Therapeutic Delivery,
Journal Year:
2024,
Volume and Issue:
15(2), P. 135 - 155
Published: Jan. 12, 2024
Bioactive
compounds
derived
from
plants
have
been
investigated
for
treating
various
pathological
conditions.
However,
the
utilization
of
these
has
challenges
such
as
instability,
low
solubility
and
bioavailability.
To
overcome
challenges,
encapsulation
bioactive
molecules
with
in
a
novel
nano
carrier
system
enabling
effective
delivery
clinical
translation
become
essential.
Lipid-based
nanocarriers
provide
versatile
platforms
encapsulating
delivering
challenges.
These
carriers
can
improve
solubility,
stability,
improved
drug
retention
therapeutic
efficacy
plant
compounds.
The
current
review
evaluates
bioactives
highlights
potential
lipid-based
designed
to
its
efficacy.
Drug Delivery,
Journal Year:
2022,
Volume and Issue:
29(1), P. 2130 - 2161
Published: July 10, 2022
Chemotherapy
drugs
have
been
used
for
a
long
time
in
the
treatment
of
cancer,
but
serious
side
effects
are
caused
by
inability
drug
to
be
solely
delivered
tumor
when
treating
cancer
with
chemotherapy.
Natural
products
attracted
more
and
attention
due
antitumor
effect
multiple
ways,
abundant
resources
less
effects.
Therefore,
combination
natural
active
ingredients
chemotherapy
may
an
effective
strategy,
which
can
inhibit
growth
multidrug
resistance,
reduce
drugs.
Nano-drug
co-delivery
system
(NDCDS)
play
important
role
This
review
provides
comprehensive
summary
research
status
application
prospect
nano-delivery
strategies
drugs,
aiming
provide
basis
development
anti-tumor
Vaccines,
Journal Year:
2022,
Volume and Issue:
10(11), P. 1946 - 1946
Published: Nov. 17, 2022
Vaccination
is
still
the
most
cost-effective
way
to
combat
infectious
illnesses.
Conventional
vaccinations
may
have
low
immunogenicity
and,
in
situations,
only
provide
partial
protection.
A
new
class
of
nanoparticle-based
has
shown
considerable
promise
addressing
majority
shortcomings
traditional
and
subunit
vaccines.
This
due
recent
breakthroughs
chemical
biological
engineering,
which
allow
for
exact
regulation
nanoparticle
size,
shape,
functionality,
surface
characteristics,
resulting
improved
antigen
presentation
robust
immunogenicity.
blend
physicochemical,
immunological,
toxicological
experiments
can
be
used
accurately
characterize
nanovaccines.
narrative
review
will
an
overview
current
scenario
nanovaccine.
Drug Delivery and Translational Research,
Journal Year:
2024,
Volume and Issue:
14(10), P. 2845 - 2916
Published: July 13, 2024
Abstract
Several
efforts
have
been
extensively
accomplished
for
the
amelioration
of
cancer
treatments
using
different
types
new
drugs
and
less
invasives
therapies
in
comparison
with
traditional
therapeutic
modalities,
which
are
widely
associated
numerous
drawbacks,
such
as
drug
resistance,
non-selectivity
high
costs,
restraining
their
clinical
response.
The
application
natural
compounds
prevention
treatment
cells
has
attracted
significant
attention
from
pharmaceuticals
scientific
communities
over
past
decades.
Although
use
nanotechnology
therapy
is
still
preliminary
stages,
nanotherapeutics
demonstrated
to
decrease
various
limitations
related
compounds,
physical/chemical
instability,
poor
aqueous
solubility,
low
bioavailability.
Despite
emerged
a
promise
improve
bioavailability
there
limited
trials
performed
challenges
required
pre-clinical
trials,
production
at
an
industrial
level,
assurance
long-term
stability,
physiological
barriers
safety
regulatory
issues.
This
review
highlights
most
recent
advances
nanocarriers
secreted
plants,
bacteria,
fungi,
marine
organisms,
well
role
on
cell
signaling
pathways
anticancer
treatments.
Additionally,
status
main
regarding
loaded
applications
were
also
discussed.
Graphical
abstract
Molecules,
Journal Year:
2022,
Volume and Issue:
27(21), P. 7232 - 7232
Published: Oct. 25, 2022
Cancer
remains
the
leading
cause
of
death
worldwide
despite
advances
in
treatment
options
for
patients.
As
such,
safe
and
effective
therapeutics
are
required.
Short
peptides
provide
advantages
to
be
used
cancer
management
due
their
unique
properties,
amazing
versatility,
progress
biotechnology
overcome
peptide
limitations.
Several
appealing
peptide-based
therapeutic
strategies
have
been
developed.
Here,
we
an
overview
conjugates,
better
equivalents
antibody-drug
as
next
generation
drugs
required
precise
targeting,
enhanced
cellular
permeability,
improved
drug
selectivity,
reduced
toxicity
efficient
cancers.
We
discuss
basic
components
conjugates
release
action,
including
cytotoxins
from
linker.
also
present
peptide-drug
under
different
stages
clinical
development
well
regulatory
other
challenges.
Critical Reviews in Food Science and Nutrition,
Journal Year:
2022,
Volume and Issue:
64(2), P. 381 - 406
Published: Aug. 8, 2022
Bioactive
compounds
represent
a
broad
class
of
dietary
metabolites
derived
from
fruits
and
vegetables,
such
as
polyphenols,
carotenoids
glucosinolates
with
potential
for
cancer
prevention.
