Drug Development Research,
Journal Year:
2024,
Volume and Issue:
85(8)
Published: Dec. 1, 2024
ABSTRACT
The
development
of
anticancer
drugs
that
target
different
organelles
has
received
extensive
attention
due
to
the
characteristics
cancer
recurrence,
metastasis,
and
drug
resistance.
endoplasmic
reticulum
(ER)
is
an
important
structure
within
cell
primarily
responsible
for
protein
synthesis,
folding,
modification,
transport
plays
a
crucial
role
in
function
health.
ER
stress
activation
induces
apoptosis.
New
with
mechanisms
selectivity
can
be
designed
because
redox
activity,
composition
diversity,
metal
complexes
regulation.
Over
past
few
decades,
dozens
have
killed
cells
through
stress,
showing
powerful
tumor‐suppressive
effects.
This
review
summarizes
progress
research
on
metallic
induce
over
years,
which
expected
bring
more
breakthroughs
field
medicine
life
science.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Feb. 12, 2024
Abstract
Cancer
treatment
faces
many
hurdles
and
resistance
is
one
among
them.
Anti-cancer
strategies
are
evolving
due
to
innate
acquired
capacity,
governed
by
genetic,
epigenetic,
proteomic,
metabolic,
or
microenvironmental
cues
that
ultimately
enable
selected
cancer
cells
survive
progress
under
unfavorable
conditions.
Although
the
mechanism
of
drug
being
widely
studied
generate
new
target-based
drugs
with
better
potency
than
existing
ones.
However,
broader
flexibility
in
resistance,
advanced
therapeutic
options
efficacy
need
be
explored.
Combination
therapy
an
alternative
a
success
rate
though
risk
amplified
side
effects
commonplace.
Moreover,
recent
groundbreaking
precision
immune
ways
overcome
has
revolutionized
anticancer
greater
extent
only
limitation
individual-specific
needs
further
attention.
This
review
will
focus
on
challenges
opted
withstand
current
therapies
at
molecular
level
also
highlights
emerging
-like
immunological,
stem
cell-based
may
prove
have
potential
challenge
problem
resistance.
Journal of drug targeting,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 18
Published: Jan. 30, 2025
Endoplasmic
Reticulum
(ER)
stress
is
intricately
involved
in
cancer
development,
progression
and
response
to
chemotherapy.
ER
related
genes
might
play
an
important
role
predicting
the
prognosis
lung
adenocarcinoma
patients
may
be
manipulated
improve
treatment
outcome
overall
survival
rate.
In
this
review,
we
analyzed
contribution
of
three
major
pathways-IRE1,
ATF6,
PERK-in
pathogenesis
via
modulation
tumor
microenvironment
(TME)
processes
as
metastasis,
angiogenesis,
apoptosis
N-glycosylation.
Furthermore,
discuss
regulatory
microRNAs
fine-tuning
pathways
Non-Small
Cell
Lung
Cancer
(NSCLC).
Our
review
also
highlights
various
promising
strategies
overcome
chemoresistance
by
targeting
pathways,
offering
new
therapeutic
opportunities.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Sept. 4, 2023
Neoadjuvant
and
adjuvant
therapies
have
made
significant
progress
in
cancer
treatment.
However,
tumor
therapy
still
faces
challenges
due
to
the
intrinsic
heterogeneity
of
cancer,
genomic
instability,
formation
an
immunosuppressive
microenvironment.
Functional
materials
possess
unique
biological
properties
such
as
long
circulation
times,
tumor-specific
targeting,
immunomodulation.
The
combination
functional
with
natural
substances
nanotechnology
has
led
development
smart
biomaterials
multiple
functions,
high
biocompatibilities,
negligible
immunogenicities,
which
can
be
used
for
precise
Recently,
subcellular
structure-targeting
received
particular
attention
various
biomedical
applications
including
diagnosis,
sensing,
imaging
tumors
drug
delivery.
Subcellular
organelle-targeting
precisely
accumulate
therapeutic
agents
organelles,
considerably
reduce
threshold
dosages
agents,
minimize
drug-related
side
effects.
This
review
provides
a
systematic
comprehensive
overview
research
organelle-targeted
based
on
nanomaterials.
Moreover,
it
explains
prospects
precision
oncology.
will
serve
excellent
cutting-edge
guide
researchers
field
therapy.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2768 - 2768
Published: Feb. 27, 2024
Ubiquitin-specific
protease
7
inhibitors
(USP7i)
are
considered
a
novel
class
of
anticancer
drugs.
Cancer
cells
occasionally
become
insensitive
to
drugs,
known
as
chemoresistance,
by
acquiring
multidrug
resistance,
resulting
in
poor
clinical
outcomes
patients
with
cancer.
However,
the
chemoresistance
cancer
USP7i
(P22077
and
P5091)
mechanisms
overcome
it
have
not
yet
been
investigated.
In
present
study,
we
generated
human
acquired
resistance
USP7i-induced
cell
death.
Gene
expression
profiling
showed
that
heat
stress
response
(HSR)-
unfolded
protein
(UPR)-related
genes
were
largely
upregulated
USP7i-resistant
cells.
Biochemical
studies
induced
phosphorylation
activation
shock
transcription
factor
1
(HSF1),
mediated
endoplasmic
reticulum
(ER)
kinase
R-like
ER
(PERK)
signaling
pathway.
Inhibition
HSF1
PERK
significantly
sensitized
cytotoxicity.
