Mystery of gamma wave stimulation in brain disorders DOI Creative Commons

Qianting Deng,

Chongyun Wu,

Emily Parker

et al.

Molecular Neurodegeneration, Journal Year: 2024, Volume and Issue: 19(1)

Published: Dec. 18, 2024

Abstract Neuronal oscillations refer to rhythmic and periodic fluctuations of electrical activity in the central nervous system that arise from cellular properties diverse neuronal populations their interactions. Specifically, gamma play a crucial role governing connectivity between distinct brain regions, which are essential perception, motor control, memory, emotions. In this context, we recapitulate various current stimulation methods induce entrainment. These include sensory stimulation, optogenetic modulation, photobiomodulation, transcranial or magnetic stimulation. Simultaneously, explore association abnormal disorders such as Alzheimer’s disease, Parkinson’s stroke, schizophrenia, autism spectrum disorders. Evidence suggests entrainment-inducing offer notable neuroprotection, although somewhat controversial. This review comprehensively discusses functional higher-order activities both physiological pathological perspectives, emphasizing entrainment potential therapeutic approach for neuropsychiatric Additionally, discuss future opportunities challenges implementing strategies.

Language: Английский

Overnight olfactory enrichment using an odorant diffuser improves memory and modifies the uncinate fasciculus in older adults DOI Creative Commons

Cynthia C. Woo,

Blake A. Miranda,

Mithra Sathishkumar

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: July 24, 2023

Cognitive loss in older adults is a growing issue our society, and there need to develop inexpensive, simple, effective in-home treatments. This study was conducted explore the use of olfactory enrichment at night improve cognitive ability healthy adults.Male female (N = 43), age 60-85, were enrolled randomly assigned an Olfactory Enriched or Control group. Individuals enriched group exposed 7 different odorants week, one per night, for 2 h, using odorant diffuser. control had same experience with de minimis amounts odorant. Neuropsychological assessments fMRI scans administered beginning after 6 months.A statistically significant 226% improvement observed compared on Rey Auditory Verbal Learning Test improved functioning left uncinate fasciculus, as assessed by mean diffusivity.Minimal produces improvements both neural functioning. Thus, may provide low-effort pathway brain health.

Language: Английский

Citations

17
Sensory gamma entrainment: Impact on amyloid protein and therapeutic mechanism DOI Creative Commons
Jiaying Hu,

Leyan Zheng,

Ziyu Guan

et al.

Brain Research Bulletin, Journal Year: 2023, Volume and Issue: 202, P. 110750 - 110750

Published: Aug. 23, 2023

The deposition of amyloid β peptide (Aβ) is one the main pathological features AD. much-talked sensory gamma entrainment may be a new treatment for Aβ load. Here we reviewed generation and clearance pathways Aβ, aberrant oscillation in AD, therapeutic effect on In addition, discuss these results based stimulus parameters possible potential mechanisms. This provides support targeting to improve

Language: Английский

Citations

6
Cholinergic modulation of sensory perception and plasticity DOI Creative Commons
Ansley J. Kunnath, René H. Gifford, Mark T. Wallace

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 152, P. 105323 - 105323

Published: July 17, 2023

Language: Английский

Citations

4
Therapeutic potential of gamma entrainment using sensory stimulation for cognitive symptoms associated with schizophrenia DOI Creative Commons
Tallan Black, Bryan W. Jenkins, Robert B. Laprairie

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 161, P. 105681 - 105681

Published: April 17, 2024

Schizophrenia is a complex neuropsychiatric disorder with significant morbidity. Treatment options that address the spectrum of symptoms are limited, highlighting need for innovative therapeutic approaches. Gamma Entrainment Using Sensory Stimulation (GENUS) an emerging treatment disorders uses sensory stimulation to entrain impaired oscillatory network activity and restore brain function. Aberrant often underlies experienced by patients schizophrenia. We propose GENUS has potential This paper reviews current status schizophrenia explores use as adjunctive treatment, specifically through gamma entrainment. Impaired frequency entrainment observed in patients, particularly response auditory visual stimuli. Thus, stimulation, such music listening, may have individuals holds novel improve lives schizophrenia, but further research required determine efficacy GENUS, optimize its delivery window, develop strategies implementation specific patient populations.

Language: Английский

Citations

1
Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor- and Cygb-associated signaling pathways DOI Creative Commons
Biao Xiao,

Chaoyang Chu,

Zhicheng Lin

et al.

