Medicinal Research Reviews,
Journal Year:
2023,
Volume and Issue:
43(4), P. 1141 - 1200
Published: March 17, 2023
Abstract
Epithelial‐mesenchymal
transition
(EMT)
is
a
complex
process
with
primordial
role
in
cellular
transformation
whereby
an
epithelial
cell
transforms
and
acquires
mesenchymal
phenotype.
This
plays
pivotal
tumor
progression
self‐renewal,
exacerbates
resistance
to
apoptosis
chemotherapy.
EMT
can
be
initiated
promoted
by
deregulated
oncogenic
signaling
pathways,
hypoxia,
cells
the
microenvironment,
resulting
loss‐of‐epithelial
polarity,
cell–cell
adhesion,
enhanced
invasive/migratory
properties.
Numerous
transcriptional
regulators,
such
as
Snail,
Slug,
Twist,
ZEB1/ZEB2
induce
through
downregulation
of
markers
gain‐of‐expression
markers.
Additionally,
cascades
Wnt/β‐catenin,
Notch,
Sonic
hedgehog,
nuclear
factor
kappa
B,
receptor
tyrosine
kinases,
PI3K/AKT/mTOR,
Hippo,
transforming
growth
factor‐β
pathways
regulate
whereas
they
are
often
cancers
leading
aberrant
EMT.
Furthermore,
noncoding
RNAs,
tumor‐derived
exosomes,
epigenetic
alterations
also
involved
modulation
Therefore,
regulation
vital
strategy
control
aggressive
metastatic
characteristics
cells.
Despite
vast
amount
preclinical
data
on
cancer
progression,
there
lack
clinical
translation
at
therapeutic
level.
In
this
review,
we
have
discussed
thoroughly
aforementioned
transcription
factors,
RNAs
(microRNAs,
long
RNA,
circular
RNA),
modifications,
exosomes
cancers.
We
emphasized
contribution
drug
possible
interventions
using
plant‐derived
natural
products,
their
semi‐synthetic
derivatives,
nano‐formulations
that
described
promising
blockers.
Asian Journal of Pharmaceutical Sciences,
Journal Year:
2022,
Volume and Issue:
17(5), P. 751 - 766
Published: Aug. 1, 2022
Ferroptosis
is
a
novel
form
of
programmed
cell
death
impelled
by
iron-dependent
lipid
peroxidation,
which
may
be
potential
strategy
for
cancer
therapy.
Here
we
demonstrated
the
first
time
that
Resveratrol
(RSV),
traditional
Chinese
medicine
(TCM)
chemical
monomer,
could
effectually
inhibit
growth
colon
cells
through
ROS-dependent
ferroptosis
pathway.
Mechanistically,
RSV
evoked
increase
reactive
oxygen
species
and
peroxidation
in
colorectal
cells,
eventually
lead
to
ferroptosis.
Furthermore,
promote
downregulating
expression
channel
protein
solute
carrier
family
7
member
11
(SLC7A11)
glutathione
peroxidase
4
(GPX4).
To
improve
delivery
efficiency
RSV,
biomimetic
nanocarrier
was
developed
coating
RSV-loaded
poly(ε-caprolactone)-poly(ethylene
glycol)
(PCL-PEG)
nanoparticles
with
erythrocyte
membrane
(RSV-NPs@RBCm).
The
RSV-NPs@RBCm
provide
possibility
escape
macrophage
phagocytosis
have
long
circulation
effect.
In
addition,
when
coupled
tumor-penetrating
peptide
iRGD,
trigger
enhanced
tissue
penetration
tumor-specifically,
into
tumors
would
significantly
improved
results
from
vivo
study
an
excellent
treatment
efficacy
CRC.
Altogether,
our
highlighted
therapeutic
as
ferroptosis-inducing
anticancer
agent
loaded
nanoplatform,
it
might
pave
way
application
nanosystems
treatment.
Phytotherapy Research,
Journal Year:
2023,
Volume and Issue:
38(2), P. 880 - 911
Published: Dec. 13, 2023
Abstract
Current
pharmaceutical
research
is
energetically
excavating
the
pharmacotherapeutic
role
of
herb‐derived
ingredients
in
multiple
malignancies’
targeting.
