Neuroinflammaging: A Tight Line Between Normal Aging and Age-Related Neurodegenerative Disorders DOI Creative Commons
Luca Soraci, Andrea Corsonello, Ersilia Paparazzo

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Aging in the healthy brain is characterized by a low-grade, chronic, and sterile inflammatory process known as neuroinflammaging. This condition, mainly consisting an up-regulation of response at level, contributes to pathogenesis age-related neurodegenerative disorders. Development this proinflammatory state involves interaction between genetic environmental factors, able induce epigenetic modifications. Indeed, exposure compounds, drugs, infections, can contribute modifications DNA methylome, histone fold proteins, nucleosome positioning, leading modulation neuroinflammatory responses. Furthermore, some modifiers, which combine interact during life course, modeling epigenome dynamics sustain, or dampen phenotype. The aim review summarize current knowledge about neuroinflammaging with particular focus on mechanisms underlying onset progression cascades central nervous system; furthermore, we describe diagnostic biomarkers that may increase accuracy help tailor therapeutic strategies patients diseases.

Language: Английский

Solving neurodegeneration: common mechanisms and strategies for new treatments DOI Creative Commons
Lauren K. Wareham, Shane A. Liddelow, Sally Temple

et al.

Molecular Neurodegeneration, Journal Year: 2022, Volume and Issue: 17(1)

Published: March 21, 2022

Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology site disease pathology. To address these and discuss emerging treatments, in April, 2021, Glaucoma Research Foundation, BrightFocus the Melza M. Frank Theodore Barr Foundation collaborated to bring together key opinion leaders experts field for a virtual meeting titled "Solving Neurodegeneration". This "think-tank" style focused uncovering mechanistic roots promising new catalyzed by goal finding treatments glaucoma, world's leading cause irreversible blindness interest three hosting foundations. Glaucoma, which causes vision loss through degeneration optic nerve, likely shares early cellular molecular events with other diseases central nervous system. Here we major areas overlap between system: neuroinflammation, bioenergetics metabolism, genetic contributions, neurovascular interactions. We summarize important discussion points emphasis research that are most innovative treatment neurodegeneration yet require further development. The is highlighted provides unique opportunities collaboration will lead efforts preventing ultimately loss.

Language: Английский

Citations

196
Targeting Akt/CREB/BDNF signaling pathway by ginsenosides in neurodegenerative diseases: A mechanistic approach DOI

Seyede Nazanin Zarneshan,

Sajad Fakhri, Haroon Khan

et al.

Pharmacological Research, Journal Year: 2022, Volume and Issue: 177, P. 106099 - 106099

Published: Jan. 26, 2022

Language: Английский

Citations

109
The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets DOI Creative Commons

Alhamdu Adamu,

Shuo Li,

Fankai Gao

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: April 12, 2024

Neuroinflammation refers to a highly complicated reaction of the central nervous system (CNS) certain stimuli such as trauma, infection, and neurodegenerative diseases. This is cellular immune response whereby glial cells are activated, inflammatory mediators liberated reactive oxygen nitrogen species synthesized. key process that helps protect brain from pathogens, but inappropriate, or protracted inflammation yields pathological states Parkinson’s disease, Alzheimer’s, Multiple Sclerosis, other disorders showcase various pathways neurodegeneration distributed in parts CNS. review reveals major neuroinflammatory signaling associated with neurodegeneration. Additionally, it explores promising therapeutic avenues, stem cell therapy, genetic intervention, nanoparticles, aiming regulate neuroinflammation potentially impede decelerate advancement these conditions. A comprehensive understanding intricate connection between diseases pivotal for development future treatment strategies can alleviate burden imposed by devastating disorders.

Language: Английский

Citations

101
Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer’s Disease, Parkinson’s Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome DOI Creative Commons

Takumi Satoh,

Dorit Trudler, Chang-ki Oh

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(1), P. 124 - 124

Published: Jan. 6, 2022

Rosemary (

Language: Английский

Citations

92
New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) DOI Creative Commons
Chella Perumal Palanisamy, Jinjin Pei, Phaniendra Alugoju

et al.

Theranostics, Journal Year: 2023, Volume and Issue: 13(12), P. 4138 - 4165

Published: Jan. 1, 2023

Neurodegenerative diseases are characterized by the progressive loss of neurons and intricate interactions between different cell types within affected regions.Reliable biomarkers that can accurately reflect disease activity, diagnose, monitor progression neurodegenerative crucial for development effective therapies.However, identifying suitable has been challenging due to heterogeneous nature these diseases, affecting specific subsets in brain regions.One promising approach promoting regeneration recovery involves transplantation mesenchymal stem cells (MSCs).MSCs have demonstrated ability modulate immune system, promote neurite outgrowth, stimulate angiogenesis, repair damaged tissues, partially through release their extracellular vesicles (EVs).MSC-derived EVs retain some therapeutic characteristics parent MSCs, including regulate facilitate tissue repair.This review aims explore potential MSC-derived as an emerging strategy highlighting role modulating neuronal recovery.By elucidating mechanisms which exert effects, we advance our understanding leverage novel treatment approaches field diseases.

Language: Английский

Citations

70
Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases (Review) DOI Creative Commons
Xiaolu Zhang, Ziyu Wang,

Yujia Zheng

et al.

