Brain stimulation with 40 Hz heterochromatic flicker extended beyond red, green, and blue DOI Creative Commons
Mark Alexander Henney,

Marcus Carstensen,

Martin Thorning-Schmidt

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 25, 2024

Abstract Alzheimer’s disease (AD) is associated with electrophysiological changes in the brain. Pre-clinical and early clinical trials have shown promising results for possible therapy of AD 40 Hz neurostimulation. The most notable findings used stroboscopic flicker, but this technique poses an inherent barrier human applications due to its visible flickering resulting high level perceived discomfort. Therefore, alternative options should be investigated entraining brain activity light sources that appear less flickering. Previously, chromatic flicker based on red, green, blue (RGB) been studied context brain-computer interfaces, incomplete representation colours visual spectrum. This study introduces a new kind heterochromatic spectral combinations blue, cyan, lime, amber, red (BCGLAR). These are by steady-state visually evoked potential (SSVEP) response from aim optimising choice stimulation spectrally similar colour BCGLAR space. Thirty healthy young volunteers were stimulated electroencephalography experiment randomised complete block design. Responses quantified as signal-to-noise ratio analysed using mixed linear models. size SSVEP dependent influenced both non-visual effects. amber-red combination highest SSVEP, included and/or consistently higher than only mid-spectrum colours. Including either extreme spectrum (blue red) at least one dyadic phases appears more important choosing pairs far each other Spectrally adjacent perceiver, thus motivate investigations into limits how alike two can still evoke response. Specifically, combining another proximal might provide best trade-off between sensation magnitude.

Language: Английский

Home-based transcranial alternating current stimulation (tACS) in Alzheimer’s disease: rationale and study design DOI Creative Commons
Daniele Altomare, Alberto Benussi, Valentina Cantoni

et al.

Alzheimer s Research & Therapy, Journal Year: 2023, Volume and Issue: 15(1)

Published: Sept. 15, 2023

Gamma (γ) brain oscillations are dysregulated in Alzheimer's disease (AD) and can be modulated using transcranial alternating stimulation (tACS). In the present paper, we describe rationale design of a study assessing safety, feasibility, clinical biological efficacy, predictors outcome home-based intervention consisting γ-tACS over precuneus.In first phase, 60 AD patients will randomized into two arms: ARM1, 8-week precuneus (frequency: 40 Hz, intensity: 2 mA, duration: 5 60-min sessions/week); ARM2, sham tACS (same parameters as real γ-tACS, with current being discontinued s after beginning stimulation). second all participants receive phase). The outcomes collected at several timepoints throughout duration include information on safety neuropsychological assessment, blood sampling, electroencephalography, magnetic neurotransmitter measures, resonance imaging or amyloid positron emission tomography.We expect that this is safe feasible results improvement cognition, entrainment gamma oscillations, increased functional connectivity, reduction pathological burden, cholinergic transmission.If our expected achieved, interventions either alone combination other therapies, may become reality for treating AD.PNRR-POC-2022-12376021.

Language: Английский

Citations

8
Compensatory cognition in neurological diseases and aging: A review of animal and human studies DOI Creative Commons

Kanishka Kanishka,

Sushil K. Jha

Aging Brain, Journal Year: 2022, Volume and Issue: 3, P. 100061 - 100061

Published: Dec. 26, 2022

Specialized individual circuits in the brain are recruited for specific functions. Interestingly, multiple neural circuitries continuously compete with each other to acquire specialized function. However, dominant among them and become central network that particular For example, hippocampal principal networks many which involved learning processes. But, event of damage circuitry, times, less compensate primary network. This review highlights psychopathologies functional loss aspects recuperation absence hippocampus.

Language: Английский

Citations

14
Treatment effects on event-related EEG potentials and oscillations in Alzheimer's disease DOI Creative Commons
Görsev Yener, Duygu Hünerli-Gündüz, Ebru Yıldırım

et al.

International Journal of Psychophysiology, Journal Year: 2022, Volume and Issue: 177, P. 179 - 201

Published: May 17, 2022

Language: Английский

Citations

13
Auditory or Audiovisual Stimulation Ameliorates Cognitive Impairment and Neuropathology in ApoE4 Knock-In Mice DOI Open Access
Harry Jung,

Yeonkyeong Lee,

Sang‐Hwa Lee

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 938 - 938

Published: Jan. 4, 2023

We hypothesized that auditory stimulation could reduce the progression of Alzheimer’s disease (AD), and audiovisual have additional effects through multisensory integration. exposed 12 month old Apoetm1.1(APOE*4)Adiuj mice (a mouse model sporadic AD) to (A) or (AV) at 40 Hz for 14 days in a soundproof chamber system (no stimulation, N). Behavioral tests were performed before after each session, their brain tissues assessed amyloid-beta expression apoptotic cell death, days. Furthermore, levels acetylcholine apoptosis-related proteins analyzed. In Y-maze test, percentage relative alternation was significantly higher group A than N mice. Amyloid-beta TUNEL positivity hippocampal CA3 region lower AV (p < 0.05). Acetylcholine Compared mice, proapoptotic Bax caspase-3 A, antiapoptotic protein Bcl-2 AV. early-stage AD, improved cognitive performance neuropathology.

Language: Английский

Citations

7
Brain stimulation with 40 Hz heterochromatic flicker extended beyond red, green, and blue DOI Creative Commons
Mark Alexander Henney,

Marcus Carstensen,

Martin Thorning-Schmidt

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 25, 2024

Abstract Alzheimer’s disease (AD) is associated with electrophysiological changes in the brain. Pre-clinical and early clinical trials have shown promising results for possible therapy of AD 40 Hz neurostimulation. The most notable findings used stroboscopic flicker, but this technique poses an inherent barrier human applications due to its visible flickering resulting high level perceived discomfort. Therefore, alternative options should be investigated entraining brain activity light sources that appear less flickering. Previously, chromatic flicker based on red, green, blue (RGB) been studied context brain-computer interfaces, incomplete representation colours visual spectrum. This study introduces a new kind heterochromatic spectral combinations blue, cyan, lime, amber, red (BCGLAR). These are by steady-state visually evoked potential (SSVEP) response from aim optimising choice stimulation spectrally similar colour BCGLAR space. Thirty healthy young volunteers were stimulated electroencephalography experiment randomised complete block design. Responses quantified as signal-to-noise ratio analysed using mixed linear models. size SSVEP dependent influenced both non-visual effects. amber-red combination highest SSVEP, included and/or consistently higher than only mid-spectrum colours. Including either extreme spectrum (blue red) at least one dyadic phases appears more important choosing pairs far each other Spectrally adjacent perceiver, thus motivate investigations into limits how alike two can still evoke response. Specifically, combining another proximal might provide best trade-off between sensation magnitude.

Language: Английский

Citations

2