PLoS ONE, Journal Year: 2024, Volume and Issue: 19(8), P. e0309348 - e0309348
Published: Aug. 28, 2024
The complex effects of Long-COVID, a syndrome marked by enduring symptoms after COVID-19 infection, with an emphasis on patients' differing degrees fibro fatigue (FF). Electrolyte disturbances may affect the severity FF and be used as predictive tool for severe in Long-COVID patients.
Language: Английский
Exploration of Immunology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 13, 2025
Nociplastic pain is the fourth category of defined in recent years. It a arising from altered nociception, despite lack clear evidence actual or threatened tissue damage that causes activation peripheral nociceptors nor for disease lesion somatosensory system causing pain. This type usually multifocal, more diffuse intense than expected and it associated with other central nervous system-derived symptoms, such as fatigue, sleep, memory, mood problems. can occur isolation part mixed-pain state combination ongoing nociceptive neuropathic increased social sanitary costs due to difficulty adequately treating it. Its pathogenesis still poorly understood, even if mounting body suggests pivotal role inflammation immunity, which may be triggered by an infection and/or trauma. narrative review aims summarise current knowledge about interplay immune nociplastic pathways amplification. The challenge future will identify exact cause this activation, its link pathogenetic factors pain, diet microbiota alteration, phycological factors, together genetic epigenetic predisposition.
Language: Английский
Citations
0
Brazilian Journal of Health Review, Journal Year: 2025, Volume and Issue: 8(1), P. e76715 - e76715
Published: Jan. 10, 2025
Após o período de infecção pelo SARS-CoV-2, constatou-se aumento indivíduos com diversos sintomas multissistêmicos persistentes por semanas ou meses. Entre as sequelas, destacam-se os impactos neurológicos, em especial a depressão e ansiedade. Assim, torna-se necessário investigar componentes genéticos que contribuem nos transtornos depressivos ansiosos pós-covid. Para tanto, foi realizada uma curadoria manual critérios pré-estabelecidos, seguida da coleta códigos no UNIPROT construção das redes proteicas Cytoscape. A partir análise holística dos dados, foram identificados parâmetros topológicos funcionais relevantes. Como resultado, papel inflamação sistêmica sistema nervoso central, relação bidirecional estresse oxidativo, influência proteínas na crônica. Sugere-se humor são desencadeados pela inflamação, possam interferir biossíntese serotonina, neurodegeneração neurotoxicidade eventuais alterações cerebrais, áreas relacionadas ao controle emocional. Dessa forma, este estudo apresentou potenciais biomarcadores visam auxiliar futuras pesquisas in vivo vitro prospecção alvos terapêuticos, porém é preciso aprofundar ansiedade condições pós- COVID.
Citations
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Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111279 - 111279
Published: Feb. 1, 2025
Language: Английский
Citations
0
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0316373 - e0316373
Published: March 6, 2025
Patients with Long COVID (LC) often experience neuropsychiatric symptoms such as depression, anxiety, and chronic fatigue syndrome (CFS), collectively referred to the physio-affective phenome of LC. Activated immune-inflammatory pathways insulin resistance significantly contribute associated In a cohort 90 individuals, categorized into those without LC, we evaluated, 3-6 months following acute SARS-CoV-2 infection, correlations between Hamilton Depression (HAMD), Anxiety (HAMA), Fibro-Fatigue (FF) Rating Scale scores, serum C-reactive protein (CRP), prostaglandin E2 (PGE2), galanin-galanin receptor 1 (GAL-GALR1) signaling, resistance, insulin-like growth factor (IGF-1), plasminogen activator inhibitor-1 (PAI1), S100B neuron-specific enolase (NSE). HAMD, HAMA, FF CRP, PGE2, GAL-GALR1 PAI1, NSE, are all higher in people LC compared The HAMD/HAMA/FF scores were correlated PGE, GAL, GALR1, PAI1 levels, composite score based on peak body temperature (PBT) - oxygen saturation (SpO2) (PBT/SpO2 index) during infectious phase. A combination biomarkers explained large part variance CFS affective (33.6%-42.0%), CRP being top 3 most important biomarkers. inclusion PBT/SpO2 index increased prediction (55.3%-67.1%). predicted increases signaling. These results indicate that linked consequence metabolic aberrations, activated pathways, severity inflammation phase infection.
