Flavonoids and Their Role in Preventing the Development and Progression of MAFLD by Modifying the Microbiota DOI Open Access
Aneta Sokal, Sara Jarmakiewicz-Czaja, Rafał Filip

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11187 - 11187

Published: Oct. 17, 2024

With the increasing prevalence and serious health consequences of metabolic-associated fatty liver disease (MAFLD), early diagnosis intervention are key to effective treatment. Recent studies highlight important role dietary factors, including use flavonoids, in improving health. These compounds possess anti-inflammatory, antioxidant, liver-protective properties. Flavonoids have been shown affect gut microbiota, which plays a function progression. Therefore, their preventing development progression MAFLD through modulation microbiome seems be interest. This narrative review aims consolidate current evidence on effects selected flavonoids progression, potential mechanisms action, implications for personalized interventions management disease.

Language: Английский

Hepatoprotective effects of natural drugs: Current trends, scope, relevance and future perspectives DOI
Sonal Datta, Diwakar Aggarwal, Nirmala Sehrawat

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 121, P. 155100 - 155100

Published: Sept. 18, 2023

Language: Английский

Citations

23
The genetic architecture of biological age in nine human organ systems DOI
Junhao Wen, Ye Tian,

Ioanna Skampardoni

et al.

Nature Aging, Journal Year: 2024, Volume and Issue: 4(9), P. 1290 - 1307

Published: June 28, 2024

Language: Английский

Citations

13
Higher habitual intakes of flavonoids and flavonoid-rich foods are associated with a lower incidence of type 2 diabetes in the UK Biobank cohort DOI Creative Commons
Alysha S. Thompson, Amy Jennings, Nicola P. Bondonno

et al.

Nutrition and Diabetes, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 22, 2024

Abstract Aim To examine the associations of a diet high in flavonoid-rich foods, as reflected by “Flavodiet Score” (FDS), major individual food contributors to flavonoid intake, and subclasses with type 2 diabetes (T2D) risk UK Biobank cohort. Materials methods Flavonoid intakes were estimated from ≥2 dietary assessments among 113,097 study participants [age at enrolment: 56 ± 8 years; 57% female] using U.S Department Agriculture (USDA) databases. Multivariable Cox proportional hazards models used investigate between exposures T2D. Results During 12 years follow-up, 2628 incident cases T2D identified. A higher FDS (compared lower [Q4 vs. Q1]), characterised an average 6 servings foods per day, was associated 26% [HR: 0.74 (95% CI: 0.66–0.84), p trend = <0.001]. Mediation analyses showed that body fatness basal inflammation, well better kidney liver function partially explain this association. In food-based analyses, black or green tea, berries, apples significantly 21%, 15%, 12% risk. Among subclasses, 19–28% risks observed those highest, compared lowest intakes. Conclusions consumption risk, potentially mediated benefits obesity/sugar metabolism, function. Achievable increases specific have potential reduce

Language: Английский

Citations

10
The Effect of Flavonoids and Topiramate on Glucose Carbon Metabolism in a HepG2 Steatosis Cell Culture Model: A Stable Isotope Study DOI Open Access
Li Ma, Qing‐Yi Lu,

