Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategies DOI Creative Commons
Eun‐Ji Park, Chang‐Woo Lee

Experimental & Molecular Medicine, Journal Year: 2024, Volume and Issue: 56(1), P. 100 - 109

Published: Jan. 5, 2024

Abstract Soluble receptors are soluble forms of found in the extracellular space. They have emerged as pivotal regulators cellular signaling and disease pathogenesis. This review emphasizes their significance cancer diagnostic/prognostic markers potential therapeutic targets. We provide an overview mechanisms by which generated along with functions. By exploring involvement progression, metastasis, immune evasion, we highlight importance receptors, particularly cytokine checkpoints, tumor microenvironment. Although current research has illustrated emerging clinical relevance applications remain underexplored. As landscape treatment evolves, understanding targeting might pave way for novel strategies diagnosis, prognosis, therapy.

Language: Английский

The interplay between cytokines, inflammation, and antioxidants: mechanistic insights and therapeutic potentials of various antioxidants and anti-cytokine compounds DOI Creative Commons

Nitish Kumar Bhol,

Madhabi M. Bhanjadeo,

Anup K. Singh

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117177 - 117177

Published: July 24, 2024

Cytokines regulate immune responses essential for maintaining homeostasis, as deregulated cytokine signaling can lead to detrimental outcomes, including inflammatory disorders. The antioxidants emerge promising therapeutic agents because they mitigate oxidative stress and modulate pathways. Antioxidants potentially ameliorate inflammation-related disorders by counteracting excessive cytokine-mediated responses. A comprehensive understanding of pathways the interplay with is paramount developing natural targeting helping improve clinical outcomes enhance quality life patients. Among these antioxidants, curcumin, vitamin C, D, propolis, allicin, cinnamaldehyde have garnered attention their anti-inflammatory properties potential benefits. This review highlights interrelationship between cytokines-mediated in various diseases approaches involving antioxidants.

Language: Английский

Citations

74
Exploring the dynamic interplay between cancer stem cells and the tumor microenvironment: implications for novel therapeutic strategies DOI Creative Commons
Yan-Ruide Li,

Ying Fang,

Zibai Lyu

et al.

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Oct. 2, 2023

Cancer stem cells (CSCs) have emerged as key contributors to tumor initiation, growth, and metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby compromising the effectiveness of cancer treatments. The reciprocal communication between microenvironment (TME) is observed, with TME providing supportive niche for CSC survival self-renewal, while CSCs, turn, influence polarization persistence TME, promoting an immunosuppressive state. Consequently, these interactions hinder efficacy current therapies, necessitating exploration novel therapeutic approaches modulate target CSCs. this review, we highlight intricate strategies employed by evade surveillance develop resistance therapies. Furthermore, examine dynamic interplay shedding light on how interaction impacts progression. Moreover, provide overview advanced that specifically which hold promise future clinical translational studies treatment.

Language: Английский

Citations

65
Smart Nanozymes for Cancer Therapy: The Next Frontier in Oncology DOI Creative Commons

P. N. Navya,

Sunil Mehla,

Amrin Begum

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(25)

Published: July 1, 2023

Nanomaterials that mimic the catalytic activity of natural enzymes in complex biological environment human body are called nanozymes. Recently, nanozyme systems have been reported with diagnostic, imaging, and/or therapeutic capabilities. Smart nanozymes strategically exploit tumor microenvironment (TME) by situ generation reactive species or modulation TME itself to result effective cancer therapy. This topical review focuses on such smart for diagnosis, and therapy modalities enhanced effects. The dominant factors guide rational design synthesis include an understanding dynamic TME, structure-activity relationships, surface chemistry imparting selectivity, site-specific therapy, stimulus-responsive activity. article presents a comprehensive analysis subject including diverse mechanisms different types systems, overview synergistic therapies. strategic application treatment can well be game changer future oncology. Moreover, recent developments may pave way deployment into other healthcare challenges, as genetic diseases, immune disorders, ageing.

Language: Английский

Citations

46
The paradoxical role of cytokines and chemokines at the tumor microenvironment: a comprehensive review DOI Creative Commons
Toufik Abdul‐Rahman, Shankhaneel Ghosh, Sarah M. Badar

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Feb. 15, 2024

Abstract Tumor progression and eradication have long piqued the scientific community's interest. Recent discoveries about role of chemokines cytokines in these processes fueled renewed interest related research. These roles are frequently viewed as contentious due to their ability both suppress promote cancer progression. As a result, this review critically appraised existing literature discuss unique tumor microenvironment, well challenges future opportunities for exploiting develop novel targeted treatments. While modulatory molecules play an important suppression via enhanced cancer-cell identification by cytotoxic effector cells directly recruiting immunological stromal TME, we observed that they also proliferation. Many cytokines, including GM-CSF, IL-7, IL-12, IL-15, IL-18, IL-21, entered clinical trials people with advanced cancer, while FDA has approved interferon-alpha IL-2. Nonetheless, low efficacy dose-limiting toxicity limit agents' full potential. Conversely, Chemokines tremendous potential increasing immune-cell penetration microenvironment promoting beneficial interactions. When combined activate lymphocytes, producing IL-2, CD80, all which strong anticancer effect. This phenomenon opens door development effective combination therapies, such therapies can reverse escape, chemotaxis immunosuppressive like Tregs, MDSCs, TAMs.

