Anticancer Activity of Propolis and Its Compounds

Nutrients, Journal Year: 2021, Volume and Issue: 13(8), P. 2594 - 2594

Published: July 28, 2021

Propolis is a natural material that honey bees (Apis mellifera) produce from various botanical sources. The therapeutic activity of propolis, including antibacterial, antifungal, and anti-inflammatory effects, have been known since antiquity. Cancer one the major burdens disease worldwide, therefore, numerous studies are being conducted to develop new chemotherapeutic agents treatments for cancer. rich source biologically active compounds, which affect signaling pathways regulating crucial cellular processes. results latest research show propolis can inhibit proliferation, angiogenesis, metastasis cancer cells stimulate apoptosis. Moreover, it may influence tumor microenvironment multidrug resistance cancers. This review briefly summarizes molecular mechanisms anticancer its compounds highlights potential benefits reduce side effects chemotherapy radiotherapy.

Language: Английский

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Propolis: An update on its chemistry and pharmacological applications

Chinese Medicine, Journal Year: 2022, Volume and Issue: 17(1)

Published: Aug. 26, 2022

Propolis, a resinous substance produced by honeybees from various plant sources, has been used for thousands of years in traditional medicine several purposes all over the world. The precise composition propolis varies according to source, seasons harvesting, geography, type bee flora, climate changes, and honeybee species at site collection. This apiary product broad clinical applications such as antioxidant, anti-inflammatory, antimicrobial, anticancer, analgesic, antidepressant, anxiolytic well asimmunomodulatory effects. It is also known uses treating purulent disorders, improving wound healing, alleviating many related discomforts. Even if its use was already widespread since ancient times, after First Second World War, it grown even more studies identify chemical pharmacological features, allowing discriminate qualities terms profile relative biological activity based on geographic place origin. Recently, vitro vivo have carried out new insights into pharmaceutical prospects this management different highlighted. Specifically, available literature confirms efficacy bioactive compounds reduction cancer progression, inhibition bacterial viral infections mitigation parasitic-related symptoms, paving way an alternative approach improve human health. However, conscious standardized extracts are needed substantiate these health claims.

Language: Английский

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The Profile of Polyphenolic Compounds, Contents of Total Phenolics and Flavonoids, and Antioxidant and Antimicrobial Properties of Bee Products

Molecules, Journal Year: 2022, Volume and Issue: 27(4), P. 1301 - 1301

Published: Feb. 15, 2022

This study aimed to characterize bee products (bee bread, pollen, beeswax, and multiflorous honey) with the profile of phenolic compounds, total (TPC) flavonoid (TFC) contents, antioxidant microbiological properties. The TP TF contents could be ordered as follows: pollen > bread beeswax honey. UPLC-PDA-MS/MS analysis allowed identifying 20 polyphenols. Sinapic acid dominated in gallic honey, while pinobanksin was major compound beeswax. data showed that had a stronger potential than honey Moreover, antibacterial activity studied using 14 bacterial strains. Bee bread's pollen's antimicrobial higher towards Gram-negative In comparison, more potent inhibiting Gram-positive bacteria. Our indicates may represent valuable sources bioactive compounds offering functional

Language: Английский

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Chemical Variability and Pharmacological Potential of Propolis as a Source for the Development of New Pharmaceutical Products