Shu Lim

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 564 - 564

Published: Jan. 31, 2025

Background: Insufficient treatment options are available for metabolic dysfunction-associated steatotic liver disease (MASLD). Flavonoids and topiramate have been studied weight loss but need investigation into their effects on metabolism. This study’s aim was to examine the of flavonoids or glucose carbon flux in a cell culture model steatosis. Methods: Steatosis induced HepG2 cells through exposure oleic acid (OA, 0.5 mml/L) conjugated bovine serum albumin (2:1). Additionally, 50% U13C-glucose supplied medium as stable isotope tracer. Cells were treated with DMSO, 10 μM naringenin, morin, silibinin, (44 μM) 72 h. A non-steatotic, untreated control included. Cell extracts analyzed by gas chromatography/mass spectrometry mass isotopomer distribution analysis glycogen synthesis, de novo fatty tricarboxylic (TCA) cycle activity, ribose synthesis. Groups compared ANOVA Tukey’s pair-wise testing. Results: Compared controls, OA-exposed exhibited increased lipid accumulation ORO staining (1.6-fold), enhanced palmitate reduced pyruvate carboxylase/pyruvate dehydrogenase (PC/PDH) ratio, Treatment silibinin ameliorated (1.3-fold) mitigated enhancement Morin-treated synthesis suppressed Conclusions: Potential mechanisms may include suppression relative decrease PDH pathway. Further studies needed potential utility MASLD based specific effects.

Language: Английский

Citations

1
The Roles of NFR2-Regulated Oxidative Stress and Mitochondrial Quality Control in Chronic Liver Diseases DOI Creative Commons
Jeong-Su Park, Nodir Rustamov,

Yoon-Seok Roh

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(11), P. 1928 - 1928

Published: Oct. 29, 2023

Chronic liver disease (CLD) affects a significant portion of the global population, leading to substantial number deaths each year. Distinct forms like non-alcoholic fatty (NAFLD) and alcoholic (ALD), though they have different etiologies, highlight shared pathologies rooted in oxidative stress. Central metabolism, mitochondria are essential for ATP production, gluconeogenesis, acid oxidation, heme synthesis. However, diseases NAFLD, ALD, fibrosis, mitochondrial function is compromised by inflammatory cytokines, hepatotoxins, metabolic irregularities. This dysfunction, especially electron leakage, exacerbates production reactive oxygen species (ROS), augmenting damage. Amidst this, nuclear factor erythroid 2-related 2 (NRF2) emerges as cellular protector. It not only counters stress regulating antioxidant genes but also maintains health overseeing autophagy biogenesis. The synergy between NRF2 modulation introduces new therapeutic potentials CLD, focusing on preserving integrity against threats. review delves into intricate role shedding light innovative strategies its prevention treatment, through pathways.

Language: Английский

Citations

22
Plant‐derived flavonoids are a potential source of drugs for the treatment of liver fibrosis DOI
Bolin Zhao, Kai Liu, Xing Liu

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(6), P. 3122 - 3145

Published: April 12, 2024

Abstract Liver fibrosis is a dynamic pathological process that can be triggered by any chronic liver injury. If left unaddressed, it will inevitably progress to the severe outcomes of cirrhosis or even hepatocellular carcinoma. In past few years, prevalence and fatality hepatic have been steadily rising on global scale. As result its intricate pathogenesis, quest for pharmacological interventions targeting has remained formidable challenge. Currently, no pharmaceuticals are exhibiting substantial clinical efficacy in management fibrosis. Hence, utmost importance expedite development novel therapeutics treatment this condition. Various research studies revealed ability different natural flavonoid compounds alleviate reverse through range mechanisms, which related regulation inflammation, oxidative stress, synthesis secretion fibrosis‐related factors, stellate cells activation, proliferation, extracellular matrix degradation these compounds. This review summarizes sources flavonoids with inhibitory effects over last decades. The anti‐fibrotic increasingly studied, making them potential source drugs due their good biosafety.

Language: Английский

Citations

8
Fruit and vegetable intake and the risk of non-alcoholic fatty liver disease: a meta-analysis of observational studies DOI Creative Commons
Rui Wang,

Ruijuan Yan,

Junzhe Jiao

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: June 21, 2024

This systematic review and meta-analysis of clinical observational studies aims to clarify the correlation between intake levels fruits vegetables non-alcoholic fatty liver disease (NAFLD).

