Targeted Nanoparticle-Based Diagnostic and Treatment Options for Pancreatic Cancer

Cancers, Journal Year: 2024, Volume and Issue: 16(8), P. 1589 - 1589

Published: April 20, 2024

Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest cancers, presents significant challenges in diagnosis and treatment due to its aggressive, metastatic nature lack early detection methods. A key obstacle PDAC is highly complex tumor environment characterized by dense stroma surrounding tumor, which hinders effective drug delivery. Nanotechnology can offer innovative solutions these challenges, particularly creating novel delivery systems for existing anticancer drugs PDAC, such as gemcitabine paclitaxel. By using customization methods incorporating conjugated targeting ligands, tumor-penetrating peptides, therapeutic nucleic acids, nanoparticle-based enhance solubility, extend circulation time, improve targeting, control release, thereby minimizing side effects toxicity healthy tissues. Moreover, nanoparticles have also shown potential precise diagnostic PDAC. This literature review will delve into targeted mechanisms, pathways, approaches treating pancreatic cancer. Additional emphasis placed on study systems, with a brief mention those clinical trials. Overall, overview illustrates advances nanomedicine, underscoring role transcending constraints conventional therapies diagnostics.

Language: Английский

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Artificial intelligence applied in cardiovascular disease: a bibliometric and visual analysis

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Feb. 16, 2024

Background With the rapid development of technology, artificial intelligence (AI) has been widely used in diagnosis and prognosis prediction a variety diseases, including cardiovascular disease. Facts have proved that AI broad application prospects accurate diagnosis. Objective This study mainly summarizes research on field disease through bibliometric analysis explores possible future hotpots. Methods The articles reviews regarding between 2000 2023 were selected from Web Science Core Collection 30 December 2023. Microsoft Excel 2019 was applied to analyze targeted variables. VOSviewer (version 1.6.16), Citespace 6.2.R2), online platform conduct co-authorship, co-citation, co-occurrence countries, institutions, authors, references, keywords this field. Results A total 4,611 study. AI-related increased exponentially recent years, which USA most productive country with 1,360 publications, had close cooperation many countries. institutions researchers Cedar sinai medical center Acharya, Ur. However, among or not even if high outputs. Circulation is journal largest number publications important are “classification”, “diagnosis”, “risk”. Meanwhile, current hotpots “late gadolinium enhancement” “carotid ultrasound”. Conclusions disease, growing scholars devoted Cardiovascular imaging techniques selection appropriate algorithms represent extensively studied areas, considerable boost these areas predicted coming years.

Language: Английский

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Mapping knowledge structure and research of the biologic treatment of asthma: A bibliometric study

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 9, 2023

Background Bronchial asthma (asthma) is a chronic inflammatory disease of the airways, involving variety cells and cellular components, that manifests clinically as recurrent episodes wheezing, shortness breath, with or without chest tightness cough, airway hyperresponsiveness, variable airflow limitation. The number people has reached 358 million worldwide causes huge economic loss. However, there subset patients who are not sensitive to existing drugs have many adverse effects. Therefore, it’s important find new for patients. Methods Publications related biologics in published from 2000 2022 were retrieved Web Science Core Collection. search strategies follows: topic: TS=(biologic* OR “biologic* product*” therap*” biotherapy* agent*” Benralizumab “MEDI-563” Fasenra “BIW-8405” Dupilumab SAR231893 “SAR-231893” Dupixent REGN668 “REGN-668” Mepolizumab Bosatria “SB-240563” SB240563 Nucala Omalizumab Xolair Reslizumab “SCH-55700” SCH55700 “CEP-38072” CEP38072 Cinqair “DCP-835” DCP835 Tezspire “tezepelumab-ekko” “AMG-157” tezspire “MEDI-9929” “MEDI-19929” MEDI9929 Itepekimab “REGN-3500”OR REGN3500 “SAR-440340”OR SAR440340 Tralokinumab “CAT-354” Anrukinzumab “IMA-638” Lebrikizumab “RO-5490255”OR “RG-3637”OR “TNX-650”OR “MILR1444A”OR “MILR-1444A”OR”PRO301444”OR “PRO-301444”OR Pitrakinra altrakincept “AMG-317”OR”AMG317” Etokimab Pascolizumab “IMA-026”OR Enokizumab “MEDI-528”OR “7F3COM-2H2” 7F3COM2H2 Brodalumab “KHK-4827” “KHK4827”OR “AMG-827”OR Siliq Ligelizumab “QGE-031” QGE031 Quilizumab Talizumab “TNX-901” TNX901 Infliximab Etanercept “PRS-060”) AND TS=asthma*. document type was set articles review language restriction English. Three different analysis tools including one online platform, VOS viewer1.6.18, CiteSpace V 6.1.R1 software used conduct this bibliometric study. Results This study included 1,267 English papers 244 journals 2,012 institutions 69 countries/regions. Omalizumab, benralizumab, mepolizumab, tezepelumab relation research hotspots field. Conclusion systematically uncovers holistic picture literature biologic treatment over past 20 years. We consulted scholars order understand key information field perspective bibliometrics, which we believe may greatly facilitate future

