Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 154, P. 109961 - 109961
Published: Oct. 11, 2024
Language: Английский
Antioxidants, Journal Year: 2024, Volume and Issue: 13(1), P. 76 - 76
Published: Jan. 5, 2024
Heavy metals are often found in soil and can contaminate drinking water, posing a serious threat to human health. Molecular pathways curation therapies for mitigating heavy metal toxicity have been studied long time. Recent studies on oxidative stress aging shown that the molecular foundation of cellular damage caused by metals, namely, apoptosis, endoplasmic reticulum stress, mitochondrial share same as those involved senescence aging. In recent studies, many types exposures used both animal models. Chelation therapy is traditional treatment toxicity. However, recently, various antioxidants be effective treating metal-induced damage, shifting research focus investigating interplay between metals. this review, we introduce basis its relationship with aging, summarize clinical implications, discuss other agents protective effects against damage.
Language: Английский
Citations
32
Neuroglia, Journal Year: 2025, Volume and Issue: 6(1), P. 4 - 4
Published: Jan. 6, 2025
Overexposure of humans to heavy metals and essential poses a significant risk for the development neurological neurodevelopmental disorders. The mechanisms through which these exert their effects include generation reactive oxygen species, mitochondrial dysfunction, activation inflammatory pathways, disruption cellular signaling. function glial cells in brain maintenance homeostasis cannot be overlooked. are particularly susceptible metal-induced neurotoxicity. Accumulation promotes microglial activation, triggering responses that can coincide with other neurotoxicity, inducing alteration synaptic transmission, cognitive deficit, neuronal damage. In this review, we highlighted role dysfunction some selected neurodegenerative diseases We further dive into how exposure such as nickel, manganese, methyl mercury, cadmium, iron, arsenic, lead affect functions microglia, astrocytes, oligodendrocytes they on relation Potential therapeutic interventions use new improved chelating agents antioxidant therapies might approach alleviating perturbations.
Language: Английский
Citations
3
Frontiers in Veterinary Science, Journal Year: 2023, Volume and Issue: 10
Published: June 29, 2023
Arsenic (As), lead (Pb), cadmium (Cd), and mercury (Hg) have been recognized as most toxic heavy metals that are continuously released into the environment, both from natural sources anthropogenic production of fertilizers, industrial activities, waste disposal. Therefore, As, Cd, Hg, Pb found in increasing concentrations bodies water, fodder, feed, tissues livestock, including poultry, surroundings areas, leading to metabolic, structural, functional abnormalities various organs all animals. In bioaccumulation Pb, Hg occurs many (mainly kidneys, liver, reproductive organs, lungs) a result continuous exposure metals. Consumption Cd lowers efficiency feed conversion, egg production, growth poultry. Chronic at low doses can change microscopic structure brain, organs) increased content these tissues. Histopathological changes occurring reflected their negative impact on enzyme activity serum biochemical parameters. Metal toxicity is determined by route exposure, length absorbed dosage, whether chronic acute. This review presents discussion poultry associated histopathological different
Language: Английский
Citations
23
Behavioural Brain Research, Journal Year: 2024, Volume and Issue: 476, P. 115212 - 115212
Published: Aug. 24, 2024
Language: Английский
Citations
14
Toxics, Journal Year: 2025, Volume and Issue: 13(2), P. 108 - 108
Published: Jan. 29, 2025
Copper accumulation in neurons induces oxidative stress, disrupts mitochondrial activity, and accelerates neuronal death, which is central to the pathophysiology of neurodegenerative diseases like Wilson disease. Standard treatments for copper toxicity, such as D-penicillamine, trientine, chloroquine, are frequently associated with severe side effects, creating a need safer therapeutic alternatives. To address this, we developed curcumin-loaded nanoemulsion (CUR-NE) using spontaneous emulsification technique, aimed at enhancing bioavailability efficacy curcumin. The optimized displayed particle size 76.42 nm, zeta potential −20.4 mV, high encapsulation efficiency 93.69%, stable uniform structure. vitro tests on SH-SY5Y neuroblastoma cells demonstrated that CUR-NE effectively protected against copper-induced promoting significant cellular uptake. Pharmacokinetic studies revealed exhibited longer half-life extended circulation time compared free Additionally, pharmacodynamic evaluations, including biochemical assays histopathological analysis, confirmed provided superior neuroprotection overload conditions. These results emphasize ability augment effects curcumin, presenting novel approach managing neurodegeneration. study highlights effectiveness nanoemulsion-based delivery platforms improving chelation neurological diseases.
