Folic Acid Prevents High-Fat Diet-Induced Postpartum Weight Retention in Rats, Which Is Associated with a Reduction in Endoplasmic Reticulum Stress-Mediated Hepatic Lipogenesis DOI Open Access
Zhihong Zhang, Li Zhang,

Xuenuo Zhao

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4377 - 4377

Published: Dec. 19, 2024

Background: Proactively preventing postpartum weight retention (PPWR) is one of the effective intervention strategies to reduce occurrence obesity in women. Population studies have shown that serum folate levels are closely related body weight. The regulation folic acid on lipid metabolism has been fully confirmed both vivo and vitro studies. For many years, supplementation widely used periconceptional women due its role fetal neural tube defects. However, whether prior throughout pregnancy exerts preventive effects PPWR remains uncertain. This study aims investigate effect rats further explore underlying mechanisms. Methods: In this study, pregnant were administered dietary schedules: control diet (CON), high-fat (HF), combined with (FA) (HF + FA). Results: We discovered inhibited diet-induced elevations weight, visceral fat liver hepatic at 1 week post-weaning (PW). Western blot analysis showed expression endoplasmic reticulum (ER) stress-specific proteins including GRP78, PERK, eIF2α, IRE1α, XBP1 ATF6, subsequently decreasing synthesis SREBP-1c, ACC1 FAS. Conclusions: conclusion, rats, mechanism associated inhibition ER stress-mediated lipogenesis signaling pathways liver. Folic may serve as a potential strategy for PPWR. future, effectiveness prevention can be verified by population

Language: Английский

Impact of Transgenerational Nutrition on Nonalcoholic Fatty Liver Disease Development: Interplay between Gut Microbiota, Epigenetics and Immunity DOI Open Access
Hong‐Tai Tzeng, Wei‐Chia Lee

Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1388 - 1388

Published: May 3, 2024

Nonalcoholic fatty liver disease (NAFLD) has emerged as the most prevalent pediatric disorder, primarily attributed to dietary shifts in recent years. NAFLD is characterized by accumulation of lipid species hepatocytes, leading inflammation that can progress steatohepatitis, fibrosis, and cirrhosis. Risk factors contributing encompass genetic variations metabolic disorders such obesity, diabetes, insulin resistance. Moreover, transgenerational influences, resulting an imbalance gut microbial composition, epigenetic modifications, dysregulated hepatic immune responses offspring, play a pivotal role development. Maternal nutrition shapes profile microbiota-derived metabolites exerting significant influence on system regulation development syndrome offspring. In this review, we summarize evidence elucidating intricate interplay between microbiota, epigenetics, immunity fetuses exposed maternal nutrition, its impact onset Furthermore, potential therapeutic strategies targeting network are also discussed.

Language: Английский

Citations

7
Toxic effects of triclosan on hepatic and intestinal lipid accumulation in zebrafish via regulation of m6A-RNA methylation DOI

Jinyun Li,

Fang Lü,

M Xi

et al.

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 269, P. 106884 - 106884

Published: March 2, 2024

Language: Английский

Citations

5
Fucoidan Improves D-Galactose-Induced Cognitive Dysfunction by Promoting Mitochondrial Biogenesis and Maintaining Gut Microbiome Homeostasis DOI Open Access
Yan Xu, Meilan Xue, Jing Li

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1512 - 1512

Published: May 17, 2024

Recent studies have indicated that fucoidan has the potential to improve cognitive impairment. The objective of this study was demonstrate protective effect and possible mechanisms in D-galactose (D-gal)-induced dysfunction. Sprague Dawley rats were injected with (200 mg/kg, sc) administrated (100 mg/kg or 200 ig) for 8 weeks. Our results suggested significantly ameliorated impairment D-gal-exposed reversed histopathological changes hippocampus. Fucoidan reduced D-gal-induced oxidative stress, declined inflammation level improved mitochondrial dysfunction hippocampal. promoted biogenesis by regulating PGC-1α/NRF1/TFAM pathway, thereby improving regulation on PGC-1α is linked upstream protein APN/AMPK/SIRT1. Additionally, neuroprotective action could be related maintaining intestinal flora homeostasis up-regulation Bacteroidota, Muribaculaceae Akkermansia down-regulation Firmicutes. In summary, may a natural, promising candidate active ingredient age-related interventions.

