ENO1 and Cancer

Molecular Therapy — Oncolytics, Journal Year: 2022, Volume and Issue: 24, P. 288 - 298

Published: Jan. 4, 2022

Language: Английский

Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids

Marine Drugs, Journal Year: 2021, Volume and Issue: 19(10), P. 531 - 531

Published: Sept. 23, 2021

Acute inflammation is a key component of the immune system's response to pathogens, toxic agents, or tissue injury, involving stimulation defense mechanisms aimed removing pathogenic factors and restoring homeostasis. However, uncontrolled acute inflammatory may lead chronic inflammation, which involved in development many diseases, including cancer. Nowadays, need find new potential therapeutic compounds has raised worldwide scientific interest study marine environment. Specifically, microalgae are considered rich sources bioactive molecules, such as carotenoids, natural isoprenoid pigments with important beneficial effects for health due their biological activities. Carotenoids essential nutrients mammals, but they unable synthesize them; instead, dietary intake these required. classified carotenes (hydrocarbon carotenoids), α- β-carotene, xanthophylls (oxygenate derivatives) zeaxanthin, astaxanthin, fucoxanthin, lutein, β-cryptoxanthin, canthaxanthin. This review summarizes present up-to-date knowledge anti-inflammatory anticancer activities microalgal carotenoids both vitro vivo, well latest status human studies use prevention treatment diseases

Language: Английский

Combination of Radix Astragali and Safflower Promotes Angiogenesis in Rats with Ischemic Stroke via Silencing PTGS2

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2126 - 2126

Published: Jan. 21, 2023

Promotion of angiogenesis and restoration the blood flow in ischemic penumbra is an effective treatment for patients with stroke (IS). Radix astragali-safflower (AS), a classic herbal pair accelerating circulation dispersing stasis, has been used thousands years to treat IS China. Even so, mechanism by AS still undecipherable. In current study, network pharmacology was firstly employed unveil treating IS, which showed that might promote associated PTGS2 silence. Middle cerebral artery occlusion/reperfusion (MCAO/R) model rats were then as experimental animals verify prediction result. The results revealed improved infarct volume, neurological damage, histopathological damage; inhibited cell apoptosis; increased contents PDGF-BB, EPO, TGF-β1; reduced levels PF4, Ang-2, TIMP-1 serum. Immunohistochemical staining demonstrated expression dramatically hippocampus cortex MCAO/R, this trend reversed AS. Immunofluorescent expressed down-regulation VEGF further promoted CD31, indicated MCAO/R rats. abnormal protein or mRNA PTGS2, PGI2, bFGF, TSP-1, transposed Celecoxib (an inhibitor PTGS2). conclusion, protective involved

Language: Английский

Clinical impact of epithelial–mesenchymal transition for cancer therapy

Clinical and Translational Discovery, Journal Year: 2024, Volume and Issue: 4(1)

Published: Jan. 28, 2024

Abstract The epithelial–mesenchymal transition (EMT) represents a pivotal frontier in oncology, playing central role the metastatic cascade of cancer—a leading global health challenge. This comprehensive review delves into complexities EMT, process where cancer cells gain exceptional mobility, facilitating their invasion distant organs and establishment secondary malignancies. We thoroughly examine myriad factors influencing encompassing transcription factors, signalling pathways, metabolic alterations, microRNAs, long non‐coding RNAs, epigenetic changes, exosomal interactions intricate dynamics tumour microenvironment. Particularly, emphasises advanced stages crucial for development highly aggressive phenotypes. During this phase, penetrate vascular barrier exploit bloodstream to propagate life‐threatening metastases through mesenchymal–epithelial transition. also explore EMT's significant fostering dormancy, senescence, emergence stem formidable challenge therapeutic resistance. Our transcends mere inventory EMT‐inducing elements; it critically assesses current state EMT‐focused clinical trials, revealing both hurdles breakthroughs. Highlighting potential EMT research, we project its transformative impact on future therapy. exploration is aimed at paving way towards an era effectively managing relentless disease, positioning forefront innovative research strategies.

Language: Английский

Golgi protein 73: the driver of inflammation in the immune and tumor microenvironment

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 8, 2025

Golgi Protein 73 (GP73) is a Golgi-resident protein that highly expressed in primary tumor tissues. Initially identified as an oncoprotein, GP73 has been shown to promote development, particularly by mediating the transport of proteins related epithelial-mesenchymal transition (EMT), thus facilitating cell EMT. Though our previous review summarized functional roles intracellular signal transduction and its various mechanisms promoting EMT, recent studies have revealed plays crucial role regulating immune microenvironment. can modulate signaling pathways influence cytokine chemokine networks, resulting inflammation caused viral bacterial infection or diseases, leading microenvironment deteriorated. Additionally, extracellular also regulate target cells binding their cell-surface receptors entering acceptor cells, thereby development. In this review, we aim summarize findings, providing insights for future investigations on potential therapeutic ameliorating chronic

Language: Английский

C-Reactive Protein Signaling Pathways in Tumor Progression

Biomolecules & Therapeutics, Journal Year: 2023, Volume and Issue: 31(5), P. 473 - 483

