Locus coeruleus activation 'resets' hippocampal event representations and separates adjacent memories DOI Creative Commons
David Clewett, Ringo Huang, Lila Davachi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 18, 2024

Memories reflect the ebb and flow of experiences, capturing unique meaningful events from our lives. Using a combination functional magnetic resonance imaging (fMRI), neuromelanin imaging, pupillometry, we show that arousal locus coeruleus (LC) activation transform otherwise continuous experiences into distinct episodic memories. As sequences unfold, encountering context shift, or event boundary, triggers LC processes predict later memory separation. Boundaries furthermore promote temporal pattern separation within left hippocampal dentate gyrus, which correlates with heightened responses to those same transition points. We also find neurochemical index prolonged diminished at boundaries, suggesting connection between elevated output impaired processing. These findings align idea initiate neural reset in response significant changes, constructing very episodes define everyday memory.

Language: Английский

Damage to the Locus Coeruleus Alters the Expression of Key Proteins in Limbic Neurodegeneration DOI Open Access
Francesca Biagioni, Michela Ferrucci, Gloria Lazzeri

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3159 - 3159

Published: March 9, 2024

The present investigation was designed based on the evidence that, in neurodegenerative disorders, such as Alzheimer’s dementia (AD) and Parkinson’s disease (PD), damage to locus coeruleus (LC) arising norepinephrine (NE) axons (LC-NE) is documented hypothesized foster onset progression of neurodegeneration within target regions. Specifically, experiments were assess whether selective LC-NE may alter key proteins involved specific limbic regions, hippocampus piriform cortex, compared with dorsal striatum. To achieve this, a loss induced by neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) C57 Black mice, assessed NE dopamine-beta-hydroxylase In these experimental conditions, amount alpha-synuclein (alpha-syn) protein levels increased along alpha-syn expressing neurons cortex. Similar findings obtained concerning phospho-Tau immunoblotting. contrast, decrease inducible HSP70-expressing sequestosome (p62)-expressing cells, at immunoblotting, reported. data provide further understand why AD engagement during PD.

Language: Английский

Citations

3
Cannabinoids and monoaminergic system: implications for learning and memory DOI Creative Commons
Sha Zhao,

Zhaoliang Gu,

Ya-Nan Yue

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 14, 2024

Cannabinoids and the endocannabinoid system (ECS) have been intensively studied for their neuroregulatory roles in central nervous (CNS), especially regulating learning memory. However, many experimental clinical studies obtained conflicting results indicating a complex network of interaction underlying regulation memory by different cannabinoids ECS. The ECS influences neuronal synaptic communications, therefore may exert via impact on other neurotransmitters. monoaminergic includes variety neurotransmitters, such as dopamine, norepinephrine, serotonin, which play important mood, cognition, reward. among cannabinoids, has drawn particular attention, contributions to In this review, we summarized current understanding how contribute process memory, discussed neurotransmission during process.

Language: Английский

Citations

3
Distortion of overlapping memories relates to arousal and anxiety DOI

Erin Morrow,

David Clewett

Cognitive Affective & Behavioral Neuroscience, Journal Year: 2024, Volume and Issue: 25(1), P. 154 - 172

Published: Oct. 8, 2024

Language: Английский

Citations

1
Astrocytes and Tinnitus DOI Creative Commons
Paola Perin, Roberto Pizzala

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(12), P. 1213 - 1213

Published: Nov. 29, 2024

Tinnitus is correlated with anomalies of neural plasticity and has been found to be affected by inflammatory status. The current theories on tinnitus, although still somewhat incomplete, are based maladaptive mechanisms. Astrocytes play a major role in both responses inflammation regulation; moreover, they have recently discovered encode “context” for neuronal circuits, which similar the “expectation” Bayesian brain models. Therefore, this narrative review explores possible likely roles astrocytes mechanisms leading acute chronic tinnitus.

Language: Английский

Citations

0
Locus coeruleus activation 'resets' hippocampal event representations and separates adjacent memories DOI Creative Commons
David Clewett, Ringo Huang, Lila Davachi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 18, 2024

Memories reflect the ebb and flow of experiences, capturing unique meaningful events from our lives. Using a combination functional magnetic resonance imaging (fMRI), neuromelanin imaging, pupillometry, we show that arousal locus coeruleus (LC) activation transform otherwise continuous experiences into distinct episodic memories. As sequences unfold, encountering context shift, or event boundary, triggers LC processes predict later memory separation. Boundaries furthermore promote temporal pattern separation within left hippocampal dentate gyrus, which correlates with heightened responses to those same transition points. We also find neurochemical index prolonged diminished at boundaries, suggesting connection between elevated output impaired processing. These findings align idea initiate neural reset in response significant changes, constructing very episodes define everyday memory.

Language: Английский

Citations

0