Reduced muscle strength in patients with long-COVID-19 syndrome is mediated by limb muscle mass

Journal of Applied Physiology, Journal Year: 2022, Volume and Issue: 134(1), P. 50 - 58

Published: Nov. 30, 2022

Understanding the impact of COVID-19 on muscle strength may help to elucidate organ systems that contribute acute and chronic sequelae. We questioned whether patients with postdischarge symptoms after had compromised compared a control group, if this potential relationship was mediated by lower appendicular lean mass index (ALMI). A total 99 long-COVID-19 97 participants were screened. Maximal grip assessed TKK 5101 digital dynamometer, leg extension 1RM measured using EGYM Smart Strength machines. Body composition (fat percentage, mass, visceral fat, index) determined whole body dual-energy X-ray densitometer. Results showed significantly higher in controls than survivors (mean [SD], 32.82 [10.01] vs. 26.94 [10.33] kg; difference, 5.87

Language: Английский

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SARS-CoV-2 infection and replication kinetics in different human cell types: The role of autophagy, cellular metabolism and ACE2 expression

Life Sciences, Journal Year: 2022, Volume and Issue: 308, P. 120930 - 120930

Published: Sept. 6, 2022

Language: Английский

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Antioxidant Genetic Profile Modifies Probability of Developing Neurological Sequelae in Long-COVID

Antioxidants, Journal Year: 2022, Volume and Issue: 11(5), P. 954 - 954

Published: May 12, 2022

Understanding the sequelae of COVID-19 is utmost importance. Neuroinflammation and disturbed redox homeostasis are suggested as prevailing underlying mechanisms in neurological propagation long-COVID. We aimed to investigate whether variations antioxidant genetic profile might be associated with Neurological examination (SOD2, GPXs GSTs) determination, well as, genotype analysis Nrf2 ACE2, were conducted on 167 patients. Polymorphisms determined by appropriate PCR methods. Only polymorphisms GSTP1AB GSTO1 independently long-COVID manifestations. Indeed, individuals carrying GSTP1 Val or Asp allele exhibited lower odds myalgia development, both combination. Furthermore, combined presence Ile Ala alleles cumulative risk regarding carriers GPX1 LeuLeu/GPX3 CC genotype. Moreover, GSTM1-null/GPX1LeuLeu more prone developing "brain fog", while this probability further enlarged if A was also present. The fact that certain variants enzymes, combination, affect manifestations, emphasizes involvement susceptibility when SARS-CoV-2 infection initiated host cells, months after.

Language: Английский

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The role of COVID-19 in myopathy: incidence, causes, treatment, and prevention

Journal of Medicine and Life, Journal Year: 2022, Volume and Issue: 15(12), P. 1458 - 1463

Published: Dec. 1, 2022

Myopathy is a disease characterized by muscle dysfunction in general and may be associated with genetics, medication such as statins, or inflammation. In 2019, an epidemic viral infection (SARS-CoV-2 virus) that invaded most countries worldwide appeared caused acute respiratory disease. Consequently, patients had to take group of drugs for relatively long treatment period. According several studies, there was increase the cases muscular disorders due factors. This study aimed (1) investigate relationship between COVID-19 myopathy (2) identify causes prevention methods. A systematic review conducted, analyzing articles from following databases: ResearchGate, Medline, DOAJ (The Directory Open-Access Journals), PubMed, Google Scholar. After performing search filtering results, we included 61 articles. There strong myopathy, especially admitted ICU department, neurological dysregulation multiorgan dysfunctions polyneuropathy, peripheral nerve involvement, dysautonomia, Guillain-Barré syndrome, many others.

