Mitochondrial ROS, a trigger for mitochondrial dysfunction and inflammasome activation and a therapeutic target in liver diseases DOI Creative Commons

Hala Saeed Jaara,

Sandra Torres

Published: Dec. 10, 2024

Mitochondria are essential organelles responsible for intracellular energy production and play crucial roles in cellular metabolism, inflammation, apoptosis. Reactive oxygen species (ROS) primarily produced the mitochondria endoplasmic reticulum of hepatocytes due to activity cytochrome P450 enzymes. Under ideal conditions, cells have specific molecular mechanisms that manage oxidative stress levels, thus ensuring a balance between oxidants antioxidants. The interplay ROS-induced mitochondrial dysfunction activation NLRP3 (nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3) inflammasome context liver diseases has been extensively studied. However, exact by which promote contribute onset disease remain unclear. This review aims elucidate recently discovered regulation disorders, including alcohol-related (ALD), metabolic-associated steatotic (MASLD), hepatocellular carcinoma (HCC). Finally, it summarizes various natural pharmaceutical agents can mitigate damage modulating through pathways. work serves as an important resource identifying new therapeutic approaches provides further support advancing understanding diseases.

Language: Английский

Antioxidant-Rich Functional Foods and Exercise: Unlocking Metabolic Health Through Nrf2 and Related Pathways DOI Open Access
Halyna Tkachenko, Natalia Kurhaluk

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1098 - 1098

Published: Jan. 27, 2025

This article reviews the synergistic effects of antioxidant-enriched functional foods and exercise in improving metabolic health, focusing on underlying molecular mechanisms. The review incorporates evidence from PubMed, SCOPUS, Web Science, PsycINFO, reference lists relevant up to 20 December 2024, highlighting central role Nrf2 pathway. As a critical regulator oxidative stress adaptation, mediates benefits these interventions. presents an innovative approach understanding regulation inflammation, its potential prevention treatment various diseases, including cancer, neurodegenerative disorders, cardiovascular pulmonary diabetes, inflammatory conditions, ageing, infections such as COVID-19. novelty this study is investigate bioactive compounds found (such polyphenols, flavonoids, vitamins) exercise-induced activation combined reveals their improve insulin sensitivity lipid metabolism reduce offering promising strategy for management chronic diseases. However, there are significant gaps current research, particularly regarding mechanisms interaction between diet, physical activity, activation, well long-term different populations, those with In addition, interactions other signalling pathways, AMPK, NF-κB, PI3K/Akt, collective contributions health explored. Furthermore, novel biomarkers presented assess impact strategies, NAD+/NADH ratio, GSH markers mitochondrial health. findings provide valuable insights into how integration antioxidant-rich diet regular can by activating related pathways represent strategies disorders. Further studies needed fully understand therapeutic interventions diseases stress, disease, cancer.

Language: Английский

Citations

2
Emerging advanced approaches for diagnosis and inhibition of liver fibrogenesis DOI Creative Commons

Tamer A. Addissouky,

Majeed M. A. Ali, Ibrahim El Tantawy El Sayed

et al.

The Egyptian Journal of Internal Medicine, Journal Year: 2024, Volume and Issue: 36(1)

Published: Feb. 12, 2024

Abstract Background Liver fibrosis results from chronic liver injury and is characterized by excessive deposition of extracellular matrix proteins including collagen. It can progress to cirrhosis failure. Main body the abstract Multiple cellular signaling pathways drive hepatic stellate cell activation fibrogenesis. Advances in biomarkers, imaging modalities, omics platforms enable noninvasive diagnosis staging fibrosis. Emerging antifibrotic approaches include medications like pirfenidone, obeticholic acid, monoclonal antibodies targeting pro-fibrotic mediators. Cell therapies using mesenchymal stem cells demonstrate potential through paracrine immunosuppression. Tissue-engineered grafts biomaterial carriers for localized drug delivery are promising technologies. Microfluidic liver-on-a-chip with patient-derived provide unprecedented models study human test candidates. Short conclusion Significant has elucidated mechanisms underlying fibrogenesis uncovered novel therapeutic targets. Ongoing challenges translating preclinical findings, improving efficacy, enabling personalized precision medicine approaches. Further research into combinatorial therapies, tissue engineering technologies will advance treatment all causes.