Language: Английский

Citations

8
From gut to liver: unveiling the differences of intestinal microbiota in NAFL and NASH patients DOI Creative Commons
Furong Huang, Bo Lyu,

Fanci Xie

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: April 4, 2024

Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized for its global prevalence and potential progression to more severe diseases such as non-alcoholic steatohepatitis (NASH). The gut microbiota plays a pivotal role in the pathogenesis of NAFLD, yet detailed characteristics ecological alterations microbial communities during from (NAFL) NASH remain poorly understood. Methods: In this study, we conducted comparative analysis composition individuals with NAFL elucidate differences characteristics. We utilized 16S rRNA sequencing compare intestinal among healthy control group (65 cases), (64 (53 cases). Random forest machine learning database validation methods were employed analyze data. Results: Our findings indicate significant decrease diversity flora NAFLD ( p &lt; 0.05). At phylum level, high abundances Bacteroidetes Fusobacteria observed both patients, whereas Firmicutes less abundant. genus Prevotella expression was seen (AUC 0.738), an increase combination Megamonas Fusobacterium noted 0.769). Furthermore, KEGG pathway highlighted disturbances various types glucose metabolism pathways compared group, well notably compromised flavonoid flavonol biosynthesis functions. study uncovers distinct microecological changes within transition NASH, providing insights that could facilitate discovery novel biomarkers therapeutic targets NAFLD.

Language: Английский

Citations

7
The Genetic Architecture of Biological Age in Nine Human Organ Systems DOI Creative Commons
Junhao Wen, Ye Tian,

Ioanna Skampardoni

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 12, 2023

Abstract Understanding the genetic basis of biological aging in multi-organ systems is vital for elucidating age-related disease mechanisms and identifying therapeutic interventions. This study characterized architecture age gap (BAG) across nine human organ 377,028 individuals European ancestry from UK Biobank. We discovered 393 genomic loci-BAG pairs (P-value<5×10 -8 ) linked to brain, eye, cardiovascular, hepatic, immune, metabolic, musculoskeletal, pulmonary, renal systems. observed BAG-organ specificity inter-organ connections. Genetic variants associated with BAGs are predominantly specific respective system while exerting pleiotropic effects on traits multiple A gene-drug-disease network confirmed involvement metabolic BAG-associated genes drugs targeting various disorders. correlation analyses supported Cheverud’s Conjecture 1 – between mirrors their phenotypic correlation. causal revealed potential linking chronic diseases (e.g., Alzheimer’s disease), body weight, sleep duration BAG Our findings shed light promising interventions enhance health within a complex network, including lifestyle modifications drug repositioning strategies treating diseases. All results publicly available at https://labs-laboratory.com/medicine .

Language: Английский

Citations

12
Associations of the Intake of Individual and Multiple Flavonoids with Metabolic Dysfunction Associated Steatotic Liver Disease in the United States DOI Open Access
Chen Wang,

Meng-Chu Li,

Jiali Zhang

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 205 - 205

Published: Jan. 7, 2025

Evidence regarding the individual and combined impact of dietary flavonoids on risk metabolic dysfunction associated with steatotic liver disease (MASLD) remains scarce. Our objective is to evaluate association between multiple MASLD in adults. Data sets were obtained from National Health Nutrition Examination Survey (NHANES), 2017-2018. In total, 2581 participants aged over 18 years, complete information flavonoid intake, MASLD, covariates, included. Flavonoid intake was energy-adjusted using residual method. Logistic regression analysis employed examine total MASLD. Weighted quantile sum (WQS) analyses used effects identify predominant types most significant contribution prevention. The highest tertile a 29% reduction compared lowest after multivariable adjustments (OR: 0.71, 95% CI: 0.51-0.97). WQS revealed that anthocyanidins, flavones, flavanones critical contributors among six subclasses (weights = 0.317, 0.279, 0.227, respectively) naringenin, apigenin, delphinidin 29 monomers. 0.240, 0.231, 0.114, respectively). Also, higher linked reduced (p < 0.05). findings suggested lower flavanones, delphinidin, myricetin contributing protective flavonoids.

Language: Английский

Citations

0