Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Dec. 5, 2024
The
potential
of
natural
phytochemicals
in
mitigating
depression
has
been
supported
by
substantial
evidence.
This
study
evaluated
a
total
88
with
antidepressant
properties
targeting
serotonin
(5-HT)
receptors
(5-HT1A,
5-HT4,
and
5-HT7)
using
molecular
docking,
ADMET
(Absorption,
Distribution,
Metabolism,
Excretion,
Toxicity)
analysis,
internal
coordinates
normal
mode
analysis
(NMA),
dynamics
simulation
(MDS),
free
energy
calculation.
Five
compounds
(Genistein,
Kaempferol,
Daidzein,
Peonidin,
glycitein)
exhibited
favorable
pharmacokinetic
improved
binding
scores,
indicating
their
as
effective
antidepressants.
Redocking
superimposition
5-HT
cocrystal
structures
validated
these
findings.
Furthermore,
NMA,
MDS,
calculations
confirmed
the
stability
deformability
ligand-receptor
complexes,
suggesting
that
can
effectively
interact
to
modulate
depressive
symptoms.
These
powerful
phytochemicals,
abundantly
found
soybeans,
fruits,
vegetables,
herbs,
represent
promising
avenue
for
developing
treatments
depression.
Further
vitro
vivo
studies
are
warranted
explore
efficacy
alleviating
stress
through
interactions
receptors.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12767 - 12767
Published: Nov. 27, 2024
The
tryptophan-kynurenine
(KYN)
pathway
has
long
been
recognized
for
its
essential
role
in
generating
metabolites
that
influence
various
physiological
processes.
Traditionally,
these
have
categorized
into
distinct,
often
opposing
groups,
such
as
pro-oxidant
versus
antioxidant,
excitotoxic/neurotoxic
neuroprotective.
This
dichotomous
framework
shaped
much
of
the
research
on
conditions
like
neurodegenerative
and
neuropsychiatric
disorders,
well
cancer,
where
metabolic
imbalances
are
a
key
feature.
effects
significantly
influenced
by
factors,
including
concentration
particular
cellular
milieu
which
they
generated.
A
molecule
acts
neuroprotective
at
low
concentrations
may
exhibit
neurotoxic
elevated
levels.
oxidative
equilibrium
surrounding
environment
can
alter
function
KYN
from
an
antioxidant
to
pro-oxidant.
narrative
review
offers
comprehensive
examination
analysis
contemporary
understanding
metabolites,
emphasizing
their
multifaceted
biological
functions
relevance
numerous
pathological
underscores
pressing
necessity
paradigm
shift
comprehension
metabolism.
Understanding
context-dependent
roles
is
vital
novel
therapies
Alzheimer's
disease,
multiple
sclerosis,
cancer.
Comprehensive
modulation,
balancing
inflammatory
signals
enzyme
regulation,
promising
avenues
targeted,
effective
treatments.
Natural Product Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 9
Published: Feb. 12, 2025
Citrus
species
have
a
history
of
use
in
treating
neurological
conditions
like
insomnia,
anxiety,
and
nervousness,
though
these
claims
lack
exhaustive
validation.
This
study
evaluated
the
anxiolytic
activity
paradisi
Macfayden
var.
redblush
leaves,
aiming
to
isolate
characterise
bioactive
constituent.
Four
leaf
extracts
(petroleum
ether
(60–80
°C),
chloroform,
methanol
aqueous)
were
for
using
elevated
plus
maze
(EPM)
mice.
The
extract
showed
was
subjected
bioactivity
guided
isolation
solvent
partitioning,
column
chromatography
preparative
HPLC
compound,
CP-1,
characterised
as
rhoifolin
(based
on
spectroscopic
analysis).
Rhoifolin,
at
0.705%
w/w
confirmed
compound
through
additional
tests
(light-dark
box
social
interaction
tests)
holds
promise
potential
treatment
anxiety
disorders.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 2079 - 2079
Published: Feb. 27, 2025
Parkinson's
disease
(PD)
is
one
of
the
most
common
neurodegenerative
diseases.
Constipation
a
prodromal
symptom
PD.
It
important
to
investigate
pathogenesis
constipation
symptoms
in
Rotenone
has
been
successfully
used
establish
PD
animal
models.
However,
specific
mechanism
rotenone-induced
not
well
understood.
In
this
work,
we
found
that
appeared
earlier
than
motor
impairment
mice
gavaged
with
low
dose
rotenone
(30
mg/kg·BW).
only
caused
loss
dopaminergic
neurons
and
accumulation
α-synuclein,
but
also
significantly
reduced
serum
5-HT
levels
5-HTR4
striatum
colon.
