Generation of a medicine food homology formula and its likely mechanism in treatment of microvascular angina DOI Creative Commons

Zhidie Jin,

Mingwang Liu,

Beili Xie

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 30, 2024

Microvascular angina (MVA) is the most common cause of cardiac ischemic chest pain in patients without obstructive coronary artery disease (CAD) and lacks effective treatment means. Medicine food homology (MFH) involves substances with both nutritional medicinal qualities that have potential to improve MVA symptoms as medicines, dietary supplements. However, research on MFH formula (MFHF) for not available. The study aims generate a core MFHF through data mining offer scientific backing utilization edible medications prevention alleviation MVA. 11 databases were utilized construct database drugs, was generated frequency analysis, association rule clustering analysis. composition Codonopsis Radix, Astragali Platycodonis Persicae Semen, Glycyrrhizae Radix Et Rhizoma, Angelicae Sinensis Allii Macrostemonis Bulbus. Through network pharmacology molecular docking, we identified five major active components MFHF: Adenosine, Nonanoic Acid, Lauric Caprylic Enanthic along nine targets (NFKB1, ALB, AKT1, ACTB, TNF, IL6, ESR1, CASP3, PTGS) improvement These 5 various biological activities, such reducing oxidative stress, anti-inflammation, analgesia effect, inhibiting platelet aggregation, vasodilatation, vascular endothelial protection, cardio-protection. GO KEGG enrichment analyses revealed mainly acted response xenobiotic stimulus, integrative component plasma membrane, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, pathways cancer, lipid atherosclerosis, human cytomegalovirus infection, PI3K-Akt signaling pathway, which are main pathogenesis

Language: Английский

Transformation from traditional medicine-food homology to modern food-medicine homology DOI
Dongxiao Sun‐Waterhouse, Jia Yu, Zhenhua Liu

et al.

Food & medicine homology., Journal Year: 2024, Volume and Issue: 1(1), P. 9420014 - 9420014

Published: July 25, 2024

Language: Английский

Citations

30
The evolution and significance of medicine and food homology DOI Creative Commons
Huan Zhong,

Zhi-Qing Tang,

Yi-Fang Li

et al.

Acupuncture and Herbal Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: March 5, 2024

Language: Английский

Citations

10
Berberine alleviates enterotoxigenic Escherichia coli-induced intestinal mucosal barrier function damage in a piglet model by modulation of the intestinal microbiome DOI Creative Commons

Min Du,

Xinran Liu, Xu Ji

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 14, 2025

Introduction Enterotoxic Escherichia coli (ETEC) is the main pathogen that causes diarrhea, especially in young children. This disease can lead to substantial morbidity and mortality a major global health concern. Managing ETEC infections challenging owing increasing prevalence of antibiotic resistance. Berberine, categorized as substance with similarities “medicine food,” has been used China for hundreds years treat gastrointestinal disorders bacteria-induced diarrhea. study investigated preventive effect dietary berberine on intestinal mucosal barrier induced by microbial community within intestines weaned piglets. Methods Twenty-four piglets were randomly divided into four groups. Piglets administered either standard diet or supplemented at concentrations 0.05 0.1%. orally saline. Results Dietary supplementation reduced diamine oxidase, d-lactate, endotoxin levels infected ( P < 0.05). Berberine increased jejunal villus height, villus/crypt ratio, thickness 0.05), goblet cell numbers villi crypts Furthermore, optical density mucin 2 2, P-glycoprotein, CYP3A4 mRNA expression expressions zonula occludins-1 (ZO-1), occludins-2 (ZO-2), Claudin-1, Occludin, E-cadherin ileum Moreover, BCL2, epithelial apoptosis 0.05) decreased BAX BAK duodenum jejunum, well CASP3 CASP9 IL-1β, IL-6, IL-8, TNF-α, IFN-γ elevated total volatile fatty acids, acetic acid, propionic valeric isovaleric acid Notably, enhanced abundance beneficial bacteria including Enterococcus, Holdemanella, Weissella, Pediococcus, Muribaculum, Colidextribacter, Agathobacter, Roseburia, Clostridium, Fusicatenibacter , Bifidobacterium . Simultaneously, relative harmful pathogenic bacteria, such Prevotella, Paraprevotella, Corynebacterium, Catenisphaera, Streptococcus, Enterobacter Collinsella Discussion alleviated ETEC-induced damage models. associated enhancement physical, chemical, immune functions enhancing microbiota homeostasis.

Language: Английский

Citations

1
A review of medicine and food homology on traditional Chinese medicine as functional food DOI
Siukan Law, Dawn Ching Tung Au

Food & medicine homology., Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

1
Analysis on patents of health care products with substances of medicine food homology in China DOI Open Access
Haibo Liu, Yanfeng Wang,

Jiali Huang

et al.

Chinese Herbal Medicines, Journal Year: 2024, Volume and Issue: 16(3), P. 412 - 421

Published: May 18, 2024

The concept of substances medicine food homology (SMFH) has garnered significant attention in recent years. This study conducts a systematic analysis patent literature related to SMFH, and elucidates the development trends, technical hotspots, overall protection landscape SMFH China over past two decades. search focused on varieties as objects inquiry, with retrieval conducted databases. Subsequently, acquired data underwent processing, analysis, visualization. While threshold for pharmaceutical applications surpasses that service sector, former may assume prominent role future. Research (R&D) activities southeast demonstrate robust activity than other regions. Colleges scientific research institutions exhibit substantial advantages compared individuals hold greater potential future development. findings this indicate China's industry are presently undergoing transition from an extensive model high-quality model. quality standards products consistently improving. Consequently, there is need more stringent application requirements align evolving needs.

