Botox-A induced apoptosis and suppressed cell proliferation in fibroblasts pre-treated with breast cancer exosomes

Molecular and Cellular Probes, Journal Year: 2025, Volume and Issue: 79, P. 102007 - 102007

Published: Jan. 6, 2025

Language: Английский

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Circular RNAs and cervical cancer: friends or foes? A landscape on circRNA-mediated regulation of key signaling pathways involved in the onset and progression of HPV-related cervical neoplasms

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 10, 2024

Abstract Cervical cancer (CC) is a common gynecologic malignancy, accounting for significant proportion of women death worldwide. Human papillomavirus (HPV) infection one the major etiological causes leading to CC onset; however, genetic, and epigenetic factors are also responsible disease expansion. Circular RNAs (circRNAs), which known as particular subset non-coding RNA (ncRNA) superfamily, with covalently closed loop structures, have been reported be involved in progression diverse diseases, especially neoplasms. In this framework, abnormally expressed circRNAs strong correlation pathogenesis through regulating substantial signaling pathways. Also, these molecules can considered promising biomarkers therapeutic targets diagnosis/prognosis treatment, respectively. Herein, we first review key molecular mechanisms, including Wnt/β-catenin, MAPK, PI3K/Akt/mTOR pathways, well angiogenesis metastasis, by interfere development. Then, diagnostic, prognostic, potentials ncRNA will highlighted depth.

Language: Английский

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Regulatory role of PPAR in colorectal cancer

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 28, 2025

Language: Английский

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Long non-coding RNAs: Emerging regulators of invasion and metastasis in pancreatic cancer

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

The invasion and metastasis of pancreatic cancer (PC) are key factors contributing to disease progression poor prognosis. This process is primarily driven by EMT, which has been the focus recent studies highlighting role long non-coding RNAs (lncRNAs) as crucial regulators EMT. However, mechanisms lncRNAs influence invasive multifaceted, extending beyond EMT regulation alone. review aims characterize affecting in cancer. We summarize regulatory roles across multiple molecular pathways highlight their translational potential, considering implications for clinical applications diagnostics therapeutics. focuses on three principal scientific themes. First, we orchestrate various signaling pathways, such TGF-β/Smad, Wnt/β-catenin, Notch, regulate changes associated with thereby enhancing cellular motility invasivenes. Second, effects autophagy ferroptosis discuss exosomal tumor microenvironment behavior neighboring cells promote cell invasion. Third, emphasize RNA modifications (such m6A m5C methylation) stabilizing capacity mediate PC. Lastly, potential these findings, emphasizing inherent challenges using biomarkers therapeutic targets, while proposing prospective research strategies.

Language: Английский

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The landscape of circRNAs in gliomas temozolomide resistance: Insights into molecular pathways

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(4), P. 1178 - 1189

Published: May 21, 2024

As the deadliest type of primary brain tumor, gliomas represent a significant worldwide health concern. Circular RNA (circRNA), unique non-coding molecule, seems to be one most alluring target molecules involved in pathophysiology many kinds cancers. CircRNAs have been identified as prospective targets and biomarkers for diagnosis treatment numerous disorders, particularly malignancies. Recent research has established clinical link between temozolomide (TMZ) resistance certain circRNA dysregulations glioma tumors. may play therapeutic role controlling or overcoming TMZ provide guidance novel kind individualized therapy. To address biological characteristics circRNAs their potential induce TMZ, this review highlighted summarized possible roles that molecular pathways drug resistance, including Ras/Raf/ERK PI3K/Akt signaling pathway metabolic processes gliomas.

Language: Английский

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A comprehensive review of the PTEN/PI3K/Akt axis in multiple myeloma: from molecular interactions to potential therapeutic targets

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155401 - 155401

Published: June 17, 2024

Language: Английский

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Flavonoids as modulators of miRNA expression in pancreatic cancer: Pathways, Mechanisms, And Therapeutic Potential

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117347 - 117347

Published: Sept. 5, 2024

Language: Английский

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Role of lncRNA PVT1 in the progression of urological cancers: Novel insights into signaling pathways and clinical opportunities

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111736 - 111736

Published: March 1, 2025

Language: Английский

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Current advances and future prospects of blood-based techniques for identifying benign and malignant pulmonary nodules

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: 207, P. 104608 - 104608

Published: Jan. 5, 2025

Language: Английский

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The epigenetic regulatory network of long noncoding RNAs in hepatocellular carcinoma

Genes & Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 101534 - 101534

Published: Jan. 1, 2025

Language: Английский

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