International Immunopharmacology, Journal Year: 2024, Volume and Issue: 138, P. 112553 - 112553
Published: June 28, 2024
Lung adenocarcinoma (LUAD) is the most common and aggressive cancer with a high incidence. N1-specific pseudouridine methyltransferase (EMG1), highly conserved nucleolus protein, plays an important role in biological development of ribosomes. However, EMG1 progression LUAD still unclear.
Language: Английский
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 28, 2024
Background Cervical carcinoma (CC) represents a prevalent gynecological neoplasm, with discernible rise in prevalence among younger cohorts observed recent years. Nonetheless, the intrinsic cellular heterogeneity of CC remains inadequately investigated. Methods We utilized single-cell RNA sequencing (scRNA-seq) transcriptomic analysis to scrutinize tumor epithelial cells derived from four specimens cervical patients. This method enabled identification pivotal subpopulations and elucidation their contributions progression. Subsequently, we assessed influence associated molecules bulk (Bulk RNA-seq) performed experiments for validation purposes. Results Through our analysis, have discerned C3 PLP2+ Tumor Epithelial Progenitor Cells as noteworthy subpopulation (CC), exerting on differentiation progression CC. established an independent prognostic indicator—the EPCs score. By stratifying patients into high low score groups based median score, that high-score group exhibits diminished survival rates compared low-score group. The correlations between these immune infiltration, enriched pathways, single-nucleotide polymorphisms (SNPs), drug sensitivity, other factors, further underscore impact prognosis. Cellular validated significant ATF6 proliferation migration cell lines. Conclusion study enriches comprehension determinants shaping CC, elevates cognizance microenvironment offers valuable insights prospective therapies. These discoveries contribute refinement diagnostics formulation optimal therapeutic approaches.
Language: Английский
Citations
32
Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e26604 - e26604
Published: Feb. 24, 2024
BackgroundColorectal cancer (CRC) is the third most prevalent tumor globally. The liver common site for CRC metastasis, and involvement of a cause death in patients with late-stage CRC. Consequently, mitigating metastasis (CRLM) key to improving prognosis increasing survival. Exercise has been shown be an effective method many types. However, ability exercise inhibit CRLM yet thoroughly investigated.MethodsThe GSE157600 GSE97084 datasets were used analysis. A pan-cancer dataset which was uniformly normalized downloaded analyzed from UCSC database: TCGA, TARGET, GTEx (PANCAN, n = 19,131, G 60,499). Several advanced bioinformatics analyses conducted, including single-cell sequencing analysis, correlation algorithm, prognostic screen. microarray (TMA) as well cell/animal experiments are further validate results analysis.ResultsThe greatest variability found epithelial cells group. RPS4X generally upregulated all types CRC, while downregulated expression. lowered expression may prolong survival reduce metastasis. stemness marker-CD44 highly positively correlated knockdown reduced both vitro vivo.ConclusionRPS4X upregulation enhance increase odds through regulation RPS4X.
Language: Английский
Citations
9
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Aug. 24, 2023
Lung cancer constitutes a formidable menace to global health and well-being, as its incidence mortality rate escalate at an alarming pace. In recent years, research has indicated that exercise potential roles in both the prevention treatment of lung cancer. However, exact mechanism coordinating effect on is unclear, limiting use clinical practice. The purpose this review explore mechanisms through which exerts anticancer effects against This will analyze biological basis exercise’s cancer, with focus aspects such tumor microenvironment, matrix regulation, apoptosis angiogenesis. Finally, we discuss future directions applications.
Language: Английский
Citations
20
BMB Reports, Journal Year: 2023, Volume and Issue: 56(7), P. 365 - 373
Published: June 1, 2023
Loss of skeletal muscle mass is a primary feature sarcopenia and cancer cachexia. In patients, tumor-derived inflammatory factors promote atrophy via tumor-to-muscle effects, which closely associated with poor prognosis. During the past decade, has been considered to function as an autocrine, paracrine, endocrine organ by releasing numerous myokines. The circulating myokines can modulate pathophysiology in other organs, well tumor microenvironment, suggesting muscleto-tumor signaling molecules. Here, we highlight roles tumorigenesis, particularly terms crosstalk between tumor. Better understanding muscle-to-tumor effects will shed light on novel strategies for diagnosis treatment cancer. [BMB Reports 2023; 56(7): 365-373].
Language: Английский
Citations
19
Frontiers in Genetics, Journal Year: 2023, Volume and Issue: 13
Published: Jan. 9, 2023
Head and neck squamous cell carcinoma (HNSCC), the most common malignancy of head neck, has an overall 5-year survival rate <50%. Genes associated with cuproptosis, a newly identified copper-dependent form death, are aberrantly expressed in various tumours. However, their role HNSCC remains unknown. In this study, bioinformatic analysis revealed that cuproptosis-related gene CDKN2A was correlated malignant behaviour HNSCC. Kaplan-Meier (KM) curves showed patients high expression had better prognosis. Multiomic may be cycle immune infiltration tumour microenvironment is important for maintaining systemic homeostasis body. Furthermore, molecular docking dynamics simulations suggested strong binding between plicamycin CDKN2A. And inhibits progression cellular assays. conclusion, study elucidated potential mechanism action cuproptosis-associated targets to improve prognosis patients.
