Natural Compounds and Products from an Anti-Aging Perspective

Molecules, Journal Year: 2022, Volume and Issue: 27(20), P. 7084 - 7084

Published: Oct. 20, 2022

Aging is a very complex process that accompanied by degenerative impairment in many of the major functions human body over time. This inevitable influenced hereditary factors, lifestyle, and environmental influences such as xenobiotic pollution, infectious agents, UV radiation, diet-borne toxins, so on. Many external internal signs symptoms are related with aging senescence, including skin dryness wrinkles, atherosclerosis, diabetes, neurodegenerative disorders, cancer, etc. Oxidative stress, consequence imbalance between pro- antioxidants, one main provoking factors causing aging-related damages concerns, due to generation highly reactive byproducts oxygen nitrogen species during metabolism, which result cellular damage apoptosis. Antioxidants can prevent these processes extend healthy longevity ability inhibit formation free radicals or interrupt their propagation, thereby lowering level oxidative stress. review focuses on supporting antioxidant system organism balancing diet through consumption necessary amount natural ingredients, vitamins, minerals, polyunsaturated fatty acids (PUFA), essential amino acids, probiotics, plants’ fibers, nutritional supplements, polyphenols, some phytoextracts, drinking water.

Language: Английский

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Unraveling the Role of Antimicrobial Peptides in Insects

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5753 - 5753

Published: March 17, 2023

Antimicrobial peptides (AMPs) are short, mainly positively charged, amphipathic molecules. AMPs important effectors of the immune response in insects with a broad spectrum antibacterial, antifungal, and antiparasitic activity. In addition to these well-known roles, exhibit many other, often unobvious, functions host. They support elimination viral infections. participate regulation brain-controlled processes, e.g., sleep non-associative learning. By influencing neuronal health, communication, activity, they can affect functioning insect nervous system. Expansion AMP repertoire loss their specificity is connected aging process lifespan insects. Moreover, take part maintaining gut homeostasis, regulating number endosymbionts as well reducing foreign microbiota. turn, presence venom prevents spread infection social insects, where prey may be source pathogens.

Language: Английский

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Current Status of the Bioactive Properties of Royal Jelly: A Comprehensive Review with a Focus on Its Anticancer, Anti-Inflammatory, and Antioxidant Effects

Molecules, Journal Year: 2023, Volume and Issue: 28(3), P. 1510 - 1510

Published: Feb. 3, 2023

Royal jelly (RJ) has been one of the most widely used natural products in alternative medicine for centuries. Being produced by both hypopharyngeal and mandibular glands, RJ exhibits an extraordinary complexity terms its composition, including proteins, lipids, carbohydrates, polyphenols, vitamins, hormones. Due to heterogeneous structure, displays various functional roles honeybees, being involved nutrition, learning, memory, social behavior. Furthermore, a wide range studies reported therapeutic properties, anticancer, anti-inflammatory, antioxidant activities, name few. In this direction, there is health-related problems which medical area specialists researchers are continuously trying find cure, such as cancer, atherosclerosis, or infertility. For mentioned diseases more, it proven that key player finding valuable treatment. review, great impact agent highlighted, with focus on activities. Moreover, we link apitherapeutic potential discussing composition. Herein, discuss novel present latest research work.

Language: Английский

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Royal Jelly: Biological Action and Health Benefits

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6023 - 6023

Published: May 30, 2024

Royal jelly (RJ) is a highly nutritious natural product with great potential for use in medicine, cosmetics, and as health-promoting food. This bee mixture of important compounds, such proteins, vitamins, lipids, minerals, hormones, neurotransmitters, flavonoids, polyphenols, that underlie the remarkable biological therapeutic activities RJ. Various bioactive molecules like 10-hydroxy-2-decenoic acid (10-HDA), antibacterial protein, apisin, major royal specific peptides apisimin, royalisin, royalactin, apidaecin, defensin-1, jelleins are characteristic ingredients RJ shows numerous physiological pharmacological properties, including vasodilatory, hypotensive, antihypercholesterolaemic, antidiabetic, immunomodulatory, anti-inflammatory, antioxidant, anti-aging, neuroprotective, antimicrobial, estrogenic, anti-allergic, anti-osteoporotic, anti-tumor effects. Moreover, may reduce menopause symptoms improve health reproductive system, liver, kidneys, promote wound healing. article provides an overview molecular mechanisms underlying beneficial effects various diseases, aging, aging-related complications, special emphasis on components their properties. The data presented should be incentive future clinical studies hopefully will advance our knowledge about facilitate development novel RJ-based opportunities improving human well-being.

Language: Английский

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Proceedings of the International Scientific and Practical Conference

Published: Dec. 7, 2023

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Language: Английский

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In situ formed scaffold with royal jelly-derived extracellular vesicles for wound healing

Theranostics, Journal Year: 2023, Volume and Issue: 13(9), P. 2811 - 2824

Published: Jan. 1, 2023

Safe and effective wound healing can be a major clinical challenge. Inflammation vascular impairment are two main causes of inadequate healing.

