Journal of Evolutionary Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 60(S1), P. S23 - S49
Published: Dec. 1, 2024
Language: Английский
Gels, Journal Year: 2024, Volume and Issue: 10(3), P. 190 - 190
Published: March 9, 2024
The repair of nervous tissue is a critical research field in engineering because the degenerative process injured system. In this review, we summarize progress injectable hydrogels using vitro and vivo studies for regeneration tissue. Traditional treatments have not been favorable patients, as they are invasive inefficient; therefore, promising treatment damaged This review will contribute to better understanding potential scaffolds drug delivery system neural applications.
Language: Английский
Citations
10
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155139 - 155139
Published: Aug. 24, 2024
Language: Английский
Citations
8
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 263, P. 130333 - 130333
Published: Feb. 24, 2024
Language: Английский
Citations
7
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 256, P. 128388 - 128388
Published: Nov. 26, 2023
Language: Английский
Citations
13
Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 342 - 342
Published: Feb. 3, 2025
Objectives: This study evaluated the efficacy of teriparatide (TPTD) and alendronate (ALN) in mitigating bone loss, enhancing structure, facilitating motor function recovery following spinal cord injury (SCI). Methods: All rats were allocated into four groups: a sham surgery group (SHAM group), normal saline (SCI + NS TPTD treatment after SCI an ALN group). The Basso, Beattie, Bresnahan (BBB) scores gait analyses used to assess abilities effects treatment. HE staining, Masson’s trichrome LFB staining performed evaluate extent tissue damage. Micro-CT was measure 12 bone-related parameters proximal tibia create 3D images, structural changes tibial observed under light microscope staining. Results: After weeks treatment, micro-CT data indicated that significantly increased key indicators, such as mineral density, (p < 0.01), whereas did not improve these indicators > 0.05). Compared with group, presented greater BBB near-normal Analyses pathological sections revealed reduced cavity area SCI, decreased proportion scar tissue, retention neural myelin However, had no significant effect on Conclusions: more effective than at loss promoting it demonstrated advantages reducing damage improving structure.
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 6, 2025
Conductive bioinks, integrated with 3D bioprinting and electrical stimulation, are essential for advancing neural tissue engineering. This study developed a SilMA/Pectin/MXene-soybean phospholipids (SP) bioink, where SilMA (silk fibroin modified glycidyl methacrylate) provides structural base, pectin enhances printability shear-thinning properties, MXene-SP improves conductivity through superior dispersibility. Increasing concentrations reduced the hydrogel's Young's modulus, promoting stem cell (NSC) differentiation into neurons. Electrochemical analyses revealed that higher levels decreased impedance increased redox current, while measurements showed improved performance compared to unmodified MXene. NSCs encapsulated in bioink achieved maximum proliferation under stimulation at 300 μA 10 min daily over 5 days. Neuronal positively correlated concentration intensity. Synaptic activity vesicle recycling, assessed using FM1-43 dye, were significantly enhanced stimulation. successfully biocompatible conductive capable of inducing neuronal differentiation. Electrical further promoted proliferation, differentiation, synaptic function. shows great potential future applications
Language: Английский
Citations
0
Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1017 - 1017
Published: Feb. 22, 2025
Neurodegenerative disorders present significant therapeutic challenges, particularly due to the complex nature of drug delivery central nervous system. This review investigates applications various biopolymers in neuroprotection and their potential role treating neurodegeneration. We a critical analysis natural synthetic biopolymers, focusing primarily on chitosan, fish collagen/gelatin, alginate as key agents. The examines fundamental mechanisms brain development neurodegeneration, establishing framework for understanding how these interact with neural tissues. By analyzing recent experimental studies, we evaluate effectiveness different biopolymer-based systems crossing blood-brain barrier subsequent neuroprotective effects. Additionally, promising materials, including lignin, poly lactic-co-glycolic acid, glucose-modified bovine serum albumin/procyanidin complexes, are briefly explored provide comprehensive overview current developments field. Our reveals that approaches offer unique advantages both delivery, potentially opening new avenues neurodegenerative conditions. synthesizes knowledge identifies directions future research strategies.
Language: Английский
Citations
0
Bulletin of Experimental Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: March 28, 2025
Language: Английский
Citations
0
Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19
Published: April 1, 2025
Spinal cord injury involves complex pathobiological mechanisms, necessitating a multidimensional approach for its cure. Previous studies have shown that α9-integrin expression and activation in mature dorsal root ganglion neurons enable the regeneration of injured axons within spinal cord. However, tissue cavitation fibrosis impede regenerating from following their usual pathways, forcing them to seek alternative routes rich tenascin-C, primary ligand integrin. Fibrin gel, an FDA-approved biocompatible material, can offer three-dimensional support axonal extension through cavitated area, thus preventing formation aberrant paths connections occur absence suitable scaffold. The aim this study was investigate how combining by adeno-associated virus with use fibrin gel as extracellular microenvironment affects growth DRG neurites vitro. Additionally, we sought functionalize integrin peptides, specifically AEIDGIEL, active domain ensure activation. Our results indicate gels are biomaterial promoting neurite AEIDGIEL peptide effectively activates Furthermore, corroborate autocrine signaling loop TN-C produced neurons. proposed combination therapy biomaterials incorporating shows promise addressing challenges effective neural regeneration, laying foundation further vivo research.
Language: Английский
Citations
0
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13
Published: April 23, 2025
Spinal cord injury (SCI) is a severe condition that frequently leads to permanent disabilities and neurological dysfunction. Its progression driven by multifaceted pathophysiology, encompassing direct trauma, secondary cascades, intricate cellular molecular responses. While current therapies focus on alleviating symptoms restoring functionality, achieving effective neural regeneration in the spinal continues be significant challenge. Hydrogels, recognized for their exceptional biocompatibility, conductivity, injectability, have shown great potential as advanced scaffolds support neuronal axonal regeneration. Recently, these materials attracted interest field of SCI rehabilitation research. This review concludes recent progress hydrogel-based strategies rehabilitation, emphasizing distinct properties, underlying mechanisms, integration with bioactive molecules, stem cells, complementary biomaterials. Hydrogels foster providing tailored microenvironment, while features such self-repair, electrical controlled drug release significantly enhance therapeutic experimental models. explores hydrogel technologies applications, underscoring address challenges treatment paving way future clinical implementation.
Language: Английский
Citations
0