Drug Resistance Updates, Journal Year: 2021, Volume and Issue: 59, P. 100789 - 100789
Published: Nov. 23, 2021
Language: Английский
Genes & Diseases, Journal Year: 2022, Volume and Issue: 10(4), P. 1367 - 1401
Published: March 18, 2022
Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and produce aggressive malignancies that causes millions deaths every year. With the new understanding molecular mechanism(s) disease progression, our knowledge about snowballing, leading to evolution many therapeutic regimes their successive trials. In past few decades, various combinations therapies have been proposed are presently employed in treatment diverse cancers. Targeted drug therapy, immunotherapy, personalized medicines now largely being employed, which were not common a years back. The field cancer discoveries therapeutics evolving fast as type-specific biomarkers progressively identified several types cancers nowadays undergoing systematic therapies, extending patients' disease-free survival thereafter. Although growing evidence shows targeted approach could be future medicine, chemotherapy remains opted option despite its known side effects on patient's physical psychological health. Chemotherapeutic agents/pharmaceuticals served great purpose over decades remained frontline choice for advanced-stage surgery and/or radiation therapy cannot prescribed due specific reasons. present report succinctly reviews existing contemporary advancements assesses status enrolled drugs/pharmaceuticals; it also comprehensively discusses emerging role specific/targeted strategies achieve better clinical success/survival rate patients.
Language: Английский
Citations
755
Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 143, P. 112175 - 112175
Published: Sept. 27, 2021
Withania somnifera (L.) Dunal (Solanaceae) has been used as a traditional Rasayana herb for long time. Traditional uses of this plant indicate its ameliorative properties against plethora human medical conditions, viz. hypertension, stress, diabetes, asthma, cancer etc. This review presents comprehensive summary the geographical distribution, use, phytochemistry, and pharmacological activities W. active constituents. In addition, it detailed account presence an constituent in many commercial preparations with curative health benefits. Clinical studies toxicological considerations extracts constituents are also elucidated. Comparative analysis relevant in-vitro, in-vivo, clinical investigations indicated potent bioactivity phytochemicals anti-cancer, anti-inflammatory, apoptotic, immunomodulatory, antimicrobial, anti-diabetic, hepatoprotective, hypoglycaemic, hypolipidemic, cardio-protective spermatogenic agents. was found to be especially neurological psychological conditions like Parkinson's disease, Alzheimer's Huntington's ischemic stroke, sleep deprivation, amyotrophic lateral sclerosis, attention deficit hyperactivity disorder, bipolar anxiety, depression, schizophrenia obsessive-compulsive disorder. The probable mechanism action that imparts potential explored. However, in-depth needed on use diseases. Besides, is performed safe efficacious preclinical health-promoting herb.
Language: Английский
Citations
182
Journal of Ethnopharmacology, Journal Year: 2021, Volume and Issue: 284, P. 114744 - 114744
Published: Oct. 15, 2021
Traditional knowledge is a particular form of practice or skill set that was developed in ancient times and sustained through generations via the passing knowledge, essentially confined within specific tribe, local people, family lineages. Ethnodermatological use medicinal plants India still subject to conduct more studies see if there chemical, microbiological, and/or clinical evidence, from scientific perspective, their effectiveness for those skin disorders. Thus, this review can be basis further may provide targets drug development. We compile emphasize most important part ethnodermatology, namely, traditional applications several diseases India. also include brief explanation on dermatology Ayurvedic Unani medicine. pharmacological activity extracts derived some cited against problem as well. Different kinds key phrases such "Indian ethnodermatology", "ethnodermatology", "ethnobotany", "skin diseases", "Ayurveda dermatology", "pharmacological activity" were searched online search servers/databases Google Scholar (https://scholar.google.com/), ResearchGate (https://www.researchgate.net/), PubMed (https://pubmed.ncbi.nlm.nih.gov/), NISCAIR Online Periodicals Repository (NOPR) (http://nopr.niscair.res.in/). Based upon analyses data obtained 178 articles, we formulated findings which are summary shown Tables. A total 119 records plants' uses have been found across 39 diseases. These depicted with localities report, parts used, preparation administration methods The utilisation herbal medicine Indian subcontinent has great potential treat different human plant species used topical few only administrated orally. investigated mice, bacterial fungal pathogens, cells. Complementary therapy dermatological problems treatment remains main option millions people subcontinent. This practices ethnobotanical confirms belief analysis will accelerate discovery new, effective therapeutic agents However, evidence required determine identified contribute condition treatment, particularly atopic eczema. Today, ethnodermatology well-accepted international discipline many new initiated numerous countries. hope article development area identify generation natural treatments help meet growing consumer demand safe, sustainable, treatments. In context, research utilised elsewhere should intensified.
Language: Английский
Citations
114
ACS Nano, Journal Year: 2023, Volume and Issue: 17(5), P. 4601 - 4618
Published: Feb. 24, 2023
Injudicious or inappropriate use of antibiotics has led to the prevalence drug-resistant bacteria, posing a huge menace global health. Here, self-assembled aggregation-induced emission (AIE) nanosphere (AIE-PEG1000 NPs) that simultaneously possesses near-infrared region II (NIR-II) fluorescence emissive, photothermal, and photodynamic properties is prepared using multifunctional AIE luminogen (AIE-4COOH). The AIE-PEG1000 NPs were encapsulated with teicoplanin (Tei) ammonium bicarbonate (AB) into lipid nanovesicles form laser-activated "nanobomb" (AIE-Tei@AB NVs) for multimodal theranostics bacterial infections. In vivo experiments validate enables high-performance NIR-II fluorescence, infrared thermal, ultrasound (AB decomposition during photothermal process produce numerous CO2/NH3 bubbles, which an efficient contrast agent) imaging multidrug-resistant bacteria-infected foci after intravenous administration AIE-Tei@AB NVs followed by 660 nm laser stimulation. highly features NVs, combined excellent pharmacological property rapidly released Tei bubble generation NV disintegration, collectively promote broad-spectrum eradication three clinically isolated bacteria strains rapid healing infected wounds. This imaging-guided synergistic therapeutic strategy can be extended superbugs.