Curcumin,
resveratrol,
quercetin,
β-carotene
have
been
the
most
widely
applied
bioactive
in
chemoprevention.
Lately,
many
approaches
to
encapsulating
components
nano-delivery
systems
improved
biomolecules'
stability
targeted
delivery.
In
this
review,
we
critically
analyze
compounds,
including
polymeric
nanoparticles
(NPs),
solid
lipid
(SLN),
nanostructured
carriers
(NLC),
liposomes,
niosomes,
nanoemulsions
(NEs)
use
therapy.
Efficacy
studies
nanoformulations
using
cell
lines
vivo
models
updated
human
clinical
trials
are
also
discussed.
Nano-delivery
were
found
improve
therapeutic
efficacy
molecules
against
various
types
(e.g.,
breast,
prostate,
colorectal
lung
cancer)
mainly
due
antiproliferation
pro-apoptotic
effects
tumor
cells.
Furthermore,
some
promised
combination
therapy
standard
chemotherapeutic
agents,
increased
efficiency
fewer
side
effects.
These
opportunities
identified
developed
ensure
more
excellent
safety
novel
herbal
medicines
enabling
insights
designing
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(14), P. 3136 - 3136
Published: July 13, 2023
Polyphenols
derived
from
fruits,
vegetables,
and
plants
are
bioactive
compounds
potentially
beneficial
to
human
health.
Notably,
such
as
quercetin,
curcumin,
epigallocatechin-3-gallate
(EGCG),
resveratrol
have
been
highlighted
antiproliferative
agents
for
cancer.
Due
their
low
solubility
limited
bioavailability,
some
alternative
nanotechnologies
applied
encapsulate
these
compounds,
aiming
improve
efficacy
against
In
this
comprehensive
review,
we
evaluate
the
main
nanotechnology
approaches
therapeutic
potential
of
polyphenols
cancer
using
in
vitro
studies
vivo
preclinical
models,
highlighting
recent
advancements
field.
It
was
found
that
polymeric
nanomaterials,
lipid-based
inorganic
carbon-based
nanomaterials
most
used
classes
nanocarriers
encapsulating
polyphenols.
These
delivery
systems
exhibit
enhanced
antitumor
activity
pro-apoptotic
effects,
particularly
breast,
lung,
prostate,
cervical,
colorectal
cells,
surpassing
performance
free
compounds.
Preclinical
trials
xenograft
animal
models
revealed
decreased
tumor
growth
after
treatment
with
polyphenol-loaded
systems.
Moreover,
interaction
polyphenol
co-delivery
polyphenol–drug
is
a
promising
approach
increase
anticancer
decrease
chemotherapy
side
effects.
innovative
hold
significant
implications
advancement
clinical
research.
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: March 31, 2023
Mantle
cell
lymphoma
(MCL)
is
a
subtype
of
Non-Hodgkin
(NHL)
mature
B-cells
characterized
by
translocation,
which
typically
due
to
excess
expression
Cyclin
D1.
Although
with
the
progress
in
our
knowledge
causes
for
MCL
and
available
treatments
MCL,
this
cancer
still
incurable.
Age,
male
gender,
rapid
advancement,
significant
nodal
involvement,
elevated
serum
lactate
dehydrogenase
level,
prognostic
indications
including
increased
Ki-67
presence
TP53
mutation,
are
symbols
poor
outcome.
Advanced
immunotherapy
using
chimeric
antigen
receptor
(CAR)-T
cells
advantageous
patients
suffering
from
B-cell
malignancies
MCL.
Targeting
antigens
on
surface
feasible
approach
re-occurring
(R/R)
because
responses
obtained
other
cancers.
USFDA
has
approved
brexucabtagene
autoleucel
(Tecartus,
KTE-X19),
novel
CAR
T-cell
therapy
be
used
who
have
not
responded
previous
or
relapsed.
The
FDA
new
treatment
depending
outcomes
ZUMA-2
clinical
trial.
Serious
adverse
reactions,
moderate
anti-tumor
activity,
allergen
withdrawal,
escape,
limited
tumor
infiltration,
trafficking
major
barriers
successful
therapy.
This
review
brief
synopsis
development
Journal of Drug Delivery Science and Technology,
Journal Year:
2023,
Volume and Issue:
85, P. 104579 - 104579
Published: May 18, 2023
Exosomes
are
multivesicular
bodies
of
which
the
plasma
membrane
fuse
to
release
caring
moiety
into
surrounding
body
fluids.
They
best
known
for
their
function
in
mediating
intercellular
connectivity
by
transferring
various
biomolecules,
such
as
proteins,
RNAs,
and
lipids,
from
one
cell
another.
These
"naturally
equipped"
nanovesicles
could
be
therapeutically
targeted
or
engineered
drug
delivery
systems.
The
use
exosomes
cancer
detection
prognosis
has
attracted
a
great
deal
interest
academics.
In
addition
chemical,
biological,
genetic
engineering
approaches,
other
current
exosomal
alteration
methodologies
hold
promise
advancement
therapeutic
medicines
cancer.
this
review,
we
highlight
theranostic
potential
cancers.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(20), P. 14017 - 14040
Published: Jan. 1, 2024
Nanotechnology
revolutionizes
breast
cancer
treatment
by
improving
drug
delivery,
overcoming
barriers,
and
reducing
side
effects.
This
review
highlights
its
potential
superiority
over
conventional
methods,
transforming
management.