Language: Английский

Citations

31
STIMULI-RESPONSIVE SUPRAMOLECULAR HYDROGELS FOR PACLITAXEL DELIVERY: PROGRESS AND PROSPECTS DOI Creative Commons

Mohammad Qutub,

Amol Tatode, Jayshree Taksande

et al.

Aspects of Molecular Medicine, Journal Year: 2025, Volume and Issue: 5, P. 100062 - 100062

Published: Jan. 5, 2025

Citations

5
The Role of Chronic Inflammation in Pediatric Cancer DOI Open Access

Christine Mella,

Panogiotis Tsarouhas,

Maximillian Brockwell

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(1), P. 154 - 154

Published: Jan. 6, 2025

Inflammation plays a crucial role in wound healing and the host immune response following pathogenic invasion. However, unresolved chronic inflammation can result tissue fibrosis genetic alterations that contribute to pathogenesis of human diseases such as cancer. Recent scientific advancements exploring underlying mechanisms malignant cellular transformations cancer progression have exposed significant disparities between pediatric adult-onset cancers. For instance, cancers tend lower mutational burdens arise actively developing tissues, where cell-cycle dysregulation leads gene, chromosomal, fusion gene development not seen counterparts. As such, findings adult cannot be directly applied cancers, unique mutations inherent etiologies remain poorly understood. Here, we review processes chromosomal instability, tumor microenvironment, tumorigenesis transformation explore current therapeutic interventions maintain and/or restore inflammatory homeostasis.

Language: Английский

Citations

2
Unveiling the Link Between Chronic Inflammation and Cancer DOI Creative Commons

Siddhant Tripathi,

Yashika Sharma, Dileep Kumar

et al.

Metabolism Open, Journal Year: 2025, Volume and Issue: 25, P. 100347 - 100347

Published: Jan. 9, 2025

The highly nuanced transition from an inflammatory process to tumorigenesis is of great scientific interest. While it well known that environmental stimuli can cause inflammation, less about the oncogenic modifications chronic inflammation in tissue microenvironment bring about, as how these set off pro-tumorigenic processes. It clear no matter where factors come from, maintaining encourages carcinogenesis. In addition encouraging angiogenesis and metastatic processes, sustaining survival proliferation malignant transformed cells, possibly altering efficacy therapeutic agents, negatively regulate antitumoral adaptive innate immune responses. Because has multiple pathways involved metastasis, gained recognition a marker cancer desirable target for therapy. Recent advances our knowledge molecular mechanisms drive cancer's progression demonstrate promotes metastasis while suppressing anti-tumor immunity. many solid tumor types, including breast, lung, liver cancer, stimulates activation oncogenes impairs body's defenses against tumor. Additionally, alters As tactical approach treatment, findings have underscored importance targeting pathways. This review highlights role development focusing on its impact progression, suppression, therapy resistance. examines current anti-inflammatory strategies, NSAIDs, cytokine modulators, STAT3 inhibitors, addressing their potential limitations. emphasizes need further research unravel complex linking identify targets specific subtypes.

Language: Английский

Citations

2
Inflammation, Fibrosis and Cancer: Mechanisms, Therapeutic Options and Challenges DOI Open Access
Bocheng Wu, Quaovi H. Sodji, Adegboyega K. Oyelere

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(3), P. 552 - 552

Published: Jan. 22, 2022

Uncontrolled inflammation is a salient factor in multiple chronic inflammatory diseases and cancers. In this review, we provided an in-depth analysis of the relationships distinctions between uncontrolled inflammation, fibrosis cancers, while emphasizing challenges opportunities developing novel therapies for treatment and/or management these diseases. We described how drug delivery systems, combination therapy integration tissue-targeted pathways selective strategies could overcome current agents managing treating also recognized value re-evaluation disease-specific roles implicated pathophysiology cancers—as well as application data from single-cell RNA sequencing success future discovery endeavors.

Language: Английский

Citations

61
Interplay between stress and cancer—A focus on inflammation DOI Creative Commons
Sanja Vignjević, Maja Milošević, Dragana Marković

et al.

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: March 20, 2023

Stress is an integral part of life. While acute responses to stress are generally regarded as beneficial in dealing with immediate threats, chronic exposure threatening stimuli exerts deleterious effects and can be either a contributing or aggravating factor for many diseases including cancer. Chronic psychological has been identified significant the development progression cancer, but mechanisms that link cancer remain incompletely understood. Psychological stressors initiate multiple physiological result activation hypothalamic-pituitary-adrenal (HPA) axis, sympathetic nervous system, subsequent changes immune function. disrupts homeostatic communication between neuroendocrine systems, shifting signaling toward proinflammatory state. Stress-induced low-grade inflammation decline surveillance both implicated progression. Conversely, tumor-induced inflammatory cytokines, apart from driving tumor-supportive microenvironment, also exert their biological actions distantly via circulation therefore adversely affect response. In this minireview, we summarize current findings on relationship focusing role stress-induced neuroendocrine-immune crosstalk. We discuss underlying potential treatment prevention.

Language: Английский

Citations

30
Nano formulated Resveratrol inhibits PD-L1 in oral cancer cells by deregulating the association between tumor associated macrophages and cancer associated fibroblasts through IL-6/JAK2/STAT3 signaling axis DOI
Rajalaxmi Pradhan, Subarno Paul, S. Acharya

et al.

The Journal of Nutritional Biochemistry, Journal Year: 2024, Volume and Issue: 125, P. 109568 - 109568

Published: Jan. 6, 2024

Language: Английский

Citations

15