Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease

Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 131, P. 110622 - 110622

Published: Aug. 17, 2020

Propolis, a resinous material produced by honey bees from plant exudates, has long been used in traditional herbal medicine and is widely consumed as health aid immune system booster. The COVID-19 pandemic renewed interest propolis products worldwide; fortunately, various aspects of the SARS-CoV-2 infection mechanism are potential targets for compounds. entry into host cells characterized viral spike protein interaction with cellular angiotensin-converting enzyme 2 (ACE2) serine protease TMPRSS2. This involves PAK1 overexpression, which kinase that mediates coronavirus-induced lung inflammation, fibrosis, suppression. Propolis components have inhibitory effects on ACE2, TMPRSS2 signaling pathways; addition, antiviral activity proven vitro vivo. In pre-clinical studies, promoted immunoregulation pro-inflammatory cytokines, including reduction IL-6, IL-1 beta TNF-α. monocytes macrophages, well Jak2/STAT3, NF-kB, inflammasome pathways, reducing risk cytokine storm syndrome, major mortality factor advanced disease. also shown promise an treatment comorbidities particularly dangerous patients, respiratory diseases, hypertension, diabetes, cancer. Standardized consistent bioactive properties now available. Given current emergency caused limited therapeutic options, presented promising relevant option safe, easy to administrate orally readily available natural supplement functional food.

Language: Английский

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Antioxidant Activity in Bee Products: A Review

Antioxidants, Journal Year: 2021, Volume and Issue: 10(1), P. 71 - 71

Published: Jan. 7, 2021

Bee products have been used since ancient times both for their nutritional value and a broad spectrum of therapeutic purposes. They are deemed to be potential source natural antioxidants that can counteract the effects oxidative stress underlying pathogenesis many diseases. In view growing interest in using bioactive substances from sources promote health reduce risk developing certain illnesses, this review aims update current state knowledge on antioxidant capacity bee such as honey, pollen, propolis, beeswax, royal jelly venom, analytical methods used. The complex, variable composition these multitude study activities responsible wide range results reported by plethora available studies. This suggests need establish standardized more efficiently evaluate intrinsic characteristics make data obtained comparable.

Language: Английский

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Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals

Molecules, Journal Year: 2021, Volume and Issue: 26(15), P. 4429 - 4429

Published: July 22, 2021

This study proposes a review on hyaluronic acid (HA) known as hyaluronan or hyaluronate and its derivates their application in cosmetic formulations. HA is glycosaminoglycan constituted from two disaccharides (N-acetylglucosamine D-glucuronic acid), isolated initially the vitreous humour of eye, subsequently discovered different tissues fluids (especially articular cartilage synovial fluid). It ubiquitous vertebrates, including humans, it involved diverse biological processes, such cell differentiation, embryological development, inflammation, wound healing, etc. has many qualities that recommend over other substances used skin regeneration, with moisturizing anti-ageing effects. molecular weight influences penetration into activity. Considering that, nowadays, wide use multitude applications (in ophthalmology, arthrology, pneumology, rhinology, aesthetic medicine, oncology, nutrition, cosmetics), present describes main aspects related to cosmetology. The effect level potential adverse effects are discussed. Some available products containing have been identified brand portfolio most manufacturers composition was evaluated. Further, additional due active ingredients (plant extracts, vitamins, amino acids, peptides, proteins, saccharides, probiotics, etc.) presented, well description possible toxic

Language: Английский

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Bee Products in Dermatology and Skin Care

Molecules, Journal Year: 2020, Volume and Issue: 25(3), P. 556 - 556

Published: Jan. 28, 2020

Honey, propolis, bee pollen, bread, royal jelly, beeswax and venom are natural products which have been used in medicine since ancient times. Nowadays, studies indicate that can be for skin treatment care. Biological properties of these related to flavonoids they contain like: chrysin, apigenin, kaempferol, quercetin, galangin, pinocembrin or naringenin. Several pharmacological activities phenolic acids flavonoids, also 10-hydroxy-trans-2-decenoic acid, is present reported. Royal jelly has multitude activities: antibiotic, antiinflammatory, antiallergenic, tonic antiaging. propolis pollen heal burn wounds, possess numerous functional such as: antibacterial, anti-inflammatory, antioxidant, disinfectant, antifungal antiviral. Beeswax production cosmetics ointments pharmacy. Due a large number biological activities, could considered as important ingredients medicines applied skin.

Language: Английский

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Antioxidant Activity as Biomarker of Honey Variety

Molecules, Journal Year: 2018, Volume and Issue: 23(8), P. 2069 - 2069

Published: Aug. 18, 2018

Honey variety is commonly defined by beekeepers based on nectar flow availability and the only laboratory method to provide verification melissopalynological analysis. Therefore, a quick simple for accurate assessment of honey still being researched. The aim study was evaluate antioxidant activity as an indicator through use multivariate statistical Materials consisted 90 samples varietal Polish honeys (rape-12, tilia-10, goldenrod-11, dandelion-5, buckwheat-6, multifloral-17, nectar-honeydew-8 coniferous honeydew-16 leafy honeydew-5) obtained directly from apiaries. Honeys were investigated in aspect capacity photochemiluminescence (PCL) methods using standard ACW ACL kits. As reference FRAP DPPH used. total phenolics content (TPC) determined Folin-Ciocalteu method. strongest found buckwheat, while weakest rape regardless used Results positively correlated (r = 0.42 0.94). Analysis conducted PCL confirmed that minor fraction antioxidants exhibits hydrophobic properties. Clear separation varieties PCA Clustering indicate can be useful parameter determining botanical origin honey.