The
mRNA
expression
aquaporins,
gastrointestinal
motility
factors
(c-Kit,
Cx43,
smMLCK
MLC-3)
mouse
colon
was
regulated
by
rotenone.
addition,
both
brain
showed
inflammation
barrier
dysfunction;
PI3K/AKT
pathway
substantia
nigra
inhibited
Importantly,
structure,
composition
function
gut
microbiota
were
altered
Some
taxa
closely
associated
symptoms,
inflammation,
status
mice.
Akkermansia,
Staphylococcus
Lachnospiraceae_UCG-006
may
play
role
exacerbating
whereas
Acinetobacter,
Lactobacillus,
Bifidobacterium,
Solibacillus
Eubacterium_xylanophilum_groups
be
beneficial
stimulating
peristalsis,
maintaining
alleviating
damage
conclusion,
low-dose
can
cause
parkinsonism
disrupting
intestinal
microecosystem
inhibiting
PI3K-AKT
motility.
Healthcare,
Journal Year:
2025,
Volume and Issue:
13(6), P. 649 - 649
Published: March 16, 2025
Background/Objectives:
Globally,
there
has
been
an
increase
in
the
prevalence
of
anxiety
and
depression
among
university
students,
medical
students
are
no
exception.
Medical
especially
susceptible
to
these
mental
health
challenges,
primarily
due
multifaceted
stressors,
which
can
significantly
impact
their
academic
achievements
future
career.
There
is
a
pressing
need
for
comprehensive
research
that
not
only
investigates
but
also
explores
strategies
developing
effective
interventions
support
systems
enhance
well-being
students.
Therefore,
this
study
aimed
identify
severity
at
South
Africa,
evaluating
association
socio-demographic,
student,
clinical
variables
with
total
general
disorder
(GAD-7)
patient
questionnaire
(PHQ-9)
scores.
Methods:
A
survey-based
quantitative
cross-sectional
was
conducted
208
undergraduate
African
university.
Participants
who
provided
written
consent
completed
GAD-7
PHQ-9
questionnaires
together
variable
information.
The
relationship
between
scores
determined
using
Mann–Whitney
U
test
Kruskal–Wallis
H
test.
Correlation
analysis
used
establish
threshold
statistical
significance
set
p
≤
0.05.
Results:
More
than
half
participants
were
female
(n
=
130;
62.5%),
single
123;
59.1%),
belonged
Pedi
ethnic
group.
majority
Christian
183;
88.0%),
received
bursary
had
rural
background
155;
74.5%).
However,
small
percentage
reported
history
psychiatric
chronic
illnesses
26;
12.5%)
previously
professional
psychological
38;
18.3%).
In
study,
38%
79)
GAD
67.8%
141)
symptoms
depression.
Significant
associations
(p
<0.05)
observed
such
as
year
repeating
module,
illness
revealed
moderate
positive
correlation
(rs
0.400,
df
206,
<
0.001)
Conclusions:
This
identified
high
level
found
Addressing
challenges
crucial
healthcare,
professionals
directly
impacts
care.
European Journal of Neuroscience,
Journal Year:
2025,
Volume and Issue:
61(7)
Published: March 31, 2025
ABSTRACT
Chronic
stress
increases
susceptibility
to
anxiety
and
depression
disorders,
recurrent
common
psychiatric
conditions.
Current
antidepressant
medications
have
varying
degrees
of
efficacy
often
multiple
side
effects
limiting
treatment
adherence.
Physical
exercise
has
beneficial
on
stress‐related
mental
disorders.
However,
the
underlying
mechanisms
are
unclear.
Dentate
gyrus
granule
cells
(GCs)
excitability
may
mediate
resilience.
Here,
we
expose
young
adult
C57Bl6
mice
chronic
restraint
(CRS)
for
14
days
followed
by
30
running
treatment.
Behavioural
evaluation
before
after
showed
that
behavioural
alterations
elicited
CRS
were
mitigated
running.
Next,
evaluated
serotonergic
modulation
GC
excitability,
as
a
potential
mechanism
running‐induced
Electrophysiological
recordings
indicate
alters
excitability.
Utilising
(S)‐WAY
100135
Tropisetron,
antagonists
5‐HT
1A
3
receptors
respectively,
show
recovers
receptor
activity
lost
CRS.
Additionally,
promotes
indirect
GCs
through
activation.
Thus,
be
targets