Language: Английский

Citations

5
Effects of Heat-Treated Lactobacillus helveticus CP790-Fermented Milk on Gastrointestinal Health in Healthy Adults: A Randomized Double-Blind Placebo-Controlled Trial DOI Open Access
Reiko Tanihiro, Masahiro Yuki,

Katsuhisa Sakano

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2191 - 2191

Published: July 10, 2024

Probiotic-fermented milk is commonly used to maintain intestinal health. However, the effects of heat-treated fermented milk, which does not contain live microorganisms, on function are yet fully understood. This study aimed investigate whether Lactobacillus helveticus CP790-fermented affects fecal microbiota and gut health as a “postbiotic”. A randomized, double-blind, placebo-controlled trial was conducted in healthy Japanese individuals aged 20–59 years with tendency toward constipation. Participants consumed 100 mL either test beverage (n = 60) or placebo for four weeks. The beverages were prepared while nonfermented flavored lactic acid. Fecal samples analyzed using 16S rRNA gene sequencing. Constipation symptoms assessed defecation logs Patient Assessment Symptoms (PAC-SYM) questionnaire. Mood state also Profile States 2 (POMS2) questionnaire explore its potential “psychobiotic”. Desulfobacterota significantly decreased by intake. PICRUSt2 analysis predicted decrease proportion genes involved sulfate reduction pathway following consumption milk. intervention improved stool consistency straining during defecation. These improvements correlated Desulfobacterota. After intervention, overall mood, expressed total mood disturbance, depression–dejection better CP790 group than group. results suggest that intake could be effective modulating improving constipation states.

Language: Английский

Citations

3
Self-assembled nano delivery system of fenugreek polysaccharides: Effects on curcumin bioavailability and molecular mechanisms DOI
Qiongdan Hu,

Xinxing Tang,

Rui Long

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138294 - 138294

Published: Dec. 1, 2024

Language: Английский

Citations

3
Nicotinamide Riboside Ameliorates Fructose-Induced Lipid Metabolism Disorders in Mice by Activating Browning of WAT, and May Be Also Related to the Regulation of Gut Microbiota DOI Open Access
Zhihong Zhang,

Xuenuo Zhao,

Li Zhang

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3920 - 3920

Published: Nov. 17, 2024

This study aims to observe the preventive effect of nicotinamide riboside (NR) on fructose-induced lipid metabolism disorders and explore its mechanism.

Language: Английский

Citations

2
Impact of maternal high‐fat diet on offspring gut microbiota during short‐term high‐fat diet exposure in mice DOI Creative Commons
Henry A. Paz,

Lasya Buddha,

Ying Zhong

et al.

Physiological Reports, Journal Year: 2024, Volume and Issue: 12(21)

Published: Nov. 1, 2024

Abstract Alterations in the gut microbiome have been linked to obesity, with maternal high‐fat diet (HF) playing a role shaping offspring composition. However, sex‐specific responses HF and impact of subsequent dietary challenges remain unclear. This study investigated effects on microbiota structure predicted functional profile response short‐term postnatal exposure focus responses. Female male control (C) or were weaned onto C diet. Offspring euthanized at 13 weeks age cecal contents collected for bacterial taxonomic profiling. Maternal reduced α‐diversity, notably Sex‐specific differences observed microbial composition potential. Furthermore, influence community potential varied depending led increased relative abundance Corynebacterium female decreased Akkermansia Roseburia offspring. These findings underscore sexually dimorphic nature function, implications developmental programming metabolic health.

