Treasure on the Earth—Gold Nanoparticles and Their Biomedical Applications

Materials, Journal Year: 2022, Volume and Issue: 15(9), P. 3355 - 3355

Published: May 7, 2022

Recent advances in the synthesis of metal nanoparticles (NPs) have led to tremendous expansion their potential applications different fields, ranging from healthcare research microelectronics and food packaging. Among approaches for exploiting nanotechnology medicine, gold nanomaterials particular been found as most promising due unique advantages, such sensing, image enhancement, delivery agents. Although, first scientific article on was presented 1857 by Faraday, during last few years, progress manufacturing these has taken an enormous step forward. Due nanoscale counterparts gold, which exhibit distinct properties functionality compared bulk material, stand out, particular, therapy, imaging, detection, diagnostics, precise drug delivery. This review summarizes current state-of-the-art knowledge terms biomedical nanoparticles. The application AuNPs following aspects are discussed: (i) imaging diagnosing specific target; (ii) treatment therapies using AuNPs; (iii) systems with a carrier. medical here we either consider contrast agent computed tomography (CT), or particle used optical instead fluorophores. Moreover, nontoxic feature, gadolinium-based agents magnetic resonance shown. tunable size, shape, make them great carriers targeted Therefore, here, summarize gold-based nanodrugs that FDA approved. Finally, various treat diseases discussed, i.e., photothermal photodynamic immunotherapy.

Language: Английский

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Gold Nanoparticles: Construction for Drug Delivery and Application in Cancer Immunotherapy

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1868 - 1868

Published: July 2, 2023

Cancer immunotherapy is an innovative treatment strategy to enhance the ability of immune system recognize and eliminate cancer cells. However, dose limitations, low response rates, adverse events pose significant challenges. To address these gold nanoparticles (AuNPs) have been explored as immunotherapeutic drug carriers owing their stability, surface versatility, excellent optical properties. This review provides overview advanced synthesis routes for AuNPs utilization improve precision therapies. The also emphasises various aspects AuNP-based immunotherapy, including loading, targeting strategies, release mechanisms. application combined with therapeutic efficacy are briefly discussed. Overall, we aimed provide a recent understanding advances, challenges, prospects anticancer applications.

Language: Английский

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The quest for nanoparticle-powered vaccines in cancer immunotherapy

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 14, 2024

Abstract Despite recent advancements in cancer treatment, this disease still poses a serious threat to public health. Vaccines play an important role preventing illness by preparing the body's adaptive and innate immune responses combat diseases. As our understanding of malignancies their connection system improves, there has been growing interest priming fight more effectively comprehensively. One promising approach involves utilizing nanoparticle systems for antigen delivery, which shown potentiate as vaccines and/or adjuvants. In review, we comprehensively summarized immunological mechanisms while focusing specifically on applications various types nanoparticles field immunotherapy. By exploring these breakthroughs, hope identify significant challenges obstacles making nanoparticle-based adjuvants feasible clinical application. This review serves assess breakthroughs vaccinations shed light prospects potential barriers. doing so, aim inspire future immunotherapies that harness nanotechnology deliver effective targeted treatments. Graphical abstract

Language: Английский

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Cancer Nanovaccines: Nanomaterials and Clinical Perspectives

Small, Journal Year: 2024, Volume and Issue: 20(35)

Published: May 1, 2024

Abstract Cancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing nanotechnology to augment traditional vaccine efficacy. This review comprehensively examines the current state‐of‐the‐art nanovaccine development, elucidating innovative strategies and technologies employed their design. It explores both preclinical clinical advancements, emphasizing key studies demonstrating potential elicit robust anti‐tumor immune responses. The study encompasses various facets, including integrating biomaterial‐based nanocarriers for antigen delivery, adjuvant selection, impact of nanoscale properties on performance. Detailed insights into complex interplay between tumor microenvironment responses are provided, highlighting challenges opportunities optimizing therapeutic outcomes. Additionally, presents thorough analysis ongoing trials, presenting snapshot landscape. By curating latest scientific findings developments, this aims serve as comprehensive resource researchers clinicians engaged advancing immunotherapy. Integrating design holds immense promise revolutionizing treatment paradigms, provides timely update evolving landscape nanovaccines.

