Antiinflammatory potential of nano‐curcumin as an alternative therapeutic agent for the treatment of mild‐to‐moderate hospitalized COVID‐19 patients in a placebo‐controlled clinical trial

Phytotherapy Research, Journal Year: 2022, Volume and Issue: 36(2), P. 1023 - 1031

Published: Jan. 17, 2022

Abstract The present study conducted a placebo‐controlled clinical trial to evaluate the impact of nano‐curcumin on inflammatory cytokines in mild‐to‐moderate hospitalized COVID‐19 patients. A total 60 patients were randomly divided into and control groups, then they received 240 mg/day for 7 days. manifestation laboratory parameters recorded days 0 seven. Also, SYBR Green real‐time PCR ELISA techniques implicated assessing mRNA expression IFN‐ γ , IL‐1 β IL‐6, MCP‐1, TNF‐ α serum levels mediators, respectively. Although manifestations improved via treatment, ( p = 0.006) 0.04) significantly reduced. Besides, considerable difference was observed between groups 0.001), 0.0002), IL‐6 0.008). In addition, there significant 0.042). evidence demonstrated that could be as complementary medication act an antiinflammatory agent inhibit complications.

Language: Английский

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Oral Co-Supplementation of Curcumin, Quercetin, and Vitamin D3 as an Adjuvant Therapy for Mild to Moderate Symptoms of COVID-19—Results From a Pilot Open-Label, Randomized Controlled Trial

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: June 7, 2022

Background: Curcumin, quercetin, and vitamin D3 (cholecalciferol) are common natural ingredients of human nutrition reportedly exhibit promising anti-inflammatory, immunomodulatory, broad-spectrum antiviral, antioxidant activities. Objective: The present study aimed to investigate the possible therapeutic benefits a single oral formulation containing supplements curcumin, cholecalciferol (combinedly referred here as CQC) an adjuvant therapy for early-stage symptomatic coronavirus disease 2019 (COVID-19) in pilot open-label, randomized controlled trial conducted at Mayo Hospital, King Edward Medical University, Lahore, Pakistan. Methods: Reverse transcriptase polymerase chain reaction (RT-PCR) confirmed, mild moderate COVID-19 outpatients were receive either standard care (SOC) (n = 25) (control arm) or daily co-supplementation 168 mg 260 9 µg (360 IU) cholecalciferol, two soft capsules b.i.d. add-on SOC (CQC 14 days. includes paracetamol with without antibiotic (azithromycin). Severe acute respiratory syndrome 2 (SARS-CoV-2) RT-PCR test, symptoms, biochemistry including C-reactive protein (CRP), D-dimer, lactate dehydrogenase, ferritin, complete blood count evaluated baseline follow-up day seven. Results: Patients who received CQC showed expedited negativization SARS-CoV-2 i.e., 15 (60.0%) vs. five (20.0%) control arm, p 0.009. COVID-19- associated symptoms rapidly resolved 10 (40.0%) 0.154. arm experienced greater fall serum CRP levels, from (median (IQR) 34.0 (21.0, 45.0) 11.0 (5.0, 16.0) mg/dl compared 36.0 (28.0, 47.0) 22.0 (15.0, 25.0) mg/dl, 0.006. was safe well-tolerated by all 25 patients no treatment-emergent effects, complications, side serious adverse events reported. Conclusion: may possibly have role early stage infection speedy resolution modulation hyperinflammatory response. In combination routine care, help recovery COVID-19. Further research is warranted. Clinical Trial Registration: Clinicaltrials.gov, identifier NCT05130671.

