International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2692 - 2692
Published: March 17, 2025
Oxidative stress (OS) refers to a metabolic imbalance caused by the excessive production of reactive oxygen species (ROS) and an insufficient antioxidant defense [...]
Language: Английский
Food Chemistry X, Journal Year: 2024, Volume and Issue: 24, P. 101953 - 101953
Published: Nov. 2, 2024
Nanotechnology plays a pivotal role in food science, particularly the nanoencapsulation of bioactive compounds, to enhance their stability, bioavailability, and therapeutic potential. This review aims provide comprehensive analysis encapsulation emphasizing characteristics, applications, implications for human health. work offers detailed comparison polymers such as sodium alginate, gum Arabic, chitosan, cellulose, pectin, shellac, xanthan gum, while also examining both conventional emerging techniques, including freeze-drying, spray-drying, extrusion, coacervation, supercritical anti-solvent drying. The contribution this lies highlighting improving system controlling release rates, maintaining bioactivity under extreme conditions, reducing lipid oxidation. Furthermore, it explores recent technological advances aimed at optimizing processes targeted therapies functional foods. findings underline significant potential not only supplements foods but supportive medical treatments, showcasing its relevance health various contexts.
Language: Английский
Citations
32
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6023 - 6023
Published: May 30, 2024
Royal jelly (RJ) is a highly nutritious natural product with great potential for use in medicine, cosmetics, and as health-promoting food. This bee mixture of important compounds, such proteins, vitamins, lipids, minerals, hormones, neurotransmitters, flavonoids, polyphenols, that underlie the remarkable biological therapeutic activities RJ. Various bioactive molecules like 10-hydroxy-2-decenoic acid (10-HDA), antibacterial protein, apisin, major royal specific peptides apisimin, royalisin, royalactin, apidaecin, defensin-1, jelleins are characteristic ingredients RJ shows numerous physiological pharmacological properties, including vasodilatory, hypotensive, antihypercholesterolaemic, antidiabetic, immunomodulatory, anti-inflammatory, antioxidant, anti-aging, neuroprotective, antimicrobial, estrogenic, anti-allergic, anti-osteoporotic, anti-tumor effects. Moreover, may reduce menopause symptoms improve health reproductive system, liver, kidneys, promote wound healing. article provides an overview molecular mechanisms underlying beneficial effects various diseases, aging, aging-related complications, special emphasis on components their properties. The data presented should be incentive future clinical studies hopefully will advance our knowledge about facilitate development novel RJ-based opportunities improving human well-being.
Language: Английский
Citations
28
Biomedicines, Journal Year: 2023, Volume and Issue: 11(2), P. 259 - 259
Published: Jan. 18, 2023
Propolis is a mass of chemically diverse phytoconstituents with gummy textures that are naturally produced by honeybees upon collection plant resins for utilization in various life processes beehives. Since ancient times, propolis has been unique traditional remedy globally utilized several purposes, and it secured value pharmaceutical nutraceutical areas recent years. The chemical composition comprises constituents deviations the precise honeybee species, source used production bees, climate conditions harvesting season. Over 300 molecular structures have discovered from propolis, important classes include phenolic acids, flavonoids, terpenoids, benzofurans, benzopyrene chalcones. also reported to pharmacological activities, such as antidiabetic, anti-inflammatory, antioxidant, anticancer, immunomodulatory, antibacterial, antiviral, antifungal, anticaries. As chronic diseases risen global health threat, abundant research conducted track its alternative therapies diseases. Several clinical trials revealed potency preventing curing some This review explores beneficial effect active credible mechanisms computational studies on
Language: Английский
Citations
31
Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 428 - 428
Published: Feb. 9, 2023
Autophagy is a fundamental homeostatic process in which certain cellular components are ingested by double-membrane autophagosomes and then degraded to create energy or maintain homeostasis survival. It typically observed nutrient-deprived cells as survival mechanism. However, it has also been identified crucial maintaining disease progression. Normal metabolism produces reactive oxygen (ROS) nitrogen species at low levels. increased production causes oxidative stress, can lead diabetes, cardiovascular diseases, neurological disorders, cancer. was recently shown that redox equilibrium via autophagy critical for responses stress. little understood about the molecular cancer processes connect control of autophagy. In cells, oncogenic mutations, carcinogens, metabolic reprogramming cause ROS generation Recent studies have suggested activates pathways promote development metastasis. Moreover, relationship between programming involved malignant phenotype. Currently, while signaling events governing how affects cascades well understood, very known related this review, we focus on current knowledge modulation role further stress progression regulation. Therefore, review focuses understanding oxidation/reduction fine-tune help understand govern cancer, either leading cell death strategies
Language: Английский
Citations
25
Cells, Journal Year: 2024, Volume and Issue: 13(5), P. 390 - 390
Published: Feb. 24, 2024
Aging populations worldwide are placing age-related diseases at the forefront of research agenda. The therapeutic potential natural substances, especially propolis and its components, has led to these products being promising agents for alleviating several cellular molecular-level changes associated with diseases. With this in mind, scientists have introduced a contextual framework guide future aging research, called hallmarks aging. This encompasses various mechanisms including genomic instability, epigenetic changes, mitochondrial dysfunction, inflammation, impaired nutrient sensing, altered intercellular communication. Propolis, rich array bioactive compounds, functions as potent functional food, modulating metabolism, gut microbiota, immune response, offering significant health benefits. Studies emphasize propolis' properties, such antitumor, cardioprotective, neuroprotective effects, well ability mitigate oxidative stress, DNA damage, pathogenic bacteria growth. article underscores current scientific evidence supporting role controlling molecular characteristics linked hallmarks, hypothesizing geroscience research. aim is discover novel strategies improve quality life older individuals, addressing existing deficits perspectives area.
