Journal of Aging Research and Lifestyle,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Because
nutrition
is
one
of
the
main
factors
related
to
Alzheimer's
disease
(AD),
questions
arise
about
how
taking
nutrients
as
supplements
can
affect
its
pathophysiological
process.In
present
study,
an
overview
potential
effects
nutritional
supplementation
on
biomarkers
AD
pathophysiology
(i.e.,
amyloid-β
and
tau)
explored.Trials
testing
single
or
combined
versus
placebo
identified
some
biomarkers,
but
changes
were
not
always
accompanied
by
positive
cognitive
function.Differences
in
characteristics
studied
populations
(cognitive
status,
age,
educational
level),
choice
nutrient
combinations
doses,
duration
intervention,
adjustments
for
confounders
are
that
may
explain
discrepancies
findings.
Alzheimer’s
disease,
a
progressive
and
irreversible
neurodegenerative
disorder,
is
the
most
prevalent
form
of
dementia
with
an
increasingly
growing
incidence
rate
worldwide.
As
no
effective
therapeutic
modalities
are
still
available
for
treatment
this
serious
disabling
condition,
lifestyle
modifications,
especially
nutritional
interventions,
have
been
shown
to
be
important
in
its
prevention
symptomatic
alleviation.
In
short
perspective
article,
inverse
association
between
intake
sunflower
seeds
mortality
from
disease
proposed,
showing
that
countries
highest
consumption
seeds,
death
disorder
low.
The
bioactive
ingredients
their
possible
neuroprotective
mechanisms
further
unraveled,
highlighting
potent
antioxidant,
antiinflammatory
neurotrophic
effects
tocopherols,
unsaturated
fatty
acids
phytosterols.
Among
latter
agents,
β-sitosterol
might
particularly
combating
by
enhancing
levels
nerve
growth
factor
thereby
promoting
neurite
formation.
If
future
epidemiological
studies
will
confirm
proposed
development
dementia,
it
easy
include
appropriate
seed
products
everyday
diet
protect
against
pathogenesis
progression
individuals
genetic
predisposition.
Considering
rather
long
latency
period
before
clinical
manifestation
approaches
specific
foods
promising
strategy
fighting
dementia.
Deleted Journal,
Journal Year:
2023,
Volume and Issue:
13(4), P. 1787 - 1805
Published: Sept. 26, 2023
Alzheimer's
disease
(AD),
the
major
form
of
neurodegenerative
diseases
that
can
severely
impede
normal
cognitive
function,
makes
it
one
most
common
fatal
diseases.
There
are
currently
over
50
million
AD
patients
worldwide.
The
neuropathology
is
perplexing
and
there
a
scarcity
disease-modifying
treatments.
Currently,
early
diagnosis
has
been
made
possible
with
discovery
biological
markers
associated
pathology,
providing
strong
support
for
improvement
status.
search
inhibitors
from
dietary
supplements
(DSs)
become
hot
topic.
Especially
widespread
use
DSs,
DSs
containing
polyphenols,
alkaloids,
terpenes,
polysaccharides
other
bioactive
components
prevent
by
reducing
Aβ
deposition,
inhibiting
tau
protein
hyperphosphorylation,
reconstructing
synaptic
dysfunction,
weakening
cholinesterase
activity,
regulating
mitochondrial
oxidative
stress,
neuronal
inflammation
apoptosis.
This
review
summarizes
anti-AD
effects
main
their
constituents,
as
well
potential
molecular
mechanisms
covers
2017
to
2023.
Additionally,
we
discussed
opportunities
challenges
faced
in
process
prevention
treatment,
aiming
further
provide
new
perspectives
functional
food
development.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: June 1, 2023
Background
and
Objective:
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder,
that
is,
characterized
by
cognitive
decline.
To
date,
there
are
no
effective
treatments
for
AD.
Therefore,
the
objective
of
this
study
was
to
map
new
perspectives
on
effects
pharmacological
treatment
function
overall
psychological
state
in
patients
with
Methods:
Two
independent
researchers
searched
randomized
clinical
trials
(RCTs)
exploring
approaches
related
cognition
adults
from
2018
2023
PubMed,
Web
Science,
Scopus,
Cochrane
Library
databases.
A
total
17
RCTs
were
included
review.
Results:
The
results
show
recent
years,
drugs
have
been
tested
disease,
including
masitinib,
methylphenidate,
levetiracetam,
Jiannao
Yizhi,
Huannao
Yicong
formulas.
Most
studies
conducted
populations
mild
moderate
disease.
Conclusion:
Although
some
found
suggested
improvement
function,
scarcity
available
highlights
need
further
research
area.
Systematic
review
registration:
[www.crd.york.ac.uk/prospero],
identifier
[CRD42023409986].
Journal of Dentistry,
Journal Year:
2024,
Volume and Issue:
145, P. 104991 - 104991
Published: April 11, 2024
This
study
aimed
to
investigate
the
association
between
number
of
teeth,
food
intake,
and
cognitive
function
in
Japanese
community-dwelling
older
adults.
Journal of Aging Research and Lifestyle,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Because
nutrition
is
one
of
the
main
factors
related
to
Alzheimer's
disease
(AD),
questions
arise
about
how
taking
nutrients
as
supplements
can
affect
its
pathophysiological
process.In
present
study,
an
overview
potential
effects
nutritional
supplementation
on
biomarkers
AD
pathophysiology
(i.e.,
amyloid-β
and
tau)
explored.Trials
testing
single
or
combined
versus
placebo
identified
some
biomarkers,
but
changes
were
not
always
accompanied
by
positive
cognitive
function.Differences
in
characteristics
studied
populations
(cognitive
status,
age,
educational
level),
choice
nutrient
combinations
doses,
duration
intervention,
adjustments
for
confounders
are
that
may
explain
discrepancies
findings.