Language: Английский

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A Review of the Role of Curcumin in Metal Induced Toxicity

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 243 - 243

Published: Jan. 21, 2023

Metal toxicity poses a potential global threat to the environment and living beings. Their numerous agricultural, medical, industrial, domestic, technological applications result in widespread distribution which raises concern on effects of metals terms health hazards environmental pollution. Chelation therapy has been preferred medical treatment for metal poisoning. The chelating agent bounds ions form complex cyclic structures known as ‘chelates’ intensify their excretion from body. main disadvantage synthetic chelators is that chelation process removes vital nutrients along with toxic metals. Natural compounds are widely available, economical, have minimal adverse compared classical chelators. Herbal preparations can bind metal, reduce its absorption intestines, facilitate Curcumin, bioactive substance turmeric, used dietary supplement. Most studies shown curcumin protects against metal-induced lipid peroxidation mitigates antioxidant system. This review article provides an analysis show imparts promising toxicity-ameliorative related intrinsic activity.

Language: Английский

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Antiviral, anti-inflammatory and antioxidant effects of curcumin and curcuminoids in SH-SY5Y cells infected by SARS-CoV-2

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 10, 2024

COVID-19, caused by SARS-CoV-2, affects neuronal cells, causing several symptoms such as memory loss, anosmia and brain inflammation. Curcuminoids (Me08 e Me23) curcumin (CUR) are derived from Curcuma Longa extract (EXT). Many therapeutic actions have been linked to these compounds, including antiviral action. Given the severe implications of especially within central nervous system, our study aims shed light on potential curcuminoids against SARS-CoV-2 infection, particularly in cells. Here, we investigated effects CUR, EXT, Me08 Me23 human neuroblastoma SH-SY5Y. We observed that significantly decreased expression plasma membrane-associated transmembrane protease serine 2 (TMPRSS2) TMPRSS11D, consequently mitigating elevated ROS levels induced SARS-CoV-2. Furthermore, exhibited antioxidative properties increasing NRF2 gene restoring NQO1 activity following infection. Both effectively reduced replication SH-SY5Y cells overexpressing ACE2 (SH-ACE2). Additionally, all compounds demonstrated ability decrease proinflammatory cytokines IL-6, TNF-α, IL-17, while specifically INF-γ levels. Our findings suggest curcuminoid could serve a agent for impact context system involvement.

Language: Английский

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Innovative Delivery Systems for Curcumin: Exploring Nanosized and Conventional Formulations

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 637 - 637

Published: May 9, 2024

Curcumin, a polyphenol with rich history spanning two centuries, has emerged as promising therapeutic agent targeting multiple signaling pathways and exhibiting cellular-level activities that contribute to its diverse health benefits. Extensive preclinical clinical studies have demonstrated ability enhance the potential of various bioactive compounds. While reported advantages are manifold, predominantly attributed antioxidant anti-inflammatory properties, efficacy is hindered by poor bioavailability stemming from inadequate absorption, rapid metabolism, elimination. To address this challenge, nanodelivery systems approach, offering enhanced solubility, biocompatibility, effects for curcumin. We analyzed knowledge on curcumin nanoencapsulation synergistic other compounds, extracted electronic databases. discuss pharmacokinetic profile curcumin, current advancements in techniques, combined agents across disorders. By unifying existing knowledge, analysis intends provide insights into technologies overcome constraints associated treatments, emphasizing importance combinatorial approaches improving efficacy. Finally, compilation study data aims inform inspire future research encapsulating drugs characteristics investigating innovative drug combinations improve outcomes.

Language: Английский

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Plant-derived molecules in monkeypox management: insight and alternative therapeutic strategies

Beni-Suef University Journal of Basic and Applied Sciences, Journal Year: 2025, Volume and Issue: 14(1)