International Journal of Molecular Medicine, Journal Year: 2023, Volume and Issue: 51(4)

Published: March 21, 2023

The inflammasome regulates innate immunity by serving as a signaling platform. Nod‑like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor apoptosis‑associated speck‑like (ASC) and pro‑caspase‑1, is far most extensively studied well‑characterized inflammasome. A variety of stimuli can activate NLRP3 When activated, recruits ASC activates resulting in inflammatory cytokine maturation secretion, which associated inflammation pyroptosis. However, aberrant activation has been linked to various diseases, including atherosclerosis, ischemic stroke, Alzheimer's disease, diabetes mellitus bowel disease. Therefore, emerged promising therapeutic target for diseases. In present review, systematic searches were performed using 'NLRP3 inhibitor(s)' 'inflammatory disease(s)' key words. By browsing literature from 2012 2022, 100 articles retrieved, 35 excluded they reviews, editorials, retracted or unavailable online, 65 included. According retrieved literature, current understanding pathway diseases was summarize, inhibitors targeting other components products highlighted. Additionally, review briefly discusses novel efforts clinical research.

Language: Английский

Citations

59
Alpha Synuclein: Neurodegeneration and Inflammation DOI Open Access
Gianluigi Forloni

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5914 - 5914

Published: March 21, 2023

Alpha-Synuclein (α-Syn) is one of the most important molecules involved in pathogenesis Parkinson’s disease and related disorders, synucleinopathies, but also several other neurodegenerative disorders with a more elusive role. This review analyzes activities α-Syn, different conformational states, monomeric, oligomeric fibrils, relation to neuronal dysfunction. The damage induced by α-Syn various conformers will be analyzed its capacity spread intracellular aggregation seeds prion-like mechanism. In view prominent role inflammation virtually all activity illustrated considering influence on glial reactivity. We others have described interaction between general cerebral dysfunctional α-Syn. Differences microglia astrocyte activation been observed when vivo presence oligomers has combined lasting peripheral inflammatory effect. reactivity was amplified, while astrocytes were damaged double stimulus, opening new perspectives for control synucleinopathies. Starting from our studies experimental models, we extended perspective find useful pointers orient future research potential therapeutic strategies disorders.

Language: Английский

Citations

59
Mitochondria Dysfunction and Neuroinflammation in Neurodegeneration: Who Comes First? DOI Creative Commons
Caterina Peggion, Tito Calì, Marisa Brini

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 240 - 240

Published: Feb. 16, 2024

Neurodegenerative diseases (NDs) encompass an assorted array of disorders such as Alzheimer's disease, Parkinson's and amyotrophic lateral sclerosis, each characterised by distinct clinical manifestations underlying pathological mechanisms. While some cases have a genetic basis, many NDs occur sporadically. Despite their differences, these commonly feature chronic neuroinflammation hallmark. Consensus has recently been reached on the possibility that mitochondria dysfunction protein aggregation can mutually contribute to activation neuroinflammatory response thus onset progression disorders. In present review, we discuss contribution aetiology NDs, highlighting new potential therapeutic targets be identified tackle neurodegenerative processes alleviate pathologies.

Language: Английский

Citations

28
The role of NLRP3 inflammasome in aging and age-related diseases DOI Creative Commons
Ruikai Liang, Xinrui Qi, Qi Cai

et al.

Immunity & Ageing, Journal Year: 2024, Volume and Issue: 21(1)

Published: Feb. 5, 2024

The gradual aging of the global population has led to a surge in age-related diseases, which seriously threaten human health. Researchers are dedicated understanding and coping with complexities aging, constantly uncovering substances mechanism related like chronic low-grade inflammation. NOD-like receptor protein 3 (NLRP3), key regulator innate immune response, recognizes molecular patterns associated pathogens injury, initiating an intrinsic inflammatory response. Dysfunctional NLRP3 is linked onset particularly context aging. Therefore, profound comprehension regulatory mechanisms inflammasome aging-related diseases holds potential enhance treatment strategies for these conditions. In this article, we review significance initiation progression diverse diseases. Furthermore, explore preventive therapeutic by manipulating inflammasome, along its upstream downstream mechanisms.

Language: Английский

Citations

24
Mitochondrial Dysfunction: A Key Player in Brain Aging and Diseases DOI Creative Commons
Sydney Bartman, Giuseppe Coppotelli, Jaime M. Ross

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(3), P. 1987 - 2026

Published: March 2, 2024

Mitochondria are thought to have become incorporated within the eukaryotic cell approximately 2 billion years ago and play a role in variety of cellular processes, such as energy production, calcium buffering homeostasis, steroid synthesis, growth, apoptosis, well inflammation ROS production. Considering that mitochondria involved multitude mitochondrial dysfunction has been shown several age-related diseases, including cancers, diabetes (type 2), neurodegenerative although underlying mechanisms not entirely understood. The significant increase lifespan increased incidence diseases over recent decades confirmed necessity understand by which impacts process aging diseases. In this review, we will offer brief overview mitochondria, along with structure function important organelle. We then discuss cause consequence process, particular focus on its inflammation, cognitive decline, Huntington’s disease, Parkinson’s Alzheimer’s disease. insight into therapies interventions currently used preserve or restore functioning during neurodegeneration.

Language: Английский

Citations

19