Language: Английский

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Nanomedicine and epigenetics: New alliances to increase the odds in pancreatic cancer survival

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115179 - 115179

Published: July 21, 2023

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers worldwide, primarily due to its robust desmoplastic stroma and immunosuppressive tumor microenvironment (TME), which facilitate progression metastasis. In addition, fibrous tissue leads sparse vasculature, high interstitial fluid pressure, hypoxia, thereby hindering effective systemic drug delivery immune cell infiltration. Thus, remodeling TME enhance perfusion, increase retention, reverse immunosuppression has become a key therapeutic strategy. recent years, targeting epigenetic pathways emerged as promising approach overcome cancer progression. Moreover, progress in nanotechnology provided new opportunities for enhancing efficacy of conventional drugs. Nano-based systems (NDDSs) offer several advantages, including improved pharmacokinetics, enhanced penetration, reduced toxicity. Smart NDDSs enable precise stromal components augment effectiveness immunotherapy through multiple options. This review offers an overview latest nano-based approaches developed achieve superior resistance. We specifically focus on epigenetic-targeted therapies context PDAC, discussing advantages limitations current strategies while highlighting developments. By emphasizing immense potential improving outcomes our paves way future research this rapidly evolving field.

Language: Английский

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Global trends in research related to functional dyspepsia and anxiety or depression over the past two decades: a bibliometric analysis

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Nov. 2, 2023

Functional dyspepsia (FD) is a prevalent global disorder of the upper digestive tract characterized by functional impairment. It often coexists with anxiety/depression, significantly impairing occupational productivity and overall quality life. This study aimed to identify emerging patterns prominent themes within FD anxiety/depression research through bibliometric analysis help explore new innovative avenues for investigating this type FD. A comprehensive review literature encompassing was conducted using Science Citation Index Extension Web Core Collection from 2003 2023. Information extracted comprised "Full Record Cited References." Bibliometric relevant publications, including country, institution, author, journal, citations, keywords, CiteSpace, VOSviewer, Bibliometrix package in R Excel. Studies related have demonstrated an ascending trajectory since 2003. Our identified 338 studies published NEUROGASTROENTEROLOGY AND MOTILITY emerged as most prolific while GASTROENTEROLOGY retained pre-eminence top 10 journals. China two institutions terms volume publications. The Mayo Clinic stood foremost institution publication volume, Chengdu University Traditional Chinese Medicine exhibiting robust collaborative engagement. Eminent author influence attributed Talley NJ Newcastle University, Australia. Clusters extensively cited papers keywords delineate status trend research. encompasses FD, anxiety, depression, sleep disorders, gastrointestinal disorders. Furthermore, timeline view map or trend-term suggested that duodenal low-grade inflammation ("duodenal eosinophilia" "mast cells") might be concern associated anxiety/depression. Employing analysis, revealed focal areas trends These insights serve valuable guidance scholars seeking delve into avenues.