Language: Английский

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Evidence on the Health Benefits of Supplemental Propolis

Nutrients, Journal Year: 2019, Volume and Issue: 11(11), P. 2705 - 2705

Published: Nov. 8, 2019

Propolis is a honey-related product with reported health benefits such as improved immunity, lowered blood pressure, treated allergies and skin conditions. A literature review narrative synthesis were conducted to investigate the evidence on future direction of propolis products. Using predefined search strategy we searched Medline (OvidSP), Embase Central for quantitative qualitative studies (1990–2018). Citation, reference, hand searches expert consultation also undertaken. Studies randomised control trials observational data humans health-related outcomes included. Collected entered into NVivo software (Version 12, QRS International) analysed using thematic framework emergent themes. total 63 publications discussed. The majority cell-based animal studies, few key human conducted. There significant promise an effective antioxidant anti-inflammatory agent particular in cardiometabolic health.

Language: Английский

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Bee Venom: An Updating Review of Its Bioactive Molecules and Its Health Applications

Nutrients, Journal Year: 2020, Volume and Issue: 12(11), P. 3360 - 3360

Published: Oct. 31, 2020

Bee venom (BV) is usually associated with pain since, when humans are stung by bees, local inflammation and even an allergic reaction can be produced. BV has been traditionally used in ancient medicine acupuncture. It consists of a mixture substances, principally proteins peptides, including enzymes as well other types molecules very low concentration. Melittin phospholipase A2 (PLA2) the most abundant studied compounds BV. Literature main biological activities exerted shows that studies focuses on comprehension test anti-inflammatory effects its mechanisms action. Other properties such antioxidant, antimicrobial, neuroprotective or antitumor have also assessed, both vitro vivo. Moreover, human trials necessary to confirm those clinical applications. However, notwithstanding therapeutic potential BV, there certain problems regarding safety possible appearance adverse effects. On this perspective, new approaches developed avoid these complications. This manuscript aimed at reviewing actual knowledge components latest advances subject.

Language: Английский

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Health Promoting Properties of Bee Royal Jelly: Food of the Queens

Nutrients, Journal Year: 2021, Volume and Issue: 13(2), P. 543 - 543

Published: Feb. 7, 2021

Royal jelly (RJ) demand is growing every year and so the market for functional foods in general. RJ formed by different substances, mainly carbohydrates, proteins, lipids, but also vitamins, minerals, phenolic or volatile compounds lower proportion. Major royal proteins (MRJP) are, together with 10-hydroxy-2-decenoic acid (10-HDA), key substances of due to their biological properties. In particular, 10-HDA a unique substance this product. has been historically employed as health enhancer still very relevant China traditional medicine apitherapy. Nowadays, it consumed food found supplements other formulations its health-beneficial Within these properites, anti-lipidemic, antioxidant, antiproliferative, antimicrobial, neuroprotective, anti-inflammatory, immunomodulatory, antiaging, estrogenic activities have reported specific components. This manuscript aimed at reviewing current knowledge on components, assessment terms authenticity, activities, related applications.

Language: Английский

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Natural Compounds and Products from an Anti-Aging Perspective

Molecules, Journal Year: 2022, Volume and Issue: 27(20), P. 7084 - 7084

Published: Oct. 20, 2022

Aging is a very complex process that accompanied by degenerative impairment in many of the major functions human body over time. This inevitable influenced hereditary factors, lifestyle, and environmental influences such as xenobiotic pollution, infectious agents, UV radiation, diet-borne toxins, so on. Many external internal signs symptoms are related with aging senescence, including skin dryness wrinkles, atherosclerosis, diabetes, neurodegenerative disorders, cancer, etc. Oxidative stress, consequence imbalance between pro- antioxidants, one main provoking factors causing aging-related damages concerns, due to generation highly reactive byproducts oxygen nitrogen species during metabolism, which result cellular damage apoptosis. Antioxidants can prevent these processes extend healthy longevity ability inhibit formation free radicals or interrupt their propagation, thereby lowering level oxidative stress. review focuses on supporting antioxidant system organism balancing diet through consumption necessary amount natural ingredients, vitamins, minerals, polyunsaturated fatty acids (PUFA), essential amino acids, probiotics, plants’ fibers, nutritional supplements, polyphenols, some phytoextracts, drinking water.

Language: Английский

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The Honey Bee Apis mellifera: An Insect at the Interface between Human and Ecosystem Health

Biology, Journal Year: 2022, Volume and Issue: 11(2), P. 233 - 233

Published: Feb. 1, 2022

The concept of ecosystem services is widely understood as the and benefits thatecosystems provide to humans, they have been categorised into provisioning, regulating, supporting, cultural services. This article aims an updated overview that honey bee Apis mellifera provides humans well ecosystems. We revised role bees pollinators in natural ecosystems preserve restore local biodiversity wild plants; agro-ecosystems, this species used enhance crop yield quality, meeting increasing food demand. Beekeeping activity not only with high-quality but also substances raw materials pharmaceuticals, polluted areas, convey valuable information on environmental presence pollutants their impact human health. Finally, symbolic tradition, mysticism, values habitats are presented. Overall, we suggest value most important played by insect species, it may help revitalise strengthen intimate reciprocal relationship between world, avoiding inaccuracy considering mere providers humans.

Language: Английский

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