A novel prognostic risk model construction and immune landscape analysis of gastric cancer based on disulfidptosis-related lncRNAs DOI Creative Commons
Yuan Tian,

Guanlong Wang,

Rui Li

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: April 18, 2023

Abstract Background : Disulfidptosis is a novel form of cell death that induces disulfide stress leading to death. Therefore, this may be new direction for future cancer therapy. More and more studies have shown long non-coding RNAs (lncRNAs) can regulate gastric cancer-related biological processes. At present, there no research on disulfidptosis-related lncRNAs (DRLs) in GC. Methods The Cancer Genome Atlas (TCGA) was used retrieve information about RNA sequencing data, clinical genetic mutation data GC patients. genomic patients were downloaded from the Atlas. First, TCGA are randomly assigned training set validation set. Then, predictive risk model built using univariate multivariate Cox regression models, as well least absolute shrinkage selection operator (LASSO). value verified by receiver operating characteristic (ROC) curves concordance index (C-index) entire analysis, nomogram, correlation analysis clinicopathological characteristics confirm utility prognostic model. Finally, we further tumor burden (TMB) immune dysfunction exclusion (TIDE) scores evaluate effectiveness immunotherapy analyze sensitivity related drugs. Results Six prognostically-related DRLs (TNFRSF10A-AS1, LINC02829, LINC00460, AL139147.1, IGFL2-AS1, AC104123.1) construct overall survival (OS) high-risk group low-risk statistically significant, according Kaplan-Meier graph. ROC C-index show has good ability. Risk score revealed an independent factor analysis. negatively correlated with TMB. According results TIDE, better therapeutic effect group. In addition, significantly drug sensitivity. Conclusions summary, study identified six predictors prognosis, which potential biomarker predicting efficacy future.

Language: Английский

Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer DOI Creative Commons
Ying Liu, Wei Ding, Wanpeng Yu

et al.

Molecular Therapy — Oncolytics, Journal Year: 2021, Volume and Issue: 23, P. 458 - 476

Published: Nov. 11, 2021

Gastric cancer (GC) is one of the most prevalent malignant tumor types and third leading cause cancer-related death worldwide. Its morbidity mortality are very high due to a lack understanding about its pathogenesis slow development novel therapeutic strategies. Long non-coding RNAs (lncRNAs) class with length more than 200 nt. They play crucial roles in wide spectrum physiological pathological processes by regulating expression genes involved proliferation, differentiation, apoptosis, cell cycle, invasion, metastasis, DNA damage, carcinogenesis. The aberrant lncRNAs has been found various types. A growing amount evidence demonstrates that many aspects GC pathogenesis, including occurrence, recurrence, indicating their potential role as biomarkers diagnosis, prognosis, targets GC. This review systematically summarizes biogenesis, biological properties, functions highlights critical clinical significance information may contribute better diagnostics treatments for

Language: Английский

Citations

107
Novel biomarkers for early detection of gastric cancer DOI Creative Commons
Tasuku Matsuoka, Masakazu Yashiro

World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(17), P. 2515 - 2533

Published: May 5, 2023

Gastric cancer (GC) remains a leading cause of cancer-related death worldwide. Less than half GC cases are diagnosed at an advanced stage due to its lack early symptoms. is heterogeneous disease associated with number genetic and somatic mutations. Early detection effective monitoring tumor progression essential for reducing burden mortality. The current widespread use semi-invasive endoscopic methods radiologic approaches has increased the treatable cancers: However, these invasive, costly, time-consuming. Thus, novel molecular noninvasive tests that detect alterations seem be more sensitive specific compared methods. Recent technological advances have enabled blood-based biomarkers could used as diagnostic indicators postsurgical minimal residual disease. These include circulating DNA, RNA, extracellular vesicles, proteins, their clinical applications currently being investigated. identification ideal markers high sensitivity specificity would improve survival rates contribute advancement precision medicine. This review provides overview topics regarding novel, recently developed GC.

Language: Английский

Citations

36
Global progress and future prospects of early gastric cancer screening DOI Creative Commons
Yixiao Huang, Yongfu Shao,

Xuan Yu

et al.