Published: Feb. 19, 2025

Abstract The WHO and CDC recently declared monkeypox virus (MPXV) a zoonotic disease known as (Mpox) Public Health Emergency of International Concern. According to the CDC, no treatment is specifically approved for Mpox infections. Medicinal plants are crucial in healthcare economic development, particularly low- middle-income countries. This review offers valuable insights into pathogenesis management through therapeutic approaches vaccination strategies using plant-based molecules. Core structural proteins necessary both viral entry immune response, including A29, H3L, L1R, involved MPXV. Potential targets vaccines include like A35R B6R, which essential propagation viruses. MPXV evades system by concealing its DNA, suppressing interferon limiting T NK cell activation, preventing apoptosis, complicating vaccine development. Antivirals (tecovirimat, brincidofovir) vaccinations (JYNNEOS, ACAM2000) manage Mpox. A recent study revealed early clinical trial results, indicating that antiviral drug tecovirimat, well-known conventional treatment, more effective than placebo against clade I type Research gaps, low effectiveness, availability challenges. novel perspective on combating global threat investigating alternative centered plant-derived compounds. Graphical

Language: Английский

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Current clinical developments in curcumin‐based therapeutics for cancer and chronic diseases

Phytotherapy Research, Journal Year: 2021, Volume and Issue: 35(12), P. 6768 - 6801

Published: Sept. 8, 2021

The last decade has seen an unprecedented rise in the prevalence of chronic diseases worldwide. Different mono‐targeted approaches have been devised to treat these multigenic diseases, still most them suffer from limited success due off‐target debilitating side effects and their inability target multiple pathways. Hence a safe, efficacious, multi‐targeted approach is need for hour circumvent challenging diseases. Curcumin, natural compound extracted rhizomes Curcuma longa , under intense scrutiny its wide medicinal biological properties. Curcumin known manifest antibacterial, antiinflammatory, antioxidant, antifungal, antineoplastic, proapoptotic effects. A plethora literature already established immense promise curcuminoids treatment clinical management various like cancer, cardiovascular, metabolic, neurological, inflammatory, infectious To date, more than 230 trials opened investigations understand pharmacological aspects curcumin human systems. Still, further randomized studies different ethnic populations warrant transition marketed drug. This review summarizes results curcumin‐based therapeutics prevention

Language: Английский

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Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?

Foods, Journal Year: 2022, Volume and Issue: 11(18), P. 2884 - 2884

Published: Sept. 17, 2022

The beginning of the end or beginning? After two years mastered by coronavirus disease 19 (COVID-19) pandemic, we are now witnessing a turnaround. reduction severe cases and deaths from COVID-19 led to increasing importance new called post-COVID syndrome. term is used indicate permanency symptoms in patients who have recovered acute respiratory syndrome 2 (SARS-CoV-2) infection. Immune, antiviral, antimicrobial therapies, as well ozone therapy been treat disease. Vaccines then become available administered worldwide prevent insurgence However, pandemic not over yet at all given emergence omicron variants. New therapeutic strategies urgently needed. In this view, great interest was found nutraceutical products, including vitamins (C, D, E), minerals (zinc), melatonin, probiotics, flavonoids (quercetin), curcumin. This review summarizes role nutraceuticals prevention and/or treatment

Language: Английский

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Curcumin-Incorporated Biomaterials: In silico and in vitro evaluation of biological potentials

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 492, P. 215233 - 215233

Published: June 6, 2023

Language: Английский

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The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis: a randomized double-blind controlled trial

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 11, 2024

Abstract Non-alcoholic fatty liver disease (NAFLD) is a metabolic dysfunction of the defined as an abnormal accumulation fat within without secondary triggers like alcohol consumption or viral hepatitis. Piperine, bio-active ingredient black pepper, can exert significant function in treatment individuals with NAFLDand early cirrhosis. We investigated impact piperine duration 12 weeks on patients NAFLD and cirrhosis compared toplacebo consumption. In double-blind study, stage were haphazardly distributed into case control groups. They prescribed placebo 5 mg for weeks, respectively. The demographic laboratory parameters assessed baseline after intake. Piperine daily dosage could significantly decrease hepatic enzymes glucose, alleviate dyslipidemia arm rather than arm. Moreover, HOMA levels insulin resistance reduced participants to counterparts. absence approved medicinal intervention NAFLD, regarding favorable more studies this subject are warranted.

Language: Английский

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