Language: Английский

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Research Progress of Nanodelivery Systems for Pancreatic Cancer

Highlights in Science Engineering and Technology, Journal Year: 2025, Volume and Issue: 125, P. 264 - 270

Published: Feb. 18, 2025

Pancreatic cancer is characterised by its aggressive nature and poor prognosis, mainly due to complex biology. The tumour microenvironment plays an important role composed of different cellular components that enable growth metastasis. Cellular heterogeneity further complicates treatment, as cell populations within the behave respond differently treatment. Against this background, nano-delivery systems such liposomes, micelles exosomes have emerged promising strategies improve drug delivery efficacy. These can bioavailability targeting overcome some limitations conventional therapies. However, challenges remain in optimising mechanisms, ensuring biocompatibility managing complexity microenvironment. Future research should focus on overcoming these obstacles order realise full potential nanotransduction treatment pancreatic cancer.

Language: Английский

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A bibliometric and visual analysis of the research status and hotspots of Pulmonary Aspergillosis based on Web of Science

Diagnostic Microbiology and Infectious Disease, Journal Year: 2025, Volume and Issue: 112(4), P. 116864 - 116864

Published: April 20, 2025

Language: Английский

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Current trends and emerging patterns in the application of nanomaterials for ovarian cancer research: a bibliometric analysis

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: March 8, 2024

Introduction: Ovarian cancer remains to be a significant cause of global cancer-related mortality. In recent years, there has been surge studies in investigating the application nanomaterials diagnosis and treatment ovarian cancer. This study aims conduct comprehensive bibliometric analysis regarding nanomaterial-based researches on evaluate current state emerging patterns this field. Methods: A thorough literature search Web Science Core Collection database was conducted identify articles focused researches. The that met inclusion criteria were selected for further analysis. VOSviewer CiteSpace applied visual analyses publications. Results: total 2,426 included study. number annual publications showed consistent upward trend from 2003 2023. Notably, China, United States, India have emerged as leading contributors field, accounting 37.39%, 34.04%, 5.69% publications, respectively. Chinese Academy Sciences Anil K. Sood identified most influential institution author, Furthermore, International Journal Nanomedicine frequently cited journal. terms research focus, attention directed towards nanomaterial-related drug delivery, while exploration immunogenic cell death metal-organic frameworks represented areas interest. Conclusion: Through analyses, an overview trends interest illustrated. These findings offered valuable insights into status future directions dynamic

Language: Английский

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Knowledge mapping and research trends of exosomes in pancreatic cancer: a bibliometric analysis and review (2013-2023)

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: April 24, 2024

This review aims to provide a quantitative and qualitative bibliometric analysis of literature from 2013 2023 on the role exosomes in PC, with goal identifying current trends predicting future hotspots.

Language: Английский

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Mapping the intellectual structure and landscape of nano-drug delivery systems in colorectal cancer

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 14, 2023

Background: Colorectal cancer (CRC) is a prevalent malignancy affecting the digestive tract, and its incidence has been steadily rising over years. Surgery remains primary treatment modality for advanced colorectal cancer, complemented by chemotherapy. The development of drug resistance to chemotherapy significant contributor failure in cancer. Nanodrug delivery systems (NDDS) can significantly improve efficacy antitumor drugs multiple ways. However, there lack visualization NDDS research structures hotspots field elaboration potential areas be discovered. Objective: To comprehensively explore current status trend CRC research. Methods: Bibliometric analysis articles reviews on published between 2002 2022 using tools including CiteSpace, VOSviewer, R-bibliometrix, Microsoft Excel was performed. Results: A total 1866 publications authored 9,870 individuals affiliated with 6,126 institutions across 293 countries/regions were included analysis. These appeared 456 journals. Abnous Khalil highest number this field. most journals are International Journal Nanomedicine, Pharmaceutics, Biomaterials. Notably, Controlled Release citation count third-highest H-index. Thematic identified "inflammatory bowel disease"," "oral delivery," "ulcerative colitis" as requiring further development. Keyword revealed that colitis," "exosomes," "as1411"have emerged keywords within last 2 emerging may become focal points future Conclusion: Our findings reveal landscape intellectual structure which helps researchers understand trends hot spots

Language: Английский

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