Our
study
demonstrated
stress–PERK
axis
is
responsible
for
USP7i,
inhibiting
potential
strategy
improving
efficacy
USP7i.
Computer Methods in Biomechanics & Biomedical Engineering,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 14
Published: Jan. 27, 2025
Breast
cancer
(BC)
is
a
malignant
tumor
that
occurs
in
breast
tissue.
This
project
aims
to
predict
the
prognosis
of
BC
patients
using
genes
related
hypoxia
and
endoplasmic
reticulum
stress
(ERS).
RNA-seq
clinical
data
for
were
downloaded
from
TCGA
GEO
databases.
Hypoxia
ERS-related
collected
Genecards
database.
Univariate/multivariate
Cox
regression
Lasso
analyses
used
screen
construct
prognostic
models.
Patients
divided
into
high-risk
(HR)
low-risk
(LR)
groups
based
on
risk
scores.
The
CIBERSORT
algorithm
was
analyze
differences
immune
infiltration
between
two
groups.
mutations
analyzed
statistically.
CellMiner
database
drug
prediction
TISCH
single-cell
sequencing
analysis.
We
screened
8
feature
model.
HR
group
had
remarkably
worse
prognosis.
TP53
exhibited
higher
mutation
frequency
group.
analysis
uncovered
remarkable
increase
levels
Macrophages
M0
Tregs
patients.
Drug
sensitivity
demonstrated
expression
IVL
greatly
negatively
linked
with
COLCHICINE.
PTGS2
negative
correlation
Vincristine
sensitivity.
model
can
survival,
status,
potential
drugs
patients,
bringing
new
perspective
individualized
treatment.
Metabolites,
Journal Year:
2025,
Volume and Issue:
15(4), P. 221 - 221
Published: March 24, 2025
Background/Objectives:
Endoplasmic
reticulum
(ER)
stress
occurs
when
ER
homeostasis
is
disrupted,
leading
to
the
accumulation
of
misfolded
or
unfolded
proteins.
This
condition
activates
protein
response
(UPR),
which
aims
restore
balance
trigger
cell
death
if
cannot
be
achieved.
In
cancer,
plays
a
key
role
due
heightened
metabolic
demands
tumor
cells.
review
explores
how
metabolomics
can
provide
insights
into
stress-related
alterations
and
their
implications
for
cancer
therapy.
Methods:
A
comprehensive
literature
was
conducted
analyze
recent
findings
on
stress,
metabolomics,
metabolism.
Studies
examining
profiling
cells
under
conditions
were
selected,
with
focus
identifying
potential
biomarkers
therapeutic
targets.
Results:
Metabolomic
studies
highlight
significant
shifts
in
lipid
metabolism,
synthesis,
oxidative
management
stress.
These
are
crucial
adaptation
survival.
Additionally,
targeting
pathways
has
shown
preclinical
models,
suggesting
new
strategies.
Conclusions:
Understanding
impact
provides
valuable
opportunities
drug
development.
Metabolomics-based
approaches
may
help
identify
novel
targets,
enhancing
effectiveness
antitumor
therapies.
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: April 26, 2025
Lung
cancer
is
the
leading
cause
of
cancer-related
mortality
worldwide;
however,
despite
development
and
clinical
application
various
drugs,
prognosis
remains
poor.
One
reason
for
this
high
rate
recurrence
metastasis.
The
stem
cell
(CSC)
theory
has
been
proposed
to
explain
their
root
cause,
removal
CSCs
necessary
cure
completely;
detailed
profiles
lung
have
not
clarified.
Here,
we
used
single-cell
RNA
sequencing
(scRNA-seq)
data
identify
novel
markers
validated
expression
function
in
vitro.
A549-derived
tumorspheres
were
as
a
model
CSCs.
To
genes
upregulated
CSC-like
cells,
reanalyzed
two
publicly
available
scRNA-seq
datasets
from
human
tissues.
Additionally,
trajectory
analysis
was
performed
examine
changes
candidate
gene
during
CSC
differentiation.
role
these
regulation
further
investigated
through
functional
assays.
Tumorspheres
exhibited
increased
well-established
markers.
suggested
that
SIGMAR1
significantly
cells
decreased
with
Furthermore,
siRNA-mediated
knockdown
suppressed
tumorsphere
self-renewal
capacity
reduced
marker
expression.
We
propose
serves
potential
plays
crucial
regulating
capacity.
Targeting
may
provide
therapeutic
strategy
preventing
metastasis
recurrence-major
challenges
treatment.
Future
studies
should
investigate
underlying
mechanisms
by
which
modulates
properties.
Immunology and Cell Biology,
Journal Year:
2024,
Volume and Issue:
102(3), P. 167 - 178
Published: Jan. 11, 2024
Abstract
Vimentin,
an
intermediate
filament
protein
primarily
recognized
for
its
intracellular
role
in
maintaining
cellular
structure,
has
recently
garnered
increased
attention
and
emerged
as
a
pivotal
extracellular
player
immune
regulation
host–pathogen
interactions.
While
the
functions
of
vimentin
were
initially
overshadowed
by
cytoskeletal
role,
accumulating
evidence
now
highlights
significance
diverse
physiological
pathological
events.
This
review
explores
multifaceted
modulating
responses
orchestrating
interactions
between
host
cells
pathogens.
It
delves
into
mechanisms
underlying
vimentin's
release
milieu,
elucidating
unconventional
secretion
pathways
identifying
critical
molecular
triggers.
In
addition,
future
perspectives
using
diagnostics
target
treatment
diseases
are
discussed.