Journal of Cancer, Journal Year: 2024, Volume and Issue: 15(10), P. 3045 - 3064

Published: Jan. 1, 2024

Gastric cancer is a prevalent malignancy that poses serious threat to global health.Despite advances in medical technologies, screening methods, and public awareness, gastric remains significant cause of morbidity mortality worldwide.Early frequently does not present with characteristic symptoms, while advanced stage disease characterized by dismal prognosis.As such, early great importance.In recent years, have been made globally both clinical basic research for the cancer.The current predominant methods include imaging screening, endoscopic serum biomarker screening.Imaging encompasses upper gastrointestinal barium meal, multidimensional spiral computed tomography (MDCT), Magnetic resonance (MRI), ultrasonography.Endoscopic white light endoscopy, chromoendoscopy, virtual other techniques like endocytoscopy, confocal laser endomicroscopy, optical coherence so on.Biomarkers involves assessment conventional biomarkers such as CEA, CA19-9 CA72-4 well more emerging peptides (PG, G-17, GCAA, TAAs others), DNA (cfDNA, methylation, MSI), noncoding RNA (miRNA, lncRNA, circRNA, tsRNA) others.Each method has its strengths limitations.This article systematically summarizes worldwide progress future development provide new perspectives approaches diagnostic treatment advancements worldwide.

Language: Английский

Citations

15
Liquid Biopsy: An Emerging Diagnostic, Prognostic, and Predictive Tool in Gastric Cancer DOI
Hye Sook Han, Keun‐Wook Lee

Journal of the Korean Gastric Cancer Association, Journal Year: 2024, Volume and Issue: 24(1), P. 4 - 4

Published: Jan. 1, 2024

Liquid biopsy, a minimally invasive procedure that causes minimal pain and complication risks to patients, has been extensively studied for cancer diagnosis treatment. Moreover, it facilitates comprehensive quantification serial assessment of the whole-body tumor burden. Several biosources obtained through liquid biopsy have as important biomarkers establishing early diagnosis, monitoring residual disease, predicting prognosis response treatment in patients with cancer. Although clinical application gastric is not robust other cancers, biomarker studies using are being actively conducted Herein, we aimed review role various can be from biopsies, such blood, saliva, juice, urine, stool, peritoneal lavage fluid, ascites, by dividing them into cellular acellular components. In addition, reviewed previous on diagnostic, prognostic, predictive discussed limitations challenges overcome these

Language: Английский

Citations

14
LncRNAs orchestration of gastric cancer - particular emphasis on the etiology, diagnosis, and treatment resistance DOI
Hanan Elimam,

Rewan Moussa,

Abdullah Radwan

et al.

Functional & Integrative Genomics, Journal Year: 2024, Volume and Issue: 24(5)

Published: Sept. 26, 2024

Language: Английский

Citations

9
Long non-coding RNAs and gastric cancer: An update of potential biomarkers and therapeutic applications DOI Open Access
Sayedeh Azimeh Hosseini, Mohammad Hossein Haddadi, Hadis Fathizadeh

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 163, P. 114407 - 114407

Published: April 24, 2023

The frequent metastasis of gastric cancer (GC) complicates the cure and therefore development effective diagnostic therapeutic approaches is urgently necessary. In recent years, lncRNA has emerged as a drug target in treatment GC, particularly areas immunity, metabolism, metastasis. This led to demonstration importance these RNAs prognostic, agents. this review, we provide an overview biological activities lncRNAs GC update latest pathological activities, prognostic strategies, options for GC-related lncRNAs.

Language: Английский

Citations

15
Human Endogenous Retroviruses in Breast Cancer: Altered Expression Pattern Implicates Divergent Roles in Carcinogenesis DOI Creative Commons
Luděk Záveský,

Eva Jandáková,

Vít Weinberger

et al.

Oncology, Journal Year: 2024, Volume and Issue: 102(10), P. 858 - 867

Published: Feb. 26, 2024

Breast cancer is the most common and leading cause of death in women. Recent research indicates that human endogenous retroviruses (HERVs) may be linked to carcinogenesis, but data remain controversial.