Language: Английский

Citations

8
Multifunctional thiolated chitosan/puerarin composite hydrogels with pH/glutathione dual responsiveness for potential drug carriers DOI
Hao Yuan, Zhaoxiang Zeng, Dongru Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 130841 - 130841

Published: March 29, 2024

Language: Английский

Citations

5
Berberine alleviates ETEC-induced intestinal inflammation and oxidative stress damage by optimizing intestinal microbial composition in a weaned piglet model DOI Creative Commons
Yue Wang,

Z. Zhang,

Min Du

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 16, 2024

Introduction Enterotoxigenic Escherichia coli (ETEC) is the main diarrhea-causing pathogen in children and young animals has become a global health concern. Berberine type of “medicine food homology” long history use China, particularly treating gastrointestinal disorders bacterial diarrhea. Methods In this study, we explored effects berberine on growth performance, intestinal inflammation, oxidative damage, microbiota weaned piglet model ETEC infection. Twenty-four piglets were randomly divided into four groups—a control group (fed basal diet [BD] infused with saline), BD+ETEC ETEC), LB+ETEC 0.05% infection), HB+ETEC 0.1% ETEC). Results significantly improved final body weight (BW), average daily gain (ADG), feed intake (ADFI) ( P <0.05) piglets, effectively decreased incidence diarrhea among <0.05). Additionally, downregulated expression levels genes encoding TNF-α, IL-1β, IL-6, IL-8, TLR4, MyD88, NF-κB, IKKα, IKKβ small intestine infection upregulated coding for Nrf2, CAT, SOD1, GPX1, GST, NQO1, HO-1, GCLC, GCLM 12 functional COG categories 7 KEGG signaling pathways. A correlation analysis showed that increased relative abundance beneficial bacteria (Gemmiger, Pediococcus, Levilactobacillus, Clostridium, Lactiplantibacillus, Weissella, Enterococcus, Blautia, Butyricicoccus) pathogenic (Prevotella, Streptococcus, Parabacteroides, Flavonifractor, Alloprevotella) known to be closely related inflammation stress piglets. conclusion, disrupted upregulating TLR4/MyD88/NF-κB Nrf2 pathways, consequently leading stress-induced damage. Discussion Our data indicated can optimize balance modulate thus helping alleviate damage caused by

Language: Английский

Citations

5
Exploring the Molecular Mechanisms of Fisetin in Treating Periodontitis Through Multiomics and Network Pharmacology DOI Creative Commons
Lingzhi Ma,

Hongrong Zhang,

Yali Liu

et al.

International Dental Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Periodontitis (PD) is a common chronic inflammatory oral disease that severely affects patients' quality of life. Fisetin has been shown to possess antioxidant and anti-inflammatory properties in various biological systems.

Language: Английский

Citations

0
Detection of volatile organic compounds in Farfarae flos using HS-GC-IMS across different flower colors DOI Creative Commons
Xiaoying Chen, J. Y. Shi,

Yonggang Yan

et al.

Food Chemistry X, Journal Year: 2025, Volume and Issue: 26, P. 102227 - 102227

Published: Feb. 1, 2025

Farfarae flos is valued for its nutritional and medicinal benefits. This study used headspace gas chromatography-ion mobility spectrometry to investigate the volatile compounds in various colors of flos, including green (G), yellow white (YW), purplish red (PR), deep (DPR). A total 92 signal peaks representing 68 identified compounds, which are mainly composed aldehydes, alcohols, ketones. The fingerprints showed that types different were same, but contents different. PCA further confirmed clear segregation among four color categories. content a key determinant flavor expressed by flower buds. In this study, differential within identified, providing reference selection breeding varieties with desirable qualities.

Language: Английский

Citations

0
Nephroprotective effects of substances of medicine food homology and traditional Chinese medicine phytochemicals against acute kidney injury DOI Creative Commons
Ling Chen,

Yanyan Deng,

Jing Hu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 19, 2025

Acute kidney injury (AKI) represents significant medical challenges due to its elevated rates of morbidity and mortality, with limited therapeutic options currently available. Hence, the exploration novel medicinal treatments for AKI management remains vital. Substances medicine food homology (SMFH), referring substances having characteristics both medicine, have been applied in China thousands years.They could be used daily diets body conditioning. Traditional Chinese (TCM), naturally derived components demonstrated effectiveness, presents distinctive benefits treatment. Numerous studies shown that SMFH TCM phytochemicals function satisfactorily nephroprotective effects a effect on alleviating as well complications. In this review, pathogenesis was illustrated. We concentrated against tried summarize underlying mechanisms various kinds AKI, highlighting crucial phytochemical prevention therapy. Besides, strategies globalization are analysed. This review comprehensively reveals exhibit promising potential intervention by targeting signal pathways targets, which would contribute AKI's cognition, preventive treatments, global promotion.

Language: Английский

Citations

0