Language: Английский

Citations

2
Effects of fermented Arctium lappa L. root by Lactobacillus casei on hyperlipidemic mice DOI Creative Commons

Ming-yong CHEN,

Yuxiao Wu,

Huiying Yang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 28, 2024

Introduction This study aimed to establish a fermentation system based on Lactobacillus casei (LC) and Arctium lappa L. root (AR) investigate its effects. The objectives included comparing metabolite profiles pre- post-fermentation using untargeted metabolomics evaluating the impact of LC-AR in high-fat diet-induced hyperlipidemic mice. Methods Untargeted was used analyze differences metabolites before after fermentation. In vitro antioxidant activity, liver injury, lipid levels, pro-inflammatory cytokine cholesterol-related mRNA expression were assessed. 16S rRNA sequencing conducted evaluate changes gut microbiota composition. Results exhibited stronger activity higher levels than AR. It also improved injury as well better regulation mRNA. analysis revealed that decreased Firmicutes/Bacteroidetes ratio, which correlated negatively with triglycerides, total cholesterol, low-density lipoprotein cholesterol levels. Discussion These findings suggest may serve promising functional food drug raw material for improving hyperlipidemia, particularly through beneficial effects regulation.

Language: Английский

Citations

0
The roles of the gut microbiota, metabolites, and epigenetics in the effects of maternal exercise on offspring metabolism DOI
Jing Ren, Liyuan Zhou, Shunhua Li

et al.

AJP Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 327(6), P. E760 - E772

Published: Nov. 13, 2024

Metabolic diseases, including obesity, dyslipidemia, and type 2 diabetes, have become severe challenges worldwide. The developmental origins of health disease (DOHaD) hypothesis suggests that an adverse intrauterine environment can increase the risk metabolic disorders in offspring. Studies demonstrated maternal exercise is effective intervention for improving offspring health. However, pathways through which works are unclear. It has been reported gut microbiota mediates effect on metabolism, epigenetic modifications also proposed to be important molecular mechanisms. Microbial metabolites influence epigenetics by providing substrates DNA or histone modifications, binding G-protein coupled receptors affect downstream pathways, regulating activity modifying enzymes. This review aims summarize intergenerational proposes microbiota-metabolites-epigenetic regulation mechanism improves may yield novel targets early prevention diseases.

Language: Английский

Citations

0
Folic Acid Prevents High-Fat Diet-Induced Postpartum Weight Retention in Rats, Which Is Associated with a Reduction in Endoplasmic Reticulum Stress-Mediated Hepatic Lipogenesis DOI Open Access
Zhihong Zhang, Li Zhang,

Xuenuo Zhao

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4377 - 4377

Published: Dec. 19, 2024

Background: Proactively preventing postpartum weight retention (PPWR) is one of the effective intervention strategies to reduce occurrence obesity in women. Population studies have shown that serum folate levels are closely related body weight. The regulation folic acid on lipid metabolism has been fully confirmed both vivo and vitro studies. For many years, supplementation widely used periconceptional women due its role fetal neural tube defects. However, whether prior throughout pregnancy exerts preventive effects PPWR remains uncertain. This study aims investigate effect rats further explore underlying mechanisms. Methods: In this study, pregnant were administered dietary schedules: control diet (CON), high-fat (HF), combined with (FA) (HF + FA). Results: We discovered inhibited diet-induced elevations weight, visceral fat liver hepatic at 1 week post-weaning (PW). Western blot analysis showed expression endoplasmic reticulum (ER) stress-specific proteins including GRP78, PERK, eIF2α, IRE1α, XBP1 ATF6, subsequently decreasing synthesis SREBP-1c, ACC1 FAS. Conclusions: conclusion, rats, mechanism associated inhibition ER stress-mediated lipogenesis signaling pathways liver. Folic may serve as a potential strategy for PPWR. future, effectiveness prevention can be verified by population

Language: Английский

Citations

0