Language: Английский

Citations

5
HCP5 Derived Novel Microprotein Triggers Progression of Gastric Cancer through Regulating Ferroptosis DOI Creative Commons
Qiuhui Li, Guoqing Guo, Yuli Chen

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Abstract The context of long noncoding RNAs (lncRNAs) contains many unannotated open reading frames (ORFs). These ORFs potentially encode novel proteins or peptides with crucial roles in various human cancers, yet the translational potential these lncRNAs and functions protein products remain largely unexplored, especially gastric cancer (GC). In this study, a comprehensive analysis is performed identified GC associated lncRNA known as HCP5, which non‐canonical ORF. Further showed that HCP5‐132aa, microprotein encoded by HCP5 harboring ORF, highly expressed cells tissues, can promote proliferation inhibiting ferroptosis. Mechanistically, HCP5‐132aa enhances interaction between YBX1 ELAVL1, facilitates recognition at m 5 C site 3′UTR SLC7A11 G6PD mRNA, preserves their stability via ELAVL1. By employing Cas9/sgRNA delivery system AAV vivo, effectively knocked out inhibition tumor growth patient‐derived xenograft model are achieved. findings demonstrate derived from mediates repression ferroptosis, thereby driving progression identifying new therapeutic target for its treatment.

Language: Английский

Citations

4
LncRNA‐HHCP5 Regulates KLF5 in ceRNA and m6A Pathways to Inhibit the Progression of Osteoarthritis DOI
Peng Jiang, Yuxuan Song, Pengfei Li

et al.

International Journal of Rheumatic Diseases, Journal Year: 2025, Volume and Issue: 28(1)

Published: Jan. 1, 2025

ABSTRACT Background Osteoarthritis (OA) is one of the most common bone disorders and has a serious impact on quality life patients. LncRNA‐HCP5 (HCP5) downregulated in OA tissues. However, latent function regulatory mechanisms HCP5 are unclear. Methods In current study, IL‐1β‐induced C28/I2 cells were used to establish an vitro model OA. The expression cartilage tissue was detected by RT‐qPCR. Cell viability apoptosis assessed CCK‐8 Annexin V‐PI double staining. Western blotting employed detect protein MMP‐13 aggrecan. Results results showed that findings suggested cells. overexpression greatly enhanced proliferation cells, as well prevented cell degradation extracellular matrix (ECM). Besides, we have shown ceRNA regulates KLF5 sponging miR‐375. Furthermore, also regulated m6A regulation induced HCP5. Finally, miR‐375, modification inhibitor, inhibition reversed Conclusion summary, present study demonstrated HCP5/KLF5 axis inhibited progression osteoarthritis.

Language: Английский

Citations

0
Mechanistic insights into Jianpi Qinghua Sanyu Yin treatment of raised erosive gastritis: ceRNA-mediated PI3K/AKT signaling pathways DOI Creative Commons

Liya Liu,

Ying Cheng,

Guosheng Lin

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 3, 2025

Background Raised erosive gastritis (REG) is a chronic with high risk of malignant transformation. Current treatments often result in recurrence rates and complications. Jianpi Qinghua Sanyu Yin (JPQHSYY), traditional Chinese medicine, shows promise treating REG. However, the underlying molecular mechanisms remain unclear. This study aimed to investigate potential mechanism JPQHSYY’s therapeutic effects on Methods RNA-seq was employed systematically analyze mRNA, lncRNA, miRNA profiles gastric mucosal tissues from REG patients before after JPQHSYY treatment. The pivotal lncRNA-miRNA miRNA-mRNA networks were predicted sequencing data bioinformatic analysis, results exported using Cytoscape software. Gene Ontology (GO) analysis Kyoto Encyclopedia Genes Genomes (KEGG) analyses used for functional exploration. Real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) performed validate results. CCK8, cell cycle, apoptosis western blot detect miR-122-5p GES-1 cells vitro . Results revealed 576 differentially expressed lncRNAs (269 upregulated, 307 downregulated), 33 miRNAs (13 20 1717 mRNAs (777 940 downregulated) JPQHSYY-treated patients. GO KEGG highlighted key pathways, including PI3K/AKT signaling pathway, involved cycle regulation. ceRNA network suggested that impacts miRNA–lncRNA interactions. Validation experiments confirmed inhibits reducing viability, colony formation, promoting transfected cells. Conclusion efficacy might be mediated by ceRNA-driven pathway which implicated proliferation epithelial Furthermore, investigation could reveal more information new targets management

Language: Английский

Citations

0