Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: June 10, 2024
Language: Английский
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(2), P. 234 - 234
Published: Feb. 3, 2023
Inducing cancer cell death has always been a research hotspot in life sciences. With the continuous deepening and diversification of related research, potential value metal elements inducing explored. Taking iron as an example, ferroptosis, mainly characterized by increasing load driving production large amounts lipid peroxides eventually leading to death, recently attracted great interest community. After iron, copper, trace element, received extensive attention especially tumor death. Copper its complexes can induce autophagy or apoptosis cells through variety different mechanisms action (activation stress pathways, arrest cycle, inhibition angiogenesis, cuproptosis, paraptosis), which are promising therapy have become new hotspots treatment research. This article reviews main applications novel copper compound-induced focusing on compounds their anticancer applications.
Language: Английский
Citations
85
Redox Biology, Journal Year: 2023, Volume and Issue: 59, P. 102601 - 102601
Published: Jan. 7, 2023
Hydrogen sulfide (H2S) is an important signaling molecule in colorectal cancer (CRC). It produced the colon by catalytic synthesis of colonocytes' enzymatic systems and release intestinal microbes, oxidatively metabolized mitochondria. Both endogenous H2S colonic epithelial cells exogenous lumen contribute to onset progression CRC. The up-regulation synthetases thought be cause elevated levels CRC cells. Different diagnostic probes combination therapies, as well tumor treatment approaches through modulation, have been developed recent years become active area investigation for diagnosis In this review, we focus on specific mechanisms production oxidative metabolism function occurrence, progression, diagnosis, We also discuss present challenges provide insights into future research burgeoning field.
Language: Английский
Citations
64
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 541 - 569
Published: Jan. 1, 2024
Natural products have proven to significant curative effects and are increasingly considered as potential candidates for clinical prevention, diagnosis, treatment. Compared with synthetic drugs, natural not only diverse structures but also exhibit a range of biological activities against different disease states molecular targets, making them attractive development in the field medicine. Despite advancements use purposes, there remain obstacles that hinder their full potential. These challenges include issues such limited solubility stability when administered orally, well short durations effectiveness. To address these concerns, nano-drug delivery systems emerged promising solution overcome barriers faced application products. offer notable advantages, large specific surface area, enhanced targeting capabilities, ability achieve sustained controlled release. Extensive vitro vivo studies provided further evidence supporting efficacy safety nanoparticle-based delivering preclinical models. This review describes limitations product applications current status combined nanotechnology. The latest advances from three aspects: connecting warheads, self-assembly, co-delivery. Finally, translation nano-drugs discussed.
Language: Английский
Citations
45
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 234, P. 113743 - 113743
Published: Jan. 5, 2024
Language: Английский
Citations
21
International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 4275 - 4311
Published: July 1, 2023
Abstract: Breast cancer (BC) is the most prevalent type of in world and main reason women die from cancer. Due to significant side effects conventional treatments such as chemotherapy radiotherapy, search for supplemental alternative natural drugs with lower toxicity interest researchers. Curcumin (CUR) a polyphenol extracted turmeric. Numerous studies have demonstrated that CUR an effective anticancer drug works by modifying different intracellular signaling pathways. CUR's therapeutic utility severely constrained its short half-life vivo, low water solubility, poor stability, quick metabolism, oral bioavailability, potential gastrointestinal discomfort high doses. One practical solutions aforementioned issues development targeted delivery systems (TDDSs) based on nanomaterials. To improve targeting efficacy serve reference use TDDSs clinical setting, this review describes physicochemical properties bioavailability mechanism action BC, emphasis recent BC combination CUR, including passive TDDSs, active TDDSs. Keywords: breast cancer, curcumin, system, targeting,
Language: Английский
Citations
40
Nanomaterials, Journal Year: 2022, Volume and Issue: 12(19), P. 3323 - 3323
Published: Sept. 24, 2022
In recent years, gene therapy has made remarkable achievements in tumor treatment. a successfully cancer therapy, smart delivery system is necessary for both protecting the therapeutic genes circulation and enabling high expression sites. Magnetic iron oxide nanoparticles (IONPs) have demonstrated their bright promise highly efficient target to tissues, partly due good biocompatibility, magnetic responsiveness, extensive functional surface modification. this review, latest progress targeting introduced, unique properties of IONPs contributing are summarized with detailed examples. Furthermore, diagnosis potentials synergistic treatment capacity highlighted. addition, aiming at potential risks during process, several strategies improve efficiency or reduce using introduced addressed. The applications review provide general understanding therapy.