Language: Английский

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COVID-19 and athletes: Endurance sport and activity resilience study—CAESAR study

Frontiers in Physiology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 16, 2022

Background: The COVID-19 pandemic and imposed restrictions influenced athletic societies, although current knowledge about mild consequences on cardiopulmonary physiologic parameters remains inconclusive. This study aimed to assess the impact of inflection exercise test (CPET) performance among endurance athletes (EA) with varied fitness level. Materials Methods: 49 EA (n male = 43, n female 6, mean age 39.94 ± 7.80 yr, height 178.45 cm, weight 76.62 kg; BMI 24.03 kgm −2 ) underwent double treadmill or cycle ergometer CPET body analysis (BA) pre- post-mild infection. Mild infection was defined as: (1) without hospitalization (2) prolonged health complications lasting for >14 days. Speed, power, heart rate (HR), oxygen uptake (VO 2 ), pulmonary ventilation, blood lactate concentration (at anaerobic threshold (AT)), respiratory compensation point (RCP), maximum exertion were measured before after Pearson’s Spearman’s r correlation coefficients Student t-test applied relationship between variables time. Results: anthropometric measurements did not differ significantly COVID-19. There a significant reduction in VO at AT RCP (both p < 0.001). Pre-COVID-19 34.97 6.43 ml kg·min −1 , 43.88 7.31 47.81 7.81 respectively AT, maximal post-COVID-19 32.35 5.93 40.49 6.63 44.97 7.00 maximal. Differences HR ( 0.001) observed. 145.08 10.82 bpm 168.78 9.01 141.12 9.99 165.14 9.74 RCP. Time-adjusted measures showed significance fat (r 0.46, 0.001), mass 0.33, 0.020), cycling power −0.29, 0.045), −0.30, 0.036). Conclusion: A resulted decrease EA’s performance. most changes observed HR. Medical Professionals Training Specialists should be aware order recommend optimal therapeutic methods properly adjust intensity training.

Language: Английский

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Electrical stimulation to regain lower extremity muscle perfusion and endurance in patients with post‐acute sequelae of SARS CoV‐2: A randomized controlled trial

Physiological Reports, Journal Year: 2023, Volume and Issue: 11(5)

Published: March 1, 2023

Abstract Muscle deconditioning and impaired vascular function in the lower extremities (LE) are among long‐term symptoms experienced by COVID‐19 patients with a history of severe illness. These part post‐acute sequelae Sars‐CoV‐2 (PASC) currently lack evidence‐based treatment. To investigate efficacy extremity electrical stimulation (E‐Stim) addressing PASC‐related muscle deconditioning, we conducted double‐blinded randomized controlled trial. Eighteen ( n = 18) LE were randomly assigned to either intervention (IG) or control (CG) group, resulting 36 being assessed. Both groups received daily 1 h E‐Stim on both gastrocnemius muscles for 4 weeks, device functional IG nonfunctional CG. Changes plantar oxyhemoglobin (OxyHb) endurance (GNMe) response weeks At each study visit, outcomes measured at onset t 0 ), 60 min 10 after therapy 70 ) recording ΔOxyHb near‐infrared spectroscopy. ΔGNMe was surface electromyography two time intervals: 0–5 (Intv and: 55–60 2 ). Baseline OxyHb decreased (IG: p 0.046; CG: 0.026) (IG 0.021; 0.060) from . IG's increased < 0.001), while CG's 0.003). The had higher values than CG 0.004). GNMe did not increase group Intv 0.031), whereas change. There significant association between r 0.628, 0.003) IG. In conclusion, can improve perfusion individuals PASC experiencing deconditioning.

Language: Английский

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Graphene Oxide Decreases Pro-Inflammatory Proteins Production in Skeletal Muscle Cells Exposed to SARS-CoV-2 Spike Protein

Nanotechnology Science and Applications, Journal Year: 2023, Volume and Issue: Volume 16, P. 1 - 18