Language: Английский
Citations
85
Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 155, P. 113658 - 113658
Published: Sept. 23, 2022
Anti-microbial resistance (AMR) has recently emerged as an area of high interest owing to the rapid surge AMR phenotypes. Metal oxide NPs (MeONPs) have been identified novel phytomedicine and peaked a lot due their potential applications in combating phytopathogens, besides enhancing plant growth yields. Numerous MeONPs (Ti2O, MgO, CuO, Ag2O, SiO2, ZnO, CaO) synthesized tested validate antimicrobial roles without causing toxicity cells. This review discusses application with special emphasis on anti-microbial activities agriculture enlists how cellular caused through reactive oxygen species (ROS) production affects growth, morphology, viability. further highlights two-facet role silver copper including toxicities. Furthermore, factor modulating nanotoxicity immunomodulation for cytokine also discussed. Thus, this article will not only provide researchers bottlenecks but emphasizes comprehensive outline breakthroughs applicability agriculture.
Language: Английский
Citations
83
The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 821, P. 153472 - 153472
Published: Jan. 29, 2022
Antibiotic resistance is one of the current threats to human health, forcing use drugs that are more noxious, costlier, and with low efficiency. There several causes behind antibiotic resistance, including over-prescription antibiotics in both humans livestock. In this scenario, researchers shifting new alternatives fight back concerning situation.
Language: Английский
Citations
81
Journal of Cellular and Molecular Medicine, Journal Year: 2022, Volume and Issue: 26(11), P. 3083 - 3119
Published: May 2, 2022
Piper betle L. (synonym: betel Blanco), or vine, an economically and medicinally important cash crop, belongs to the family Piperaceae, often known as green gold. The plant can be found all over world is cultivatedprimarily in South East Asian countries for its beautiful glossy heart-shaped leaves, which are chewed consumed betelquidand widely used Chinese Indian folk medicine, carminative, stimulant,astringent, against parasitic worms, conjunctivitis, rheumatism, wound, etc., andis also religious purposes. Hydroxychavicol most bioactive compound among wide range of phytoconstituents essential oil extracts. pharmacological attributes P. antiproliferation, anticancer, neuropharmacological, analgesic, antioxidant, antiulcerogenic, hepatoprotective, antifertility, antibacterial, antifungal many more. Immense attention has been paid nanoformulations their applications. application did not show cytotoxicity preclinical experiments, suggesting that it could serve a promising therapeutic candidate different diseases. present review comprehensively summarizes botanical description, geographical distribution, economic value cultivation, ethnobotanical uses, properties with insights toxicological, clinical efficacy, safety betle. findings suggest represents orally active safe natural agent exhibits great potential managing various human medical conditions. However, further research needed elucidate underlying molecular mechanisms action, aspects, structure-activity relationships, bioavailability synergistic interactions other drugs.
Language: Английский
Citations
72
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 162 - 162
Published: Jan. 24, 2024
Biofilm formation is considered one of the primary virulence mechanisms in Gram-positive and Gram-negative pathogenic species, particularly those responsible for chronic infections promoting bacterial survival within host. In recent years, there has been a growing interest discovering new compounds capable inhibiting biofilm formation. This promising antivirulence strategy that could potentially overcome antibiotic resistance issues. Effective antibiofilm agents should possess distinctive properties. They be structurally unique, enable easy entry into cells, influence quorum sensing signaling, synergize with other antibacterial agents. Many these properties are found both natural systems isolated from plants synthetic like nanoparticles nanocomposites. this review, we discuss clinical nature biofilm-associated some associated their tolerance. We focus on advantages efficacy various as therapeutic approach to control biofilms address multidrug bacteria.
Language: Английский
Citations
17
Process Biochemistry, Journal Year: 2025, Volume and Issue: 150, P. 94 - 120
Published: Jan. 5, 2025
Language: Английский
Citations
2
Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 455 - 455
Published: Jan. 21, 2025
The escalating presence of antibiotic-resistant bacteria (ARB) in food systems presents a pressing challenge, particularly preventing contamination and ensuring safety. Traditional sanitation methods, such as cooking chemical disinfectants, provide effective means to reduce ARB, yet there is growing need for additional preventive measures directly on surfaces. This review explores the potential chitosan–phytochemical composites (CPCs) surface coatings prevent initial by thereby offering novel complementary approach conventional safety practices. Chitosan, combined with active plant-derived metabolites (phytochemicals), forms notable antibacterial antioxidant properties that enhance its protective effects. We examine CPC synthesis methodologies, including modifications, free radical-induced grafting, enzyme-mediated techniques, which stability activity CPCs against ARB. Highlighting recent findings CPCs’ efficacy through minimum inhibitory concentrations (MIC) zones inhibition, this underscores ARB risks surfaces, seafood, meat, postharvest products. insights provided here aim encourage future strategies leveraging preventative treatment mitigate production processing environments.
Language: Английский
Citations
2