European Journal of Medicinal Chemistry Reports, Journal Year: 2024, Volume and Issue: 12, P. 100239 - 100239
Published: Nov. 4, 2024
Language: Английский
Molecules, Journal Year: 2024, Volume and Issue: 29(4), P. 896 - 896
Published: Feb. 18, 2024
Non-communicable diseases (NCDs) are described as a collection of chronic that do not typically develop from an acute infection, have long-term health effects, and frequently require ongoing care therapy. These include heart disease, stroke, cancer, lung neurological diseases, osteoporosis, mental disorders, etc. Known synthetic drugs for the treatment or prevention NCDs become increasingly dangerous over time pose high risks due to side effects such hallucination, attack, liver failure, As result, scientists had look other alternatives natural products known be less detrimental contain useful bioactive compounds. The increasing understanding biological pharmacological significance carbohydrates has helped raise awareness their importance in living systems medicine, given they play numerous roles. For example, pectin been identified class secondary metabolites found medicinal plants may significant role management variety NCDs. Pectin is mainly made homogalacturonan, which linear polymer composed primarily D-galacturonic acid units (at least 65%) linked chain by α-(1,4)-glycosidic linkages. There also modified pectins derivatives improve pectin’s bioavailability. cell walls higher (pteridophytes, angiosperms, gymnosperms), particularly middle lamella plant material. Citrus used various industries. This article compiles information available years about therapeutic different modes extraction, chemistry pectin, potency its derivatives.
Language: Английский
Citations
7
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102389 - 102389
Published: June 19, 2024
Language: Английский
Citations
5
Pharmacological Research, Journal Year: 2023, Volume and Issue: 194, P. 106821 - 106821
Published: June 16, 2023
The essential oil of the resinous exudate from Pistacia lentiscus Chios namely Mastiha Essential Oil (CMEO), is a natural volatile rich in monoterpenes α-pinene, β-myrcene, β-pinene. In present randomized controlled trial, we investigated effects CMEO on individuals with abdominal obesity and metabolic abnormalities i.e., dyslipidemia, hypertension, insulin resistance. Eligible patients (N = 94) were randomly assigned to either intervention group, receiving capsules containing 200 mg daily for 3 months adjunct current treatment disorder(s), or control group. Anthropometric measurements, blood markers, quality life (QoL) assessed. Statistical analysis was performed an intention-to-treat basis. A significant improvement lipid profile, triglycerides (p 0.026) low-density lipoprotein 0.05) group versus controls observed. Systolic pressure alanine aminotransferase 0.022) significantly decreased only after intake. Alike, weight 0.02), while mean changes % body fat 0.005) visceral 0.045) different between groups post-intervention. Lower oxidized LDL 0.044) higher adiponectin 0.007) recorded QoL, as assessed by Short Form-12 questionnaire improved compared 0.041 Physical Composite Score, p 0.035 Mental Score). No adverse reported. An anti-obesity effect CMEO, probably attributed modulation inflammatory antioxidant processes, suggested. Conclusively, can be safe effective regulating abnormalities, treatment. (ClinicalTrials.gov. Metabolic Syndrome, ID Number: NCT04785573).
Language: Английский
Citations
12
The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: 12(1), P. 100004 - 100004
Published: Jan. 1, 2025
Alzheimer's disease is a complicated, multifaceted, neurodegenerative illness that places an increasing strain on healthcare systems. Due to malfunction and death of nerve cells, the person suffering from (AD) slowly steadily loses their memories, cognitive functions even personality. Although medications may temporarily enhance memory, there are currently no permanent therapies can halt or cure this irreversible process. Nonetheless, fast progress in comprehending cellular molecular abnormalities responsible for neuronal degeneration has increased confidence development viable prevention treatments. All FDA-approved anti-AD have merely symptomatic effects cannot illness. This necessitates pursuit alternate Accumulating data shows systemic neuroinflammation, oxidative stress associated mitochondrial dysfunction play crucial roles etiology AD precede its clinical presentation. Therefore, innovative therapeutic approaches targeting these pathophysiological components being explored aggressively present scenario. Phytochemicals such as resveratrol, curcumin, quercetin, genistein catechins prospective owing capacity alter key pathogenetic pathways, stress, dysfunction. The use new phytochemical delivery strategies would certainly provide possibility solve several issues with standard medicines. In review, phytophenolic compound-based treatment discussed.
Language: Английский
Citations
0
Journal of Agriculture and Food Research, Journal Year: 2025, Volume and Issue: unknown, P. 101779 - 101779
Published: Feb. 1, 2025
Language: Английский
Citations
0
Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)
Published: March 5, 2025
Language: Английский
Citations
0
Neurochemistry International, Journal Year: 2024, Volume and Issue: 180, P. 105868 - 105868
Published: Sept. 25, 2024
Language: Английский
Citations
3
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2023, Volume and Issue: 396(11), P. 2813 - 2830
Published: May 25, 2023
Language: Английский
Citations
8
Caspian Journal of Neurological Sciences, Journal Year: 2024, Volume and Issue: 10(1), P. 1 - 19
Published: Jan. 1, 2024
Monoterpenes and Diterpenes in Combating Alzheimer Disease, Mechanisms, Clinical Insights: A Comprehensive Review
Language: Английский
Citations
2
Life, Journal Year: 2023, Volume and Issue: 13(10), P. 2086 - 2086
Published: Oct. 20, 2023
The investigation of monoterpenes as natural products has gained significant attention in the search for new pharmacological agents due to their ability exhibit a wide range biological activities, including antifungal, antibacterial, antioxidant, anticancer, antispasmodic, hypotensive, and vasodilating properties. In vitro vivo studies reveal antidepressant, anxiolytic, memory-enhancing effects experimental dementia Parkinson’s disease. Chemical modification substances by conjugation with various synthetic components is modern method obtaining biologically active compounds. discovery potential drugs among monoterpene derivatives progressive avenue within pharmacology, offering promising approach therapy diverse pathological conditions. Biologically such monoterpenes, example, borneol, camphor, geraniol, pinene, thymol, are used synthesize compounds analgesic, anti-inflammatory, anticonvulsive, anti-Alzheimer’s, antiparkinsonian, antiviral antibacterial (antituberculosis) Myrtenal perspective monoterpenoid therapeutic fields medicine. Its chemical modifications often lead or more pronounced effects. As an myrtenal established pharmacophore adamantane enables augmentation several its pivotal Myrtenal–adamantane exhibited variety beneficial characteristics, antimicrobial, antiviral, neuroprotective properties, which worth examining detail at length.
Language: Английский
Citations
5