Published: Jan. 1, 2023

The experiments aimed to document the presence of ACE2 receptor on human muscle cells and effects interaction these with spike protein SARS-CoV-2 virus in terms induction pro-inflammatory proteins, as well assess possibility reducing pool proteins use graphene oxide (GO) flakes.Human Skeletal Myoblast (HSkM), purchased from Gibco were maintained standard condition according manufacturer's instruction. divided into 4 groups; 1. C-control, 2. S-with addition protein, 3. GO-with oxide, 4. GO-S-with GO followed by S protein. Protein (PX-COV-P049) was ProteoGenix (France). obtained Advanced Graphene Products (Zielona Gora, Poland). influence all factors morphology investigated using light confocal microscopy. expression visualized 40 cytokines membrane antibody array method. profile lysate individual groups also analyzed mass spectrometry.The confirmed skeletal cells. It has been documented that influences activation selected promote cytokine storm oxidative stress low levels does not adversely affect cells, most including proteins. can be assumed may support anti-inflammatory therapy muscles scavenging activate storm.

Language: Английский

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C188-9, a specific inhibitor of STAT3 signaling, prevents thermal burn-induced skeletal muscle wasting in mice

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 16, 2022

Burn injury is the leading cause of death and disability worldwide places a tremendous economic burden on society. Systemic inflammatory responses induced by thermal burn can muscle wasting, severe involuntary loss skeletal that adversely affects survival functional outcomes these patients. Currently, no pharmacological interventions are available for treatment burn-induced wasting. Elevated levels cytokines, such as interleukin-6 (IL-6), important hallmarks injury. The signal transducer activator transcription 3 (STAT3)—a downstream component IL-6 signaling—are elevated with wasting in various pro-catabolic conditions, STAT3 has been implicated regulation atrophy. Here, we tested effects STAT3-specific signaling inhibitor C188-9 injury-induced vivo C2C12 myotube atrophy vitro after administration plasma from model mice. In mice, severity dependently increased tibialis anterior muscles activated (increased ratio phospho-STAT3/STAT3) ubiquitin-proteasome proteolytic pathways Atrogin-1/MAFbx MuRF1). These resulted reduced grip strength. murine myotubes, mice same pathways, to injury, intraperitoneal injection (50 mg/kg) activation reversed atrophy, Similarly, pretreatment myotubes (10 µM) ameliorated taken Collectively, results indicate inhibition may be novel therapeutic strategy

Language: Английский

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Dermatomyositis in Association With SARS‐CoV‐2 Infection or COVID‐19 Vaccine

Arthritis Care & Research, Journal Year: 2023, Volume and Issue: 76(1), P. 98 - 104

Published: Sept. 20, 2023

New-onset and relapsed dermatomyositis (DM) has been reported following SARS-CoV-2 infection or COVID-19 vaccination. This study aims to show the characteristics of a DM cohort after

Language: Английский

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The regenerative potential of Pax3/Pax7 on skeletal muscle injury

Journal of Genetic Engineering and Biotechnology, Journal Year: 2022, Volume and Issue: 20(1), P. 143 - 143

Published: Oct. 17, 2022

Skeletal muscle mishaps are the most well-known incidents in society, especially among athletes and military population. From various urgency, this accident needs to be cured more quickly. However, current treatment still has some shortcomings is less effective. In case, Paired box 3 7 (Pax3/Pax7) proteins that induce stem cells could potentially an alternative for skeletal injuries. This paper aimed analyse potential of Pax3/Pax7 inducing cell We did a narrative review by gathering several scientific journals from leading platforms like PubMed Scopus. As common accidents, disease due workplace non-workplace causes. The highest risk occurs athlete environment. injuries protection, rest, ice, compression, elevation (PRICE), non-steroidal anti-inflammatory drugs (NSAIDs), mechanical stimulation. it considered effective, NSAIDs, inhibiting myogenic proliferation. finding indicates have markers known as Pax3/Pax7. role both injury, Pax3/Pax7, transcription factors will division H3K4 methylation mechanisms chromatin modifications stimulate gene activation. Regulation affect proliferation one treatments. regulation can accelerate healing injury victims, muscles. Finally, after being compared, induces Pax3 Pax7, muscle, Athlete, Stem cells, Cell proliferation, Injuries.

Language: Английский

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