Language: Английский

Citations

9
Caffeic acid ameliorates metabolic dysfunction-associated steatotic liver disease via alleviating oxidative damage and lipid accumulation in hepatocytes through activating Nrf2 via targeting Keap1 DOI
Jinyu Zhang, Hao Ouyang,

Xin-Nan Gu

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 224, P. 352 - 365

Published: Aug. 28, 2024

Language: Английский

Citations

9
Antioxidant Effects and Potential Molecular Mechanism of Action of Diplocyclos palmatus (L.) C. Jeffrey Fruits Based on Systematic Network Pharmacology with Experimental Validation DOI
Mitesh Patel,

Lamya Ahmed Al‐Keridis,

Sarah Owdah Alomrani

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1313, P. 138638 - 138638

Published: May 14, 2024

Language: Английский

Citations

6
The Mitochondrial-Derived Peptide MOTS-c Alleviates Radiation Pneumonitis via an Nrf2-Dependent Mechanism DOI Creative Commons
Yanli Zhang,

Jianfeng Huang,

Yaru Zhang

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 613 - 613

Published: May 17, 2024

Radiation pneumonitis (RP) is a prevalent and fatal complication of thoracic radiotherapy due to the lack effective treatment options. RP primarily arises from mitochondrial injury in lung epithelial cells. The mitochondrial-derived peptide MOTS-c has demonstrated protective effects against various diseases by mitigating injury. C57BL/6 mice were exposed 20 Gy irradiation (IR) received daily intraperitoneal injections for 2 weeks. significantly ameliorated tissue damage, inflammation, oxidative stress caused radiation. Meanwhile, reversed apoptosis damage alveolar cells mice. Furthermore, inhibited MLE-12 primary mouse Mechanistically, increased nuclear factor erythroid 2-related (Nrf2) level promoted its translocation. Notably, Nrf2 deficiency abolished function with RP. In conclusion, alleviates protecting through an Nrf2-dependent mechanism, indicating that may be novel potential agent

Language: Английский

Citations

4
Human Umbilical Cord-Derived Mesenchymal Stem Cells Attenuate Liver Fibrosis by Inhibiting Hepatocyte Ferroptosis Through Mitochondrial Transfer DOI Creative Commons

Zhiyu Xiong,

Ping Chen, Zheng Wang

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: 231, P. 163 - 177

Published: Feb. 27, 2025

Language: Английский

Citations

0
Diet, oxidative stress and MAFLD: a mini review DOI Creative Commons
Zhiai Hu, Hui Yue,

Na Jiang

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 4, 2025

Globally, metabolic dysfunction-associated fatty liver disease (MAFLD), also known as non-alcoholic (NAFLD) or steatotic (MASLD), is a common chronic disease. The progression of MAFLD leads to vicious cycle in which oxidative stress results from the that augmenting de-novo lipid levels and increases steatosis. Most non-enzymatic antioxidants are present food. Therefore, review summarizes findings studies on food-derived presents an stress-related regulatory network MAFLD, offering new ideas for prevention treatment.

Language: Английский

Citations

0
Silymarin attenuates post-weaning bisphenol A-induced renal injury by suppressing ferroptosis and amyloidosis through Kim-1/Nrf2/HO-1 signaling modulation in male Wistar rats DOI
Roland Eghoghosoa Akhigbe, Adebayo Oluwafemi Adekunle, Moyosore Salihu Ajao

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151668 - 151668

Published: March 1, 2025

Language: Английский

Citations

0
Antioxidant Properties of Dendrobium nobile and its Potential Health Benefits DOI
Archana Jain, Surendra Sarsaiya, Qihai Gong

et al.

CABI eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 61 - 79

Published: March 24, 2025

Language: Английский

Citations

0
Cell-Free DNA (cfDNA) Regulates Metabolic Remodeling, Sustaining Proliferation, Quiescence, and Migration in MDA-MB-231, a Triple-Negative Breast Carcinoma (TNBC) Cell Line DOI Creative Commons
Isabel Lemos, Catarina Freitas-Dias,

Ana Hipólito

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(4), P. 227 - 227

Published: March 27, 2025

Background: The clinical relevance of circulating cell-free DNA (cfDNA) in oncology has gained significant attention, with its potential as a biomarker for cancer diagnosis and monitoring. However, precise role biology progression remains unclear. cfDNA patients' blood been shown to activate signaling pathways, such those mediated by toll-like receptors (TLRs), suggesting involvement cell adaptation the tumor microenvironment. Methods: This impact released from MDA-MB-231, triple-negative breast (TNBC) line was assessed, focusing on glucose availability culture duration. proliferation MDA-MB-231 cells investigated using curves, while cellular migration evaluated through wound healing assays. metabolic alterations induced distinct variants were nuclear magnetic resonance (NMR) spectroscopy, their effect cisplatin resistance flow cytometry. Furthermore, expression levels DNA-sensitive Toll-like receptor 9 (TLR9) quantified via immunofluorescence, alongside colocalization lysosome-associated membrane protein 1 (LAMP1). Results: study indicates that facilitates adaptation, particularly under stress, modulating glutamine consumption, key pathways metabolism. Exposure shifts, favoring energy production oxidative phosphorylation. anti-cancer activity isolated conditioned media cultured stressful conditions is influenced duration, emphasizing importance se-lection releasing can drive pro-tumoral processes. Additionally, exposure proliferation, quiescence, migration, processes linked metastasis treatment resistance. These findings underscore mediator reprogramming adaptive responses cells, contributing therapy activation TLR9 suggests mechanistic basis cfDNA-induced phenotypic changes. Conclusions: Overall, serves crucial molecule microenvironment, orchestrating enhance survival progression.

Language: Английский

Citations

0