Molecules, Journal Year: 2022, Volume and Issue: 27(5), P. 1600 - 1600

Published: Feb. 28, 2022

This review aims to analyze propolis as a potential raw material for the development and manufacture of new health-promoting products. Many scientific publications were retrieved from Scopus, PubMed, Google Scholar databases via searching word "propolis". The different extraction procedures, key biologically active compounds, biological properties, therapeutic analyzed. It was concluded that possesses variety properties because very complex chemical composition mainly depends on plant species visited by bees bees. Numerous studies found versatile pharmacological activities propolis: antimicrobial, antifungal, antiviral, antioxidant, anticancer, anti-inflammatory, immunomodulatory, etc. In this review, are presented point view origin standardization purpose pharmaceutical products its base. revealed some types propolis, especially European contain flavonoids phenolic acids, which could be markers quality evaluation preparations. One more focus paper overview microorganisms' sensitivity further antimicrobial antioxidant treatment various infectious diseases with an emphasis illnesses oral cavity. established activity is quite significant, Gram-negative bacteria lipophilic viruses. present study also interest industry appropriate design standardized preparations such mouthwashes, toothpastes, drops, sprays, creams, ointments, suppositories, tablets, capsules, Moreover, regarded source isolation substances. Furthermore, can facilitate partially overcoming problem preparations, principal obstacle broader use in industry. Finally, area food nutritionally well-balanced results indicate deserves better studied promising effects connection locality collection, vegetation, methods, standardization.

Language: Английский

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Royal Jelly: Biological Action and Health Benefits

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6023 - 6023

Published: May 30, 2024

Royal jelly (RJ) is a highly nutritious natural product with great potential for use in medicine, cosmetics, and as health-promoting food. This bee mixture of important compounds, such proteins, vitamins, lipids, minerals, hormones, neurotransmitters, flavonoids, polyphenols, that underlie the remarkable biological therapeutic activities RJ. Various bioactive molecules like 10-hydroxy-2-decenoic acid (10-HDA), antibacterial protein, apisin, major royal specific peptides apisimin, royalisin, royalactin, apidaecin, defensin-1, jelleins are characteristic ingredients RJ shows numerous physiological pharmacological properties, including vasodilatory, hypotensive, antihypercholesterolaemic, antidiabetic, immunomodulatory, anti-inflammatory, antioxidant, anti-aging, neuroprotective, antimicrobial, estrogenic, anti-allergic, anti-osteoporotic, anti-tumor effects. Moreover, may reduce menopause symptoms improve health reproductive system, liver, kidneys, promote wound healing. article provides an overview molecular mechanisms underlying beneficial effects various diseases, aging, aging-related complications, special emphasis on components their properties. The data presented should be incentive future clinical studies hopefully will advance our knowledge about facilitate development novel RJ-based opportunities improving human well-being.

Language: Английский

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A Mechanistic Overview on Green Assisted Formulation of Nanocomposites and Their Multifunctional Role in Biomedical Applications

Heliyon, Journal Year: 2025, Volume and Issue: 11(3), P. e41654 - e41654

Published: Jan. 8, 2025

The importance of nanocomposites constantly attains attention because their unique properties all across the fields especially in medical perspectives. study green-synthesized has grown to be extremely fascinating field research. Nanocomposites are more promising than mono-metallic nanoparticles they exhibit synergistic effects. This review encapsulates current development formulation plant-mediated by using several plant species and impact secondary metabolites on biocompatible functioning. Phyto-synthesis produces diverse nanomaterials with biocompatibility, environment-friendliness, vivo actions, characterized varying sizes, shapes, biochemical nature. process is advantageous conventional physical chemical procedures. New studies have been conducted determine biomedical efficacy against various diseases. Unfortunately, there inadequate investigation into green-assisted nanocomposites. Incorporating phytosynthesized therapeutic interventions not only enhances healing processes but also augments host's immune defenses infections. highlights phytosynthesis applications, including antibacterial, antidiabetic, antiviral, antioxidant, antifungal, anti-cancer, other as well toxicity. explores mechanistic action achieve designated tasks. Biogenic for multimodal imaging potential exchange methods materials Well-designed utilized innovative theranostic agents subsequent objective efficiently diagnosing treating a variety human disorders.