Language: Английский

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Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(8), P. 3432 - 3456

Published: May 13, 2024

The advent of cancer immunotherapy has imparted a transformative impact on treatment paradigms by harnessing the power immune system. However, challenge practical and precise targeting malignant cells persists. To address this, engineered nanoparticles (NPs) have emerged as promising solution for enhancing targeted drug delivery in immunotherapeutic interventions, owing to their small size, low immunogenicity, ease surface modification. This comprehensive review delves into contemporary research at nexus NP engineering immunotherapy, encompassing an extensive spectrum morphologies strategies tailored toward optimizing tumor augmenting therapeutic effectiveness. Moreover, it underscores mechanisms that NPs leverage bypass numerous obstacles encountered regimens probes combined potential when co-administered with both established novel modalities. Finally, evaluates existing limitations platforms which could shape path future advancements this field.

Language: Английский

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Transforming Medicine: Cutting-Edge Applications of Nanoscale Materials in Drug Delivery

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Since their inception in the early 1960s, development and use of nanoscale materials have progressed tremendously, roles diverse fields ranging from human health to energy electronics are undeniable. The application nanotechnology inventions has revolutionized many aspects everyday life including various medical applications specifically drug delivery systems, maximizing therapeutic efficacy contained drugs by means bioavailability enhancement or minimization adverse effects. In this review, we utilize CAS Content Collection, a vast repository scientific information extracted journal patent publications, analyze trends nanoscience research relevant an effort provide comprehensive detailed picture field. We examine publication landscape area insights into current knowledge advances developments. review major classes nanosized routes, targeted diseases. outline most discussed concepts assess advantages nanocarriers. objective is broad overview evolving regarding challenges, evaluate growth opportunities. merit stems extensive, wide-ranging coverage up-to-date information, allowing unmatched breadth analysis in-depth insights.

Language: Английский

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Preclinical advance in nanoliposome-mediated photothermal therapy in liver cancer

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 31, 2025

Language: Английский

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Cancer immunotherapy by immune checkpoint blockade and its advanced application using bio-nanomaterials

Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 86, P. 909 - 922

Published: Feb. 16, 2022

Language: Английский

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Photothermal Effect of Gold Nanoparticles as a Nanomedicine for Diagnosis and Therapeutics

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(9), P. 2349 - 2349

Published: Sept. 19, 2023

Gold nanoparticles (AuNPs) have received great attention for various medical applications due to their unique physicochemical properties. AuNPs with tunable optical properties in the visible and near-infrared regions been utilized a variety of such as vitro diagnostics, vivo imaging, therapeutics. Among applications, this review will pay more recent developments diagnostic therapeutic based on photothermal (PT) effect AuNPs. In particular, PT has played an important role utilizing light, photoacoustic photon polymerase chain reaction (PCR), hyperthermia therapy. First, we discuss fundamentals detail understand background For ability efficiently convert absorbed light energy into heat generate enhanced acoustic waves can lead significant enhancements signal intensity. Integration PCR may open new opportunities technological innovation called photonic PCR, where is used enable fast accurate temperature cycling DNA amplification. Additionally, beyond existing thermotherapy AuNPs, be further applied cancer immunotherapy. Controlled damage cells triggers immune response, which useful obtaining better outcomes combination checkpoint inhibitors or vaccines. Therefore, examines nanomedicine among understands basic principles, advantages disadvantages each technology, importance multidisciplinary approach. Based this, it expected that help current status development direction nanoparticle-based disease diagnosis methods treatment methods, hope inspire innovative technologies.

Language: Английский

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Nanomedicine in Lung Cancer Immunotherapy

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: March 17, 2023

Lung cancer is the major cause of death worldwide. Cancer immunotherapy has been introduced as a promising and effective treatment that can improve immune system’s ability to eliminate cells help establish immunological memory. Nanoparticles contribute rapidly evolving field by simultaneously delivering variety agents target site tumor microenvironment. Nano drug delivery systems precisely biological pathways be implemented reprogram or regulate responses. Numerous investigations have conducted employ different types nanoparticles for lung cancer. Nano-based adds strong tool diverse collection therapies. This review briefly summarizes remarkable potential opportunities in its challenges.

Language: Английский

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