Asian Journal of Surgery, Journal Year: 2023, Volume and Issue: 47(2), P. 1143 - 1145
Published: Nov. 29, 2023
Language: Английский
Redox Biology, Journal Year: 2024, Volume and Issue: 73, P. 103208 - 103208
Published: May 24, 2024
Recently, numerous studies have reported the interaction between senescence and oxidative stress in cancer. However, there is a lack of comprehensive understanding precise mechanisms involved.
Language: Английский
Citations
23
Cancer Medicine, Journal Year: 2024, Volume and Issue: 13(11)
Published: May 31, 2024
Abstract Background En‐Bloc transurethral resection of bladder tumor (ERBT) was clinically used to resect non‐muscle‐invasive cancer (NMIBC). However, discrepancies persist regarding the comparisons between ERBT and conventional (cTURBT). Methods We conducted a comprehensive search in PubMed, Embase, Web Science, Cochrane Database Systematic Reviews, performed manual searches reference lists collect extract data. Data evaluation carried out using Review Manager 5.4.0, Rx64 4.1.3, relevant packages. Results There were nine eligible meta‐analyses RCTs our study. NMIBC patients undergoing significant associated with lower rate perforation obturator nerve reflex compared those receiving cTURBT. Our pooled result indicated that cTURBT required similar operation time. Regarding postoperative outcomes, demonstrated superior performance terms detrusor muscle presence, catheterization time, residual tumor. exhibited higher three‐month recurrence‐free survival (RFS) ( p < 0.05; I 2 = 0%). In bipolar subgroup, had better 12‐month RFS than Simultaneously, exclusion Hybrid Knife data revealed improvement 50%). Conclusion Using combination umbrella review meta‐analysis, we or comparable perioperative outcome improved 3 12 month suggest maybe surgical method for
Language: Английский
Citations
11
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: Aug. 19, 2024
Drug resistance remains a significant challenge in cancer treatment. Recently, the interactions among various cell types within tumor microenvironment (TME) have deepened our understanding of mechanisms behind treatment resistance. Therefore, this review aims to synthesize current research focusing on infiltrating cells and drug suggesting that targeting TME could be viable strategy combat issue. Numerous factors, including inflammation, metabolism, senescence, hypoxia, angiogenesis, contribute Overexpression STAT3 is commonly associated with drug-resistant or stromal cells. Current often generalizes impact resistance, lacking specificity statistical robustness. Thus, future should take notice issue aim provide high-quality evidence. Despite existing limitations, overcome therapy hold promising valuable potential.
Language: Английский
Citations
9
Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0
Published: Jan. 1, 2024
Numerous research works have emphasized the critical role that circadian rhythm plays in tumor microenvironment (TME). The goal of clarifying chrono-pharmacological strategies for improving cancer treatment clinical settings is a continuous endeavor. Consequently, to enhance use time-based pharmaceutical therapies oncology, combining existing knowledge on rhythms' roles within TME essential. This perspective elucidates functions rhythms across various stages development, progression, and metastasis. Specifically, aging, angiogenesis, inflammation are implicated modulating TME. Furthermore, exerts profound influence current treatments thereby generates chronotheray manage tumors. From perspective, offers promising opportunities prevention treatment; nevertheless, further study needed address unanswered scientific problems.
Language: Английский
Citations
8
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12311 - 12311
Published: Aug. 1, 2023
The tumor microenvironment (TME) is complex and involves many different cell types that seemingly work together in helping cancer cells evade immune monitoring survive therapy. advent of single-cell sequencing has greatly increased our knowledge the present their role developing cancer. This, coupled with clinical data showing development response to therapy may be influenced by drugs indirectly influence environment, highlights need better understand how TME together. This review looks at (cancer cells, stem endothelial pericytes, adipose cancer-associated fibroblasts, neuronal cells) bladder microenvironment. Their impact on activation shaping are discussed as well effects hypertensive anesthetics
Language: Английский
Citations
11
Therapeutic Advances in Medical Oncology, Journal Year: 2024, Volume and Issue: 16
Published: Jan. 1, 2024
Bladder preservation (BP) has emerged as a clinical alternative to radical cystectomy (RC) for alleviating the substantial physical and psychological burden imposed on localized bladder cancer patients. Nevertheless, disparities persist in comparative evaluations of BP RC. We aimed address between An umbrella review meta-analysis were conducted explore these disparities. extracted data from meta-analyses randomized controlled trials (RCTs) selected after searching PubMed, Embase, Web Science, Cochrane Database Systematic Reviews. Review Manager 5.4.0 R x64 4.1.3 used evaluate collected data. Our study included 11 3 RCTs. In terms progression-free survival, all reported that patients with who underwent exhibited outcomes comparable those Meta-analyses regarding cancer-specific survival (CSS) overall (OS) are controversial. To solve issues, we pooled analysis CSS data, which supported similarity RC no significant heterogeneity [odds ratio (OR): 1.2; 95% confidence interval (CI): 0.71–2.02; I 2 = 26%]. Similarly, OS results three RCTs indicated comparability (OR: 1.12; CI: 0.41–3.07; 33%). A combination suggested had rates suggest may be more eligible therapy than muscle-invasive cancer. This conclusion warrants further validation through trials.