Language: Английский
Citations
1
International Journal of Microbiology, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
The escalating threat of infectious diseases, exacerbated by antimicrobial resistance (AMR) and biofilm formation, necessitates innovative therapeutic strategies. This review presents a comprehensive exploration the potential nanoparticles synthesized from natural sources, including plant extracts, microbial products, marine compounds, as agents. These naturally derived demonstrated significant antibiofilm antivirulence effects, with specific examples revealing their capacity to reduce mass up 78% inhibit bacterial quorum sensing 65%. integration bioactive such polyphenols chitosan, facilitates nanoparticle stability enhances efficacy, while green synthesis protocols environmental risks. Notably, identifies silver using tea achieving 85% inhibition polymicrobial growth in vitro. Despite these promising results, challenges standardization scalability persist. study underscores transformative leveraging sourced sustainable alternatives conventional antimicrobials, offering quantitative insights for future application combating mono- infections.
Language: Английский
Citations
1
Antioxidants, Journal Year: 2023, Volume and Issue: 12(9), P. 1760 - 1760
Published: Sept. 13, 2023
Stroke and acute myocardial infarction are leading causes of mortality worldwide. The latter accounts for approximately 9 million deaths annually. In turn, ischemic stroke is a significant contributor to adult physical disability globally. While reperfusion crucial tissue recovery, it can paradoxically exacerbate damage through oxidative stress (OS), inflammation, cell death. Therefore, imperative explore diverse approaches aimed at minimizing ischemia/reperfusion injury enhance clinical outcomes. OS primarily arises from an excessive generation reactive oxygen species (ROS) and/or decreased endogenous antioxidant potential. Natural compounds counteract the mechanisms linked ROS. promising preclinical results, based on monotherapies, account protective effects against by ROS, translating these models into human applications has yielded controversial evidence. However, since wide spectrum antioxidants having chemical characteristics offers varied biological actions signaling pathways, multitherapy emerged as valuable therapeutic resource. Moreover, combination in holds potential synergistic effects. This study was designed with aim providing updated overview natural suitable preventing cerebral injuries.
Language: Английский
Citations
22
Chemosphere, Journal Year: 2024, Volume and Issue: 357, P. 142090 - 142090
Published: April 20, 2024
Language: Английский
Citations
8
Communications in Soil Science and Plant Analysis, Journal Year: 2024, Volume and Issue: 55(22), P. 3609 - 3637
Published: Sept. 22, 2024
Language: Английский
Citations
5
Toxicology Reports, Journal Year: 2023, Volume and Issue: 11, P. 355 - 367
Published: Oct. 12, 2023
Confronting the profound public health concern of alcohol-induced liver damage calls for inventive therapeutic measures. The social, economic, and clinical ramifications are extensive demand a comprehensive understanding. This thorough examination uncovers complex relationship between alcohol intake damage, with special emphasis on pivotal roles Toll-like receptor 4 (TLR4)/NF-κB p65 CYP2E1/ROS/Nrf2 signalling networks. Different consumption patterns, determined by myriad factors, have significant implications health, leading to spectrum adverse effects. TLR4/NF-κB pathway, principal regulator inflammation immune responses, significantly contributes various disease states when its balance is disrupted. Notably, TLR4/MD-2-TNF-α pathway has been linked non-alcohol related disease, while NF-κB activation associated (ALD). subunit NF-κB, primarily responsible release inflammatory cytokines, hastens progression ALD. Breakthrough insights suggest that curcumin, robust antioxidant anti-inflammatory compound sourced from turmeric, effectively disrupts pathway. heralds new approach managing damage. Initial trials support curcumin's potential, highlighting ability substantially reduce enzyme levels. narrative surrounding alcohol-related injury gradually becoming more intricate, intertwining networks such as CYP2E1/ROS/Nrf2. protective role curcumin against marks dawn treatment possibilities. However, full realisation this promising potential necessitates rigorous future research definitively understand these mechanisms establish effectiveness safety in disorders.
Language: Английский
Citations
11