Language: Английский

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New Insights on Quality, Safety, Nutritional, and Nutraceutical Properties of Honeydew Honeys from Italy

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 410 - 410

Published: Jan. 19, 2025

Honeydew honey is less studied than nectar honey, although it characterized by peculiar nutritional properties. This mainly due to its challenging production, which leads easy counterfeiting and difficult valorization. contribution aims provide a comprehensive characterization of the physico-chemical, palynological, functional, food safety properties large sampling honeydew honeys collected throughout Italy. The elements, conductivity, color, antioxidant properties, total polyphenol content, hydroxymethylfurfural, major trace toxic rare earth pesticide residues were measured in 59 samples from forest, eucalyptus, fir, oak, citrus sources. Physico-chemical unable differentiate botanical origin Italian honeys. Similarly, mineral composition did not vary significantly, whereas elements appeared be promising markers for classifying their origin. Multivariate analysis allowed discriminating fir honeydews other varieties. Concerning aspects, detected 90% samples, with exhibiting lowest contamination levels, probably production industrialized areas. Acetamiprid imidacloprid most prevalent residues, but concentrations below limit indicated EFSA. These findings suggest need continuous monitoring program contaminants ensure assess risk.

Language: Английский

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A Review on Plant-Mediated Synthesis of Bimetallic Nanoparticles, Characterisation and Their Biological Applications

Materials, Journal Year: 2021, Volume and Issue: 14(24), P. 7677 - 7677

Published: Dec. 13, 2021

The study of bimetallic nanoparticles (BNPs) has constantly been expanding, especially in the last decade. biosynthesis BNPs mediated by natural extracts is simple, low-cost, and safe for environment. Plant contain phenolic compounds that act as reducing agents (flavonoids, terpenoids, tannins, alkaloids) stabilising ligands moieties (carbonyl, carboxyl, amine groups), useful green synthesis (NPs), are free toxic by-products. Noble NPs (containing silver, gold, platinum, palladium) have potential biomedical applications due to their safety, stability biological environment, low toxicity. They substantially impact human health (applications medicine pharmacy) proven effects (catalytic, antioxidant, antibacterial, antidiabetic, antitumor, hepatoprotective, regenerative activity). To best our knowledge, there no review papers literature on characterisation plant-mediated pharmacological potential. Thus, an effort made provide a clear perspective anticancer, size/shape-dependent BNPs. Furthermore, we discussed factors influence biosyntheses such pH, temperature, time, metal ion concentration, plant extract.

Language: Английский

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A Comprehensive Review of Stingless Bee Products: Phytochemical Composition and Beneficial Properties of Honey, Propolis, and Pollen

Applied Sciences, Journal Year: 2022, Volume and Issue: 12(13), P. 6370 - 6370

Published: June 23, 2022

The stingless bee has been gaining more attention in recent years due to the uniqueness and benefits of its products. Similar common honeybee, bees also produce honey, propolis, pollen, which offer superior for direct or indirect consumption. However, reports on products are scarce. This article summarises function application properties such as phenolic compounds, antioxidant properties, chemical content elucidated. antimicrobial anticancer potential highlighted. Future trends, potential, discussed. Stingless honey is highlighted a superfood that exceptionally be an active ingredient treating cancer. propolis extensively studied rich beneficial compounds contribute properties. Though studies pollen scarce, it reported being functional food.

Language: Английский

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Therapeutic Use of Bee Venom and Potential Applications in Veterinary Medicine

Veterinary Sciences, Journal Year: 2023, Volume and Issue: 10(2), P. 119 - 119

Published: Feb. 4, 2023

Apitherapy is a branch of alternative medicine that consists the treatment diseases through products collected, processed, and secreted by bees, specifically pollen, propolis, honey, royal jelly, bee venom. In traditional medicine, virtues honey propolis have been well-known for centuries. The same, however, cannot be said use venom particularly relevant many therapeutic aspects. recent decades, scientific studies confirmed enabled us to understand its properties. Bee has anti-inflammatory, antioxidant, central nervous system inhibiting, radioprotective, antibacterial, antiviral, antifungal properties, among others. Numerous often summarised in reviews literature focused on results obtained with mouse models their subsequent transposition human patient. contrast, few work veterinary exist. This review aims take stock research achievements this particular discipline, view recapitulation stabilisation different fields.

Language: Английский

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