Gut redox and microbiome: charting the roadmap to T-cell regulation

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 21, 2024

The gastrointestinal (GI) tract redox environment, influenced by commensal microbiota and bacterial-derived metabolites, is crucial in shaping T-cell responses. Specifically, metabolites from gut (GM) exhibit robust anti-inflammatory effects, fostering the differentiation regulation of CD8 + tissue-resident memory (TRM) cells, mucosal-associated invariant T (MAIT) stabilizing gut-resident Treg cells. Nitric oxide (NO), a pivotal mediator, emerges as central regulator functions inflammation. NO impacts composition microbiome, driving pro-inflammatory Th17 cells exacerbating intestinal inflammation, supports expansion, showcasing its dual role immune homeostasis. This review delves into complex interplay between GI balance GM elucidating their profound impact on regulation. Additionally, it comprehensively emphasizes critical redox, particularly reactive oxygen species (ROS) NO, phenotype functions. These insights offer valuable perspectives disease mechanisms potential therapeutic strategies for conditions associated with oxidative stress. Understanding cross-talk responses provides avenues immune-mediated diseases, underscoring significance maintaining optimal health.

Language: Английский

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Marine-Derived Fucose-Containing Carbohydrates: Review of Sources, Structure, and Beneficial Effects on Gastrointestinal Health

Foods, Journal Year: 2024, Volume and Issue: 13(21), P. 3460 - 3460

Published: Oct. 29, 2024

Fucose, fucose-containing oligosaccharides, and polysaccharides have been widely applied in the fields of food medicine, including applications

Language: Английский

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Casearia sylvestris var. lingua (Càmbess.) Eichler leaves aqueous extract improves colon inflammation through mucogenic, antioxidant and anti-inflammatory actions in TNBS- induced IBD rats

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 332, P. 118393 - 118393

Published: May 25, 2024

Language: Английский

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Marine Algae and Deriving Biomolecules for the Management of Inflammatory Bowel Diseases: Potential Clinical Therapeutics to Decrease Gut Inflammatory and Oxidative Stress Markers?

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(8), P. 336 - 336

Published: July 25, 2024

The term "inflammatory bowel disease" (IBD) describes a class of relapse-remitting conditions that affect the gastrointestinal (GI) tract. Among these, Crohn's disease (CD) and ulcerative colitis (UC) are two most globally prevalent debilitating conditions. Several articles have brought attention to significant role inflammation oxidative stress cooperatively play in development IBD, offering different viewpoint both on its etiopathogenesis strategies for effective treatment these Marine ecosystems may be source physiologically active substances, supporting search new potential clinical therapeutics. Based this evidence, review aims comprehensively evaluate activity marine algae deriving biomolecules decreasing pathological features CD UC. To match purpose, deep literature PubMed (MEDLINE) Google Scholar was performed highlight primary biological mechanisms, modulation inflammatory biochemical parameters, benefits from species. From our findings, macroalgae microalgae shown as therapeutic solutions IBD due their bioactive compounds anti-inflammatory antioxidant activities which capable modulating markers such cytokines, NF-κB pathway, reactive nitrosative species (ROS RNS), trefoil factor 3 (TFF3), lactoferrin, SIRT1, etc. However, while we found promising preclinical more extensive long-term studies necessary establish efficacy safety treatment.

Language: Английский

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Anticancer Potential of Postbiotic Derived from Lactobacillus brevis and Lactobacillus casei: In vitro Analysis of Breast Cancer Cell Line

Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: unknown

Published: May 17, 2024

Language: Английский

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