Language: Английский
Citations
4
Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104705 - 104705
Published: March 1, 2025
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: March 30, 2025
Despite remarkable advancements in therapeutic strategies, a considerable proportion of patients with bladder cancer (BC) still experience disease progression and unfavorable prognosis. The heterogeneity biological functions tumor endothelial cells (ECs) during BC remain poorly understood. We collected scRNA-seq data from samples identified two EC subpopulations through hierarchical clustering analysis. activity signaling pathways distinct was assessed utilizing AUCell Gene regulatory networks (GRN) were constructed analyzed for different using the pySCENIC algorithm. Additionally, we investigated association between abundance both clinical prognosis immune cell infiltration. effects ESM1 protein on further validated EdU Transwell assays. 7,519 CD45-negative single tissues discerned subpopulations. characterized by high expression (S1 ECs) CXCL2 (S2 ECs), respectively. In S1 ECs, observed significant activation involved promotion, including angiogenesis proliferation. our GRN analysis uncovered notable differences transcription factor S2 ECs. Moreover, promoted proliferation migration cells. Patients higher subpopulation exhibited more outcomes increased infiltration inhibitory Our findings elucidate transcriptional profiles roles ESM1-expression BC. This is associated poor immunosuppressive microenvironment. Accordingly, targeting may offer novel strategy
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)
Published: Sept. 8, 2023
Adhesion-regulating molecule 1 (ADRM1) has been implicated in tumor development, yet its specific role bladder cancer (BC) remains undefined. This study aimed to elucidate the function of ADRM1 BC through a combination bioinformatics analysis and immunohistochemical (IHC). Utilizing R version 3.6.3 relevant packages, we analyzed online database data. Validation was conducted IHC data, approved by Institutional Ethics Committee (Approval No. K20220830). In both paired unpaired comparisons, expression significantly elevated tissues compared adjacent tissues, as evidenced results TCGA dataset Patients with high had statistically worse overall survival than those low dataset, GSE32548 GSE32894 Functional unveiled enrichment immune-related pathways, robust positive correlation emerged between pivotal immune checkpoints, including CD274, PDCD1, PDCD1LG2. microenvironment, samples contained statistical higher proportion CD8 + T cells Macrophage infiltration. Meanwhile, these ADRM1-expressing displayed mutation burden scores stemness indices, implying potential benefits from immunotherapy. were sensitive cisplatin, docetaxel, vinblastine, mitomycin C, methotrexate. According findings analyses, demonstrates prognostic significance for patients holds predictive immunotherapy chemotherapy responses. underscores biomarker therapeutic target BC.
Language: Английский
Citations
10
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: May 12, 2024
Abstract Background A greater emphasis has been placed on the part of cell cycle progression (CCP) in cancer recent years. Nevertheless, precise connection between CCP-related genes and bladder (BCa) remained elusive. This study endeavors to establish validate a reliable risk model incorporating factors, aiming predict both prognosis immune landscape BCa. Methods Clinical information RNA sequencing data were collected from GEO TCGA databases. Univariate multivariate Cox regression analyses conducted construct associated with CCP. The performance was assessed using ROC Kaplan–Meier survival analyses. Functional enrichment analysis employed investigate potential cellular functions signaling pathways. characterized CIBERSORT algorithms. Integration various clinical variables led development nomogram. Results To build model, three (RAD54B, KPNA2, TPM1) carefully chosen. confirm that our good performance. About immunological infiltration, high-risk group showed decreased levels regulatory T cells dendritic coupled increased activated CD4 + memory cells, M2 macrophages, neutrophils. Furthermore, nomogram impressive predictive power for OS at 1, 3, 5 Conclusion provides new insights into association BCa, as well its impact landscape.
Language: Английский
Citations
3