Language: Английский
Citations
39
Phytotherapy Research, Journal Year: 2023, Volume and Issue: 38(2), P. 880 - 911
Published: Dec. 13, 2023
Abstract Current pharmaceutical research is energetically excavating the pharmacotherapeutic role of herb‐derived ingredients in multiple malignancies’ targeting. Luteolin one major phytochemical components that exist various traditional Chinese medicine or medical herbs. Mounting evidence reveals this phytoconstituent endows prominent therapeutic actions on diverse malignancies, with underlying mechanisms, combined medication strategy, and pharmacokinetics elusive. Additionally, clinical trial investigation luteolin remain to be systematically delineated. The present review aimed comprehensively summarize updated information regard anticancer mechanism, strategies, pharmacokinetics, trials, researches luteolin. survey corroborates executes effects mainly by dampening proliferation invasion, spurring apoptosis, intercepting cell cycle, regulating autophagy immune, inhibiting inflammatory response, inducing ferroptosis, pyroptosis, as well epigenetic modification, so on. can applied combination numerous anticarcinogens natural synergistically enhance efficacy malignancies while reducing adverse reactions. For has an unfavorable oral bioavailability, it persists plasma glucuronides sulfate‐conjugates after being metabolized, regarded potent inhibitors OATP1B1 OATP2B1, which may messed pharmacokinetic interactions miscellaneous bioactive substances vivo. Besides, innovation leading‐edge drug delivery systems such host–guest complexes, nanoparticles, liposomes, nanoemulsion, microspheres, hydrogels are beneficial exploitation luteolin‐based products. Moreover, some registered trials carried out, yet should continuously promoted.
Language: Английский
Citations
25
Materials Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 7(17), P. 3668 - 3679
Published: Jan. 1, 2023
Schematic illustration of the amphiphilic BODIPY-based photosensitizers for multimodal imaging-guided phototherapy through J -aggregation.
Language: Английский
Citations
24
Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(7), P. 1662 - 1692
Published: Jan. 1, 2024
In this review, we have summarized the common self-assembled mechanism of NSMs-based SANDDSs. Meanwhile, potential applications for cancer treatment and future development prospects are also prospected.
Language: Английский
Citations
15
Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107150 - 107150
Published: March 21, 2024
Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global morbidity, disability, mortality, highlighting the necessity for transformative treatment approaches. Photodynamic therapy (PDT) has aroused continuous interest as viable alternative conventional cancer treatments that encounter drug resistance. Nanotechnology brought new advances in medicine shown great potential delivery treatment. For precise efficient therapeutic utilization of such tumor approach high spatiotemporal selectivity minimal invasiveness, carrier-free noncovalent nanoparticles (NPs) based on chemo-photodynamic combination essential. Utilizing natural products foundation nanodrug development offers unparalleled advantages, including exceptional pharmacological activity, easy functionalization/modification, well biocompatibility. The natural-product-based, carrier-free, NPs revealed excellent synergistic anticancer activity comparison free photosensitizers bioactive products, representing an favorable avenue improve efficacy. Herein, comprehensive summary current strategies representative application examples past decade (such paclitaxel, 10-hydroxycamptothecin, doxorubicin, etoposide, combretastatin A4, epigallocatechin gallate, curcumin) therapy. We highlight insightful design synthesis smart aim enhance PDT Meanwhile, we discuss future challenges opportunities associated these provide enlightenment, spur innovative ideas, facilitate PDT-mediated clinical transformation.
Language: Английский
Citations
15