Language: Английский
Citations
12
Discover Food, Journal Year: 2025, Volume and Issue: 5(1)
Published: Feb. 7, 2025
Language: Английский
Citations
2
Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13
Published: Oct. 7, 2022
Melatonin is an important endogenous hormone that modulates homeostasis in the microenvironment. Recent studies have indicated serum melatonin levels are closely associated with occurrence and development of osteoporosis postmenopausal women. Exogenous could also improve bone mass increase skeletal strength. To determine underlying mechanisms prevention treatment osteoporosis, we performed this review to analyze role metabolism according its physiological functions. Serum related mass, measurement which a potential method for diagnosis osteoporosis. has direct effect on remodeling by promoting osteogenesis suppressing osteoclastogenesis. regulates biological rhythm tissue, benefits osteogenic effect. Additionally, participates modulation attenuates damage induced oxidative stress inflammation osteoblasts prevents osteolysis from reactive oxygen species inflammatory factors. As alternative drug can gut ecology, remodel microbiota composition, regulate substance absorption maintain metabolic balance, all beneficial health structure. In conclusion, our systematically demonstrates effects metabolism. Based evidence review, will play more diagnosis,
Language: Английский
Citations
33
Molecules, Journal Year: 2022, Volume and Issue: 27(19), P. 6694 - 6694
Published: Oct. 8, 2022
The incidence of allergic diseases and their complications are increasing worldwide. Today, people increasingly use natural products, which has been termed a “return to nature”. Natural products with healing properties, especially those obtained from plants bees, have used in the prevention treatment numerous chronic diseases, including allergy and/or inflammation. Propolis is multi-component resin rich flavonoids, collected transformed by honeybees buds plant wounds for construction adaptation nests. This article describes current views regarding possible mechanisms multiple benefits flavonoids combating allergy-related complications. These arise flavonoid anti-allergic, anti-inflammatory, antioxidative, wound activities effects on microbe-immune system interactions developing host responses different allergens. Finally, this presents various aspects pathobiology molecular approaches treatment. Possible antiallergic action propolis microbiota digestive respiratory tracts skin as method selectively remove allergenic molecules process bacterial biotransformation also reported.
Language: Английский
Citations
31
Toxics, Journal Year: 2023, Volume and Issue: 11(2), P. 135 - 135
Published: Jan. 30, 2023
Autophagy is an evolutionarily conserved cellular system crucial for homeostasis that protects cells from a broad range of internal and extracellular stresses. decreases metabolic load toxicity by removing damaged components. Environmental contaminants, particularly industrial substances, can influence autophagic flux enhancing it as protective response, preventing it, or converting its function into pro-cell death mechanism. toxic materials are also notorious their tendency to bioaccumulate induce pathophysiological vulnerability. Many environmental pollutants have been found stress which increases autophagy. Increasing autophagy was recently shown improve resistance reduce genetic damage. Moreover, suppressing depleting resources either toxicity, depending on the circumstances. The essential process selective utilized mammalian in order eliminate particulate matter, nanoparticles, metals, smoke exposure without inflicting damage cytosolic cigarette aging chief causes chronic obstructive pulmonary disease (COPD)-emphysema; however, disease’s molecular mechanism poorly known. Therefore, understanding impacts via offers new approaches risk assessment, protection, preventative actions will counter harmful effects contaminants human animal health.
Language: Английский
Citations
23
Discover Sustainability, Journal Year: 2024, Volume and Issue: 5(1)
Published: Aug. 8, 2024
Abstract This review explores the therapeutic potential of propolis, a natural resin produced by bees, analyzing recent literature spanning from 2005 to 2023. Various databases including Google Scholar, Web Science, Science Direct, PubMed, SCOPUS, and WoS were searched uncover findings. Propolis exhibits diverse array pharmacological properties, antimicrobial, anti-inflammatory, antioxidant, immunomodulatory, wound-healing effects. It shows promise in treating respiratory infections, oral diseases, gastrointestinal disorders, skin conditions. Additionally, research suggests its as an anticancer agent. The also investigates efficacy propolis addressing antiviral, antibacterial, metabolic disorders (diabetes), reproductive disorder (PCOS), cardiovascular hepatotoxicity, wound healing properties propolis. Hence, could emerge remedy with significant for enhancing healthcare outcomes.
Language: Английский
Citations
9