Language: Английский

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An Overview of the Nutritional Requirements of Honey Bees (Apis mellifera Linnaeus, 1758)

Insects, Journal Year: 2025, Volume and Issue: 16(1), P. 97 - 97

Published: Jan. 18, 2025

Honey bees are known for their wide global distribution, ease of handling, and economic ecological value. However, they often exposed to a variety stress factors. Therefore, it is essential beekeepers maintain healthy bee colonies. In this context, balanced diet recommended support the growth strong honey The purpose review therefore provide an overview nutritional requirements Apis mellifera importance maintenance An adequate includes consumption sufficient amounts proteins, carbohydrates, lipids, amino acids, vitamins, minerals, water, sterols, based on multi-floral pollen desirable. when colonies located near agroecosystems with lower resource diversity, both brood rearing colony longevity may decrease, making them more susceptible parasites diseases. On other hand, efforts have been made improve health help supplements consisting components. Nevertheless, studies shown that even these supplements, lack nutrients can still be issue Furthermore, future research should focus identifying better replicate natural diversity assessing long-term effects resilience, especially in low-flowering areas. This discusses interaction between nutrient health.

Language: Английский

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Combination of 10-hydroxy-decanoic acid and ZnO nanoparticles abrogates lead acetate-induced nephrotoxicity in rats: targeting oxidative stress and inflammatory signalling

BMC Pharmacology and Toxicology, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 25, 2025

Abstract Lead is a heavy metal contaminant that can cause significant alterations in renal structure and function, resulting nephrotoxicity. The fatty acids of royal jelly exhibit immunoregulatory, anticancer, anti-inflammatory, antioxidant properties, which have garnered interest. most prevalent among them 10-hydroxydecanoic acid (10-HDA). Zinc oxide nanoparticles (ZnONPs) demonstrate renoprotective effect, likely due to their antioxidant, antiapoptotic properties. This study evaluated the therapeutic efficacy 10-HDA ZnONPs, administered either as monotherapy or combination, against lead-induced Male rats were orally lead acetate (PbAc) for three months, followed by administration and/or ZnONPs one month. Exposure PbAc resulted elevated concentration, well increased serum levels urea, creatinine, cystatin C. condition damage parenchyma, characterised degenerative glomeruli tubules, exhibited highest lesion score. Nrf2 HO-1 reduced expression diminished enzyme subsequent poisoning. Additionally, there was an increase inflammatory apoptotic signalling through p-IKK/NF-κB axis. significantly decreased improved capacity. Moreover, markers (TNF-α, p-IKK, IL-1β, IL-6, IL-8) proapoptotic indicators (Bax Caspase-3) suppressed. combined therapy demonstrated synergistic effect (combination index < 1). In conclusion, results indicated potential be supplement even effective treatment alleviate adverse effects potentially attributed potent ameliorative actions oxidation, inflammation, apoptosis.

Language: Английский

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Bee Products: A Representation of Biodiversity, Sustainability, and Health

Life, Journal Year: 2021, Volume and Issue: 11(9), P. 970 - 970

Published: Sept. 15, 2021

Biodiversity strengthens the productivity of any ecosystem (agricultural land, forest, lake, etc.). The loss biodiversity contributes to food and energy insecurity; increases vulnerability natural disasters, such as floods or tropical storms; decreases quality both life health. Wild managed bees play a key role in maintaining recovery restoration degraded habitats. novelty character this perspective is give an updated representation bee products’ biodiversity, sustainability, health relationship. bioindicators, their importance conservation services, variety products are described herein. An overview main components products, biological potentials, highlighted detailed follows: (i) nutritional value (ii) bioactive profile related beneficial properties; (iii) focus on honey through literature quantitative analysis, (iv) explored databases. Moreover, example interconnection between health, case study, namely “Cellulose Park”, realized Rome (Italy), presented here. This study highlights how activities can be used assess track changes agricultural ecosystems—hive could valid indicators surrounding environment, well induced by biotic abiotic factors that impact sustainability production peri-urban areas.

Language: Английский

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Royal Jelly as a Nutraceutical Natural Product with a Focus on Its Antibacterial Activity

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(6), P. 1142 - 1142

Published: May 27, 2022

Royal jelly (RJ) is one of the most valued natural products and known for its health-promoting properties. Due to therapeutic effects, it has been used in medicine since antiquity. Nowadays, several studies indicate that RJ acts as a powerful antimicrobial agent. Indeed, researchers shed light on antioxidant anticancer activity. RJ’s biological properties are related bioactive compounds, such proteins, peptides, phenolic, fatty acids. The aim this review highlight recent findings main compounds correlated with available literature suggests these can be an alternative approach order enhance human health. Moreover, throughout paper, we underline prominent antibacterial effect against target bacterial strains. In addition, briefly discuss other activities, antioxidative outstanding product.

Language: Английский

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