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 179 - 236
Published: Jan. 1, 2025
Citations
0
Molecular Pain, Journal Year: 2024, Volume and Issue: 20
Published: Jan. 1, 2024
Chronic pain is a debilitating symptom with significant negative impact on the quality of life and socioeconomic status, particularly among adults elderly. Major Depressive Disorder (MDD) stands out as one most important comorbid disorders accompanying chronic pain. The kynurenine pathway serves primary route for tryptophan degradation holds critical significance in various biological processes, including regulation neurotransmitters, immune responses, cancer development, metabolism, inflammation. This review encompasses key research studies related to context headache, neuropathic pain, gastrointestinal disorders, fibromyalgia, fatigue syndrome, MDD. Various metabolites produced pathway, such kynurenic acid quinolinic acid, exhibit neuroprotective neurotoxic effects, respectively. Recent have highlighted involvement its pathophysiology Moreover, pharmacological interventions targeting shown therapeutic promise management. Understanding underlying mechanisms this presents an opportunity developing personalized, innovative, non-opioid approaches treatment. Therefore, narrative explores role association depression
Language: Английский
Citations
3
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown
Published: July 24, 2023
Abstract Background Persistent infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), reactivation of dormant viruses, and immune-oxidative responses are involved in Long COVID. Objectives To investigate whether COVID depressive, anxiety chronic fatigue (CFS) symptoms, associated IgA/IgM/IgG to SARS-CoV-2, human Herpesvirus type 6 (HHV-6), Epstein-Barr Virus (EBV), biomarkers. Methods We examined 90 patients healthy controls. measured serum against HHV-6 EBV their deoxyuridine 5′-triphosphate nucleotidohydrolase (duTPase), activin-A, C-reactive protein (CRP), advanced oxidation products (AOPP), insulin resistance (HOMA2-IR). Results showed significant elevations IgG/IgM-SARS-CoV-2, IgG/IgM-HHV-6 HHV-6-duTPase, IgA/IgM-activin-A, CRP, AOPP, HOMA2-IR. Neural network analysis yielded a highly predictive accuracy 80.6% for the diagnosis (sensitivity: 78.9%, specificity: 81.8%, area under ROC curve=0.876); topmost predictors were: IGA-activin-A, IgG-HHV-6, IgM-HHV-6-duTPase, IgG-SARS-CoV-2, IgM-HHV-6 (all positively) factor extracted from all IgA levels viral antigens (inversely). The top-5 affective symptoms due education, IgA-activin-A (predictive r=0.636). CFS were descending order: IgG-HHV-6-duTPase, IgM-activin-A, IgM-SARS-CoV-2, accuracy: r=0.709). Conclusion Reactivation HHV-6, SARS-CoV-2 persistence, autoimmune reactions activin-A combined activated pathways play major role pathophysiology as well severity
Language: Английский
Citations
7
Neuroscience, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Language: Английский
Citations
2
Journal of Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 23(12)
Published: Dec. 24, 2024
The coexistence of anxiety or depression with coronary heart disease (CHD) is a significant clinical challenge in cardiovascular medicine. Recent studies have indicated that hypothalamic-pituitary-adrenal (HPA) axis activity could be promising focus understanding and addressing the development treatments for comorbid CHD depression. HPA helps to regulate levels inflammatory factors, thereby reducing oxidative stress damage, promoting platelet activation, stabilizing gut microbiota, which enhance survival regeneration neurons, endothelial cells, other cell types, leading neuroprotective cardioprotective benefits. This review addresses relevance nervous systems, as well latest research advancements regarding its mechanisms action. discussion includes detailed function regulating processes mentioned. Above all, it summarizes therapeutic potential biomarker atherosclerotic combined
Language: Английский
Citations
2
Journal of Diabetes & Metabolic Disorders, Journal Year: 2024, Volume and Issue: 23(1), P. 305 - 322
Published: Jan. 20, 2024
Language: Английский
Citations
1