Luteolin
one
major
phytochemical
components
that
exist
various
traditional
Chinese
medicine
or
medical
herbs.
Mounting
evidence
reveals
this
phytoconstituent
endows
prominent
therapeutic
actions
on
diverse
malignancies,
with
underlying
mechanisms,
combined
medication
strategy,
and
pharmacokinetics
elusive.
Additionally,
clinical
trial
investigation
luteolin
remain
to
be
systematically
delineated.
The
present
review
aimed
comprehensively
summarize
updated
information
regard
anticancer
mechanism,
strategies,
pharmacokinetics,
trials,
researches
luteolin.
survey
corroborates
executes
effects
mainly
by
dampening
proliferation
invasion,
spurring
apoptosis,
intercepting
cell
cycle,
regulating
autophagy
immune,
inhibiting
inflammatory
response,
inducing
ferroptosis,
pyroptosis,
as
well
epigenetic
modification,
so
on.
can
applied
combination
numerous
anticarcinogens
natural
synergistically
enhance
efficacy
malignancies
while
reducing
adverse
reactions.
For
has
an
unfavorable
oral
bioavailability,
it
persists
plasma
glucuronides
sulfate‐conjugates
after
being
metabolized,
regarded
potent
inhibitors
OATP1B1
OATP2B1,
which
may
messed
pharmacokinetic
interactions
miscellaneous
bioactive
substances
vivo.
Besides,
innovation
leading‐edge
drug
delivery
systems
such
host–guest
complexes,
nanoparticles,
liposomes,
nanoemulsion,
microspheres,
hydrogels
are
beneficial
exploitation
luteolin‐based
products.
Moreover,
some
registered
trials
carried
out,
yet
should
continuously
promoted.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 5, 2024
Colorectal
cancer
is
the
third
most
common
type
of
worldwide
and
has
become
one
major
human
disease
burdens.
In
clinical
practice,
treatment
colorectal
been
closely
related
to
use
irinotecan.
Irinotecan
combines
with
many
other
anticancer
drugs
a
broader
range
drug
combinations.
Combination
therapy
important
means
improving
anti-tumor
efficacy
overcoming
resistance.
Reasonable
combination
can
lead
better
patient
options,
inappropriate
will
increase
risk.
For
therapeutic
field,
significance
improve
efficacy,
reduce
adverse
effects,
ease
treatment.
Therefore,
we
explored
advantages
its
based
on
mechanism
or
metabolism
reviewed
rationale
basis
limitations
in
conducting
exploratory
trials
irinotecan
therapy,
including
results
potentiation
cytotoxic
drugs,
targeted
agents,
herbal
medicine.
We
hope
that
these
evoke
more
efforts
conduct
laboratory
for
further
studies
evaluations,
as
well
possibility
in-depth
development
future
trials.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 9, 2024
Colorectal
cancer
(CRC)
is
a
significant
global
health
burden,
with
high
morbidity
and
mortality
rates.
It
often
diagnosed
at
middle
to
advanced
stage,
affecting
approximately
35%
of
patients
the
time
diagnosis.
Currently,
chemotherapy
has
been
used
improve
patient
prognosis
increase
overall
survival.
However,
can
also
have
cytotoxic
effects
lead
adverse
reactions,
such
as
inhibiting
bone
marrow
hematopoiesis,
causing
digestive
dysfunction,
hand-foot
syndrome,
even
life-threatening
conditions.
In
response
these
effects,
researchers
proposed
using
Traditional
Chinese
Medicine
(TCM)
an
option
treat
cancer.
TCM
research
focuses
on
prescriptions,
herbs,
components,
which
form
essential
components
current
in
medicine.
The
study
implementation
prescriptions
herbs
demonstrate
its
distinctive
holistic
approach
therapy,
characterized
by
applying
multi-component
multi-target
treatment.
TMC
advantages
developing
new
drugs
they
consist
single
ingredients,
require
smaller
medication
dosages,
precise
measure
pharmacodynamic
clear
mechanism
action
compared
herbs.
further
still
needed
determine
whether
fully
substitute
therapeutic
efficacy
prescriptions.
This
paper
presents
comprehensive
analysis
advancements
made
components.
findings
this
serve
theoretical
basis
for
who
are
interested
exploring
potential
treatment
colorectal