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(9), P. 2706 - 2726

Published: July 29, 2024

JOURNAL/nrgr/04.03/01300535-202509000-00031/figure1/v/2024-11-05T132919Z/r/image-tiff A reduction in adult neurogenesis is associated with behavioral abnormalities patients Alzheimer’s disease. Consequently, enhancing represents a promising therapeutic approach for mitigating disease symptoms and progression. Nonetheless, non-pharmacological interventions aimed at inducing are currently limited. Although individual interventions, such as aerobic exercise, acousto-optic stimulation, olfactory have shown limited capacity to improve cognitive function disease, the effect of strategy that combines these has not been fully explored. In this study, we observed an age-dependent decrease concurrent increase amyloid-beta accumulation hippocampus amyloid precursor protein/presenilin 1 mice aged 2–8 months. Amyloid deposition became evident 4 months, while declined by 6 further deteriorating progressed. However, following 4-week multifactor stimulation protocol, which encompassed treadmill running (46 min/d, 10 m/min, days per week), 40 Hz (1 hour/day, days/week), found significant number newborn cells (5′-bromo-2′-deoxyuridine–positive cells), immature neurons (doublecortin-positive (5′-bromo-2′-deoxyuridine-positive/doublecortin-positive astrocytes (5′-bromo-2′-deoxyuridine-positive/glial fibrillary acidic protein–positive cells). Additionally, load decreased. These findings suggest can enhance hippocampal mitigate neuropathology mice. Furthermore, abilities were improved, depressive alleviated evidenced Morris water maze, novel object recognition, forced swimming test, tail suspension test results. Notably, efficacy consolidating persisted least 2 weeks after treatment cessation. At molecular level, upregulated expression neuron-related proteins (NeuN, doublecortin, postsynaptic density protein-95, synaptophysin), anti-apoptosis–related (Bcl-2 PARP), autophagy-associated protein (LC3B), decreasing apoptosis-related (BAX caspase-9), observations might be attributable both brain-derived neurotrophic factor-mediated signaling pathway antioxidant pathways. serum metabolomics analysis indicated regulated differentially expressed metabolites cell apoptosis, oxidative damage, cognition. Collectively, non-invasive prevention

Language: Английский

Citations

1
CD2AP is Co-Expressed with Tropomyosin-Related Kinase A and Ras-Related Protein Rab-5A in Cholinergic Neurons of the Murine Basal Forebrain DOI Open Access
Lindsey A. Fitzsimons,

Mohammad Atif-Sheikh,

Jayden Lovely

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 24, 2024

ABSTRACT Basal forebrain cholinergic neurons project to the hippocampus and cortex, are critical for learning memory, central pathogenesis of Alzheimer’s disease (AD). GWAS have consistently shown that genomic variants at CD2AP gene locus associated with significant increased risk AD. studies also genetic in endocytosis genes, including RAB5A , significantly increase susceptibility Previous work our lab has functions as a docking-scaffold/adaptor protein coordinator nerve growth factor (NGF) trophic signaling neurons. We demonstrated positively regulates Rab5-mediated mechanisms primary sensory The purpose this study was perform an vivo characterization expression brain regions most relevant AD investigate colocalization Rab5 murine basal forebrain. Brain tissue perfused, harvested from ChAT BAC -eGFP transgenic mice (N=4 male, N=4 female; aged 10 mo), where (co-) express green fluorescence (GFP) peripheral choline acetyltransferase (ChAT). Frozen sections were used assess specificity reporter mouse along localization both using immunofluorescence (IF) analysis ChAT-GFP+ antibodies against ChAT, Rab5. Image J software develop optimize assay puncta. Experiments repeated follow-up cohort aged-adult (N=2 N=2 18 mo). IF quantified forebrain, diagonal band Broca (vDB), striatal compared results cortical adult brain. Colocalization observed cell bodies striatum, vDB regions, intensity well number positive signal incrementally. analyses revealed near-complete overlap region. conclude healthy brains. These data provide first evidence quantifiable specific (vDB) Together previous research lab, these support role through orchestration retrograde signaling. Ongoing underway verify findings novel model incorporates humanized variant created by MODEL-AD, we aim further how may affect mechanistic components subsequent survival context known amyloid beta Tau pathologies.

Language: Английский

Citations

0
Mystery of gamma wave stimulation in brain disorders DOI Creative Commons

Qianting Deng,

Chongyun Wu,

Emily Parker

et al.

Molecular Neurodegeneration, Journal Year: 2024, Volume and Issue: 19(1)

Published: Dec. 18, 2024

Abstract Neuronal oscillations refer to rhythmic and periodic fluctuations of electrical activity in the central nervous system that arise from cellular properties diverse neuronal populations their interactions. Specifically, gamma play a crucial role governing connectivity between distinct brain regions, which are essential perception, motor control, memory, emotions. In this context, we recapitulate various current stimulation methods induce entrainment. These include sensory stimulation, optogenetic modulation, photobiomodulation, transcranial or magnetic stimulation. Simultaneously, explore association abnormal disorders such as Alzheimer’s disease, Parkinson’s stroke, schizophrenia, autism spectrum disorders. Evidence suggests entrainment-inducing offer notable neuroprotection, although somewhat controversial. This review comprehensively discusses functional higher-order activities both physiological pathological perspectives, emphasizing entrainment potential therapeutic approach for neuropsychiatric Additionally, discuss future opportunities challenges implementing strategies.

Language: Английский

Citations

0