The Impact of Cesarean Section Delivery on Intestinal Microbiota: Mechanisms, Consequences, and Perspectives—A Systematic Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1055 - 1055

Published: Jan. 15, 2024

The relationship between cesarean section (CS) delivery and intestinal microbiota is increasingly studied. CS-born infants display distinct gut microbial compositions due to the absence of maternal birth canal microorganisms. These alterations potentially link long-term health implications like immune-related disorders allergies. This correlation underscores intricate connection mode establishment diverse microbiota. A systematic literature review was conducted on PubMed, Scopus, Web Science databases by analyzing articles examining interactions CS infant's analysis, based a wide-ranging selection studies, elucidates multifaceted dynamics involved in CS-associated shifts fetal We also explore potential ramifications these changes neonatal development, providing comprehensive overview for clinicians researchers. By synthesizing current findings, this contributes deeper understanding interplay early colonization, paving way informed clinical decisions future investigations field perinatal medicine.

Language: Английский

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From Birth to Weaning: A Window of Opportunity for Microbiota

Nutrients, Journal Year: 2024, Volume and Issue: 16(2), P. 272 - 272

Published: Jan. 17, 2024

(1) Background: The first 1000 days of life constitute a critical window opportunity for microbiota development. Nutrients play crucial role in enriching and diversifying the microbiota, derived not only from solid food but also maternal dietary patterns during gestation. (2) Methods: We conducted comprehensive literature review using PubMed database, covering eleven years (2013–2023). included English-language reviews, original research papers, meta-analyses, while excluding case reports letters. (3) Results: Consensus emphasizes that our interaction with multitude microorganisms begins intrauterine environment continues throughout lives. existing data suggest early nutritional education programs, initiated pregnancy guiding infant diets development, may influence shaping gut promoting long-term health. (4) Conclusions: Further is necessary coming to assess potential interventions models aimed at modulating pediatric especially vulnerable populations such as premature newborns.

Language: Английский

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Microbiome and its impact on fetal and neonatal brain development: current opinion in pediatrics

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2024, Volume and Issue: 27(3), P. 297 - 303

Published: March 12, 2024

Purpose of review Emerging evidence suggests that the gut microbiota and its metabolites regulate neurodevelopment cognitive functioning via a bi-directional communication system known as microbiota-gut-brain axis (MGBA). Recent findings The MGBA influences brain development function hypothalamic-pituitary axis, vagal nerve, immune signaling, bacterial production neurotransmitters, microbial like short-chain fatty acids, tryptophan derivatives, bile acids. Animal studies show fetal is mediated by maternal activation, diet. Furthermore, manipulation during critical windows development, antibiotic exposure fecal transplantation, can affect behavior in mice. Evidence from human studies, particularly preterm infants, also disrupted colonization may negatively neurodevelopment. Early signatures were linked to favorable adverse neurodevelopmental outcomes. Summary link between evident. Future including experimental larger participant cohort with longitudinal analyses microbes, their metabolites, randomized controlled trials are warranted further elucidate mechanisms MGBA. Identification early, predictive markers could pave way for novel early microbiota-based intervention strategies, such targeted probiotics, vaginal or aimed at improving infant

Language: Английский

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The impact of gut microbiota on morbidities in preterm infants

The Kaohsiung Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 40(9), P. 780 - 788

Published: July 29, 2024

Abstract The gut microbiota undergoes substantial development from birth, and its in the initial years of life has a potentially lifelong effect on health individual. However, various factors can disrupt microbiota, leading to condition known as dysbiosis, particularly preterm infants. Current studies involving adults have suggested that not only influences but also multidimensional effects remote organs; these pathways are often referred gut–organ axis. Imbalance may lead multiple diseases. Recent revealed dysbiosis infants cause several acute morbidities—such necrotizing enterocolitis, late‐onset sepsis, bronchopulmonary dysplasia, retinopathy prematurity—and it influence long‐term outcomes including neurodevelopment somatic growth. This review mainly presents existing evidence regarding relationships between morbidities explores role axis morbidities. paper thus offers insights into future perspectives interventions for promoting

Language: Английский

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Prenatal Nutritional Factors and Neurodevelopmental Disorders: A Narrative Review

Life, Journal Year: 2024, Volume and Issue: 14(9), P. 1084 - 1084

Published: Aug. 29, 2024

According to the DSM-5, neurodevelopmental disorders represent a group of heterogeneous conditions, with onset during developmental period, characterized by an alteration communication and social skills, learning, adaptive behavior, executive functions, psychomotor skills. These deficits determine impairment personal, social, scholastic, or occupational functioning. Neurodevelopmental are increased incidence multifactorial etiology, including genetic environmental components. Data largely explain role factors, also through epigenetic modifications such as DNA methylation miRNA. Despite nutritional factors play significant in pathophysiology these disorders, both prenatal postnatal underscoring that control modifiable could decrease disorders. The preventive nutrition is widely studied regards many chronic diseases, diabetes, hypertension, cancer, but actually we know effects on embryonic brain development influence preconceptional predisposition various pathologies. not limited only correct caloric intake good BMI, rather adequate balanced macro micronutrients, type diet, other elements exposure heavy metals. This review represents analysis literature physiopathological mechanisms which food influences our state health, especially age (from birth adolescence), changes, underlying how controlling should improve mothers' significantly reduce risk offspring. We searched key words "maternal disorders" Pubmed Google Scholar, selecting main reviews excluding individual cases. Therefore, nutrigenetics nutrigenomics teach us importance personalized for health. So future perspectives may include well-established reference values order mothers integration.

