigate whole pregnancy stage‐specific individual components modifying effects sex. The ranges log 10 ‐transformed first trimester 3.39 4.61 ng/L. Barium showed positive scores, triglycerides negative association cholesterol. These significant relationships mainly manifested second third trimesters. Positive observed between trimesters negatively associated boys. In girls, a detected. Conclusions pregnancy, especially increase Boys are more vulnerable than girls. findings support need reductions pregnancy.

Language: Английский

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Differences in fetal brain development

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 123 - 137

Published: Jan. 1, 2025

Language: Английский

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Maternal prenatal stress induces sex-dependent changes in tRNA fragment families and cholinergic pathways in newborns

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 5, 2025

Abstract Maternal perceived prenatal stress (PPS) is a known risk factor for diverse developmental impairments in newborns, but the underlying molecular processes are incompletely understood. Here, we report that maternal PPS altered birth profiles of blood transfer RNA fragments (tRFs), 16–50 nt long non-random cleavage products tRNAs, sex-dependent manner. Importantly, comparing stressed versus control and umbilical cord serum presented alterations were not limited to individual tRFs, rather reflected selective changes particular tRF families grouped by their mitochondrial or nuclear genome origin, parental tRNA coded amino acid, type. Specifically, show stress- sex-specific effects, revealed shared length expression patterns which strongest female newborns. Several these tRFs carry complementary motifs cholinergic mRNAs, suggesting possible translational regulation similar microRNAs. Compatible with reactions, those “CholinotRFs” achieved an AUC 95% when classifying newborns according PPS. Moreover, found catalytic activity acetylcholinesterase, was particularly elevated male marking second effect. Our findings demonstrate association families’ newborns’ response may lead better diagnosis therapeutic tools other stressors.

Language: Английский

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A Comparative Assessment of Yogasana and Karate Training on Cardio-Autonomic Function in Children: An Empirical Study

Journal of Bodywork and Movement Therapies, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Dynamic touch induces autonomic changes in preterm infants as measured by changes in heart rate variability

Brain Research, Journal Year: 2022, Volume and Issue: 1799, P. 148169 - 148169

Published: Nov. 21, 2022

Language: Английский

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Impact of maternal emotional state during pregnancy on fetal heart rate variability

Comprehensive Psychoneuroendocrinology, Journal Year: 2023, Volume and Issue: 14, P. 100181 - 100181

Published: Feb. 28, 2023

The fetal autonomic nervous system (ANS) is believed to be negatively affected by maternal adverse emotional states. In this study, we evaluated how depression, anxiety and stress during pregnancy are related heart rate variability (HRV) as recorded with magnetocardiography (MCG). We also considered metabolic factors such adiposity circulating levels of cortisol gestation. Furthermore, followed up these fetuses after birth, recording HRV saliva in infants establish any effects postpartum.We calculated spontaneous MCG recordings from 32 healthy between 38 weeks gestational age. Maternal state was assessed using standardized questionnaires about anxiety, depression stress. An overall indicator well-being z-scoring each individual questionnaire summation. used a median split divide the group into high low z-scores (HZS LZS), respectively. Standard measures were determined time frequency domain. T-test analyses performed LZS HZS, dependent variables.We found an impaired HZS both birth. No differences observed for factors. Depression symptoms seem affect differently. relationship infant levels.On basis our results on different parameters, propose that might development utero.

Language: Английский

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Heartbeat detector from ECG and PPG signals based on wavelet transform and upper envelopes

Physical and Engineering Sciences in Medicine, Journal Year: 2023, Volume and Issue: 46(2), P. 597 - 608

Published: March 6, 2023

The analysis of cardiac activity is one the most common elements for evaluating state a subject, either to control possible health risks, sports performance, stress levels, etc. This can be recorded using different techniques, with electrocardiogram and photoplethysmogram being common. Both techniques make significantly waveforms, however first derivative photoplethysmographic data produces signal structurally similar electrocardiogram, so any technique focusing on detecting QRS complexes, thus heartbeats in potentially applicable photoplethysmogram. In this paper, we develop based wavelet transform envelopes detect both used enhance complexes respect other elements, while are as an adaptive threshold determine their temporal location. We compared our approach three signals from Physionet database DEAP database. Our proposal showed better performances when others. When electrocardiographic was considered, method had accuracy greater than 99.94%, true positive rate 99.96%, prediction value 99.76%. were investigated, 99.27%, 99.98% 99.50% obtained. These results indicate that adapted recording technology.

Language: Английский

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The Vagus Nerve Regulates Immunometabolic Homeostasis in the Ovine Fetus near Term: The Impact on Terminal Ileum

Biology, Journal Year: 2024, Volume and Issue: 13(1), P. 38 - 38

Published: Jan. 9, 2024

BACKGROUND. Glucosensing elements are widely distributed throughout the body and relay information about circulating glucose levels to brain via vagus nerve. However, while anatomical wiring has been established, little is known physiological role of nerve in glucosensing. The contribution inflammation fetus poorly understood. Increased act synergistically when causing organ injury, but their interplay remains incompletely We hypothesized that vagotomy (Vx) will trigger a rise systemic this be enhanced during organ-specific inflammation. Efferent stimulation (VNS) should reverse phenotype. METHODS. Near-term fetal sheep (n = 57) were surgically prepared using vascular catheters ECG electrodes as control treatment groups (lipopolysaccharide (LPS), Vx + LPS, LPS selective efferent VNS). experiment was started 72 h postoperatively allow for post-surgical recovery. Inflammation induced with bolus intravenously (LPS group, 400 ng/fetus/day 2 days; n 23). For group 11), bilateral cervical performed surgery; these 5 received double dose, LPS800. VNS 8) probes bilaterally distal from eight animals. administered 20 min on days 1 +/10 around bolus. Fetal arterial blood samples drawn each postoperative day recovery (-72 h, -48 -24 h) well at baseline seven selected time points (3–54 profile (ELISA IL-6, pg/mL), insulin (ELISA), gas, metabolism (glucose). At 54 post-LPS, necropsy performed, terminal ileum macrophages’ CD11c (M1 phenotype) immunofluorescence quantified detect results reported p < 0.05 Spearman R2 > 0.1. presented median (IQR). RESULTS. Across groups, gas cardiovascular changes indicated mild septicemia. 3 IL-6 peaked. That peak decreased LPS400 doubled LPS800 group. sped up reduction inflammatory response over h. M1 macrophage activity increased only. concentrations were, respectively, 1.3-fold (throughout experiment) 2.3-fold higher vs. (at h). normalized concentrations. CONCLUSIONS. complete withdrawal vagal innervation resulted 72-h delayed onset sustained increase least intermittent hyperinsulinemia. Under conditions moderate inflammation, related gut reduced restored both degree not Supporting our hypothesis, findings revealed novel regulatory, hormetic, immunometabolic endotoxin near-term fetuses.

Language: Английский

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Prenatal Substance Exposure

Annual Review of Developmental Psychology, Journal Year: 2023, Volume and Issue: 5(1), P. 19 - 44

Published: Aug. 4, 2023

This is an evaluative review of the field prenatal substance exposure, with a focus on neurobiological and behavioral outcomes from infancy to young adulthood. We provide overall evaluation state comment current conceptual methodological issues in need attention. Although there are many studies developmental frameworks that incorporate reflect lived experiences children families have seldom been employed this field. In addition, although some common effects (e.g., fetal growth) between major substances, also unique effects. Thus, we discuss role specific substances but note polysubstance exposure common, models methods used date may not be sufficient advance understanding coexposure or polyexposure these weaknesses suggestions for future directions.

Language: Английский

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