Published: Aug. 11, 2023

Many cancers arise from sites of chronic inflammation, which creates an inflammatory microenvironment surrounding the tumor.Inflammatory substances secreted by cells in environment can induce proliferation and survival cancer cells, thereby promoting metastasis angiogenesis.Therefore, it is important to identify role factors progression.This review summarizes signaling pathways roles C-reactive protein (CRP) various types, including breast, liver, renal, pancreatic cancer, tumor microenvironment.Mounting evidence suggests CRP breast especially triple-negative (TNBC) generally displays worse prognosis.Increased contributes enhanced invasiveness formation TNBC cells.CRP promotes endothelial cell angiogenesis initiation progression atherosclerosis.In kidney cancers, progression.In liver regulates responses lipid metabolism.CRP modulates activity molecules macrophages monocytes present microenvironment, contributing development, immune response, inflammation.In review, we overviewed association between inflammation types cancer.Identifying interactions other mediators crucial for understanding complex relationship cancer.

Language: Английский

The arachidonic acid metabolome reveals elevation of prostaglandin E2 biosynthesis in colorectal cancer

The Analyst, Journal Year: 2024, Volume and Issue: 149(6), P. 1907 - 1920

Published: Jan. 1, 2024

Arachidonic acid metabolites are a family of bioactive lipids derived from membrane phospholipids.

Language: Английский

Novel diagnostic biomarkers of oxidative stress, ferroptosis, immune infiltration characteristics and experimental validation in ischemic stroke

Aging, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 9, 2024

Ischemic stroke (IS) is a prominent type of cerebrovascular disease leading to death and disability in an aging society closely related oxidative stress. Gene expression profiling (GSE222551) was derived from Expression Omnibus (GEO), 1934 stress (OS) genes were obtained the GeneCards database. Subsequently, we identified 149 differentially expressed OS (DEOSGs). Finally, PTGS2, FOS, RYR1 as diagnostic markers IS. Moreover, GSE16561 used validate DEOSGs. Two (PTGS2 FOS) significantly highly expressed, while lowly IS group. Remarkably, immune infiltration characteristics these three analyzed, found that mainly correlated with Mast cells activated, Neutrophils, Plasma cells, respectively. Next, intersected DEOSGs ferroptosis gene set, findings revealed only PTGS2 ferroptosis. High levels infarcted cortex middle cerebral artery occlusion (MCAO) rats confirmed by immunofluorescence (IF), western blotting (WB), Immunohistochemistry (IHC). Inhibition clearly improved neurological outcome decreasing infarct volume, problems, modified severity scores following compared controls. The protective effect silencing may be anti-oxidative In conclusion, this work provide new perspective for research IS, further based on breakthrough.

Language: Английский

Boosting curcumin activity against human prostatic cancer PC3 cells by utilizing scorpion venom conjugated phytosomes as promising functionalized nanovesicles

Drug Delivery, Journal Year: 2022, Volume and Issue: 29(1), P. 807 - 820

Published: March 10, 2022

Prostate cancer (PC) is emerging as one of the leading causes mortality and morbidity worldwide. Curcumin (CUR) a well-known phytochemical, scorpion venom (SV) natural peptide with proven anticancer properties. However, these bioactive agents are limited by low solubility, bioavailability, poor thermal stability, short half-lives. Therefore, aim this study was to fabricate SV-conjugated CUR phytosomes promising functionalized nanovesicles assess their efficacy in human prostatic PC3 cells. CUR-Phytosome-SV fabricated using experimental design software which zeta potential particle sizes were used dependent variables. The effect formulation determined performing tetrazolium (MTT) assay, cell cycle analysis, annexin V staining, examining expression levels Bcl-associated X-protein (Bax), p53, caspase-3, B-cell lymphoma 2 (Bcl-2), nuclear factor kappa beta (NF-kB), tumor necrosis alpha (TNF-α). size nanoconjugates found be range 137.5 ± 7.9 298.4 11.9 nm, 2.9 0.1 26.9 1.2 mV. outcome MTT assay showed that curcumin-Phospholipon

Language: Английский

The Prostaglandin E2 Pathway and Breast Cancer Stem Cells: Evidence of Increased Signaling and Potential Targeting

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 11

Published: Jan. 19, 2022

Culprits of cancer development, metastasis, and drug resistance, stem cells (CSCs) are characterized by specific markers, active developmental signaling pathways, metabolic plasticity, increased motility, invasiveness, epithelial-mesenchymal transition. In breast cancer, these often more prominent in aggressive disease, amplified drug-resistant tumors, contribute to recurrence. For two distinct CSC populations exist typically defined CD44+/CD24- cell surface marker expression or aldehyde dehydrogenase (ALDH) activity. These share many the same properties but also exhibit pathways that ALDH+ populations. Understanding their shared may lead development novel therapeutic strategies will improve patient outcomes. Herein, we review current evidence assess published tumor datasets sorted for heightened prostaglandin E2 (PGE 2 ) activity PGE is a biologically lipid mediator promotes progression poor prognosis. Overall, data suggests important propagating CSCs enhancing inherent tumor-initiating capacities. Development anti-PGE therapeutics be beneficial inhibiting growth limiting

Language: Английский