Language: Английский
Citations
17
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: July 31, 2024
Breast cancer ranks as one of the most prevalent malignancies among women globally, with increasing incidence rates. Physical activity, particularly exercise, has emerged a potentially significant modifier prognosis, influencing tumor biology and patient outcomes.
Language: Английский
Citations
7
Military Medical Research, Journal Year: 2024, Volume and Issue: 11(1)
Published: Jan. 2, 2024
Abstract Background One-third of veterans returning from the 1990–1991 Gulf War reported a myriad symptoms including cognitive dysfunction, skin rashes, musculoskeletal discomfort, and fatigue. This symptom cluster is now referred to as Illness (GWI). As underlying mechanisms GWI have yet be fully elucidated, diagnosis treatment are based on symptomatic presentation. One confounding factor tied illness high presence post-traumatic stress disorder (PTSD). Previous research efforts demonstrated that both PTSD associated with immunological dysfunction. such, this endeavor aimed provide insight into complex relationship between symptoms, cytokine presence, immune cell populations pinpoint impact these measures in GWI. Methods Symptom were gathered through Multidimensional fatigue inventory (MFI) 36-item short form health survey (SF-36) scales biological obtained & cytometry analysis. Subgrouping was conducted using Davidson Trauma Scale scores Structured Clinical Interview for Diagnostic statistical manual mental disorders (DSM)-5, probability (GWI H ) low L ). Data analyzed Analysis variance (ANOVA) analysis along correlation graph We mapped correlations cells signaling measures, hormones identify patterns regulation , healthy control groups. Results comorbid resulted poorer outcomes compared Healthy (HC) subgroup. Significant differences found basophil levels HC at peak exercise regardless comorbidity (ANOVA F = 4.7, P 0.01,) indicating its potential usage biomarker general control. While unique identification less clear, subgroup delineated IL-15 across an challenge > 3.75, < 0.03). Additional natural killer (NK) numbers function highlight absence symptoms. Conclusion conclude disentangling by defining trauma-based subgroups may aid biosignatures can help improve target more effectively.
Language: Английский
Citations
5
Cancer Medicine, Journal Year: 2024, Volume and Issue: 13(3)
Published: Jan. 17, 2024
Abstract Background Mammary carcinoma, a pervasive and potentially lethal affliction, is conjectured to be profoundly influenced by physical exercise, both in prophylaxis therapeutic contexts. This study endeavors explore the repercussions of exercise training on progression mammary particularly mechanisms which amalgamation an regimen doxorubicin induces tumor cell apoptosis. Methods Female BALB/c mice were categorized into four distinct groups: A sedentary group (SED), (Ex), (Dox, 5 mg/kg), combined treatment (Dox + Ex). The lasted for 21 days included aerobic rotarod resistance training. impact growth, immune proportions, inflammatory factor levels, apoptosis pathway was assessed. Results Exercise significantly curtailed growth mouse model breast cancer. Both Ex Dox groups exhibited significant reductions volume weight ( p < 0.01) comparison SED group, while had lower than 0.01). also increased proportion NK T cells various parts body tissue, decreasing blood vessels density. IL‐6 IL‐15 levels altered expression apoptosis‐related proteins with showing even more changes. Conclusions Physical improves effectiveness treating cancer activating cytotoxic cells, releasing suppressor factors, initiating mt‐apoptosis, all mitigating adverse effects chemotherapy.
Language: Английский
Citations
4
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Aug. 5, 2024
Breast cancer, one of the most prevalent malignancies among women worldwide, has rising incidence rates. Physical activity, particularly exercise, emerged as a significant modifier cancer prognosis, influencing both tumor biology and patient outcomes.
Language: Английский
Citations
4
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 22, 2025
Bladder cancer is one of the most common malignancies urinary system and has always presented great challenges in treatment due to its intricate biological features high recurrence rates. Although developments were achieved immunotherapy targeted therapies within last decade, therapeutic outcomes for a number patients remain unsatisfactory, particularly as long-term efficacy. Review discusses molecular mechanisms developed during process bladder progression: genetic epigenetic alterations, dynamics tumor microenvironment (TME), dysregulation abnormal activation various signaling pathways—all contributing resistance. It mutation, especially both low- high-grade tumors, that, alongside modifications, plays considerable role aggressiveness drug TME, comprising cancer-associated fibroblasts (CAFs), immunosuppressive cells, different components extracellular matrix (ECM), orchestrates setting that fosters growth immune evasion confers resistance on any regime might be used. The review also provides an overview PI3K/AKT MAPK pathways progression development against them. Further, it immunotherapy, including those involving checkpoint inhibitors. Other promising approaches include new strategies target not only but checkpoints combination therapies. This aims contribute elaboration more effective personalized by fully understanding underlying involved cancer.
Language: Английский
Citations
0