Language: Английский

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The Influence of Cecal Microbiota Transplantation on Chicken Injurious Behavior: Perspective in Human Neuropsychiatric Research

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 1017 - 1017

Published: Aug. 16, 2024

Numerous studies have evidenced that neuropsychiatric disorders (mental illness and emotional disturbances) with aggression (or violence) pose a significant challenge to public health contribute substantial economic burden worldwide. Especially, social disorganization inequality) associated childhood adversity has long-lasting effects on mental health, increasing the risk of developing disorders. Intestinal bacteria, functionally as an endocrine organ second brain, release various immunomodulators bioactive compounds directly or indirectly regulating host’s physiological behavioral homeostasis. Under challenges, stress-induced dysbiosis increases gut permeability causes serial reactions: releasing neurotoxic compounds, leading neuroinflammation neuronal injury, eventually aggressive, violent, impulsive behavior in humans animals via complex bidirectional communication microbiota–gut–brain (MGB) axis. The dysregulation MGB axis also been recognized one reasons for prevalence injurious behaviors (feather pecking, aggression, cannibalistic pecking) chickens. However, existing knowledge preventing treating these both chickens is not well understood. In previous studies, we developed non-mammal model abnormal investigation by rationalizing microbiota Based our earlier success, perspective article outlines possibility reducing through modifying cecal transplantation, potential providing biotherapeutic rationale among individuals restoring diversity function.

Language: Английский

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Dynamics and Crosstalk between Gut Microbiota, Metabolome, and Fecal Calprotectin in Very Preterm Infants: Insights into Feeding Intolerance

Nutrients, Journal Year: 2023, Volume and Issue: 15(22), P. 4849 - 4849

Published: Nov. 20, 2023

Feeding intolerance (FI) is a significant concern in the care of preterm infants, impacting their growth and development. We previously reported that FI linked to lower fecal calprotectin (FC) levels. This study aims explore postnatal dynamics interplay between microbiota, metabolic profiles, host immunity infants with without FI.Infants gestational age <32 weeks or birth weight <1500 g were enrolled at Children's Hospital Fudan University January 2018 October 2020. Weekly samples analyzed for bacterial profiling, metabolome, levels, exploring longitudinal development interrelationships.Of 118 very studied, 48 showed FI. These experienced an interrupted microbial-immune trajectory, particularly 3-4 age, marked by reduced abundance, alpha diversity, FC Metabolic changes pronounced 3 6 weeks. Pantothenic acid two polyamine metabolites closely associated abundance levels negatively correlated duration attain full enteral feeding.FI demonstrated compromised microbiome-immune interactions, potentially influenced specific metabolites. research underscored importance early microbial pathogenesis infants.

Language: Английский

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Gut microbiota in preterm infants receiving breast milk or mixed feeding

World Journal of Clinical Pediatrics, Journal Year: 2024, Volume and Issue: 13(2)

Published: June 7, 2024

Preterm birth is the leading cause of mortality in newborns, with very-low-birth-weight infants usually experiencing several complications. Breast milk considered gold standard nutrition, especially for preterm delayed gut colonization, because it contains beneficial microorganisms, such as

Language: Английский

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Severe anemia in preterm infants associated with increased bacterial virulence potential and metabolic disequilibrium

Pediatric Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Language: Английский

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Multi-omics insights into beagle dog fed with a sucking-rewarded automatic feeding device

Frontiers in Pediatrics, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 28, 2024

Background Facilitating the development of sucking function in early stages preterm infants holds substantial potential for influencing their long-term outcomes. To this end, our team has devised a sucking-rewarded automatic feeding device specifically tailored infants. The present study is designed to investigate impacts innovative device, utilizing multi-omics profiling approach, on beagle dogs as surrogate model. Methods This involved seven-day-old male newborn puppies, carefully selected and matched terms body weights. participants were stratified into two groups: experimental group (AFG, group) control (PFG). After 14-day intervention period, fecal blood samples systematically collected from each dog. then subjected distinct analyses, encompassing assessment gut microbial composition, plasma metabolic profiles, proteomic expression profiles. Results data showed significant difference between AFG PFG groups based Bray-Curtis dissimilarity ( P = 0.048), relative abundance Lactobacillus was significantly more abundant compared group. different metabolites enriched functional pathways related amino acids, fatty acid metabolism, nervous system. Notably, neurotransmitter L-glutamic up-regulated Moreover, proteins GO oxygen transport, binding, iron ion hemoglobin complex, heme binding. Among them, A0A8C0MTD2, P60524, P60529 , acid, correlated with other through correlation analysis, these molecules play important roles neural neurodevelopment. Conclusion Our investigation elucidated discernible modifications patterns device.

Language: Английский

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